UniProtKB - Q9Y4K0 (LOXL2_HUMAN)
Lysyl oxidase homolog 2
LOXL2
Functioni
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (PubMed:27735137).
Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (PubMed:27735137).
Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (PubMed:27735137).
Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (PubMed:25959397).
LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency including POU5F1/OCT4, NANOG, KLF4 and SOX2 (By similarity).
Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin CDH1, probably by mediating deamination of histone H3 (PubMed:16096638, PubMed:27735137, PubMed:24414204).
During EMT, involved with SNAI1 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292).
SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292).
Interacts with the endoplasmic reticulum protein HSPA5 which activates the IRE1-XBP1 pathway of the unfolded protein response, leading to expression of several transcription factors involved in EMT and subsequent EMT induction (PubMed:28332555).
Involved in E-cadherin repression following hypoxia, a hallmark of EMT believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression (PubMed:20026874).
When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:20306300).
Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952).
Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity).
By similarity8 PublicationsMiscellaneous
Caution
Catalytic activityi
- EC:1.4.3.134 Publications
Cofactori
Protein has several cofactor binding sites:- Cu cation1 Publication
- lysine tyrosylquinone residue1 PublicationNote: Contains 1 lysine tyrosylquinone.By similarity
Activity regulationi
Kineticsi
- KM=1.01 mM for 1,5-diaminopentane2 Publications
- KM=1.05 mM for spermine2 Publications
- KM=0.59 µM for tropoelastin (without the first three SRCR domains)2 Publications
- KM=0.62 µM for tropoelastin (without all four SRCR domains)2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 549 | Calcium1 Publication | 1 | |
Metal bindingi | 550 | Calcium; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 626 | Copper1 Publication | 1 | |
Metal bindingi | 628 | Copper1 Publication | 1 | |
Metal bindingi | 630 | Copper1 Publication | 1 | |
Metal bindingi | 722 | Calcium1 Publication | 1 | |
Metal bindingi | 724 | Calcium; via carbonyl oxygen1 Publication | 1 | |
Metal bindingi | 727 | Calcium1 Publication | 1 | |
Metal bindingi | 728 | Calcium1 Publication | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- copper ion binding Source: UniProtKB
- electron transfer activity Source: UniProtKB
- oligosaccharide binding Source: UniProtKB
- protein-lysine 6-oxidase activity Source: UniProtKB
- scavenger receptor activity Source: InterPro
GO - Biological processi
- aging Source: ProtInc
- cell adhesion Source: ProtInc
- cellular protein modification process Source: UniProtKB
- collagen fibril organization Source: UniProtKB
- endothelial cell migration Source: UniProtKB
- endothelial cell proliferation Source: UniProtKB
- epithelial to mesenchymal transition Source: UniProtKB
- heterochromatin organization Source: UniProtKB
- negative regulation of stem cell population maintenance Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- peptidyl-lysine oxidation Source: UniProtKB
- positive regulation of chondrocyte differentiation Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- response to copper ion Source: UniProtKB
