Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 171 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

WD repeat domain phosphoinositide-interacting protein 2

Gene

WIPI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066).3 Publications
Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y4P8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1632852, Macroautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y4P8

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y4P8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 2
Short name:
WIPI-2
Alternative name(s):
WIPI49-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WIPI2
ORF Names:CGI-50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000157954.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32225, WIPI2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609225, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4P8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intellectual developmental disorder with short stature and variable skeletal anomalies (IDDSSA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by severe mental retardation, speech and language impairment, developmental delay, and cardiac, thyroid and skeletal abnormalities. Skeletal features include short stature, camptodactyly, fifth finger clinodactyly, thumb hypoplasia, overlapping toes, and kyphosis or lumbar vertebral abnormalities.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082589249V → M in IDDSSA; altered autophagosome assembly shown in patient cells. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi126R → E: Impairs interaction with ATG16L1. 1 Publication1
Mutagenesisi143R → E: Decreasess interaction with ATG16L1. 1 Publication1
Mutagenesisi242R → T: Impairs preautophagosomal localization; when associated with T-243. 1 Publication1
Mutagenesisi243R → T: Impairs preautophagosomal localization; when associated with T-242. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
26100

MalaCards human disease database

More...
MalaCardsi
WIPI2
MIMi618453, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000157954

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670576

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y4P8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WIPI2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514401 – 454WD repeat domain phosphoinositide-interacting protein 2Add BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4P8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4P8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y4P8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4P8

PeptideAtlas

More...
PeptideAtlasi
Q9Y4P8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4P8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86236 [Q9Y4P8-1]
86237 [Q9Y4P8-2]
86238 [Q9Y4P8-3]
86239 [Q9Y4P8-4]
86240 [Q9Y4P8-5]
86241 [Q9Y4P8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is repressed by ZKSCAN3.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000157954, Expressed in middle temporal gyrus and 254 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4P8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4P8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000157954, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TECPR1 (PubMed:21575909).

Interacts with ATG16L1 (PubMed:24954904, PubMed:28561066).

Interacts with ATG5 (PubMed:24954904).

Interacts with WIPI1 (PubMed:28561066).

Interacts with WDR45 (PubMed:28561066). May interact with NUDC (PubMed:28561066).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117550, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4P8, 45 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000288828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y4P8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4P8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati15 – 60WD 1Sequence analysisAdd BLAST46
Repeati67 – 104WD 2Sequence analysisAdd BLAST38
Repeati110 – 142WD 3Sequence analysisAdd BLAST33
Repeati149 – 189WD 4Sequence analysisAdd BLAST41
Repeati193 – 232WD 5Sequence analysisAdd BLAST40
Repeati238 – 277WD 6Sequence analysisAdd BLAST40
Repeati320 – 359WD 7Sequence analysisAdd BLAST40

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi241 – 244FRRG motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FRRG motif is required for recruitment to PtdIns3P.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2110, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155537

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025895_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4P8

KEGG Orthology (KO)

More...
KOi
K17908

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRMCAIT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4P8

TreeFam database of animal gene trees

More...
TreeFami
TF314879

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
IPR032911, WIPI2

The PANTHER Classification System

More...
PANTHERi
PTHR11227:SF27, PTHR11227:SF27, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y4P8-1) [UniParc]FASTAAdd to basket
Also known as: WIPI-2 alpha, WIPI2a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK
60 70 80 90 100
SGYKFFSLSS VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK
110 120 130 140 150
VCHFKKGTEI CNYSYSNTIL AVKLNRQRLI VCLEESLYIH NIRDMKVLHT
160 170 180 190 200
IRETPPNPAG LCALSINNDN CYLAYPGSAT IGEVQVFDTI NLRAANMIPA
210 220 230 240 250
HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE FRRGVKRCVS
260 270 280 290 300
ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM
310 320 330 340 350
ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA
360 370 380 390 400
DGYLYMYNLD PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY
410 420 430 440 450
GAAAGKGTYV PSSPTRLAYT DDLGAVGGAC LEDEASALRL DEDSEHPPMI

LRTD
Length:454
Mass (Da):49,408
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB69CEC399B56F35C
GO
Isoform 2 (identifier: Q9Y4P8-2) [UniParc]FASTAAdd to basket
Also known as: WIPI-2 beta, WIPI2d

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.
     407-417: Missing.

