UniProtKB - Q9Y4K3 (TRAF6_HUMAN)
TNF receptor-associated factor 6
TRAF6
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 70 – 109 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 150 – 202 | TRAF-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 203 – 259 | TRAF-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: IntAct
- mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- thioesterase binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: MGI
- ubiquitin protein ligase activity Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-protein transferase activity Source: Reactome
- zinc ion binding Source: InterPro
GO - Biological processi
- activation of MAPK activity Source: Reactome
- activation of NF-kappaB-inducing kinase activity Source: UniProtKB
- activation of protein kinase activity Source: UniProtKB
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Ensembl
- bone resorption Source: Ensembl
- cell development Source: Ensembl
- cellular response to cytokine stimulus Source: ARUK-UCL
- cellular response to DNA damage stimulus Source: UniProtKB-KW
- cellular response to lipopolysaccharide Source: MGI
- Fc-epsilon receptor signaling pathway Source: Reactome
- I-kappaB kinase/NF-kappaB signaling Source: Reactome
- interleukin-1-mediated signaling pathway Source: GO_Central
- JNK cascade Source: Reactome
- membrane protein intracellular domain proteolysis Source: Reactome
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of apoptotic process Source: Reactome
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- neural tube closure Source: Ensembl
- nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
- odontogenesis of dentin-containing tooth Source: Ensembl
- ossification Source: UniProtKB-KW
- osteoclast differentiation Source: Ensembl
- positive regulation of apoptotic process Source: Reactome
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-12 production Source: Ensembl
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of JNK cascade Source: GO_Central
- positive regulation of JUN kinase activity Source: BHF-UCL
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: ARUK-UCL
- positive regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
- positive regulation of osteoclast differentiation Source: UniProtKB
- positive regulation of protein ubiquitination Source: BHF-UCL
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of T cell cytokine production Source: UniProtKB
- positive regulation of T cell proliferation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription regulatory region DNA binding Source: BHF-UCL
- protein autoubiquitination Source: UniProtKB
- protein deubiquitination Source: Reactome
- protein K63-linked ubiquitination Source: UniProtKB
- protein polyubiquitination Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- regulation of immunoglobulin secretion Source: Ensembl
- response to interleukin-1 Source: UniProtKB
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: UniProtKB
- T-helper 1 type immune response Source: Ensembl
- toll-like receptor 9 signaling pathway Source: Reactome
- toll-like receptor signaling pathway Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | DNA damage, Immunity, Osteogenesis, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4K3 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-209543, p75NTR recruits signalling complexes R-HSA-209560, NF-kB is activated and signals survival R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5689880, Ub-specific processing proteases R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702, Interleukin-1 signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937042, IRAK2 mediated activation of TAK1 complex R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9645460, Alpha-protein kinase 1 signaling pathway R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | Q9Y4K3 |
SIGNORi | Q9Y4K3 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q9Y4K3, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: TNF receptor-associated factor 6 (EC:2.3.2.27)Alternative name(s): E3 ubiquitin-protein ligase TRAF6 Interleukin-1 signal transducer RING finger protein 85 RING-type E3 ubiquitin transferase TRAF6Curated |
Gene namesi | Name:TRAF6 Synonyms:RNF85 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175104.14 |
HGNCi | HGNC:12036, TRAF6 |
MIMi | 602355, gene |
neXtProti | NX_Q9Y4K3 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
- cell cortex 1 Publication
- Lipid droplet By similarity
Note: Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).By similarity
Cytosol
- cytosol Source: Reactome
Endosome
- endosome membrane Source: Reactome
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- CD40 receptor complex Source: BHF-UCL