- response to hypoxia Source: UniProtKB
- sprouting angiogenesis Source: UniProtKB
Keywordsi
Molecular function | Chromatin regulator, Oxidoreductase, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Calcium, Copper, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.4.3.13, 2681 |
PathwayCommonsi | Q9Y4K0 |
Reactomei | R-HSA-1566948, Elastic fibre formation R-HSA-2243919, Crosslinking of collagen fibrils |
SignaLinki | Q9Y4K0 |
SIGNORi | Q9Y4K0 |
Names & Taxonomyi
Protein namesi | Recommended name: Lysyl oxidase homolog 2 (EC:1.4.3.134 Publications)Alternative name(s): Lysyl oxidase-like protein 2 Lysyl oxidase-related protein 2 Lysyl oxidase-related protein WS9-14 |
Gene namesi | Name:LOXL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6666, LOXL2 |
MIMi | 606663, gene |
neXtProti | NX_Q9Y4K0 |
VEuPathDBi | HostDB:ENSG00000134013 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Nucleus
- Nucleus 2 Publications
Extracellular region or secreted
- basement membrane 1 Publication
Other locations
- Chromosome 1 Publication
Note: Associated with chromatin (PubMed:27735137). It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted (PubMed:23319596). However, a number of reports confirm its intracellular location and its key role in transcription regulation (PubMed:22204712, PubMed:22483618).4 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Extracellular region or secreted
- extracellular space Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- basement membrane Source: UniProtKB
- chromatin Source: UniProtKB
- collagen-containing extracellular matrix Source: BHF-UCL
- membrane Source: InterPro
Keywords - Cellular componenti
Basement membrane, Chromosome, Endoplasmic reticulum, Extracellular matrix, Nucleus, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 455 | N → Q: Inhibits secretion. 1 Publication | 1 | |
Mutagenesisi | 626 – 628 | HRH → ARA: Abolishes oxidase activity and oxidation of trimethylated 'Lys-4' of histone H3 but does not affect secretion, interaction with SNAI1, binding to the CDH1 promoter, repression of CDH1 transcription or ability to induce EMT. 2 Publications | 3 | |
Mutagenesisi | 626 | H → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 628 | H → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 630 | H → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 644 | N → Q: Inhibits secretion. 1 Publication | 1 | |
Mutagenesisi | 653 | K → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 689 | Y → A: Loss of enzyme activity. 1 Publication | 1 | |
Mutagenesisi | 689 | Y → F: Does not affect ability to inhibit keratinocyte differentiation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4017 |
OpenTargetsi | ENSG00000134013 |
PharmGKBi | PA30429 |
Miscellaneous databases
Pharosi | Q9Y4K0, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3714029 |
GuidetoPHARMACOLOGYi | 2853 |
Genetic variation databases
BioMutai | LOXL2 |
DMDMi | 13878585 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000018532 | 26 – 774 | Lysyl oxidase homolog 2Add BLAST | 749 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 84 ↔ 148 | PROSITE-ProRule annotation | ||
Disulfide bondi | 97 ↔ 158 | PROSITE-ProRule annotation | ||
Disulfide bondi | 128 ↔ 138 | PROSITE-ProRule annotation | ||
Disulfide bondi | 218 ↔ 291 | PROSITE-ProRule annotation | ||
Disulfide bondi | 231 ↔ 301 | PROSITE-ProRule annotation | ||
Disulfide bondi | 265 ↔ 275 | PROSITE-ProRule annotation | ||
