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Protein

E3 ubiquitin-protein ligase RNF115

Gene

RNF115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.1 Publication2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 269RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Protein family/group databases

MoonDBiQ9Y4L5 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF115Curated (EC:2.3.2.271 Publication)
Alternative name(s):
RING finger protein 115Imported
RING-type E3 ubiquitin transferase RNF115Curated
Rabring 7By similarity
Zinc finger protein 3641 Publication
Gene namesi
Name:RNF115Imported
Synonyms:ZNF3641 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000265491.4
HGNCiHGNC:18154 RNF115
neXtProtiNX_Q9Y4L5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi26K → R: Loss of autoubiquitination; when associated with R-32. 1 Publication1
Mutagenesisi32K → R: Loss of autoubiquitination; when associated with R-26. 1 Publication1
Mutagenesisi228C → A: Loss of autoubiquitination. 1 Publication1
Mutagenesisi231C → A: Loss of autoubiquitination. 1 Publication1

Organism-specific databases

DisGeNETi27246
OpenTargetsiENSG00000265491
PharmGKBiPA162401519

Polymorphism and mutation databases

BioMutaiRNF115
DMDMi56405389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000563142 – 304E3 ubiquitin-protein ligase RNF115Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

RING-type zinc finger-dependent and E2-dependent autoubiquitination.2 Publications

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ9Y4L5
MaxQBiQ9Y4L5
PaxDbiQ9Y4L5
PeptideAtlasiQ9Y4L5
PRIDEiQ9Y4L5
ProteomicsDBi86228

PTM databases

iPTMnetiQ9Y4L5
PhosphoSitePlusiQ9Y4L5

Expressioni

Tissue specificityi

Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000265491 Expressed in 237 organ(s), highest expression level in gluteal muscle
CleanExiHS_RNF115
GenevisibleiQ9Y4L5 HS

Organism-specific databases

HPAiHPA019130

Interactioni

Subunit structurei

Interacts with RAB7A. Interacts with EGFR and FLT3.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi118094, 52 interactors
IntActiQ9Y4L5, 10 interactors
MINTiQ9Y4L5
STRINGi9606.ENSP00000358297

Structurei

3D structure databases

ProteinModelPortaliQ9Y4L5
SMRiQ9Y4L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 269RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00530000062967
HOGENOMiHOG000116417
HOVERGENiHBG059832
InParanoidiQ9Y4L5
KOiK11982
OMAiSSHPFSW
OrthoDBiEOG091G0SOO
PhylomeDBiQ9Y4L5
TreeFamiTF317985

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y4L5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEASAAGAD SGAAVAAHRF FCHFCKGEVS PKLPEYICPR CESGFIEEVT
60 70 80 90 100
DDSSFLGGGG SRIDNTTTTH FAELWGHLDH TMFFQDFRPF LSSSPLDQDN
110 120 130 140 150
RANERGHQTH TDFWGARPPR LPLGRRYRSR GSSRPDRSPA IEGILQHIFA
160 170 180 190 200
GFFANSAIPG SPHPFSWSGM LHSNPGDYAW GQTGLDAIVT QLLGQLENTG
210 220 230 240 250
PPPADKEKIT SLPTVTVTQE QVDMGLECPV CKEDYTVEEE VRQLPCNHFF
260 270 280 290 300
HSSCIVPWLE LHDTCPVCRK SLNGEDSTRQ SQSTEASASN RFSNDSQLHD

RWTF
Length:304
Mass (Da):33,703
Last modified:December 7, 2004 - v2
Checksum:i22F0C8FCC0F55045
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299H → N in CAB45280 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052105194G → R. Corresponds to variant dbSNP:rs11577731Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542552 mRNA Translation: AAQ09535.1
AF419857 mRNA Translation: AAP97292.1
AK290749 mRNA Translation: BAF83438.1
AL390725, AL160282 Genomic DNA Translation: CAI13717.1
CH471244 Genomic DNA Translation: EAW71437.1
BC054049 mRNA Translation: AAH54049.1
BC064903 mRNA Translation: AAH64903.1
AL079314 mRNA Translation: CAB45280.1
CCDSiCCDS72863.1
RefSeqiNP_055270.1, NM_014455.3
UniGeneiHs.523550

Genome annotation databases

EnsembliENST00000582693; ENSP00000463650; ENSG00000265491
GeneIDi27246
KEGGihsa:27246
UCSCiuc031utf.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF542552 mRNA Translation: AAQ09535.1
AF419857 mRNA Translation: AAP97292.1
AK290749 mRNA Translation: BAF83438.1
AL390725, AL160282 Genomic DNA Translation: CAI13717.1
CH471244 Genomic DNA Translation: EAW71437.1
BC054049 mRNA Translation: AAH54049.1
BC064903 mRNA Translation: AAH64903.1
AL079314 mRNA Translation: CAB45280.1
CCDSiCCDS72863.1
RefSeqiNP_055270.1, NM_014455.3
UniGeneiHs.523550

3D structure databases

ProteinModelPortaliQ9Y4L5
SMRiQ9Y4L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118094, 52 interactors
IntActiQ9Y4L5, 10 interactors
MINTiQ9Y4L5
STRINGi9606.ENSP00000358297

Protein family/group databases

MoonDBiQ9Y4L5 Predicted

PTM databases

iPTMnetiQ9Y4L5
PhosphoSitePlusiQ9Y4L5

Polymorphism and mutation databases

BioMutaiRNF115
DMDMi56405389

Proteomic databases

EPDiQ9Y4L5
MaxQBiQ9Y4L5
PaxDbiQ9Y4L5
PeptideAtlasiQ9Y4L5
PRIDEiQ9Y4L5
ProteomicsDBi86228

Protocols and materials databases

DNASUi27246
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000582693; ENSP00000463650; ENSG00000265491
GeneIDi27246
KEGGihsa:27246
UCSCiuc031utf.2 human

Organism-specific databases

CTDi27246
DisGeNETi27246
EuPathDBiHostDB:ENSG00000265491.4
GeneCardsiRNF115
HGNCiHGNC:18154 RNF115
HPAiHPA019130
neXtProtiNX_Q9Y4L5
OpenTargetsiENSG00000265491
PharmGKBiPA162401519
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00530000062967
HOGENOMiHOG000116417
HOVERGENiHBG059832
InParanoidiQ9Y4L5
KOiK11982
OMAiSSHPFSW
OrthoDBiEOG091G0SOO
PhylomeDBiQ9Y4L5
TreeFamiTF317985

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiRNF115 human
GeneWikiiZNF364
GenomeRNAii27246
PROiPR:Q9Y4L5

Gene expression databases

BgeeiENSG00000265491 Expressed in 237 organ(s), highest expression level in gluteal muscle
CleanExiHS_RNF115
GenevisibleiQ9Y4L5 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRN115_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4L5
Secondary accession number(s): A8K3Y4, Q5T2V9, Q7Z2J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: December 7, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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