Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 149 (16 Oct 2019)
Sequence version 2 (18 Mar 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tubulin monoglycylase TTLL3

Gene

TTLL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei334ATPBy similarity1
Binding sitei336ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi321 – 324ATP bindingBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tubulin monoglycylase TTLL3 (EC:6.3.2.-)
Alternative name(s):
HOTTL
Tubulin--tyrosine ligase-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTLL3
ORF Names:PRO0207
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24483 TTLL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4R7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi469E → G: Abolishes monoglycylase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
26140

Open Targets

More...
OpenTargetsi
ENSG00000214021

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134942870

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y4R7

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00277 Theophylline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTLL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046606

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124411 – 772Tubulin monoglycylase TTLL3Add BLAST772

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4R7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y4R7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4R7

PeptideAtlas

More...
PeptideAtlasi
Q9Y4R7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4R7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86244 [Q9Y4R7-1]
86245 [Q9Y4R7-2]
86246 [Q9Y4R7-5]
86247 [Q9Y4R7-6]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9Y4R7-5 [Q9Y4R7-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4R7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4R7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y4R7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214021 Expressed in 182 organ(s), highest expression level in right uterine tube

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4R7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4R7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051413

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117575, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4R7, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000392549

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4R7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini151 – 510TTLPROSITE-ProRule annotationAdd BLAST360

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2157 Eukaryota
ENOG410XQDM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154857

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4R7

KEGG Orthology (KO)

More...
KOi
K16608

Database of Orthologous Groups

More...
OrthoDBi
1137333at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4R7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027753 TTLL3

The PANTHER Classification System

More...
PANTHERi
PTHR45870:SF1 PTHR45870:SF1, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03133 TTL, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51221 TTL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRLRNAKIY VERAVKQKKI FTIQGCYPVI RCLLRRRGWV EKKMVHRSGP
60 70 80 90 100
TLLPPQKDLD SSAMGDSDTT EDEDEDEDEE FQPSQLFDFD DLLKFDDLDG
110 120 130 140 150
THALMVGLCL NLRNLPWFDE VDANSFFPRC YCLGAEDDKK AFIEDFWLTA
160 170 180 190 200
ARNVLKLVVK SEWKSYPIQA VEEEASGDKQ PKKQEKNPVL VSPEFVDEAL
210 220 230 240 250
CACEEYLSNL AHMDIDKDLE APLYLTPEGW SLFLQRYYQV VHEGAELRHL
260 270 280 290 300
DTQVQRCEDI LQQLQAVVPQ IDMEGDRNIW IVKPGAKSRG RGIMCMDHLE
310 320 330 340 350
EMLKLVNGNP VVMKDGKWVV QKYIERPLLI FGTKFDLRQW FLVTDWNPLT
360 370 380 390 400
VWFYRDSYIR FSTQPFSLKN LDNSVHLCNN SIQKHLENSC HRHPLLPPDN
410 420 430 440 450
MWSSQRFQAH LQEMGAPNAW STIIVPGMKD AVIHALQTSQ DTVQCRKASF
460 470 480 490 500
ELYGADFVFG EDFQPWLIEI NASPTMAPST AVTARLCAGV QADTLRVVID
510 520 530 540 550
RMLDRNCDTG AFELIYKQPA VEVPQYVGIR LLVEGFTIKK PMAMCHRRMG
560 570 580 590 600
VRPAVPLLTQ RGSGEARHHF PSLHTKAQLP SPHVLRHQGQ VLRRQHSKLV
610 620 630 640 650
GTKALSTTGK ALRTLPTAKV FISLPPNLDF KVAPSILKPR KAPALLCLRG
660 670 680 690 700
PQLEVPCCLC PLKSEQFLAP VGRSRPKANS RPDCDKPRAE ACPMKRLSPL
710 720 730 740 750
KPLPLVGTFQ RRRGLGDMKL GKPLLRFPTA LVLDPTPNKK KQVKYLGLDS
760 770
IAVGGSRVDG ARPCTPGSTA RA
Note: No experimental confirmation available.
Length:772
Mass (Da):87,414
Last modified:March 18, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC89074C5E98E15C1
GO
Isoform 2 (identifier: Q9Y4R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.
     520-564: AVEVPQYVGI...VPLLTQRGSG → VTTSPASTPR...LRPCRPQARP
     565-772: Missing.

Show »
Length:352
Mass (Da):40,356
Checksum:i49FD8E8118C7C20D
GO
Isoform 3 (identifier: Q9Y4R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.
     642-646: APALL → VGLDL
     647-772: Missing.