Glycosylationi | 288 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 351 ↔ 414 | PROSITE-ProRule annotation | ||
Disulfide bondi | 364 ↔ 424 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 395 ↔ 405 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 455 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 464 ↔ 530 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 477 ↔ 543 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 511 ↔ 521 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 573 ↔ 625 | Combined sources1 Publication | ||
Disulfide bondi | 579 ↔ 695 | Combined sources1 Publication | ||
Glycosylationi | 644 | N-linked (GlcNAc...) (complex) asparagineCombined sources2 Publications | 1 | |
Cross-linki | 653 ↔ 689 | Lysine tyrosylquinone (Lys-Tyr)2 Publications | ||
Disulfide bondi | 657 ↔ 673 | Combined sources1 Publication | ||
Disulfide bondi | 663 ↔ 685 | Combined sources1 Publication | ||
Modified residuei | 689 | 2',4',5'-topaquinone1 Publication | 1 | |
Disulfide bondi | 732 ↔ 746 | PROSITE-ProRule annotationCombined sources1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, LTQ, TPQProteomic databases
EPDi | Q9Y4K0 |
jPOSTi | Q9Y4K0 |
MassIVEi | Q9Y4K0 |
MaxQBi | Q9Y4K0 |
PaxDbi | Q9Y4K0 |
PeptideAtlasi | Q9Y4K0 |
PRIDEi | Q9Y4K0 |
ProteomicsDBi | 86223 |
PTM databases
GlyConnecti | 1480, 1 N-Linked glycan (1 site) |
GlyGeni | Q9Y4K0, 3 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9Y4K0 |
PhosphoSitePlusi | Q9Y4K0 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000134013, Expressed in stromal cell of endometrium and 194 other tissues |
ExpressionAtlasi | Q9Y4K0, baseline and differential |
Genevisiblei | Q9Y4K0, HS |
Organism-specific databases
HPAi | ENSG00000134013, Tissue enhanced (smooth) |
Interactioni
Subunit structurei
Binary interactionsi
Q9Y4K0
With | #Exp. | IntAct |
---|---|---|
ELN - isoform 2 [P15502-2] | 2 | EBI-7172227,EBI-7882008 |
FN1 [P02751] | 2 | EBI-7172227,EBI-1220319 |
MARCKSL1 [P49006] | 4 | EBI-7172227,EBI-4289961 |
Protein-protein interaction databases
BioGRIDi | 110201, 113 interactors |
IntActi | Q9Y4K0, 34 interactors |
MINTi | Q9Y4K0 |
STRINGi | 9606.ENSP00000373783 |
Chemistry databases
BindingDBi | Q9Y4K0 |
Miscellaneous databases
RNActi | Q9Y4K0, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9Y4K0 |
SMRi | Q9Y4K0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 159 | SRCR 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 188 – 302 | SRCR 2PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 326 – 425 | SRCR 3PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 435 – 544 | SRCR 4PROSITE-ProRule annotationAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 548 – 751 | Lysyl-oxidase likeAdd BLAST | 204 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QSX8, Eukaryota |
GeneTreei | ENSGT00940000155874 |
HOGENOMi | CLU_002555_3_0_1 |
InParanoidi | Q9Y4K0 |
OMAi | YCTGKEA |
OrthoDBi | 815466at2759 |
PhylomeDBi | Q9Y4K0 |
TreeFami | TF326061 |
Family and domain databases
Gene3Di | 3.10.250.10, 4 hits |
InterProi | View protein in InterPro IPR001695, Lysyl_oxidase IPR019828, Lysyl_oxidase_CS IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF01186, Lysyl_oxidase, 1 hit PF00530, SRCR, 4 hits |
PRINTSi | PR00074, LYSYLOXIDASE PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 4 hits |
SUPFAMi | SSF56487, SSF56487, 4 hits |
