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Protein

Hypoxia up-regulated protein 1

Gene

HYOU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chaperone binding Source: ParkinsonsUK-UCL

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-3000484 Scavenging by Class F Receptors
R-HSA-381038 XBP1(S) activates chaperone genes
SIGNORiQ9Y4L1

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia up-regulated protein 1
Alternative name(s):
150 kDa oxygen-regulated protein
Short name:
ORP-150
170 kDa glucose-regulated protein
Short name:
GRP-170
Gene namesi
Name:HYOU1
Synonyms:GRP170, ORP150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149428.18
HGNCiHGNC:16931 HYOU1
MIMi601746 gene
neXtProtiNX_Q9Y4L1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi10525
OpenTargetsiENSG00000149428
PharmGKBiPA38427

Chemistry databases

ChEMBLiCHEMBL2216741

Polymorphism and mutation databases

BioMutaiHYOU1
DMDMi10720185

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Combined sourcesAdd BLAST32
ChainiPRO_000001353833 – 999Hypoxia up-regulated protein 1Add BLAST967

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi155N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi515N-linked (GlcNAc...) asparagine5 Publications1
Modified residuei567PhosphoserineCombined sources1
Glycosylationi596N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi830N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi862N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi869N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei883N6-acetyllysineBy similarity1
Glycosylationi922N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi931N-linked (GlcNAc...) asparagine3 Publications1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y4L1
PaxDbiQ9Y4L1
PeptideAtlasiQ9Y4L1
PRIDEiQ9Y4L1
ProteomicsDBi86227

2D gel databases

REPRODUCTION-2DPAGEiIPI00000877

PTM databases

CarbonylDBiQ9Y4L1
GlyConnecti1383
iPTMnetiQ9Y4L1
PhosphoSitePlusiQ9Y4L1
SwissPalmiQ9Y4L1

Miscellaneous databases

PMAP-CutDBiQ9Y4L1

Expressioni

Tissue specificityi

Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

Inductioni

By hypoxia and also by 2-deoxyglucose or tunicamycin.

Gene expression databases

BgeeiENSG00000149428 Expressed in 230 organ(s), highest expression level in islet of Langerhans
CleanExiHS_HYOU1
ExpressionAtlasiQ9Y4L1 baseline and differential
GenevisibleiQ9Y4L1 HS

Organism-specific databases

HPAiHPA049296

Interactioni

Subunit structurei

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115780, 117 interactors
IntActiQ9Y4L1, 46 interactors
MINTiQ9Y4L1
STRINGi9606.ENSP00000384144

Structurei

3D structure databases

ProteinModelPortaliQ9Y4L1
SMRiQ9Y4L1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi996 – 999Prevents secretion from ERSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 606Poly-Glu4
Compositional biasi636 – 641Poly-Pro6

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ9Y4L1
KOiK09486
OMAiRSLKHNK
OrthoDBiEOG091G025X
PhylomeDBiQ9Y4L1
TreeFamiTF105048

