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Protein

Ribosomal biogenesis protein LAS1L

Gene

LAS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • maturation of 5.8S rRNA Source: GO_Central
  • maturation of LSU-rRNA Source: GO_Central
  • rRNA processing Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosomal biogenesis protein LAS1L
Alternative name(s):
Protein LAS1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAS1L
ORF Names:MSTP060
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000001497.16

Human Gene Nomenclature Database

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HGNCi
HGNC:25726 LAS1L

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300964 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y4W2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Wilson-Turner X-linked mental retardation syndrome (WTS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurologic disorder characterized by severe intellectual disability, dysmorphic facial features, hypogonadism, short stature, and truncal obesity. Affected females have a milder phenotype than affected males.
See also OMIM:309585
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077824269A → G in WTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_077825415R → W in WTS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057518699Ensembl.1

Keywords - Diseasei

Disease mutation, Mental retardation, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
81887

MalaCards human disease database

More...
MalaCardsi
LAS1L
MIMi309585 phenotype

Open Targets

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OpenTargetsi
ENSG00000001497

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
404521 Spinal muscular atrophy with respiratory distress type 2
3459 Wilson-Turner syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA128394732

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LAS1L

Domain mapping of disease mutations (DMDM)

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DMDMi
73920837

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115591 – 734Ribosomal biogenesis protein LAS1LAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei441PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y4W2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y4W2

PeptideAtlas

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PeptideAtlasi
Q9Y4W2

PRoteomics IDEntifications database

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PRIDEi
Q9Y4W2

ProteomicsDB human proteome resource

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ProteomicsDBi
86250
86251 [Q9Y4W2-2]
86252 [Q9Y4W2-3]
86253 [Q9Y4W2-4]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
Q9Y4W2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y4W2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y4W2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000001497 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_LAS1L

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y4W2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y4W2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044431
HPA061463

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123620, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y4W2

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9Y4W2

Protein interaction database and analysis system

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IntActi
Q9Y4W2, 36 interactors

Molecular INTeraction database

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MINTi
Q9Y4W2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000363944

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y4W2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAS1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2425 Eukaryota
ENOG411230Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000014785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000232090

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080556

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y4W2

KEGG Orthology (KO)

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KOi
K16912

Identification of Orthologs from Complete Genome Data

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OMAi
DPKSHKN

Database of Orthologous Groups

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OrthoDBi
EOG091G04XI

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y4W2

TreeFam database of animal gene trees

More...
TreeFami
TF314042

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007174 Las1

The PANTHER Classification System

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PANTHERi
PTHR15002 PTHR15002, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04031 Las1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4W2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWESGAGPG LGSQGMDLVW SAWYGKCVKG KGSLPLSAHG IVVAWLSRAE
60 70 80 90 100
WDQVTVYLFC DDHKLQRYAL NRITVWRSRS GNELPLAVAS TADLIRCKLL
110 120 130 140 150
DVTGGLGTDE LRLLYGMALV RFVNLISERK TKFAKVPLKC LAQEVNIPDW
160 170 180 190 200
IVDLRHELTH KKMPHINDCR RGCYFVLDWL QKTYWCRQLE NSLRETWELE
210 220 230 240 250
EFREGIEEED QEEDKNIVVD DITEQKPEPQ DDGKSTESDV KADGDSKGSE
260 270 280 290 300
EVDSHCKKAL SHKELYERAR ELLVSYEEEQ FTVLEKFRYL PKAIKAWNNP
310 320 330 340 350
SPRVECVLAE LKGVTCENRE AVLDAFLDDG FLVPTFEQLA ALQIEYEDGQ
360 370 380 390 400
TEVQRGEGTD PKSHKNVDLN DVLVPKPFSQ FWQPLLRGLH SQNFTQALLE
410 420 430 440 450
RMLSELPALG ISGIRPTYIL RWTVELIVAN TKTGRNARRF SAGQWEARRG
460 470 480 490 500
WRLFNCSASL DWPRMVESCL GSPCWASPQL LRIIFKAMGQ GLPDEEQEKL
510 520 530 540 550
LRICSIYTQS GENSLVQEGS EASPIGKSPY TLDSLYWSVK PASSSFGSEA
560 570 580 590 600
KAQQQEEQGS VNDVKEEEKE EKEVLPDQVE EEEENDDQEE EEEDEDDEDD
610 620 630 640 650
EEEDRMEVGP FSTGQESPTA ENARLLAQKR GALQGSAWQV SSEDVRWDTF
660 670 680 690 700
PLGRMPGQTE DPAELMLENY DTMYLLDQPV LEQRLEPSTC KTDTLGLSCG
710 720 730
VGSGNCSNSS SSNFEGLLWS QGQLHGLKTG LQLF
Length:734
Mass (Da):83,065
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA35CC38F95C39F7D
GO
Isoform 2 (identifier: Q9Y4W2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-365: DGQTEVQRGEGTDPKSHK → E

Show »
Length:717
Mass (Da):81,243
Checksum:i651B7F0FFB3FD07F
GO
Isoform 3 (identifier: Q9Y4W2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-120: Missing.
     348-365: DGQTEVQRGEGTDPKSHK → E

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:675
Mass (Da):76,845
Checksum:iEC904EABA17F0028
GO
Isoform 4 (identifier: Q9Y4W2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-291: VLEKFRYLP → GGCAGCFSG
     292-734: Missing.