- cytoplasmic side of plasma membrane Source: BHF-UCL
- plasma membrane Source: UniProtKB
Other locations
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- lipid droplet Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 57 | D → K: Loss of interaction with UBE2N. 1 Publication | 1 | |
Mutagenesisi | 70 | C → A: Loss of ligase activity, autoubiquitination and signaling capacity. 2 Publications | 1 | |
Mutagenesisi | 72 | I → D: Loss of interaction with UBE2N. Has no effect on TRAF3IP2-mediated 'Lys-63'-linked polyubiquitination. 2 Publications | 1 | |
Mutagenesisi | 74 | L → E or K: Loss of interaction with UBE2N. 1 Publication | 1 | |
Mutagenesisi | 88 | R → A: Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis. Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis; when associated with A-122. 1 Publication | 1 | |
Mutagenesisi | 118 | F → A: Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis. 1 Publication | 1 | |
Mutagenesisi | 118 | F → W: Partially impaired polyubiquitin synthesis. 1 Publication | 1 | |
Mutagenesisi | 118 | F → Y: Partially impaired polyubiquitin synthesis. 1 Publication | 1 | |
Mutagenesisi | 122 | F → A: Loss of TRAF6 homodimerization and partially impaired polyubiquitin synthesis. Loss of TRAF6 homodimerization and impaired polyubiquitin synthesis; when associated with A-88. 1 Publication | 1 | |
Mutagenesisi | 124 | K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. Loss of TRAF3IP2-mediated 'Lys-63'-linked polyubiquitination. 4 Publications | 1 | |
Mutagenesisi | 142 | K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. 1 Publication | 1 | |
Mutagenesisi | 453 | K → R: Loss of SUMO1-modification and c-myb-mediated transcriptional repressive activation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7189 |
MalaCardsi | TRAF6 |
OpenTargetsi | ENSG00000175104 |
Orphaneti | 1810, Autosomal dominant hypohidrotic ectodermal dysplasia |
PharmGKBi | PA36713 |
Miscellaneous databases
Pharosi | Q9Y4K3, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3588728 |
Polymorphism and mutation databases
BioMutai | TRAF6 |
DMDMi | 30580642 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056407 | 1 – 522 | TNF receptor-associated factor 6Add BLAST | 522 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 124 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 124 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate2 Publications | ||
Cross-linki | 142 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Cross-linki | 453 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9Y4K3 |
jPOSTi | Q9Y4K3 |
MassIVEi | Q9Y4K3 |
MaxQBi | Q9Y4K3 |
PaxDbi | Q9Y4K3 |
PeptideAtlasi | Q9Y4K3 |
PRIDEi | Q9Y4K3 |
ProteomicsDBi | 86225 |
PTM databases
iPTMneti | Q9Y4K3 |
PhosphoSitePlusi | Q9Y4K3 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175104, Expressed in secondary oocyte and 187 other tissues |
Genevisiblei | Q9Y4K3, HS |
Organism-specific databases
HPAi | ENSG00000175104, Low tissue specificity |
Interactioni
Subunit structurei
Homotrimer. Homooligomer. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK2, IRAK3, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2.
Interacts with IL17R.
Interacts with SQSTM1 bridging NTRK1 and NGFR.
Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).
Interacts with PELI2 and PELI3. Binds UBE2V1.
Interacts with TAX1BP1.
Interacts with ZNF675.
Interacts with ARRB1 and ARRB2.
Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling.
Interacts with UBE2N.
Interacts with TGFBR1, HDAC1 and RANGAP1.
Interacts with AKT1, AKT2 and AKT3.
Interacts (via TRAF domains) with NUMBL (via C-terminal).
Interacts with RBCK1.
Interacts with LIMD1 (via LIM domains) (By similarity).
Interacts with RSAD2/viperin (By similarity).
Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity).
Interacts with ZFAND5.
Interacts with IL1RL1.
Interacts with TRAFD1.
Interacts with AJUBA.
Interacts with MAVS/IPS1.
Interacts (via TRAF domains) with DYNC2I2 (via WD domains).
Interacts with IFIT3 (via N-terminus).
Interacts with TICAM2.
Interacts with CARD14.
Interacts with CD40 and MAP3K8; the interaction is required for ERK activation (By similarity).
Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436).
Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989).
Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989).
Interacts with ZC3H12A; this interaction increases in response to DNA damage and is stimulated by TANK (PubMed:25861989).
Interacts with WDFY3 (By similarity).
Interacts with TRIM13 (PubMed:28087809).
Interacts with GPS2 (By similarity).
Interacts (via C-terminus) with SASH1 (PubMed:23776175).
Interacts with LRRC19 (PubMed:25026888).
Interacts with IL17RA AND TRAF3IP2.