Show »
Length:425
Mass (Da):46,384
Checksum:i5FD85B554CA97F41
GO
Isoform 3 (identifier: Q9Y4P8-3) [UniParc]FASTAAdd to basket
Also known as: WIPI2e

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.
     60-71: SVDKLEQIYECT → MFTHVLPFVISA
     407-417: Missing.

Show »
Length:384
Mass (Da):42,077
Checksum:iE4C83CA999C10460
GO
Isoform 4 (identifier: Q9Y4P8-4) [UniParc]FASTAAdd to basket
Also known as: WIPI2b

The sequence of this isoform differs from the canonical sequence as follows:
     26-43: Missing.

Show »
Length:436
Mass (Da):47,543
Checksum:i0266FEC9E5338877
GO
Isoform 5 (identifier: Q9Y4P8-5) [UniParc]FASTAAdd to basket
Also known as: WIPI-2 delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MNLASQSGEA...DKLEQIYECT → MLLRLQRIKT...THVLPFVISA
     407-417: Missing.

Show »
Length:438
Mass (Da):48,251
Checksum:iD9F056ACE602F833
GO
Isoform 6 (identifier: Q9Y4P8-6) [UniParc]FASTAAdd to basket
Also known as: WIPI2c

The sequence of this isoform differs from the canonical sequence as follows:
     407-417: Missing.

Show »
Length:443
Mass (Da):48,249
Checksum:iA07814F3A3C402A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139I → T in CAG38561 (PubMed:15602573).Curated1
Sequence conflicti165S → P in AAV80761 (PubMed:15602573).Curated1
Sequence conflicti380E → K in AAD34045 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082589249V → M in IDDSSA; altered autophagosome assembly shown in patient cells. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0169711 – 71MNLAS…IYECT → MLLRLQRIKTLRPPGCPHPM TTCSAGTLSAVPCVSPRQVF VFERRFCLWHSHVEMFTHVL PFVISA in isoform 5. 2 PublicationsAdd BLAST71
Alternative sequenceiVSP_0169701 – 59Missing in isoform 3. CuratedAdd BLAST59
Alternative sequenceiVSP_01697226 – 43Missing in isoform 2 and isoform 4. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_01697360 – 71SVDKL…IYECT → MFTHVLPFVISA in isoform 3. CuratedAdd BLAST12
Alternative sequenceiVSP_016974407 – 417Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY691425 mRNA Translation: AAV80761.1
AY691426 mRNA Translation: AAV80762.1
AF151808 mRNA Translation: AAD34045.1
AL080155 mRNA Translation: CAB45746.1
CR533530 mRNA Translation: CAG38561.1
AK024279 mRNA Translation: BAG51284.1
AC093376 Genomic DNA Translation: AAQ96865.1
AC093376 Genomic DNA Translation: AAQ96866.1
AC093376 Genomic DNA Translation: AAQ96867.1
CH471144 Genomic DNA Translation: EAW87328.1
BC004116 mRNA Translation: AAH04116.1
BC007596 mRNA Translation: AAH07596.1
BC021068 mRNA No translation available.
BC021200 mRNA Translation: AAH21200.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34593.1 [Q9Y4P8-4]
CCDS47531.1 [Q9Y4P8-6]
CCDS47532.1 [Q9Y4P8-2]
CCDS47533.1 [Q9Y4P8-3]
CCDS5339.1 [Q9Y4P8-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12539

NCBI Reference Sequences

More...
RefSeqi
NP_001028690.1, NM_001033518.1 [Q9Y4P8-6]
NP_001028691.1, NM_001033519.1 [Q9Y4P8-2]
NP_001028692.1, NM_001033520.1 [Q9Y4P8-3]
NP_001265228.1, NM_001278299.1
NP_056425.1, NM_015610.3 [Q9Y4P8-1]
NP_057087.2, NM_016003.3 [Q9Y4P8-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000288828; ENSP00000288828; ENSG00000157954 [Q9Y4P8-1]
ENST00000382384; ENSP00000371821; ENSG00000157954 [Q9Y4P8-2]
ENST00000401525; ENSP00000384945; ENSG00000157954 [Q9Y4P8-4]
ENST00000404704; ENSP00000385297; ENSG00000157954 [Q9Y4P8-6]
ENST00000484262; ENSP00000429654; ENSG00000157954 [Q9Y4P8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26100