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV
60 70 80 90 100
KPGVPMEIVL NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF
110 120 130 140 150
QHLLGKQADN PHVALYQARF PEHELTFDPQ RQTVHFQISS QLQFSPEEVL
160 170 180 190 200
GMVLNYSRSL AEDFAEQPIK DAVITVPVFF NQAERRAVLQ AARMAGLKVL
210 220 230 240 250
QLINDNTATA LSYGVFRRKD INTTAQNIMF YDMGSGSTVC TIVTYQMVKT
260 270 280 290 300
KEAGMQPQLQ IRGVGFDRTL GGLEMELRLR ERLAGLFNEQ RKGQRAKDVR
310 320 330 340 350
ENPRAMAKLL REANRLKTVL SANADHMAQI EGLMDDVDFK AKVTRVEFEE
360 370 380 390 400
LCADLFERVP GPVQQALQSA EMSLDEIEQV ILVGGATRVP RVQEVLLKAV
410 420 430 440 450
GKEELGKNIN ADEAAAMGAV YQAAALSKAF KVKPFVVRDA VVYPILVEFT
460 470 480 490 500
REVEEEPGIH SLKHNKRVLF SRMGPYPQRK VITFNRYSHD FNFHINYGDL
510 520 530 540 550
GFLGPEDLRV FGSQNLTTVK LKGVGDSFKK YPDYESKGIK AHFNLDESGV
560 570 580 590 600
LSLDRVESVF ETLVEDSAEE ESTLTKLGNT ISSLFGGGTT PDAKENGTDT
610 620 630 640 650
VQEEEESPAE GSKDEPGEQV ELKEEAEAPV EDGSQPPPPE PKGDATPEGE
660 670 680 690 700
KATEKENGDK SEAQKPSEKA EAGPEGVAPA PEGEKKQKPA RKRRMVEEIG
710 720 730 740 750
VELVVLDLPD LPEDKLAQSV QKLQDLTLRD LEKQEREKAA NSLEAFIFET
760 770 780 790 800
QDKLYQPEYQ EVSTEEQREE ISGKLSAAST WLEDEGVGAT TVMLKEKLAE
810 820 830 840 850
LRKLCQGLFF RVEERKKWPE RLSALDNLLN HSSMFLKGAR LIPEMDQIFT
860 870 880 890 900
EVEMTTLEKV INETWAWKNA TLAEQAKLPA TEKPVLLSKD IEAKMMALDR
910 920 930 940 950
EVQYLLNKAK FTKPRPRPKD KNGTRAEPPL NASASDQGEK VIPPAGQTED
960 970 980 990
AEPISEPEKV ETGSEPGDTE PLELGGPGAE PEQKEQSTGQ KRPLKNDEL
Length:999
Mass (Da):111,335
Last modified:November 1, 1999 - v1
Checksum:iFCE0F292466AFAB9
GO
Isoform 2 (identifier: Q9Y4L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     603-646: EEEESPAEGS...PPPEPKGDAT → MLFLCPARLP...RARPAWRLCS
     647-999: Missing.

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,757
Checksum:i007EDC619EE8FBD0
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QL06J3QL06_HUMAN
Hypoxia up-regulated protein 1
HYOU1
211Annotation score:
E9PJ21E9PJ21_HUMAN
Hypoxia up-regulated protein 1
HYOU1
656Annotation score:
A0A087X054A0A087X054_HUMAN
Hypoxia up-regulated protein 1
HYOU1
937Annotation score:
J3KTF1J3KTF1_HUMAN
Hypoxia up-regulated protein 1
HYOU1
224Annotation score:
K7EQK2K7EQK2_HUMAN
Hypoxia up-regulated protein 1
HYOU1
678Annotation score:
A0A087WWI4A0A087WWI4_HUMAN
Hypoxia up-regulated protein 1
HYOU1
677Annotation score:
J3QQH7J3QQH7_HUMAN
Hypoxia up-regulated protein 1
HYOU1
149Annotation score:
J3QLE9J3QLE9_HUMAN
Hypoxia up-regulated protein 1
HYOU1
154Annotation score:
Q9BST8Q9BST8_HUMAN
HYOU1 protein
HYOU1
147Annotation score:
A0A087WW13A0A087WW13_HUMAN
Hypoxia up-regulated protein 1
HYOU1
102Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75K → E in BAD96476 (Ref. 5) Curated1
Sequence conflicti92N → D in BAD96476 (Ref. 5) Curated1
Sequence conflicti255M → T in BAD96476 (Ref. 5) Curated1
Sequence conflicti442V → A in BAD96476 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563641 – 87Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_056365603 – 646EEEES…KGDAT → MLFLCPARLPQSKQAIDRFH TAVTCMEPPWGRRCRARPAW RLCS in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_056366647 – 999Missing in isoform 2. 1 PublicationAdd BLAST353

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65785 mRNA Translation: AAC50947.1
AB009979 Genomic DNA Translation: BAF80348.1
DQ350134 mRNA Translation: ABC75106.1
DQ372932 mRNA Translation: ABD14370.1
AK304264 mRNA Translation: BAH14145.1
AK314178 mRNA Translation: BAG36860.1
AK222756 mRNA Translation: BAD96476.1
EF444986 Genomic DNA Translation: ACA06002.1
AP003392 Genomic DNA No translation available.
CCDSiCCDS8408.1 [Q9Y4L1-1]
PIRiJC5278
RefSeqiNP_001124463.1, NM_001130991.2 [Q9Y4L1-1]
NP_006380.1, NM_006389.4 [Q9Y4L1-1]
XP_016872585.1, XM_017017096.1 [Q9Y4L1-1]
XP_016872586.1, XM_017017097.1 [Q9Y4L1-1]
UniGeneiHs.277704

