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Protein

Beta/gamma crystallin domain-containing protein 1

Gene

CRYBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

GO - Molecular functioni

Keywordsi

LigandLectin

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13

Names & Taxonomyi

Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 1Imported
Alternative name(s):
Absent in melanoma 1 protein1 Publication
Gene namesi
Name:CRYBG1Imported
Synonyms:AIM11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112297.14
HGNCiHGNC:356 CRYBG1
MIMi601797 gene
neXtProtiNX_Q9Y4K1

Pathology & Biotechi

Organism-specific databases

DisGeNETi202
OpenTargetsiENSG00000112297
PharmGKBiPA24649

Polymorphism and mutation databases

BioMutaiAIM1
DMDMi76800646

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576091 – 1723Beta/gamma crystallin domain-containing protein 1Add BLAST1723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4K1
PaxDbiQ9Y4K1
PeptideAtlasiQ9Y4K1
PRIDEiQ9Y4K1
ProteomicsDBi86224

PTM databases

iPTMnetiQ9Y4K1
PhosphoSitePlusiQ9Y4K1
SwissPalmiQ9Y4K1

Expressioni

Gene expression databases

BgeeiENSG00000112297 Expressed in 190 organ(s), highest expression level in placenta
CleanExiHS_AIM1
ExpressionAtlasiQ9Y4K1 baseline and differential
GenevisibleiQ9Y4K1 HS

Organism-specific databases

HPAiCAB026378
HPA030948
HPA030949

Interactioni

Protein-protein interaction databases

BioGridi106705, 15 interactors
ELMiQ9Y4K1
IntActiQ9Y4K1, 4 interactors
STRINGi9606.ENSP00000358062

Structurei

Secondary structure

11723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y4K1
SMRiQ9Y4K1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y4K1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1022 – 1061Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini1062 – 1117Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST56
Domaini1123 – 1163Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini1164 – 1206Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini1218 – 1270Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST53
Domaini1271 – 1313Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini1319 – 1361Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST43
Domaini1362 – 1404Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST43
Domaini1415 – 1452Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST38
Domaini1453 – 1496Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST44
Domaini1502 – 1542Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST41
Domaini1543 – 1584Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST42
Domaini1586 – 1719Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IERF Eukaryota
ENOG4110BHM LUCA
GeneTreeiENSGT00670000097933
HOGENOMiHOG000033870
HOVERGENiHBG080825
InParanoidiQ9Y4K1
OrthoDBiEOG091G007H
PhylomeDBiQ9Y4K1
TreeFamiTF331078

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00030 Crystall, 6 hits
PF00652 Ricin_B_lectin, 1 hit
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits
SUPFAMiSSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231 RICIN_B_LECTIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS
60 70 80 90 100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP
110 120 130 140 150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE
160 170 180 190 200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG
210 220 230 240 250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL
260 270 280 290 300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS
310 320 330 340 350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE
360 370 380 390 400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK
410 420 430 440 450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT
460 470 480 490 500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH
510 520 530 540 550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR
560 570 580 590 600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE
610 620 630 640 650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT
660 670 680 690 700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF
710 720 730 740 750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT
760 770 780 790 800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN
810 820 830 840 850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP
860 870 880 890 900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS
910 920 930 940 950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE
960 970 980 990 1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG
1010 1020 1030 1040 1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS
1060 1070 1080 1090 1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE
1110 1120 1130 1140 1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF
1160 1170 1180 1190 1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG
1210 1220 1230 1240 1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE
1260 1270 1280 1290 1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG
1310 1320 1330 1340 1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY
1360 1370 1380 1390 1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV
1410 1420 1430 1440 1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV
1460 1470 1480 1490 1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS
1510 1520 1530 1540 1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY
1560 1570 1580 1590 1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF
1610 1620 1630 1640 1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS
1660 1670 1680 1690 1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN
1710 1720
HIILNTVSKE KFTQVWEAMV LYT
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
Checksum:iF4137765BCE039D5
GO
Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
     27-1207: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):61,007
Checksum:i9FA2DAABFE123CCB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWL0A0A0J9YWL0_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
2,131Annotation score:
Q96QW7Q96QW7_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
316Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055687267G → D. Corresponds to variant dbSNP:rs11968933Ensembl.1
Natural variantiVAR_055688293Q → P1 PublicationCorresponds to variant dbSNP:rs1159148Ensembl.1
Natural variantiVAR_055689491C → R. Corresponds to variant dbSNP:rs3747787Ensembl.1
Natural variantiVAR_0556901096L → V. Corresponds to variant dbSNP:rs1350902Ensembl.1
Natural variantiVAR_0556911196E → A1 PublicationCorresponds to variant dbSNP:rs783396Ensembl.1
Natural variantiVAR_0556921395C → Y1 PublicationCorresponds to variant dbSNP:rs2297970Ensembl.1
Natural variantiVAR_0556931445T → S. Corresponds to variant dbSNP:rs1676015Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565801 – 26MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_05658127 – 1207Missing in isoform 2. 1 PublicationAdd BLAST1181

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83116 Genomic DNA Translation: AAB53792.1
U83115 mRNA Translation: AAB53791.1
AK300443 mRNA Translation: BAG62166.1
AL359292 Genomic DNA No translation available.
AL390074 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48412.1
CCDSiCCDS34506.1 [Q9Y4K1-1]
RefSeqiNP_001615.2, NM_001624.3 [Q9Y4K1-1]
UniGeneiHs.724262
Hs.744905

Genome annotation databases

EnsembliENST00000369066; ENSP00000358062; ENSG00000112297 [Q9Y4K1-1]
GeneIDi202
KEGGihsa:202
UCSCiuc003prh.4 human [Q9Y4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCRBG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): B4DU04, O00296, Q5VWJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: September 12, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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