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Protein

Beta/gamma crystallin domain-containing protein 1

Gene

CRYBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM13 Carbohydrate-Binding Module Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 1Imported
Alternative name(s):
Absent in melanoma 1 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYBG1Imported
Synonyms:AIM11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112297.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:356 CRYBG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601797 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4K1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
202

Open Targets

More...
OpenTargetsi
ENSG00000112297

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24649

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AIM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76800646

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000576091 – 1723Beta/gamma crystallin domain-containing protein 1Add BLAST1723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4K1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4K1

PeptideAtlas

More...
PeptideAtlasi
Q9Y4K1

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4K1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86224

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4K1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y4K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112297 Expressed in 190 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_AIM1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4K1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4K1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026378
HPA030948
HPA030949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106705, 15 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9Y4K1

Protein interaction database and analysis system

More...
IntActi
Q9Y4K1, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358062

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y4K1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4K1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y4K1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1022 – 1061Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini1062 – 1117Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST56
Domaini1123 – 1163Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini1164 – 1206Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini1218 – 1270Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST53
Domaini1271 – 1313Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini1319 – 1361Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST43
Domaini1362 – 1404Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST43
Domaini1415 – 1452Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST38
Domaini1453 – 1496Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST44
Domaini1502 – 1542Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST41
Domaini1543 – 1584Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST42
Domaini1586 – 1719Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IERF Eukaryota
ENOG4110BHM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155695

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033869

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080825

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4K1

Database of Orthologous Groups

More...
OrthoDBi
EOG091G007H

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4K1

TreeFam database of animal gene trees

More...
TreeFami
TF331078

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00161 RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00030 Crystall, 6 hits
PF00652 Ricin_B_lectin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01367 BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS
60 70 80 90 100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP
110 120 130 140 150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE
160 170 180 190 200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG
210 220 230 240 250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL
260 270 280 290 300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS
310 320 330 340 350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE
360 370 380 390 400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK
410 420 430 440 450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT
460 470 480 490 500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH
510 520 530 540 550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR
560 570 580 590 600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE
610 620 630 640 650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT
660 670 680 690 700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF
710 720 730 740 750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT
760 770 780 790 800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN
810 820 830 840 850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP
860 870 880 890 900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS
910 920 930 940 950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE
960 970 980 990 1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG
1010 1020 1030 1040 1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS
1060 1070 1080 1090 1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE
1110 1120 1130 1140 1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF
1160 1170 1180 1190 1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG
1210 1220 1230 1240 1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE
1260 1270 1280 1290 1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG
1310 1320 1330 1340 1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY
1360 1370 1380 1390 1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV
1410 1420 1430 1440 1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV
1460 1470 1480 1490 1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS
1510 1520 1530 1540 1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY
1560 1570 1580 1590 1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF
1610 1620 1630 1640 1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS
1660 1670 1680 1690 1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN
1710 1720
HIILNTVSKE KFTQVWEAMV LYT
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4137765BCE039D5
GO
Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
     27-1207: Missing.

Note: No experimental confirmation available.
Show »
Length:542
Mass (Da):61,007
Checksum:i9FA2DAABFE123CCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWL0A0A0J9YWL0_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
2,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q96QW7Q96QW7_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055687267G → D. Corresponds to variant dbSNP:rs11968933Ensembl.1
Natural variantiVAR_055688293Q → P1 PublicationCorresponds to variant dbSNP:rs1159148Ensembl.1
Natural variantiVAR_055689491C → R. Corresponds to variant dbSNP:rs3747787Ensembl.1
Natural variantiVAR_0556901096L → V. Corresponds to variant dbSNP:rs1350902Ensembl.1
Natural variantiVAR_0556911196E → A1 PublicationCorresponds to variant dbSNP:rs783396Ensembl.1
Natural variantiVAR_0556921395C → Y1 PublicationCorresponds to variant dbSNP:rs2297970Ensembl.1
Natural variantiVAR_0556931445T → S. Corresponds to variant dbSNP:rs1676015Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565801 – 26MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_05658127 – 1207Missing in isoform 2. 1 PublicationAdd BLAST1181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U83116 Genomic DNA Translation: AAB53792.1
U83115 mRNA Translation: AAB53791.1
AK300443 mRNA Translation: BAG62166.1
AL359292 Genomic DNA No translation available.
AL390074 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48412.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34506.1 [Q9Y4K1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001615.2, NM_001624.3 [Q9Y4K1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.724262
Hs.744905

