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Protein

Tubulin monoglycylase TTLL3

Gene

TTLL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei334ATPBy similarity1
Binding sitei336ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi321 – 324ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin monoglycylase TTLL3 (EC:6.3.2.-)
Alternative name(s):
HOTTL
Tubulin--tyrosine ligase-like protein 3
Gene namesi
Name:TTLL3
ORF Names:PRO0207
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000214021.15
HGNCiHGNC:24483 TTLL3
neXtProtiNX_Q9Y4R7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi469E → G: Abolishes monoglycylase activity. 1 Publication1

Organism-specific databases

DisGeNETi26140
OpenTargetsiENSG00000214021
PharmGKBiPA134942870

Polymorphism and mutation databases

BioMutaiTTLL3
DMDMi172046606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124411 – 772Tubulin monoglycylase TTLL3Add BLAST772

Proteomic databases

PaxDbiQ9Y4R7
PeptideAtlasiQ9Y4R7
PRIDEiQ9Y4R7
ProteomicsDBi86244
86245 [Q9Y4R7-2]
86246 [Q9Y4R7-5]
86247 [Q9Y4R7-6]
TopDownProteomicsiQ9Y4R7-5 [Q9Y4R7-5]

PTM databases

iPTMnetiQ9Y4R7
PhosphoSitePlusiQ9Y4R7
SwissPalmiQ9Y4R7

Expressioni

Gene expression databases

BgeeiENSG00000214021 Expressed in 182 organ(s), highest expression level in right uterine tube
CleanExiHS_TTLL3
ExpressionAtlasiQ9Y4R7 baseline and differential
GenevisibleiQ9Y4R7 HS

Organism-specific databases

HPAiHPA051413

Interactioni

Protein-protein interaction databases

BioGridi117575, 14 interactors
IntActiQ9Y4R7, 2 interactors
STRINGi9606.ENSP00000392549

Structurei

3D structure databases

ProteinModelPortaliQ9Y4R7
SMRiQ9Y4R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 510TTLPROSITE-ProRule annotationAdd BLAST360

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00760000118951
HOVERGENiHBG069401
InParanoidiQ9Y4R7
KOiK16608
PhylomeDBiQ9Y4R7

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027753 TTLL3
PANTHERiPTHR12241:SF124 PTHR12241:SF124, 2 hits
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRLRNAKIY VERAVKQKKI FTIQGCYPVI RCLLRRRGWV EKKMVHRSGP
60 70 80 90 100
TLLPPQKDLD SSAMGDSDTT EDEDEDEDEE FQPSQLFDFD DLLKFDDLDG
110 120 130 140 150
THALMVGLCL NLRNLPWFDE VDANSFFPRC YCLGAEDDKK AFIEDFWLTA
160 170 180 190 200
ARNVLKLVVK SEWKSYPIQA VEEEASGDKQ PKKQEKNPVL VSPEFVDEAL
210 220 230 240 250
CACEEYLSNL AHMDIDKDLE APLYLTPEGW SLFLQRYYQV VHEGAELRHL
260 270 280 290 300
DTQVQRCEDI LQQLQAVVPQ IDMEGDRNIW IVKPGAKSRG RGIMCMDHLE
310 320 330 340 350
EMLKLVNGNP VVMKDGKWVV QKYIERPLLI FGTKFDLRQW FLVTDWNPLT
360 370 380 390 400
VWFYRDSYIR FSTQPFSLKN LDNSVHLCNN SIQKHLENSC HRHPLLPPDN
410 420 430 440 450
MWSSQRFQAH LQEMGAPNAW STIIVPGMKD AVIHALQTSQ DTVQCRKASF
460 470 480 490 500
ELYGADFVFG EDFQPWLIEI NASPTMAPST AVTARLCAGV QADTLRVVID
510 520 530 540 550
RMLDRNCDTG AFELIYKQPA VEVPQYVGIR LLVEGFTIKK PMAMCHRRMG
560 570 580 590 600
VRPAVPLLTQ RGSGEARHHF PSLHTKAQLP SPHVLRHQGQ VLRRQHSKLV
610 620 630 640 650
GTKALSTTGK ALRTLPTAKV FISLPPNLDF KVAPSILKPR KAPALLCLRG
660 670 680 690 700
PQLEVPCCLC PLKSEQFLAP VGRSRPKANS RPDCDKPRAE ACPMKRLSPL
710 720 730 740 750
KPLPLVGTFQ RRRGLGDMKL GKPLLRFPTA LVLDPTPNKK KQVKYLGLDS
760 770
IAVGGSRVDG ARPCTPGSTA RA
Note: No experimental confirmation available.
Length:772
Mass (Da):87,414
Last modified:March 18, 2008 - v2
Checksum:iC89074C5E98E15C1
GO
Isoform 2 (identifier: Q9Y4R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.
     520-564: AVEVPQYVGI...VPLLTQRGSG → VTTSPASTPR...LRPCRPQARP
     565-772: Missing.

