We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q9Y4K1 (CRBG1_HUMAN)
Protein
Beta/gamma crystallin domain-containing protein 1
Gene
CRYBG1
Organism
Homo sapiens (Human)
Status
Functioni
May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
Keywordsi
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4K1 |
SignaLinki | Q9Y4K1 |
Protein family/group databases
CAZyi | CBM13, Carbohydrate-Binding Module Family 13 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta/gamma crystallin domain-containing protein 1ImportedAlternative name(s): Absent in melanoma 1 protein1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:356, CRYBG1 |
MIMi | 601797, gene |
neXtProti | NX_Q9Y4K1 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 202 |
PharmGKBi | PA24649 |
Miscellaneous databases
Pharosi | Q9Y4K1, Tbio |
Genetic variation databases
BioMutai | CRYBG1 |
DMDMi | 76800646 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000057609 | 1 – 1723 | Beta/gamma crystallin domain-containing protein 1Add BLAST | 1723 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 75 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 348 | PhosphoserineCombined sources | 1 | |
Modified residuei | 484 | PhosphoserineCombined sources | 1 | |
Modified residuei | 525 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y4K1 |
jPOSTi | Q9Y4K1 |
MassIVEi | Q9Y4K1 |
MaxQBi | Q9Y4K1 |
PaxDbi | Q9Y4K1 |
PeptideAtlasi | Q9Y4K1 |
PRIDEi | Q9Y4K1 |
ProteomicsDBi | 5139 86224 [Q9Y4K1-1] |
PTM databases
GlyConnecti | 2023, 2 N-Linked glycans (1 site) |
GlyGeni | Q9Y4K1, 3 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (2 sites) |
iPTMneti | Q9Y4K1 |
PhosphoSitePlusi | Q9Y4K1 |
SwissPalmi | Q9Y4K1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112297, Expressed in placenta and 202 other tissues |
ExpressionAtlasi | Q9Y4K1, baseline and differential |
Genevisiblei | Q9Y4K1, HS |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106705, 67 interactors |
ELMi | Q9Y4K1 |
IntActi | Q9Y4K1, 17 interactors |
STRINGi | 9606.ENSP00000358062 |
Miscellaneous databases
RNActi | Q9Y4K1, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y4K1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y4K1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1022 – 1061 | Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 1062 – 1117 | Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 1123 – 1163 | Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 1164 – 1206 | Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1218 – 1270 | Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 1271 – 1313 | Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1319 – 1361 | Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1362 – 1404 | Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 1415 – 1452 | Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST | 38 | |
Domaini | 1453 – 1496 | Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 1502 – 1542 | Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 1543 – 1584 | Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST | 42 | |
Domaini | 1586 – 1719 | Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 266 | DisorderedSequence analysisAdd BLAST | 266 | |
Regioni | 280 – 299 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 315 – 383 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 429 – 481 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 518 – 539 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 633 – 693 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 863 – 894 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 908 – 940 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 172 – 197 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 248 – 266 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 359 – 379 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 447 – 467 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 633 – 691 | Polar residuesSequence analysisAdd BLAST | 59 | |
Compositional biasi | 922 – 940 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the beta/gamma-crystallin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QUA4, Eukaryota |