By similarity6 PublicationsBinary interactionsi
Q9Y4K3
GO - Molecular functioni
- histone deacetylase binding Source: UniProtKB
- identical protein binding Source: IntAct
- mitogen-activated protein kinase kinase kinase binding Source: UniProtKB
- protein kinase B binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein N-terminus binding Source: UniProtKB
- thioesterase binding Source: UniProtKB
- tumor necrosis factor receptor binding Source: UniProtKB
- ubiquitin conjugating enzyme binding Source: MGI
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113041, 366 interactors |
CORUMi | Q9Y4K3 |
DIPi | DIP-27515N |
ELMi | Q9Y4K3 |
IntActi | Q9Y4K3, 121 interactors |
MINTi | Q9Y4K3 |
STRINGi | 9606.ENSP00000433623 |
Chemistry databases
BindingDBi | Q9Y4K3 |
Miscellaneous databases
RNActi | Q9Y4K3, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y4K3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y4K3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 350 – 499 | MATHPROSITE-ProRule annotationAdd BLAST | 150 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 354 | Interaction with TAX1BP11 PublicationAdd BLAST | 354 | |
Regioni | 355 – 522 | Interaction with TANK1 PublicationAdd BLAST | 168 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 288 – 348 | Sequence analysisAdd BLAST | 61 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 70 – 109 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 | |
Zinc fingeri | 150 – 202 | TRAF-type 1PROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 203 – 259 | TRAF-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00940000155426 |
HOGENOMi | CLU_021061_5_0_1 |
InParanoidi | Q9Y4K3 |
OMAi | ECAICID |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q9Y4K3 |
TreeFami | TF321154 |
Family and domain databases
CDDi | cd03776, MATH_TRAF6, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 3 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027139, TRAF6 IPR037309, TRAF6_MATH IPR041310, TRAF6_Z2 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF131, PTHR10131:SF131, 1 hit |
Pfami | View protein in Pfam PF18048, TRAF6_Z2, 1 hit PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49599, SSF49599, 3 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 2 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM
60 70 80 90 100
EEIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD
110 120 130 140 150
AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED
160 170 180 190 200
HQAHCEFALM DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAASMAFED
210 220 230 240 250
KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH
260 270 280 290 300
EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SVIPDSGYIS EVRNFQETIH
310 320 330 340 350
QLEGRLVRQD HQIRELTAKM ETQSMYVSEL KRTIRTLEDK VAEIEAQQCN
360 370 380 390 400
GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA
410 420 430 440 450
QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM
460 470 480 490 500
DAKPELLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS
510 520
TRFDMGSLRR EGFQPRSTDA GV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | S → F in AAH31052 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78798 mRNA Translation: AAB38751.1 AY228337 Genomic DNA Translation: AAO38054.1 AK292978 mRNA Translation: BAF85667.1 AC009656 Genomic DNA No translation available. AC061999 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68119.1 CH471064 Genomic DNA Translation: EAW68120.1 CH471064 Genomic DNA Translation: EAW68122.1 BC031052 mRNA Translation: AAH31052.1 |
CCDSi | CCDS7901.1 |
PIRi | S71821 |
RefSeqi | NP_004611.1, NM_004620.3 NP_665802.1, NM_145803.2 |
Genome annotation databases
Ensembli | ENST00000348124; ENSP00000337853; ENSG00000175104 ENST00000526995; ENSP00000433623; ENSG00000175104 |
GeneIDi | 7189 |
KEGGi | hsa:7189 |
UCSCi | uc001mwq.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78798 mRNA Translation: AAB38751.1 AY228337 Genomic DNA Translation: AAO38054.1 AK292978 mRNA Translation: BAF85667.1 AC009656 Genomic DNA No translation available. AC061999 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68119.1 CH471064 Genomic DNA Translation: EAW68120.1 CH471064 Genomic DNA Translation: EAW68122.1 BC031052 mRNA Translation: AAH31052.1 |
CCDSi | CCDS7901.1 |
PIRi | S71821 |
RefSeqi | NP_004611.1, NM_004620.3 NP_665802.1, NM_145803.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1LB4 | X-ray | 2.40 | A | 348-504 | [»] | |
1LB5 | X-ray | 2.40 | A | 347-504 | [»] | |
1LB6 | X-ray | 1.80 | A | 347-504 | [»] | |
