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Entry version 172 (13 Feb 2019)
Sequence version 2 (29 Mar 2005)
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Protein

Insulin receptor substrate 2

Gene

IRS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May mediate the control of various cellular processes by insulin.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-109704 PI3K Cascade
R-HSA-112399 IRS-mediated signalling
R-HSA-112412 SOS-mediated signalling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-198203 PI3K/AKT activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2586552 Signaling by Leptin
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-8853659 RET signaling
R-HSA-9006335 Signaling by Erythropoietin
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG)
R-HSA-9027283 Erythropoietin activates STAT5
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-982772 Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9Y4H2

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y4H2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin receptor substrate 2
Short name:
IRS-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185950.8

Human Gene Nomenclature Database

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HGNCi
HGNC:6126 IRS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600797 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y4H2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8660

MalaCards human disease database

More...
MalaCardsi
IRS2

Open Targets

More...
OpenTargetsi
ENSG00000185950

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA375

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IRS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62298062

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000842391 – 1338Insulin receptor substrate 2Add BLAST1338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei306PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei350PhosphothreonineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei388PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei412Omega-N-methylarginineCombined sources1
Modified residuei520PhosphothreonineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei527PhosphothreonineCombined sources1
Modified residuei540Phosphotyrosine; by INSRBy similarity1
Modified residuei560PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Modified residuei580PhosphothreonineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei608PhosphoserineCombined sources1
Modified residuei620PhosphoserineCombined sources1
Modified residuei653Phosphotyrosine; by INSRBy similarity1
Modified residuei675Phosphotyrosine; by INSRCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei779PhosphothreonineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1
Modified residuei919Phosphotyrosine; by INSRBy similarity1
Modified residuei973PhosphoserineCombined sources1
Modified residuei978Phosphotyrosine; by INSRBy similarity1
Modified residuei1082PhosphothreonineCombined sources1
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1159PhosphothreonineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1174PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1186PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1253Phosphotyrosine; by INSRBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y4H2

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y4H2

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9Y4H2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y4H2

PeptideAtlas

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PeptideAtlasi
Q9Y4H2

PRoteomics IDEntifications database

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PRIDEi
Q9Y4H2

ProteomicsDB human proteome resource

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ProteomicsDBi
86205

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4H2

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9Y4H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000185950 Expressed in 236 organ(s), highest expression level in decidua

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y4H2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016944
HPA054664

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHIP.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114209, 47 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9Y4H2

Protein interaction database and analysis system

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IntActi
Q9Y4H2, 15 interactors

Molecular INTeraction database

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MINTi
Q9Y4H2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365016

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FQWX-ray1.93C1097-1105[»]
3FQXX-ray1.70C1097-1105[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y4H2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y4H2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y4H2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 144PHPROSITE-ProRule annotationAdd BLAST129
Domaini194 – 298IRS-type PTBPROSITE-ProRule annotationAdd BLAST105

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi540 – 543YXXM motif 14
Motifi598 – 601YXXM motif 24
Motifi653 – 656YXXM motif 34
Motifi675 – 678YXXM motif 44
Motifi742 – 745YXXM motif 54
Motifi823 – 826YXXM motif 64
Motifi1072 – 1075YXXM motif 74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 28Poly-Asn10
Compositional biasi371 – 380Poly-Ala10
Compositional biasi447 – 452Poly-Ser6
Compositional biasi460 – 467Poly-Pro8
Compositional biasi533 – 537Poly-Gly5
Compositional biasi642 – 645Poly-Ser4
Compositional biasi694 – 701Poly-Ala8
Compositional biasi944 – 947Poly-Ser4
Compositional biasi1031 – 1038Poly-Pro8
Compositional biasi1265 – 1278Poly-ProAdd BLAST14

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXEK Eukaryota
ENOG410Z9EP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161407

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000542

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4H2

KEGG Orthology (KO)

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KOi
K07187

Identification of Orthologs from Complete Genome Data

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OMAi
YKAPYTC

Database of Orthologous Groups

More...
OrthoDBi
298675at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4H2