HOGENOMi | CLU_002648_0_0_1 |
InParanoidi | Q9Y4K1 |
OMAi | WEAMVLT |
PhylomeDBi | Q9Y4K1 |
TreeFami | TF331078 |
Family and domain databases
CDDi | cd00161, RICIN, 1 hit |
InterProi | View protein in InterPro IPR001064, Beta/gamma_crystallin IPR011024, G_crystallin-like IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00030, Crystall, 6 hits PF00652, Ricin_B_lectin, 1 hit |
PRINTSi | PR01367, BGCRYSTALLIN |
SMARTi | View protein in SMART SM00458, RICIN, 1 hit SM00247, XTALbg, 6 hits |
SUPFAMi | SSF49695, SSF49695, 3 hits SSF50370, SSF50370, 1 hit |
PROSITEi | View protein in PROSITE PS50915, CRYSTALLIN_BETA_GAMMA, 12 hits PS50231, RICIN_B_LECTIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS
60 70 80 90 100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP
110 120 130 140 150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE
160 170 180 190 200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG
210 220 230 240 250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL
260 270 280 290 300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS
310 320 330 340 350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE
360 370 380 390 400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK
410 420 430 440 450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT
460 470 480 490 500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH
510 520 530 540 550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR
560 570 580 590 600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE
610 620 630 640 650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT
660 670 680 690 700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF
710 720 730 740 750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT
760 770 780 790 800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN
810 820 830 840 850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP
860 870 880 890 900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS
910 920 930 940 950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE
960 970 980 990 1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG
1010 1020 1030 1040 1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS
1060 1070 1080 1090 1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE
1110 1120 1130 1140 1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF
1160 1170 1180 1190 1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG
1210 1220 1230 1240 1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE
1260 1270 1280 1290 1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG
1310 1320 1330 1340 1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY
1360 1370 1380 1390 1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV
1410 1420 1430 1440 1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV
1460 1470 1480 1490 1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS
1510 1520 1530 1540 1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY
1560 1570 1580 1590 1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF
1610 1620 1630 1640 1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS
1660 1670 1680 1690 1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN
1710 1720
HIILNTVSKE KFTQVWEAMV LYT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YWL0 | A0A0J9YWL0_HUMAN | Beta/gamma crystallin domain-contai... | CRYBG1 | 2,131 | Annotation score: | ||
A0A494C1M5 | A0A494C1M5_HUMAN | Beta/gamma crystallin domain-contai... | CRYBG1 | 587 | Annotation score: | ||
Q96QW7 | Q96QW7_HUMAN | Beta/gamma crystallin domain-contai... | CRYBG1 | 316 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055687 | 267 | G → D. Corresponds to variant dbSNP:rs11968933Ensembl. | 1 | |
Natural variantiVAR_055688 | 293 | Q → P1 PublicationCorresponds to variant dbSNP:rs1159148Ensembl. | 1 | |
Natural variantiVAR_055689 | 491 | C → R. Corresponds to variant dbSNP:rs3747787Ensembl. | 1 | |
Natural variantiVAR_055690 | 1096 | L → V. Corresponds to variant dbSNP:rs1350902Ensembl. | 1 | |
Natural variantiVAR_055691 | 1196 | E → A1 PublicationCorresponds to variant dbSNP:rs783396Ensembl. | 1 | |