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:26100

UCSC genome browser

More...
UCSCi
uc003snv.4, human [Q9Y4P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691425 mRNA Translation: AAV80761.1
AY691426 mRNA Translation: AAV80762.1
AF151808 mRNA Translation: AAD34045.1
AL080155 mRNA Translation: CAB45746.1
CR533530 mRNA Translation: CAG38561.1
AK024279 mRNA Translation: BAG51284.1
AC093376 Genomic DNA Translation: AAQ96865.1
AC093376 Genomic DNA Translation: AAQ96866.1
AC093376 Genomic DNA Translation: AAQ96867.1
CH471144 Genomic DNA Translation: EAW87328.1
BC004116 mRNA Translation: AAH04116.1
BC007596 mRNA Translation: AAH07596.1
BC021068 mRNA No translation available.
BC021200 mRNA Translation: AAH21200.1
CCDSiCCDS34593.1 [Q9Y4P8-4]
CCDS47531.1 [Q9Y4P8-6]
CCDS47532.1 [Q9Y4P8-2]
CCDS47533.1 [Q9Y4P8-3]
CCDS5339.1 [Q9Y4P8-1]
PIRiT12539
RefSeqiNP_001028690.1, NM_001033518.1 [Q9Y4P8-6]
NP_001028691.1, NM_001033519.1 [Q9Y4P8-2]
NP_001028692.1, NM_001033520.1 [Q9Y4P8-3]
NP_001265228.1, NM_001278299.1
NP_056425.1, NM_015610.3 [Q9Y4P8-1]
NP_057087.2, NM_016003.3 [Q9Y4P8-4]

3D structure databases

SMRiQ9Y4P8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117550, 58 interactors
IntActiQ9Y4P8, 45 interactors
STRINGi9606.ENSP00000288828

PTM databases

iPTMnetiQ9Y4P8
PhosphoSitePlusiQ9Y4P8

Polymorphism and mutation databases

BioMutaiWIPI2
DMDMi74762063

Proteomic databases

EPDiQ9Y4P8
jPOSTiQ9Y4P8
MassIVEiQ9Y4P8
PaxDbiQ9Y4P8
PeptideAtlasiQ9Y4P8
PRIDEiQ9Y4P8
ProteomicsDBi86236 [Q9Y4P8-1]
86237 [Q9Y4P8-2]
86238 [Q9Y4P8-3]
86239 [Q9Y4P8-4]
86240 [Q9Y4P8-5]
86241 [Q9Y4P8-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
11278, 315 antibodies

The DNASU plasmid repository

More...
DNASUi
26100

Genome annotation databases

EnsembliENST00000288828; ENSP00000288828; ENSG00000157954 [Q9Y4P8-1]
ENST00000382384; ENSP00000371821; ENSG00000157954 [Q9Y4P8-2]
ENST00000401525; ENSP00000384945; ENSG00000157954 [Q9Y4P8-4]
ENST00000404704; ENSP00000385297; ENSG00000157954 [Q9Y4P8-6]
ENST00000484262; ENSP00000429654; ENSG00000157954 [Q9Y4P8-3]
GeneIDi26100
KEGGihsa:26100
UCSCiuc003snv.4, human [Q9Y4P8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26100
DisGeNETi26100
EuPathDBiHostDB:ENSG00000157954.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WIPI2
HGNCiHGNC:32225, WIPI2
HPAiENSG00000157954, Low tissue specificity
MalaCardsiWIPI2
MIMi609225, gene
618453, phenotype
neXtProtiNX_Q9Y4P8
OpenTargetsiENSG00000157954
PharmGKBiPA142670576

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2110, Eukaryota
GeneTreeiENSGT00940000155537
HOGENOMiCLU_025895_1_1_1
InParanoidiQ9Y4P8
KOiK17908
OMAiRRMCAIT
PhylomeDBiQ9Y4P8
TreeFamiTF314879

Enzyme and pathway databases

PathwayCommonsiQ9Y4P8
ReactomeiR-HSA-1632852, Macroautophagy
SignaLinkiQ9Y4P8
SIGNORiQ9Y4P8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
26100, 17 hits in 882 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WIPI2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WIPI2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26100
PharosiQ9Y4P8, Tbio

Protein Ontology

More...
PROi
PR:Q9Y4P8
RNActiQ9Y4P8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000157954, Expressed in middle temporal gyrus and 254 other tissues
ExpressionAtlasiQ9Y4P8, baseline and differential
GenevisibleiQ9Y4P8, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
IPR032911, WIPI2
PANTHERiPTHR11227:SF27, PTHR11227:SF27, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 3 hits
SUPFAMiSSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWIPI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4P8
Secondary accession number(s): B3KNC2
, Q5MNZ8, Q6FI96, Q75L50, Q96IE4, Q9Y364
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again