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369066; ENSP00000358062; ENSG00000112297 [Q9Y4K1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:202

UCSC genome browser

More...
UCSCi
uc003prh.4 human [Q9Y4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83116 Genomic DNA Translation: AAB53792.1
U83115 mRNA Translation: AAB53791.1
AK300443 mRNA Translation: BAG62166.1
AL359292 Genomic DNA No translation available.
AL390074 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48412.1
CCDSiCCDS34506.1 [Q9Y4K1-1]
RefSeqiNP_001615.2, NM_001624.3 [Q9Y4K1-1]
UniGeneiHs.724262
Hs.744905

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DADNMR-A1416-1495[»]
3CW3X-ray1.88A1022-1117[»]
ProteinModelPortaliQ9Y4K1
SMRiQ9Y4K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106705, 15 interactors
ELMiQ9Y4K1
IntActiQ9Y4K1, 4 interactors
STRINGi9606.ENSP00000358062

Protein family/group databases

CAZyiCBM13 Carbohydrate-Binding Module Family 13

PTM databases

iPTMnetiQ9Y4K1
PhosphoSitePlusiQ9Y4K1
SwissPalmiQ9Y4K1

Polymorphism and mutation databases

BioMutaiAIM1
DMDMi76800646

Proteomic databases

EPDiQ9Y4K1
PaxDbiQ9Y4K1
PeptideAtlasiQ9Y4K1
PRIDEiQ9Y4K1
ProteomicsDBi86224

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
202
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369066; ENSP00000358062; ENSG00000112297 [Q9Y4K1-1]
GeneIDi202
KEGGihsa:202
UCSCiuc003prh.4 human [Q9Y4K1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
202
DisGeNETi202
EuPathDBiHostDB:ENSG00000112297.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CRYBG1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006103
HGNCiHGNC:356 CRYBG1
HPAiCAB026378
HPA030948
HPA030949
MIMi601797 gene
neXtProtiNX_Q9Y4K1
OpenTargetsiENSG00000112297
PharmGKBiPA24649

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IERF Eukaryota
ENOG4110BHM LUCA
GeneTreeiENSGT00940000155695
HOGENOMiHOG000033869
HOVERGENiHBG080825
InParanoidiQ9Y4K1
OrthoDBiEOG091G007H
PhylomeDBiQ9Y4K1
TreeFamiTF331078

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AIM1 human
EvolutionaryTraceiQ9Y4K1

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AIM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
202

Protein Ontology

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PROi
PR:Q9Y4K1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112297 Expressed in 190 organ(s), highest expression level in placenta
CleanExiHS_AIM1
ExpressionAtlasiQ9Y4K1 baseline and differential
GenevisibleiQ9Y4K1 HS

Family and domain databases

CDDicd00161 RICIN, 1 hit
InterProiView protein in InterPro
IPR001064 Beta/gamma_crystallin
IPR011024 G_crystallin-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00030 Crystall, 6 hits
PF00652 Ricin_B_lectin, 1 hit
PRINTSiPR01367 BGCRYSTALLIN
SMARTiView protein in SMART
SM00458 RICIN, 1 hit
SM00247 XTALbg, 6 hits
SUPFAMiSSF49695 SSF49695, 3 hits
SSF50370 SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915 CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRBG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): B4DU04, O00296, Q5VWJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: December 5, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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