Natural variantiVAR_055692 | 1395 | C → Y1 PublicationCorresponds to variant dbSNP:rs2297970Ensembl. | 1 | |
Natural variantiVAR_055693 | 1445 | T → S. Corresponds to variant dbSNP:rs1676015Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056580 | 1 – 26 | MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_056581 | 27 – 1207 | Missing in isoform 2. 1 PublicationAdd BLAST | 1181 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83116 Genomic DNA Translation: AAB53792.1 U83115 mRNA Translation: AAB53791.1 AK300443 mRNA Translation: BAG62166.1 AL359292 Genomic DNA No translation available. AL390074 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48412.1 |
CCDSi | CCDS34506.1 [Q9Y4K1-1] |
RefSeqi | NP_001615.2, NM_001624.3 [Q9Y4K1-1] |
Genome annotation databases
GeneIDi | 202 |
KEGGi | hsa:202 |
UCSCi | uc003prh.4, human [Q9Y4K1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U83116 Genomic DNA Translation: AAB53792.1 U83115 mRNA Translation: AAB53791.1 AK300443 mRNA Translation: BAG62166.1 AL359292 Genomic DNA No translation available. AL390074 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48412.1 |
CCDSi | CCDS34506.1 [Q9Y4K1-1] |
RefSeqi | NP_001615.2, NM_001624.3 [Q9Y4K1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DAD | NMR | - | A | 1416-1495 | [»] | |
3CW3 | X-ray | 1.88 | A | 1022-1117 | [»] | |
6VRO | X-ray | 2.45 | B | 716-741 | [»] | |
SMRi | Q9Y4K1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106705, 67 interactors |
ELMi | Q9Y4K1 |
IntActi | Q9Y4K1, 17 interactors |
STRINGi | 9606.ENSP00000358062 |
Protein family/group databases
CAZyi | CBM13, Carbohydrate-Binding Module Family 13 |
PTM databases
GlyConnecti | 2023, 2 N-Linked glycans (1 site) |
GlyGeni | Q9Y4K1, 3 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (2 sites) |
iPTMneti | Q9Y4K1 |
PhosphoSitePlusi | Q9Y4K1 |
SwissPalmi | Q9Y4K1 |
Genetic variation databases
BioMutai | CRYBG1 |
DMDMi | 76800646 |
Proteomic databases
EPDi | Q9Y4K1 |
jPOSTi | Q9Y4K1 |
MassIVEi | Q9Y4K1 |
MaxQBi | Q9Y4K1 |
PaxDbi | Q9Y4K1 |
PeptideAtlasi | Q9Y4K1 |
PRIDEi | Q9Y4K1 |
ProteomicsDBi | 5139 86224 [Q9Y4K1-1] |
Protocols and materials databases
Antibodypediai | 70882, 24 antibodies from 9 providers |
DNASUi | 202 |
Genome annotation databases
GeneIDi | 202 |
KEGGi | hsa:202 |
UCSCi | uc003prh.4, human [Q9Y4K1-1] |
Organism-specific databases
CTDi | 202 |
DisGeNETi | 202 |
GeneCardsi | CRYBG1 |
HGNCi | HGNC:356, CRYBG1 |
MIMi | 601797, gene |
neXtProti | NX_Q9Y4K1 |
PharmGKBi | PA24649 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUA4, Eukaryota |
HOGENOMi | CLU_002648_0_0_1 |
InParanoidi | Q9Y4K1 |
OMAi | WEAMVLT |
PhylomeDBi | Q9Y4K1 |
TreeFami | TF331078 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4K1 |
SignaLinki | Q9Y4K1 |
Miscellaneous databases
BioGRID-ORCSi | 202, 6 hits in 1024 CRISPR screens |
ChiTaRSi | AIM1, human |
EvolutionaryTracei | Q9Y4K1 |
GeneWikii | AIM1 |
GenomeRNAii | 202 |
Pharosi | Q9Y4K1, Tbio |
PROi | PR:Q9Y4K1 |
RNActi | Q9Y4K1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112297, Expressed in placenta and 202 other tissues |
ExpressionAtlasi | Q9Y4K1, baseline and differential |
Genevisiblei | Q9Y4K1, HS |
Family and domain databases
CDDi | cd00161, RICIN, 1 hit |
InterProi | View protein in InterPro IPR001064, Beta/gamma_crystallin IPR011024, G_crystallin-like IPR035992, Ricin_B-like_lectins IPR000772, Ricin_B_lectin |
Pfami | View protein in Pfam PF00030, Crystall, 6 hits PF00652, Ricin_B_lectin, 1 hit |
PRINTSi | PR01367, BGCRYSTALLIN |
SMARTi | View protein in SMART SM00458, RICIN, 1 hit SM00247, XTALbg, 6 hits |
SUPFAMi | SSF49695, SSF49695, 3 hits SSF50370, SSF50370, 1 hit |
PROSITEi | View protein in PROSITE PS50915, CRYSTALLIN_BETA_GAMMA, 12 hits PS50231, RICIN_B_LECTIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CRBG1_HUMAN | |
Accessioni | Q9Y4K1Primary (citable) accession number: Q9Y4K1 Secondary accession number(s): B4DU04, O00296, Q5VWJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 24, 2001 |
Last sequence update: | September 27, 2005 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families