PROSITEi | View protein in PROSITE PS00926, LYSYL_OXIDASE, 1 hit PS00420, SRCR_1, 2 hits PS50287, SRCR_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MERPLCSHLC SCLAMLALLS PLSLAQYDSW PHYPEYFQQP APEYHQPQAP
60 70 80 90 100
ANVAKIQLRL AGQKRKHSEG RVEVYYDGQW GTVCDDDFSI HAAHVVCREL
110 120 130 140 150
GYVEAKSWTA SSSYGKGEGP IWLDNLHCTG NEATLAACTS NGWGVTDCKH
160 170 180 190 200
TEDVGVVCSD KRIPGFKFDN SLINQIENLN IQVEDIRIRA ILSTYRKRTP
210 220 230 240 250
VMEGYVEVKE GKTWKQICDK HWTAKNSRVV CGMFGFPGER TYNTKVYKMF
260 270 280 290 300
ASRRKQRYWP FSMDCTGTEA HISSCKLGPQ VSLDPMKNVT CENGLPAVVS
310 320 330 340 350
CVPGQVFSPD GPSRFRKAYK PEQPLVRLRG GAYIGEGRVE VLKNGEWGTV
360 370 380 390 400
CDDKWDLVSA SVVCRELGFG SAKEAVTGSR LGQGIGPIHL NEIQCTGNEK
410 420 430 440 450
SIIDCKFNAE SQGCNHEEDA GVRCNTPAMG LQKKLRLNGG RNPYEGRVEV
460 470 480 490 500
LVERNGSLVW GMVCGQNWGI VEAMVVCRQL GLGFASNAFQ ETWYWHGDVN
510 520 530 540 550
SNKVVMSGVK CSGTELSLAH CRHDGEDVAC PQGGVQYGAG VACSETAPDL
560 570 580 590 600
VLNAEMVQQT TYLEDRPMFM LQCAMEENCL SASAAQTDPT TGYRRLLRFS
610 620 630 640 650
SQIHNNGQSD FRPKNGRHAW IWHDCHRHYH SMEVFTHYDL LNLNGTKVAE
660 670 680 690 700
GHKASFCLED TECEGDIQKN YECANFGDQG ITMGCWDMYR HDIDCQWVDI
710 720 730 740 750
TDVPPGDYLF QVVINPNFEV AESDYSNNIM KCRSRYDGHR IWMYNCHIGG
760 770
SFSEETEKKF EHFSGLLNNQ LSPQ
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RJL2 | E5RJL2_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 151 | Annotation score: | ||
E5RI22 | E5RI22_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 139 | Annotation score: | ||
E5RFE2 | E5RFE2_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 95 | Annotation score: | ||
H0YAR1 | H0YAR1_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 207 | Annotation score: | ||
E5RFY0 | E5RFY0_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 258 | Annotation score: | ||
E5RHH3 | E5RHH3_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 218 | Annotation score: | ||
H0YAP6 | H0YAP6_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 67 | Annotation score: | ||
R4GMS2 | R4GMS2_HUMAN | Lysyl oxidase homolog 2 | LOXL2 | 101 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | E → K in BAG35197 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 239 | E → G in BAD96197 (Ref. 3) Curated | 1 | |
Sequence conflicti | 295 | L → Q in AAD34343 (PubMed:10212285).Curated | 1 | |
Sequence conflicti | 536 | Q → R in BAG35197 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 652 | H → Q in AAD34343 (PubMed:10212285).Curated | 1 | |
Sequence conflicti | 746 | C → S in AAD34343 (PubMed:10212285).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050010 | 359 | S → W. Corresponds to variant dbSNP:rs4602894Ensembl. | 1 | |
Natural variantiVAR_024527 | 570 | M → L2 PublicationsCorresponds to variant dbSNP:rs1063582Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89942 mRNA Translation: AAB49697.1 AK312266 mRNA Translation: BAG35197.1 AK222477 mRNA Translation: BAD96197.1 AC090197 Genomic DNA No translation available. BC000594 mRNA Translation: AAH00594.1 AF117949 mRNA Translation: AAD34343.1 Sequence problems. |
CCDSi | CCDS34864.1 |
RefSeqi | NP_002309.1, NM_002318.2 |
Genome annotation databases
Ensembli | ENST00000389131.8; ENSP00000373783.3; ENSG00000134013.16 |
GeneIDi | 4017 |
KEGGi | hsa:4017 |
MANE-Selecti | ENST00000389131.8; ENSP00000373783.3; NM_002318.3; NP_002309.1 |