Genome annotation databases

EnsembliENST00000617285; ENSP00000480150; ENSG00000149428 [Q9Y4L1-1]
ENST00000630669; ENSP00000486825; ENSG00000280682 [Q9Y4L1-1]
GeneIDi10525
KEGGihsa:10525
UCSCiuc031yhc.2 human [Q9Y4L1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65785 mRNA Translation: AAC50947.1
AB009979 Genomic DNA Translation: BAF80348.1
DQ350134 mRNA Translation: ABC75106.1
DQ372932 mRNA Translation: ABD14370.1
AK304264 mRNA Translation: BAH14145.1
AK314178 mRNA Translation: BAG36860.1
AK222756 mRNA Translation: BAD96476.1
EF444986 Genomic DNA Translation: ACA06002.1
AP003392 Genomic DNA No translation available.
CCDSiCCDS8408.1 [Q9Y4L1-1]
PIRiJC5278
RefSeqiNP_001124463.1, NM_001130991.2 [Q9Y4L1-1]
NP_006380.1, NM_006389.4 [Q9Y4L1-1]
XP_016872585.1, XM_017017096.1 [Q9Y4L1-1]
XP_016872586.1, XM_017017097.1 [Q9Y4L1-1]
UniGeneiHs.277704

3D structure databases

ProteinModelPortaliQ9Y4L1
SMRiQ9Y4L1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115780, 117 interactors
IntActiQ9Y4L1, 46 interactors
MINTiQ9Y4L1
STRINGi9606.ENSP00000384144

Chemistry databases

ChEMBLiCHEMBL2216741

PTM databases

CarbonylDBiQ9Y4L1
GlyConnecti1383
iPTMnetiQ9Y4L1
PhosphoSitePlusiQ9Y4L1
SwissPalmiQ9Y4L1

Polymorphism and mutation databases

BioMutaiHYOU1
DMDMi10720185

2D gel databases

REPRODUCTION-2DPAGEiIPI00000877

Proteomic databases

EPDiQ9Y4L1
PaxDbiQ9Y4L1
PeptideAtlasiQ9Y4L1
PRIDEiQ9Y4L1
ProteomicsDBi86227

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000617285; ENSP00000480150; ENSG00000149428 [Q9Y4L1-1]
ENST00000630669; ENSP00000486825; ENSG00000280682 [Q9Y4L1-1]
GeneIDi10525
KEGGihsa:10525
UCSCiuc031yhc.2 human [Q9Y4L1-1]

Organism-specific databases

CTDi10525
DisGeNETi10525
EuPathDBiHostDB:ENSG00000149428.18
GeneCardsiHYOU1
HGNCiHGNC:16931 HYOU1
HPAiHPA049296
MIMi601746 gene
neXtProtiNX_Q9Y4L1
OpenTargetsiENSG00000149428
PharmGKBiPA38427
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919
HOGENOMiHOG000007865
HOVERGENiHBG106402
InParanoidiQ9Y4L1
KOiK09486
OMAiRSLKHNK
OrthoDBiEOG091G025X
PhylomeDBiQ9Y4L1
TreeFamiTF105048

Enzyme and pathway databases

ReactomeiR-HSA-3000484 Scavenging by Class F Receptors
R-HSA-381038 XBP1(S) activates chaperone genes
SIGNORiQ9Y4L1

Miscellaneous databases

ChiTaRSiHYOU1 human
GeneWikiiHYOU1
GenomeRNAii10525
PMAP-CutDBiQ9Y4L1
PROiPR:Q9Y4L1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149428 Expressed in 230 organ(s), highest expression level in islet of Langerhans
CleanExiHS_HYOU1
ExpressionAtlasiQ9Y4L1 baseline and differential
GenevisibleiQ9Y4L1 HS

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYOU1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4L1
Secondary accession number(s): A8C1Z0
, B7Z909, Q2I204, Q53H25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 179 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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