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UniProtKB - Q9Y4K1 (CRBG1_HUMAN)

Entry version 177 (23 Feb 2022)
Sequence version 3 (27 Sep 2005)
Previous versions | rss
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Protein

Beta/gamma crystallin domain-containing protein 1

Gene

CRYBG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y4K1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y4K1

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		CBM13, Carbohydrate-Binding Module Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta/gamma crystallin domain-containing protein 1Imported
Alternative name(s):
Absent in melanoma 1 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYBG1Imported
Synonyms:AIM11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:356, CRYBG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601797, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y4K1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		202

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24649

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y4K1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CRYBG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		76800646

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000576091 – 1723Beta/gamma crystallin domain-containing protein 1Add BLAST1723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei525PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y4K1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y4K1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y4K1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y4K1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y4K1

PeptideAtlas

More...PeptideAtlasi		Q9Y4K1

PRoteomics IDEntifications database

More...PRIDEi		Q9Y4K1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5139
86224 [Q9Y4K1-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2023, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y4K1, 3 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y4K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y4K1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y4K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112297, Expressed in placenta and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y4K1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y4K1, HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106705, 67 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9Y4K1

Protein interaction database and analysis system

More...IntActi		Q9Y4K1, 17 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358062

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y4K1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11723
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y4K1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y4K1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1022 – 1061Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST40
Domaini1062 – 1117Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST56
Domaini1123 – 1163Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini1164 – 1206Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43
Domaini1218 – 1270Beta/gamma crystallin 'Greek key' 5PROSITE-ProRule annotationAdd BLAST53
Domaini1271 – 1313Beta/gamma crystallin 'Greek key' 6PROSITE-ProRule annotationAdd BLAST43
Domaini1319 – 1361Beta/gamma crystallin 'Greek key' 7PROSITE-ProRule annotationAdd BLAST43
Domaini1362 – 1404Beta/gamma crystallin 'Greek key' 8PROSITE-ProRule annotationAdd BLAST43
Domaini1415 – 1452Beta/gamma crystallin 'Greek key' 9PROSITE-ProRule annotationAdd BLAST38
Domaini1453 – 1496Beta/gamma crystallin 'Greek key' 10PROSITE-ProRule annotationAdd BLAST44
Domaini1502 – 1542Beta/gamma crystallin 'Greek key' 11PROSITE-ProRule annotationAdd BLAST41
Domaini1543 – 1584Beta/gamma crystallin 'Greek key' 12PROSITE-ProRule annotationAdd BLAST42
Domaini1586 – 1719Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 266DisorderedSequence analysisAdd BLAST266
Regioni280 – 299DisorderedSequence analysisAdd BLAST20
Regioni315 – 383DisorderedSequence analysisAdd BLAST69
Regioni429 – 481DisorderedSequence analysisAdd BLAST53
Regioni518 – 539DisorderedSequence analysisAdd BLAST22
Regioni633 – 693DisorderedSequence analysisAdd BLAST61
Regioni863 – 894DisorderedSequence analysisAdd BLAST32
Regioni908 – 940DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi172 – 197Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi248 – 266Polar residuesSequence analysisAdd BLAST19
Compositional biasi359 – 379Polar residuesSequence analysisAdd BLAST21
Compositional biasi447 – 467Polar residuesSequence analysisAdd BLAST21
Compositional biasi633 – 691Polar residuesSequence analysisAdd BLAST59
Compositional biasi922 – 940Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QUA4, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002648_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y4K1

Identification of Orthologs from Complete Genome Data

More...OMAi		WEAMVLT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y4K1

TreeFam database of animal gene trees

More...TreeFami		TF331078

Family and domain databases

Conserved Domains Database

More...CDDi		cd00161, RICIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00030, Crystall, 6 hits
PF00652, Ricin_B_lectin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01367, BGCRYSTALLIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00458, RICIN, 1 hit
SM00247, XTALbg, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49695, SSF49695, 3 hits
SSF50370, SSF50370, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4K1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS 
        60         70         80         90        100
DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP 
       110        120        130        140        150
ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE 
       160        170        180        190        200
SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG 
       210        220        230        240        250
RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL 
       260        270        280        290        300
DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS 
       310        320        330        340        350
KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE 
       360        370        380        390        400
EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK 
       410        420        430        440        450
DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT 
       460        470        480        490        500
FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH 
       510        520        530        540        550
KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR 
       560        570        580        590        600
SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE 
       610        620        630        640        650
VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT 
       660        670        680        690        700
NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF 
       710        720        730        740        750
TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT 
       760        770        780        790        800
FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN 
       810        820        830        840        850
GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP 
       860        870        880        890        900
SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS 
       910        920        930        940        950
LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE 
       960        970        980        990       1000
LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG 
      1010       1020       1030       1040       1050
MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS 
      1060       1070       1080       1090       1100
LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE 
      1110       1120       1130       1140       1150
EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF 
      1160       1170       1180       1190       1200
GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG 
      1210       1220       1230       1240       1250
SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE 
      1260       1270       1280       1290       1300
EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG 
      1310       1320       1330       1340       1350
GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY 
      1360       1370       1380       1390       1400
GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV 
      1410       1420       1430       1440       1450
QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV 
      1460       1470       1480       1490       1500
SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS 
      1510       1520       1530       1540       1550
EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY 
      1560       1570       1580       1590       1600
GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF 
      1610       1620       1630       1640       1650
MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS 
      1660       1670       1680       1690       1700
LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN 
      1710       1720 
HIILNTVSKE KFTQVWEAMV LYT
Length:1,723
Mass (Da):188,676
Last modified:September 27, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4137765BCE039D5
GO
Isoform 2 (identifier: Q9Y4K1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MEKRSSGRRSGRRRGSQKSTDSPGAD → MQKPKTVAWENLGPEMSALGTAFSRE
     27-1207: Missing.