Show »
Length:352
Mass (Da):40,356
Checksum:i49FD8E8118C7C20D
GO
Isoform 3 (identifier: Q9Y4R7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.
     642-646: APALL → VGLDL
     647-772: Missing.

Show »
Length:434
Mass (Da):49,408
Checksum:i39E4CFA6D8650ACD
GO
Isoform 4 (identifier: Q9Y4R7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.
     520-564: AVEVPQYVGI...VPLLTQRGSG → VTTSPASTPR...LRPCRPQARP
     565-772: Missing.

Note: No experimental confirmation available.
Show »
Length:292
Mass (Da):33,305
Checksum:iA39195EC06EF0A97
GO

Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQB2J3KQB2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
915Annotation score:
C9JSD3C9JSD3_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
326Annotation score:
H0Y5E3H0Y5E3_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
619Annotation score:
H3BLT7H3BLT7_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
520Annotation score:
E5RGZ6E5RGZ6_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
108Annotation score:
C9JQ30C9JQ30_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
160Annotation score:
C9JKU2C9JKU2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
189Annotation score:
C9JWZ9C9JWZ9_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
112Annotation score:
R4GMR7R4GMR7_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
181Annotation score:
C9JRM2C9JRM2_HUMAN
Tubulin monoglycylase TTLL3
TTLL3
115Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279I → F in AAF23353 (Ref. 5) Curated1
Isoform 2 (identifier: Q9Y4R7-2)
Sequence conflicti317R → G in CAH10554 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052410174E → K. Corresponds to variant dbSNP:rs3806669Ensembl.1
Natural variantiVAR_052411418N → H. Corresponds to variant dbSNP:rs2290302Ensembl.1
Natural variantiVAR_036054454G → S in a colorectal cancer sample, abolishes monoglycylase activity; somatic mutation. 2 Publications1
Natural variantiVAR_036055476M → I in a colorectal cancer sample, abolishes monoglycylase activity; somatic mutation. 2 Publications1
Natural variantiVAR_020207502M → R3 PublicationsCorresponds to variant dbSNP:rs2290305Ensembl.1
Natural variantiVAR_052412689A → T. Corresponds to variant dbSNP:rs1057278Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0325671 – 272Missing in isoform 4. 1 PublicationAdd BLAST272
Alternative sequenceiVSP_0325681 – 212Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST212
Alternative sequenceiVSP_032572520 – 564AVEVP…QRGSG → VTTSPASTPRPSCLLPMYSD TRARSSDDSTASWWALRPCR PQARP in isoform 2 and isoform 4. 3 PublicationsAdd BLAST45
Alternative sequenceiVSP_032573565 – 772Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST208
Alternative sequenceiVSP_032576642 – 646APALL → VGLDL in isoform 3. 2 Publications5
Alternative sequenceiVSP_032577647 – 772Missing in isoform 3. 2 PublicationsAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096725 mRNA Translation: CAB46375.1
AL833939 mRNA Translation: CAD38794.1
BX648175 mRNA Translation: CAH10554.1
AC022382 Genomic DNA No translation available.
BC098298 mRNA Translation: AAH98298.1
BC098361 mRNA Translation: AAH98361.1
BC099735 mRNA Translation: AAH99735.1
BC105638 mRNA Translation: AAI05639.1
AK023960 mRNA Translation: BAB14741.1
AF078842 mRNA Translation: AAF23353.1
PIRiT12515
RefSeqiNP_001021100.3, NM_001025930.3
UniGeneiHs.726435