Show »
Length:434
Mass (Da):49,408
Checksum:i39E4CFA6D8650ACD
GO
Isoform 4 (identifier: Q9Y4R7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.
     520-564: AVEVPQYVGI...VPLLTQRGSG → VTTSPASTPR...LRPCRPQARP
     565-772: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):33,305
Checksum:iA39195EC06EF0A97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQB2J3KQB2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
915Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ30C9JQ30_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGZ6E5RGZ6_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKU2C9JKU2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNK2C9JNK2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNK7C9JNK7_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRM2C9JRM2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWZ9C9JWZ9_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZU0C9IZU0_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JW59C9JW59_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279I → F in AAF23353 (Ref. 5) Curated1
Isoform 2 (identifier: Q9Y4R7-2)
Sequence conflicti317R → G in CAH10554 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052410174E → K. Corresponds to variant dbSNP:rs3806669Ensembl.1
Natural variantiVAR_052411418N → H. Corresponds to variant dbSNP:rs2290302Ensembl.1
Natural variantiVAR_036054454G → S in a colorectal cancer sample, abolishes monoglycylase activity; somatic mutation. 2 Publications1
Natural variantiVAR_036055476M → I in a colorectal cancer sample, abolishes monoglycylase activity; somatic mutation. 2 Publications1
Natural variantiVAR_020207502M → R3 PublicationsCorresponds to variant dbSNP:rs2290305Ensembl.1
Natural variantiVAR_052412689A → T. Corresponds to variant dbSNP:rs1057278Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0325671 – 272Missing in isoform 4. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_0325681 – 212Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST212
Alternative sequenceiVSP_032572520 – 564AVEVP…QRGSG → VTTSPASTPRPSCLLPMYSD TRARSSDDSTASWWALRPCR PQARP in isoform 2 and isoform 4. 3 PublicationsAdd BLAST45
Alternative sequenceiVSP_032573565 – 772Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST208
Alternative sequenceiVSP_032576642 – 646APALL → VGLDL in isoform 3. 2 Publications5
Alternative sequenceiVSP_032577647 – 772Missing in isoform 3. 2 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL096725 mRNA Translation: CAB46375.1
AL833939 mRNA Translation: CAD38794.1
BX648175 mRNA Translation: CAH10554.1
AC022382 Genomic DNA No translation available.
BC098298 mRNA Translation: AAH98298.1
BC098361 mRNA Translation: AAH98361.1
BC099735 mRNA Translation: AAH99735.1
BC105638 mRNA Translation: AAI05639.1
AK023960 mRNA Translation: BAB14741.1
AF078842 mRNA Translation: AAF23353.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T12515

NCBI Reference Sequences

More...
RefSeqi
NP_001021100.3, NM_001025930.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383827; ENSP00000373338; ENSG00000214021 [Q9Y4R7-2]
ENST00000430793; ENSP00000403874; ENSG00000214021 [Q9Y4R7-5]
ENST00000438141; ENSP00000409246; ENSG00000214021 [Q9Y4R7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26140

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26140

UCSC genome browser

More...
UCSCi
uc003bti.5 human [Q9Y4R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096725 mRNA Translation: CAB46375.1
AL833939 mRNA Translation: CAD38794.1
BX648175 mRNA Translation: CAH10554.1
AC022382 Genomic DNA No translation available.
BC098298 mRNA Translation: AAH98298.1
BC098361 mRNA Translation: AAH98361.1
BC099735 mRNA Translation: AAH99735.1
BC105638 mRNA Translation: AAI05639.1
AK023960 mRNA Translation: BAB14741.1
AF078842 mRNA Translation: AAF23353.1
PIRiT12515
RefSeqiNP_001021100.3, NM_001025930.3

3D structure databases

SMRiQ9Y4R7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117575, 14 interactors
IntActiQ9Y4R7, 9 interactors
STRINGi9606.ENSP00000392549

Chemistry databases

DrugBankiDB00277 Theophylline

PTM databases

iPTMnetiQ9Y4R7
PhosphoSitePlusiQ9Y4R7
SwissPalmiQ9Y4R7

Polymorphism and mutation databases

BioMutaiTTLL3
DMDMi172046606

Proteomic databases

jPOSTiQ9Y4R7
MassIVEiQ9Y4R7
PaxDbiQ9Y4R7
PeptideAtlasiQ9Y4R7
PRIDEiQ9Y4R7
ProteomicsDBi86244 [Q9Y4R7-1]
86245 [Q9Y4R7-2]
86246 [Q9Y4R7-5]
86247 [Q9Y4R7-6]
TopDownProteomicsiQ9Y4R7-5 [Q9Y4R7-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
26140

Genome annotation databases

EnsembliENST00000383827; ENSP00000373338; ENSG00000214021 [Q9Y4R7-2]
ENST00000430793; ENSP00000403874; ENSG00000214021 [Q9Y4R7-5]
ENST00000438141; ENSP00000409246; ENSG00000214021 [Q9Y4R7-2]
GeneIDi26140
KEGGihsa:26140
UCSCiuc003bti.5 human [Q9Y4R7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26140
DisGeNETi26140

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTLL3
HGNCiHGNC:24483 TTLL3
HPAiHPA051413
neXtProtiNX_Q9Y4R7
OpenTargetsiENSG00000214021
PharmGKBiPA134942870

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00940000154857
InParanoidiQ9Y4R7
KOiK16608
OrthoDBi1137333at2759
PhylomeDBiQ9Y4R7

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTLL3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TTLL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26140
PharosiQ9Y4R7

Protein Ontology

More...
PROi
PR:Q9Y4R7

Gene expression databases

BgeeiENSG00000214021 Expressed in 182 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ9Y4R7 baseline and differential
GenevisibleiQ9Y4R7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027753 TTLL3
PANTHERiPTHR45870:SF1 PTHR45870:SF1, 3 hits
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTLL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4R7
Secondary accession number(s): Q4KMS8
, Q6AWA3, Q6ZU95, Q8NDN8, Q96GG8, Q9H876, Q9UI99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 18, 2008
Last modified: October 16, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again