TreeFam database of animal gene trees

More...
TreeFami
TF325994

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01204 PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR10614 PTHR10614, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00628 INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y4H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPRHGPP GPASGDGPNL NNNNNNNNHS VRKCGYLRKQ KHGHKRFFVL
60 70 80 90 100
RGPGAGGDEA TAGGGSAPQP PRLEYYESEK KWRSKAGAPK RVIALDCCLN
110 120 130 140 150
INKRADAKHK YLIALYTKDE YFAVAAENEQ EQEGWYRALT DLVSEGRAAA
160 170 180 190 200
GDAPPAAAPA ASCSASLPGA LGGSAGAAGA EDSYGLVAPA TAAYREVWQV
210 220 230 240 250
NLKPKGLGQS KNLTGVYRLC LSARTIGFVK LNCEQPSVTL QLMNIRRCGH
260 270 280 290 300
SDSFFFIEVG RSAVTGPGEL WMQADDSVVA QNIHETILEA MKALKELFEF
310 320 330 340 350
RPRSKSQSSG SSATHPISVP GARRHHHLVN LPPSQTGLVR RSRTDSLAAT
360 370 380 390 400
PPAAKCSSCR VRTASEGDGG AAAGAAAAGA RPVSVAGSPL SPGPVRAPLS
410 420 430 440 450
RSHTLSGGCG GRGSKVALLP AGGALQHSRS MSMPVAHSPP AATSPGSLSS
460 470 480 490 500
SSGHGSGSYP PPPGPHPPLP HPLHHGPGQR PSSGSASASG SPSDPGFMSL
510 520 530 540 550
DEYGSSPGDL RAFCSHRSNT PESIAETPPA RDGGGGGEFY GYMTMDRPLS
560 570 580 590 600
HCGRSYRRVS GDAAQDLDRG LRKRTYSLTT PARQRPVPQP SSASLDEYTL
610 620 630 640 650
MRATFSGSAG RLCPSCPASS PKVAYHPYPE DYGDIEIGSH RSSSSNLGAD
660 670 680 690 700
DGYMPMTPGA ALAGSGSGSC RSDDYMPMSP ASVSAPKQIL QPRAAAAAAA
710 720 730 740 750
AVPSAGPAGP APTSAAGRTF PASGGGYKAS SPAESSPEDS GYMRMWCGSK
760 770 780 790 800
LSMEHADGKL LPNGDYLNVS PSDAVTTGTP PDFFSAALHP GGEPLRGVPG
810 820 830 840 850
CCYSSLPRSY KAPYTCGGDS DQYVLMSSPV GRILEEERLE PQATPGPSQA
860 870 880 890 900
ASAFGAGPTQ PPHPVVPSPV RPSGGRPEGF LGQRGRAVRP TRLSLEGLPS
910 920 930 940 950
LPSMHEYPLP PEPKSPGEYI NIDFGEPGAR LSPPAPPLLA SAASSSSLLS
960 970 980 990 1000
ASSPASSLGS GTPGTSSDSR QRSPLSDYMN LDFSSPKSPK PGAPSGHPVG
1010 1020 1030 1040 1050
SLDGLLSPEA SSPYPPLPPR PSASPSSSLQ PPPPPPAPGE LYRLPPASAV
1060 1070 1080 1090 1100
ATAQGPGAAS SLSSDTGDNG DYTEMAFGVA ATPPQPIAAP PKPEAARVAS
1110 1120 1130 1140 1150
PTSGVKRLSL MEQVSGVEAF LQASQPPDPH RGAKVIRADP QGGRRRHSSE
1160 1170 1180 1190 1200
TFSSTTTVTP VSPSFAHNPK RHNSASVENV SLRKSSEGGV GVGPGGGDEP
1210 1220 1230 1240 1250
PTSPRQLQPA PPLAPQGRPW TPGQPGGLVG CPGSGGSPMR RETSAGFQNG
1260 1270 1280 1290 1300
LNYIAIDVRE EPGLPPQPQP PPPPLPQPGD KSSWGRTRSL GGLISAVGVG
1310 1320 1330
STGGGCGGPG PGALPPANTY ASIDFLSHHL KEATIVKE
Length:1,338
Mass (Da):137,334
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58E569E8BDBAF3D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28N → NN in AAD21531 (PubMed:10077005).Curated1
Sequence conflicti39 – 41KQK → NEE in AAD21531 (PubMed:10077005).Curated3
Sequence conflicti59E → K in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti81K → N in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti107A → P in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti171L → V in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti371A → R in AAD21531 (PubMed:10077005).Curated1
Sequence conflicti379 – 382GARP → AQRL in AAD21531 (PubMed:10077005).Curated4
Sequence conflicti406S → I in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti410 – 419GGRGSKVALL → RAAGTKWHCF in BAA24500 (PubMed:9312143).Curated10
Sequence conflicti424A → G in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti436 – 438AHS → EHL in BAA24500 (PubMed:9312143).Curated3
Sequence conflicti453G → D in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti456S → W in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti468P → L in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti662L → F in AAD21531 (PubMed:10077005).Curated1
Sequence conflicti704S → F in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti714S → F in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti848S → T in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti872P → R in AAD21531 (PubMed:10077005).Curated1
Sequence conflicti875 – 878GRPE → RRS in AAD21531 (PubMed:10077005).Curated4
Sequence conflicti956S → L in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti1252N → K in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti1303G → R in BAA24500 (PubMed:9312143).Curated1
Sequence conflicti1314 – 1338LPPAN…TIVKE → PAPCPTTYAQH in BAA24500 (PubMed:9312143).CuratedAdd BLAST25