Genome annotation databases

EnsembliENST00000383827; ENSP00000373338; ENSG00000214021 [Q9Y4R7-2]
ENST00000430793; ENSP00000403874; ENSG00000214021 [Q9Y4R7-5]
ENST00000438141; ENSP00000409246; ENSG00000214021 [Q9Y4R7-2]
GeneIDi26140
KEGGihsa:26140
UCSCiuc003bti.5 human [Q9Y4R7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096725 mRNA Translation: CAB46375.1
AL833939 mRNA Translation: CAD38794.1
BX648175 mRNA Translation: CAH10554.1
AC022382 Genomic DNA No translation available.
BC098298 mRNA Translation: AAH98298.1
BC098361 mRNA Translation: AAH98361.1
BC099735 mRNA Translation: AAH99735.1
BC105638 mRNA Translation: AAI05639.1
AK023960 mRNA Translation: BAB14741.1
AF078842 mRNA Translation: AAF23353.1
PIRiT12515
RefSeqiNP_001021100.3, NM_001025930.3
UniGeneiHs.726435

3D structure databases

ProteinModelPortaliQ9Y4R7
SMRiQ9Y4R7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117575, 14 interactors
IntActiQ9Y4R7, 2 interactors
STRINGi9606.ENSP00000392549

PTM databases

iPTMnetiQ9Y4R7
PhosphoSitePlusiQ9Y4R7
SwissPalmiQ9Y4R7

Polymorphism and mutation databases

BioMutaiTTLL3
DMDMi172046606

Proteomic databases

PaxDbiQ9Y4R7
PeptideAtlasiQ9Y4R7
PRIDEiQ9Y4R7
ProteomicsDBi86244
86245 [Q9Y4R7-2]
86246 [Q9Y4R7-5]
86247 [Q9Y4R7-6]
TopDownProteomicsiQ9Y4R7-5 [Q9Y4R7-5]

Protocols and materials databases

DNASUi26140
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383827; ENSP00000373338; ENSG00000214021 [Q9Y4R7-2]
ENST00000430793; ENSP00000403874; ENSG00000214021 [Q9Y4R7-5]
ENST00000438141; ENSP00000409246; ENSG00000214021 [Q9Y4R7-2]
GeneIDi26140
KEGGihsa:26140
UCSCiuc003bti.5 human [Q9Y4R7-1]

Organism-specific databases

CTDi26140
DisGeNETi26140
EuPathDBiHostDB:ENSG00000214021.15
GeneCardsiTTLL3
H-InvDBiHIX0003033
HIX0033847
HGNCiHGNC:24483 TTLL3
HPAiHPA051413
neXtProtiNX_Q9Y4R7
OpenTargetsiENSG00000214021
PharmGKBiPA134942870
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2157 Eukaryota
ENOG410XQDM LUCA
GeneTreeiENSGT00760000118951
HOVERGENiHBG069401
InParanoidiQ9Y4R7
KOiK16608
PhylomeDBiQ9Y4R7

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Miscellaneous databases

GeneWikiiTTLL3
GenomeRNAii26140
PROiPR:Q9Y4R7

Gene expression databases

BgeeiENSG00000214021 Expressed in 182 organ(s), highest expression level in right uterine tube
CleanExiHS_TTLL3
ExpressionAtlasiQ9Y4R7 baseline and differential
GenevisibleiQ9Y4R7 HS

Family and domain databases

InterProiView protein in InterPro
IPR004344 TTL/TTLL_fam
IPR027753 TTLL3
PANTHERiPTHR12241:SF124 PTHR12241:SF124, 2 hits
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTLL3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4R7
Secondary accession number(s): Q4KMS8
, Q6AWA3, Q6ZU95, Q8NDN8, Q96GG8, Q9H876, Q9UI99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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