UCSCi | uc003xdh.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89942 mRNA Translation: AAB49697.1 AK312266 mRNA Translation: BAG35197.1 AK222477 mRNA Translation: BAD96197.1 AC090197 Genomic DNA No translation available. BC000594 mRNA Translation: AAH00594.1 AF117949 mRNA Translation: AAD34343.1 Sequence problems. |
CCDSi | CCDS34864.1 |
RefSeqi | NP_002309.1, NM_002318.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5ZE3 | X-ray | 2.40 | A/B | 318-774 | [»] | |
AlphaFoldDBi | Q9Y4K0 | |||||
SMRi | Q9Y4K0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110201, 113 interactors |
IntActi | Q9Y4K0, 34 interactors |
MINTi | Q9Y4K0 |
STRINGi | 9606.ENSP00000373783 |
Chemistry databases
BindingDBi | Q9Y4K0 |
ChEMBLi | CHEMBL3714029 |
GuidetoPHARMACOLOGYi | 2853 |
PTM databases
GlyConnecti | 1480, 1 N-Linked glycan (1 site) |
GlyGeni | Q9Y4K0, 3 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9Y4K0 |
PhosphoSitePlusi | Q9Y4K0 |
Genetic variation databases
BioMutai | LOXL2 |
DMDMi | 13878585 |
Proteomic databases
EPDi | Q9Y4K0 |
jPOSTi | Q9Y4K0 |
MassIVEi | Q9Y4K0 |
MaxQBi | Q9Y4K0 |
PaxDbi | Q9Y4K0 |
PeptideAtlasi | Q9Y4K0 |
PRIDEi | Q9Y4K0 |
ProteomicsDBi | 86223 |
Protocols and materials databases
ABCDi | Q9Y4K0, 1 sequenced antibody |
Antibodypediai | 22758, 474 antibodies from 35 providers |
DNASUi | 4017 |
Genome annotation databases
Ensembli | ENST00000389131.8; ENSP00000373783.3; ENSG00000134013.16 |
GeneIDi | 4017 |
KEGGi | hsa:4017 |
MANE-Selecti | ENST00000389131.8; ENSP00000373783.3; NM_002318.3; NP_002309.1 |
UCSCi | uc003xdh.2, human |
Organism-specific databases
CTDi | 4017 |
DisGeNETi | 4017 |
GeneCardsi | LOXL2 |
HGNCi | HGNC:6666, LOXL2 |
HPAi | ENSG00000134013, Tissue enhanced (smooth) |
MIMi | 606663, gene |
neXtProti | NX_Q9Y4K0 |
OpenTargetsi | ENSG00000134013 |
PharmGKBi | PA30429 |
VEuPathDBi | HostDB:ENSG00000134013 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSX8, Eukaryota |
GeneTreei | ENSGT00940000155874 |
HOGENOMi | CLU_002555_3_0_1 |
InParanoidi | Q9Y4K0 |
OMAi | YCTGKEA |
OrthoDBi | 815466at2759 |
PhylomeDBi | Q9Y4K0 |
TreeFami | TF326061 |
Enzyme and pathway databases
BRENDAi | 1.4.3.13, 2681 |
PathwayCommonsi | Q9Y4K0 |
Reactomei | R-HSA-1566948, Elastic fibre formation R-HSA-2243919, Crosslinking of collagen fibrils |
SignaLinki | Q9Y4K0 |
SIGNORi | Q9Y4K0 |
Miscellaneous databases
BioGRID-ORCSi | 4017, 9 hits in 1074 CRISPR screens |
ChiTaRSi | LOXL2, human |
GeneWikii | LOXL2 |
GenomeRNAii | 4017 |
Pharosi | Q9Y4K0, Tchem |
PROi | PR:Q9Y4K0 |
RNActi | Q9Y4K0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134013, Expressed in stromal cell of endometrium and 194 other tissues |
ExpressionAtlasi | Q9Y4K0, baseline and differential |
Genevisiblei | Q9Y4K0, HS |
Family and domain databases
Gene3Di | 3.10.250.10, 4 hits |
InterProi | View protein in InterPro IPR001695, Lysyl_oxidase IPR019828, Lysyl_oxidase_CS IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf |
Pfami | View protein in Pfam PF01186, Lysyl_oxidase, 1 hit PF00530, SRCR, 4 hits |
PRINTSi | PR00074, LYSYLOXIDASE PR00258, SPERACTRCPTR |
SMARTi | View protein in SMART SM00202, SR, 4 hits |
SUPFAMi | SSF56487, SSF56487, 4 hits |
PROSITEi | View protein in PROSITE PS00926, LYSYL_OXIDASE, 1 hit PS00420, SRCR_1, 2 hits PS50287, SRCR_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LOXL2_HUMAN | |
Accessioni | Q9Y4K0Primary (citable) accession number: Q9Y4K0 Secondary accession number(s): B2R5Q0 Q9Y5Y8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families