Show »
Length:542
Mass (Da):61,007
Checksum:i9FA2DAABFE123CCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YWL0A0A0J9YWL0_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
2,131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1M5A0A494C1M5_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
587Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q96QW7Q96QW7_HUMAN
Beta/gamma crystallin domain-contai...
CRYBG1
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055687267G → D. Corresponds to variant dbSNP:rs11968933Ensembl.1
Natural variantiVAR_055688293Q → P1 PublicationCorresponds to variant dbSNP:rs1159148Ensembl.1
Natural variantiVAR_055689491C → R. Corresponds to variant dbSNP:rs3747787Ensembl.1
Natural variantiVAR_0556901096L → V. Corresponds to variant dbSNP:rs1350902Ensembl.1
Natural variantiVAR_0556911196E → A1 PublicationCorresponds to variant dbSNP:rs783396Ensembl.1
Natural variantiVAR_0556921395C → Y1 PublicationCorresponds to variant dbSNP:rs2297970Ensembl.1
Natural variantiVAR_0556931445T → S. Corresponds to variant dbSNP:rs1676015Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565801 – 26MEKRS…SPGAD → MQKPKTVAWENLGPEMSALG TAFSRE in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_05658127 – 1207Missing in isoform 2. 1 PublicationAdd BLAST1181

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U83116 Genomic DNA Translation: AAB53792.1
U83115 mRNA Translation: AAB53791.1
AK300443 mRNA Translation: BAG62166.1
AL359292 Genomic DNA No translation available.
AL390074 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48412.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34506.1 [Q9Y4K1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001615.2, NM_001624.3 [Q9Y4K1-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		202

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:202

UCSC genome browser

More...UCSCi		uc003prh.4, human [Q9Y4K1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U83116 Genomic DNA Translation: AAB53792.1
U83115 mRNA Translation: AAB53791.1
AK300443 mRNA Translation: BAG62166.1
AL359292 Genomic DNA No translation available.
AL390074 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48412.1
CCDSiCCDS34506.1 [Q9Y4K1-1]
RefSeqiNP_001615.2, NM_001624.3 [Q9Y4K1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DADNMR-A1416-1495[»]
3CW3X-ray1.88A1022-1117[»]
6VROX-ray2.45B716-741[»]
SMRiQ9Y4K1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106705, 67 interactors
ELMiQ9Y4K1
IntActiQ9Y4K1, 17 interactors
STRINGi9606.ENSP00000358062

Protein family/group databases

CAZyiCBM13, Carbohydrate-Binding Module Family 13

PTM databases

GlyConnecti2023, 2 N-Linked glycans (1 site)
GlyGeniQ9Y4K1, 3 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (2 sites)
iPTMnetiQ9Y4K1
PhosphoSitePlusiQ9Y4K1
SwissPalmiQ9Y4K1

Genetic variation databases

BioMutaiCRYBG1
DMDMi76800646

Proteomic databases

EPDiQ9Y4K1
jPOSTiQ9Y4K1
MassIVEiQ9Y4K1
MaxQBiQ9Y4K1
PaxDbiQ9Y4K1
PeptideAtlasiQ9Y4K1
PRIDEiQ9Y4K1
ProteomicsDBi5139
86224 [Q9Y4K1-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		70882, 24 antibodies from 9 providers

The DNASU plasmid repository

More...DNASUi		202

Genome annotation databases

GeneIDi202
KEGGihsa:202
UCSCiuc003prh.4, human [Q9Y4K1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		202
DisGeNETi202

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRYBG1
HGNCiHGNC:356, CRYBG1
MIMi601797, gene
neXtProtiNX_Q9Y4K1
PharmGKBiPA24649

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QUA4, Eukaryota
HOGENOMiCLU_002648_0_0_1
InParanoidiQ9Y4K1
OMAiWEAMVLT
PhylomeDBiQ9Y4K1
TreeFamiTF331078

Enzyme and pathway databases

PathwayCommonsiQ9Y4K1
SignaLinkiQ9Y4K1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		202, 6 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AIM1, human
EvolutionaryTraceiQ9Y4K1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AIM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		202
PharosiQ9Y4K1, Tbio

Protein Ontology

More...PROi		PR:Q9Y4K1
RNActiQ9Y4K1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112297, Expressed in placenta and 202 other tissues
ExpressionAtlasiQ9Y4K1, baseline and differential
GenevisibleiQ9Y4K1, HS

Family and domain databases

CDDicd00161, RICIN, 1 hit
InterProiView protein in InterPro
IPR001064, Beta/gamma_crystallin
IPR011024, G_crystallin-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00030, Crystall, 6 hits
PF00652, Ricin_B_lectin, 1 hit
PRINTSiPR01367, BGCRYSTALLIN
SMARTiView protein in SMART
SM00458, RICIN, 1 hit
SM00247, XTALbg, 6 hits
SUPFAMiSSF49695, SSF49695, 3 hits
SSF50370, SSF50370, 1 hit
PROSITEiView protein in PROSITE
PS50915, CRYSTALLIN_BETA_GAMMA, 12 hits
PS50231, RICIN_B_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRBG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4K1
Secondary accession number(s): B4DU04, O00296, Q5VWJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: September 27, 2005
Last modified: February 23, 2022
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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