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033992789H → Y. Corresponds to variant dbSNP:rs35223808Ensembl.1
Natural variantiVAR_021557879G → S1 PublicationCorresponds to variant dbSNP:rs549588978Ensembl.1
Natural variantiVAR_021558882G → A1 PublicationCorresponds to variant dbSNP:rs201499247Ensembl.1
Natural variantiVAR_033993999V → M. Corresponds to variant dbSNP:rs35927012Ensembl.1
Natural variantiVAR_0148571057G → D1 PublicationCorresponds to variant dbSNP:rs1805097EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB000732 Genomic DNA Translation: BAA24500.1
AF073310 mRNA Translation: AAD21531.1
AF322115, AF322114 Genomic DNA Translation: AAG50013.1
AL162497 Genomic DNA No translation available.
AF288517 Genomic DNA Translation: AAK83053.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9510.1

NCBI Reference Sequences

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RefSeqi
NP_003740.2, NM_003749.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.442344

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375856; ENSP00000365016; ENSG00000185950

Database of genes from NCBI RefSeq genomes

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GeneIDi
8660

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8660

UCSC genome browser

More...
UCSCi
uc001vqv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000732 Genomic DNA Translation: BAA24500.1
AF073310 mRNA Translation: AAD21531.1
AF322115, AF322114 Genomic DNA Translation: AAG50013.1
AL162497 Genomic DNA No translation available.
AF288517 Genomic DNA Translation: AAK83053.1
CCDSiCCDS9510.1
RefSeqiNP_003740.2, NM_003749.2
UniGeneiHs.442344

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FQWX-ray1.93C1097-1105[»]
3FQXX-ray1.70C1097-1105[»]
ProteinModelPortaliQ9Y4H2
SMRiQ9Y4H2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114209, 47 interactors
ELMiQ9Y4H2
IntActiQ9Y4H2, 15 interactors
MINTiQ9Y4H2
STRINGi9606.ENSP00000365016

PTM databases

iPTMnetiQ9Y4H2
PhosphoSitePlusiQ9Y4H2

Polymorphism and mutation databases

BioMutaiIRS2
DMDMi62298062

Proteomic databases

EPDiQ9Y4H2
jPOSTiQ9Y4H2
MaxQBiQ9Y4H2
PaxDbiQ9Y4H2
PeptideAtlasiQ9Y4H2
PRIDEiQ9Y4H2
ProteomicsDBi86205

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8660
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375856; ENSP00000365016; ENSG00000185950
GeneIDi8660
KEGGihsa:8660
UCSCiuc001vqv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8660
DisGeNETi8660
EuPathDBiHostDB:ENSG00000185950.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IRS2
HGNCiHGNC:6126 IRS2
HPAiCAB016944
HPA054664
MalaCardsiIRS2
MIMi600797 gene
neXtProtiNX_Q9Y4H2
OpenTargetsiENSG00000185950
PharmGKBiPA375

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXEK Eukaryota
ENOG410Z9EP LUCA
GeneTreeiENSGT00940000161407
HOVERGENiHBG000542
InParanoidiQ9Y4H2
KOiK07187
OMAiYKAPYTC
OrthoDBi298675at2759
PhylomeDBiQ9Y4H2
TreeFamiTF325994

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-112399 IRS-mediated signalling
R-HSA-112412 SOS-mediated signalling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-198203 PI3K/AKT activation
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-2586552 Signaling by Leptin
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74713 IRS activation
R-HSA-74749 Signal attenuation
R-HSA-8853659 RET signaling
R-HSA-9006335 Signaling by Erythropoietin
R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG)
R-HSA-9027283 Erythropoietin activates STAT5
R-HSA-9027284 Erythropoietin activates RAS
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiQ9Y4H2
SIGNORiQ9Y4H2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IRS2 human
EvolutionaryTraceiQ9Y4H2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IRS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8660
PMAP-CutDBiQ9Y4H2

Protein Ontology

More...
PROi
PR:Q9Y4H2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185950 Expressed in 236 organ(s), highest expression level in decidua
GenevisibleiQ9Y4H2 HS

Family and domain databases

CDDicd01204 PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011 IRS
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10614 PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit
PRINTSiPR00628 INSULINRSI
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4H2
Secondary accession number(s): Q96RR2, Q9BZG0, Q9Y6I5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 29, 2005
Last modified: February 13, 2019
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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