Show »
Length:291
Mass (Da):33,108
Checksum:i500B863F92E96866
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNF7R4GNF7_HUMAN
Ribosomal biogenesis protein LAS1L
LAS1L
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB84913 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036587170R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1371889606Ensembl.1
Natural variantiVAR_077824269A → G in WTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_077825415R → W in WTS; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057518699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01517879 – 120Missing in isoform 3. CuratedAdd BLAST42
Alternative sequenceiVSP_015179283 – 291VLEKFRYLP → GGCAGCFSG in isoform 4. 1 Publication9
Alternative sequenceiVSP_015180292 – 734Missing in isoform 4. 1 PublicationAdd BLAST443
Alternative sequenceiVSP_015181348 – 365DGQTE…PKSHK → E in isoform 2 and isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF116730 mRNA Translation: AAO15306.1
AK074087 mRNA Translation: BAB84913.1 Different initiation.
AK022587 mRNA Translation: BAB14114.1
AL050306 Genomic DNA No translation available.
BC014545 mRNA Translation: AAH14545.1
BC018610 mRNA Translation: AAH18610.1
BC019302 mRNA Translation: AAH19302.1
DQ323624 mRNA Translation: ABD39127.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14381.1 [Q9Y4W2-1]
CCDS55433.1 [Q9Y4W2-3]
CCDS55434.1 [Q9Y4W2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001164120.1, NM_001170649.1 [Q9Y4W2-2]
NP_001164121.1, NM_001170650.1 [Q9Y4W2-3]
NP_112483.1, NM_031206.4 [Q9Y4W2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.522675

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374804; ENSP00000363937; ENSG00000001497 [Q9Y4W2-3]
ENST00000374807; ENSP00000363940; ENSG00000001497 [Q9Y4W2-2]
ENST00000374811; ENSP00000363944; ENSG00000001497 [Q9Y4W2-1]
ENST00000484069; ENSP00000473471; ENSG00000001497 [Q9Y4W2-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81887

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81887

UCSC genome browser

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UCSCi
uc004dwa.3 human [Q9Y4W2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116730 mRNA Translation: AAO15306.1
AK074087 mRNA Translation: BAB84913.1 Different initiation.
AK022587 mRNA Translation: BAB14114.1
AL050306 Genomic DNA No translation available.
BC014545 mRNA Translation: AAH14545.1
BC018610 mRNA Translation: AAH18610.1
BC019302 mRNA Translation: AAH19302.1
DQ323624 mRNA Translation: ABD39127.1
CCDSiCCDS14381.1 [Q9Y4W2-1]
CCDS55433.1 [Q9Y4W2-3]
CCDS55434.1 [Q9Y4W2-2]
RefSeqiNP_001164120.1, NM_001170649.1 [Q9Y4W2-2]
NP_001164121.1, NM_001170650.1 [Q9Y4W2-3]
NP_112483.1, NM_031206.4 [Q9Y4W2-1]
UniGeneiHs.522675

3D structure databases

ProteinModelPortaliQ9Y4W2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123620, 37 interactors
CORUMiQ9Y4W2
ELMiQ9Y4W2
IntActiQ9Y4W2, 36 interactors
MINTiQ9Y4W2
STRINGi9606.ENSP00000363944

PTM databases

iPTMnetiQ9Y4W2
PhosphoSitePlusiQ9Y4W2

Polymorphism and mutation databases

BioMutaiLAS1L
DMDMi73920837

2D gel databases

SWISS-2DPAGEiQ9Y4W2

Proteomic databases

EPDiQ9Y4W2
PaxDbiQ9Y4W2
PeptideAtlasiQ9Y4W2
PRIDEiQ9Y4W2
ProteomicsDBi86250
86251 [Q9Y4W2-2]
86252 [Q9Y4W2-3]
86253 [Q9Y4W2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374804; ENSP00000363937; ENSG00000001497 [Q9Y4W2-3]
ENST00000374807; ENSP00000363940; ENSG00000001497 [Q9Y4W2-2]
ENST00000374811; ENSP00000363944; ENSG00000001497 [Q9Y4W2-1]
ENST00000484069; ENSP00000473471; ENSG00000001497 [Q9Y4W2-4]
GeneIDi81887
KEGGihsa:81887
UCSCiuc004dwa.3 human [Q9Y4W2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81887
DisGeNETi81887
EuPathDBiHostDB:ENSG00000001497.16

GeneCards: human genes, protein and diseases

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GeneCardsi
LAS1L
HGNCiHGNC:25726 LAS1L
HPAiHPA044431
HPA061463
MalaCardsiLAS1L
MIMi300964 gene
309585 phenotype
neXtProtiNX_Q9Y4W2
OpenTargetsiENSG00000001497
Orphaneti404521 Spinal muscular atrophy with respiratory distress type 2
3459 Wilson-Turner syndrome
PharmGKBiPA128394732

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2425 Eukaryota
ENOG411230Q LUCA
GeneTreeiENSGT00390000014785
HOGENOMiHOG000232090
HOVERGENiHBG080556
InParanoidiQ9Y4W2
KOiK16912
OMAiDPKSHKN
OrthoDBiEOG091G04XI
PhylomeDBiQ9Y4W2
TreeFamiTF314042

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LAS1L human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
LAS1L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81887

Protein Ontology

More...
PROi
PR:Q9Y4W2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000001497 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_LAS1L
ExpressionAtlasiQ9Y4W2 baseline and differential
GenevisibleiQ9Y4W2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007174 Las1
PANTHERiPTHR15002 PTHR15002, 2 hits
PfamiView protein in Pfam
PF04031 Las1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAS1L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4W2
Secondary accession number(s): A9X410
, Q5JXQ0, Q8TEN5, Q9H9V5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: December 5, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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