2ECI | NMR | - | A | 50-128 | [»] | |
2JMD | NMR | - | A | 67-124 | [»] | |
3HCS | X-ray | 2.20 | A/B | 50-211 | [»] | |
3HCT | X-ray | 2.10 | A | 50-159 | [»] | |
3HCU | X-ray | 2.60 | A/C | 50-159 | [»] | |
4Z8M | X-ray | 2.95 | A/B | 346-504 | [»] | |
5ZUJ | X-ray | 2.60 | A | 350-501 | [»] | |
6A33 | X-ray | 2.10 | A | 350-501 | [»] | |
SMRi | Q9Y4K3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113041, 366 interactors |
CORUMi | Q9Y4K3 |
DIPi | DIP-27515N |
ELMi | Q9Y4K3 |
IntActi | Q9Y4K3, 121 interactors |
MINTi | Q9Y4K3 |
STRINGi | 9606.ENSP00000433623 |
Chemistry databases
BindingDBi | Q9Y4K3 |
ChEMBLi | CHEMBL3588728 |
Protein family/group databases
MoonDBi | Q9Y4K3, Predicted |
PTM databases
iPTMneti | Q9Y4K3 |
PhosphoSitePlusi | Q9Y4K3 |
Polymorphism and mutation databases
BioMutai | TRAF6 |
DMDMi | 30580642 |
Proteomic databases
EPDi | Q9Y4K3 |
jPOSTi | Q9Y4K3 |
MassIVEi | Q9Y4K3 |
MaxQBi | Q9Y4K3 |
PaxDbi | Q9Y4K3 |
PeptideAtlasi | Q9Y4K3 |
PRIDEi | Q9Y4K3 |
ProteomicsDBi | 86225 |
Protocols and materials databases
Antibodypediai | 3895, 528 antibodies |
DNASUi | 7189 |
Genome annotation databases
Ensembli | ENST00000348124; ENSP00000337853; ENSG00000175104 ENST00000526995; ENSP00000433623; ENSG00000175104 |
GeneIDi | 7189 |
KEGGi | hsa:7189 |
UCSCi | uc001mwq.3, human |
Organism-specific databases
CTDi | 7189 |
DisGeNETi | 7189 |
EuPathDBi | HostDB:ENSG00000175104.14 |
GeneCardsi | TRAF6 |
HGNCi | HGNC:12036, TRAF6 |
HPAi | ENSG00000175104, Low tissue specificity |
MalaCardsi | TRAF6 |
MIMi | 602355, gene |
neXtProti | NX_Q9Y4K3 |
OpenTargetsi | ENSG00000175104 |
Orphaneti | 1810, Autosomal dominant hypohidrotic ectodermal dysplasia |
PharmGKBi | PA36713 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0297, Eukaryota |
GeneTreei | ENSGT00940000155426 |
HOGENOMi | CLU_021061_5_0_1 |
InParanoidi | Q9Y4K3 |
OMAi | ECAICID |
OrthoDBi | 918518at2759 |
PhylomeDBi | Q9Y4K3 |
TreeFami | TF321154 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9Y4K3 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-168927, TICAM1, RIP1-mediated IKK complex recruitment R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-202424, Downstream TCR signaling R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-209543, p75NTR recruits signalling complexes R-HSA-209560, NF-kB is activated and signals survival R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5689880, Ub-specific processing proteases R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9014325, TICAM1,TRAF6-dependent induction of TAK1 complex R-HSA-9020702, Interleukin-1 signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-933542, TRAF6 mediated NF-kB activation R-HSA-937039, IRAK1 recruits IKK complex R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937042, IRAK2 mediated activation of TAK1 complex R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9645460, Alpha-protein kinase 1 signaling pathway R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | Q9Y4K3 |
SIGNORi | Q9Y4K3 |
Miscellaneous databases
BioGRID-ORCSi | 7189, 22 hits in 848 CRISPR screens |
ChiTaRSi | TRAF6, human |
EvolutionaryTracei | Q9Y4K3 |
GeneWikii | TRAF6 |
GenomeRNAii | 7189 |
Pharosi | Q9Y4K3, Tbio |
PROi | PR:Q9Y4K3 |
RNActi | Q9Y4K3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175104, Expressed in secondary oocyte and 187 other tissues |
Genevisiblei | Q9Y4K3, HS |
Family and domain databases
CDDi | cd03776, MATH_TRAF6, 1 hit |
Gene3Di | 2.60.210.10, 1 hit 3.30.40.10, 3 hits |
InterProi | View protein in InterPro IPR002083, MATH/TRAF_dom IPR043211, TNF_rcpt-assoc_TRAF IPR012227, TNF_rcpt-assoc_TRAF_met IPR008974, TRAF-like IPR027139, TRAF6 IPR037309, TRAF6_MATH IPR041310, TRAF6_Z2 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS IPR001293, Znf_TRAF |
PANTHERi | PTHR10131, PTHR10131, 1 hit PTHR10131:SF131, PTHR10131:SF131, 1 hit |
Pfami | View protein in Pfam PF18048, TRAF6_Z2, 1 hit PF02176, zf-TRAF, 1 hit |
PIRSFi | PIRSF015614, TRAF, 1 hit |
SMARTi | View protein in SMART SM00061, MATH, 1 hit SM00184, RING, 1 hit |
SUPFAMi | SSF49599, SSF49599, 3 hits |
PROSITEi | View protein in PROSITE PS50144, MATH, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit PS50145, ZF_TRAF, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAF6_HUMAN | |
Accessioni | Q9Y4K3Primary (citable) accession number: Q9Y4K3 Secondary accession number(s): A6NKI7 Q8NEH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 9, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 228 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM