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Entry version 139 (18 Sep 2019)
Sequence version 4 (18 May 2010)
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Protein

Rho family-interacting cell polarization regulator 2

Gene

RIPOR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875).By similarity5 Publications
Isoform 2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation (PubMed:17150207). Maintains naive T lymphocytes in a quiescent state (PubMed:27556504).3 Publications

Miscellaneous

Cells lacking isoform 2 exhibit a severe reduction of myotube formation. In contrast, isoform 2 overexpression induces formation of filopodia.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Signal transduction inhibitor
Biological processCell adhesion, Chemotaxis, Differentiation, Hearing, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho family-interacting cell polarization regulator 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIPOR2
Synonyms:C6orf32, DIFF48, FAM65B, KIAA0386, PL481 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13872 RIPOR2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4F9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 104 (DFNB104)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21S → A: Reduces phosphorylation, interaction with HDAC6, YWHAB and 14-3-3 proteins, localization at the front of the neutrophil upon chemokine stimulation and prevents T cell proliferation inhibition; when associated with A-37; A-341; A-523 and A-585 (isoform 2). 2 Publications1
Mutagenesisi37S → A: Reduces phosphorylation, interaction with HDAC6, YWHAB and 14-3-3 proteins, localization at the front of the neutrophil upon chemokine stimulation and prevents T cell proliferation inhibition; when associated with A-21; A-341; A-523 and A-585 (isoform 2). 2 Publications1
Mutagenesisi151 – 152RL → AA: Inhibits interaction with RHOA and does not prevent T cell proliferation inhibition; in isoform 2. 2 Publications2
Mutagenesisi155 – 156GA → RR: Inhibits interaction with RHOA; in isoform 2. 2 Publications2
Mutagenesisi341S → A: Reduces phosphorylation, interaction with HDAC6, YWHAB and 14-3-3 proteins, localization at the front of the neutrophil upon chemokine stimulation and prevents T cell proliferation inhibition; when associated with A-21; A-37; A-523 and A-585 (isoform 2). 2 Publications1
Mutagenesisi523S → A: Reduces phosphorylation, interaction with HDAC6, YWHAB and 14-3-3 proteins, localization at the front of the neutrophil upon chemokine stimulation and prevents T cell proliferation inhibition; when associated with A-21; A-37; A-341 and A-585 (isoform 2). 2 Publications1
Mutagenesisi585S → A: Reduces phosphorylation, interaction with HDAC6, YWHAB and 14-3-3 proteins, localization at the front of the neutrophil upon chemokine stimulation and prevents T cell proliferation inhibition; when associated with A-21; A-37; A-341 and A-523 (isoform 2). 2 Publications1

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...
DisGeNETi
9750

MalaCards human disease database

More...
MalaCardsi
RIPOR2
MIMi616515 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000111913

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162387677

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RIPOR2

Domain mapping of disease mutations (DMDM)

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DMDMi
296439477

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891141 – 1068Rho family-interacting cell polarization regulator 2Add BLAST1068

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei21Phosphoserine; in isoform 21 Publication1
Modified residuei37Phosphoserine; in isoform 21 Publication1
Modified residuei341Phosphoserine; in isoform 21 Publication1
Modified residuei523Phosphoserine; in isoform 21 Publication1
Modified residuei573PhosphoserineBy similarity1
Modified residuei585Phosphoserine; in isoform 21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Isoform 2 is phosphorylated in T cells (PubMed:27556504). Chemokine-induced phosphorylation of isoform 2 in neutrophils occurs in a PKC- and AKT-dependent manner, resulting in RIPOR2 interaction with YWHAB and stabilization (PubMed:25588844). Isoform 2 is phosphorylated by PKCA, AKT1 and MAPKAPK1A; in vitro (PubMed:25588844).2 Publications
Acetylated during myogenic differentiation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4F9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y4F9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y4F9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y4F9

PeptideAtlas

More...
PeptideAtlasi
Q9Y4F9

PRoteomics IDEntifications database

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PRIDEi
Q9Y4F9

ProteomicsDB human proteome resource

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ProteomicsDBi
86200 [Q9Y4F9-1]
86201 [Q9Y4F9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y4F9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4F9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in primary fetal mononuclear myoblast (PubMed:17150207). Expressed strongly in naive T lymphocytes (PubMed:27556504). Expressed weakly in activated T lymphocytes (at protein level) (PubMed:27556504). Expressed in blood cells and adult tissues of hematopoietic origin, such as the secondary lymphoid organs (PubMed:23241886). Expressed in cytotrophoblast (PubMed:9055809).4 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during fetal mononuclear myoblast differentiation (PubMed:17150207, PubMed:24687993). Up-regulated during cytotrophoblast differentiation (PubMed:9055809). Up-regulated during granulocyte differentiation (PubMed:9055809). Isoform 1 and isoform 2 are down-regulated in T lymphocytes upon T-cell antigen receptor (TCR) stimulation (PubMed:27556504). Isoform 1 and isoform 2 are up-regulated by FOXO1 (PubMed:23241886).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000111913 Expressed in 197 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y4F9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y4F9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; homooligomerization is regulated by RHOC and leads to the formation of concatemers through the association of N- and C-termini (By similarity).

Interacts with 14-3-3 proteins; these interactions occur during myogenic cell differentiation (PubMed:24687993).

Interacts with HDAC6; this interaction occurs during early myogenic differentiation and prevents HDAC6 to deacetylate tubulin (PubMed:24687993).

Interacts with DYSF; this interaction occurs during early myogenic differentiation (PubMed:24687993).

Interacts with MYOF (PubMed:24687993).

Interacts with RHOC (By similarity). Isoform 1 and isoform 2 interact (via active GTP- or inactive GDP-bound forms) with RHOA; these interactions are direct, block the loading of GTP to RHOA and decrease upon chemokine CCL19 stimulation in primary T lymphocytes (PubMed:23241886, PubMed:25588844). Isoform 2 interacts (phosphorylated form) with HDAC6; this interaction induces T cell proliferation arrest (PubMed:27556504). Isoform 2 interacts (phosphorylated form) with 14-3-3 proteins; these interactions induces T cell proliferation arrest (PubMed:27556504).

Isoform 2 interacts with 14-3-3 proteins (PubMed:25588844). Isoform 2 interacts (via phosphorylated form) with YWHAB; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844).

Isoform 2 interacts with YWHAE (PubMed:25588844).

Isoform 2 interacts with YWHAQ (PubMed:25588844).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115098, 10 interactors

Protein interaction database and analysis system

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IntActi
Q9Y4F9, 10 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000482957

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y4F9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni55 – 113Involved in cell filopodia formation1 PublicationAdd BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili83 – 112Sequence analysisAdd BLAST30
Coiled coili768 – 793Sequence analysisAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIPOR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEN6 Eukaryota
ENOG410XR7R LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153717

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000112476

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y4F9

Identification of Orthologs from Complete Genome Data

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OMAi
VKGLATH

Database of Orthologous Groups

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OrthoDBi
1121546at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y4F9

TreeFam database of animal gene trees

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TreeFami
TF329332

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031780 FAM65_N
IPR033035 FAM65B
IPR026136 RIPOR3

The PANTHER Classification System

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PANTHERi
PTHR15829 PTHR15829, 1 hit
PTHR15829:SF2 PTHR15829:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15903 PL48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVGSQSFSP GGPNGIIRSQ SFAGFSGLQE RRSRCNSFIE NSSALKKPQA
60 70 80 90 100
KLKKMHNLGH KNNNPPKEPQ PKRVEEVYRA LKNGLDEYLE VHQTELDKLT
110 120 130 140 150
AQLKDMKRNS RLGVLYDLDK QIKTIERYMR RLEFHISKVD ELYEAYCIQR
160 170 180 190 200
RLQDGASKMK QAFATSPASK AARESLTEIN RSFKEYTENM CTIEVELENL
210 220 230 240 250
LGEFSIKMKG LAGFARLCPG DQYEIFMKYG RQRWKLKGKI EVNGKQSWDG
260 270 280 290 300
EETVFLPLIV GFISIKVTEL KGLATHILVG SVTCETKELF AARPQVVAVD
310 320 330 340 350
INDLGTIKLN LEITWYPFDV EDMTASSGAG NKAAALQRRM SMYSQGTPET
360 370 380 390 400
PTFKDHSFFR WLHPSPDKPR RLSVLSALQD TFFAKLHRSR SFSDLPSLRP
410 420 430 440 450
SPKAVLELYS NLPDDIFENG KAAEEKMPLS LSFSDLPNGD CALTSHSTGS
460 470 480 490 500
PSNSTNPEIT ITPAEFNLSS LASQNEGMDD TSSASSRNSL GEGQEPKSHL
510 520 530 540 550
KEEDPEEPRK PASAPSEACR RQSSGAGAEH LFLENDVAEA LLQESEEASE
560 570 580 590 600
LKPVELDTSE GNITKQLVKR LTSAEVPMAT DRLLSEGSVG GESEGCRSFL
610 620 630 640 650
DGSLEDAFNG LLLALEPHKE QYKEFQDLNQ EVMNLDDILK CKPAVSRSRS
660 670 680 690 700
SSLSLTVESA LESFDFLNTS DFDEEEDGDE VCNVGGGADS VFSDTETEKH
710 720 730 740 750
SYRSVHPEAR GHLSEALTED TGVGTSVAGS PLPLTTGNES LDITIVRHLQ
760 770 780 790 800
YCTQLVQQIV FSSKTPFVAR SLLEKLSRQI QVMEKLAAVS DENIGNISSV
810 820 830 840 850
VEAIPEFHKK LSLLSFWTKC CSPVGVYHSP ADRVMKQLEA SFARTVNKEY
860 870 880 890 900
PGLADPVFRT LVSQILDRAE PLLSSSLSSE VVTVFQYYSY FTSHGVSDLE
910 920 930 940 950
SYLSQLARQV SMVQTLQSLR DEKLLQTMSD LAPSNLLAQQ EVLRTLALLL
960 970 980 990 1000
TREDNEVSEA VTLYLAAASK NQHFREKALL YYCEALTKTN LQLQKAACLA
1010 1020 1030 1040 1050
LKILEATESI KMLVTLCQSD TEEIRNVASE TLLSLGEDGR LAYEQLDKFP
1060
RDCVKVGGRH GTEVATAF
Length:1,068
Mass (Da):118,519
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCA7DEB3A66F36AA
GO
Isoform 2 (identifier: Q9Y4F9-2) [UniParc]FASTAAdd to basket
Also known as: PL481 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     360-409: Missing.
     641-641: C → K
     642-1068: Missing.

Show »
Length:591
Mass (Da):65,692
Checksum:iAB43802AF3D551EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX51F5GX51_HUMAN
Rho family-interacting cell polariz...
RIPOR2
1,018Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z6U4B7Z6U4_HUMAN
Rho family-interacting cell polariz...
RIPOR2
647Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H029F5H029_HUMAN
Rho family-interacting cell polariz...
RIPOR2
613Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEE0A0A2R8YEE0_HUMAN
Rho family-interacting cell polariz...
RIPOR2
1,047Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7B3A0A2R8Y7B3_HUMAN
Rho family-interacting cell polariz...
RIPOR2
642Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF77A0A2R8YF77_HUMAN
Rho family-interacting cell polariz...
RIPOR2
663Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4B9A0A2R8Y4B9_HUMAN
Rho family-interacting cell polariz...
RIPOR2
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4N2A0A2R8Y4N2_HUMAN
Rho family-interacting cell polariz...
RIPOR2
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC51134 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAA20840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13P → A in AAC51134 (PubMed:9055809).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032572145A → G. Corresponds to variant dbSNP:rs11967003EnsemblClinVar.1
Natural variantiVAR_032573320V → M1 PublicationCorresponds to variant dbSNP:rs35331811EnsemblClinVar.1
Natural variantiVAR_032574424E → K. Corresponds to variant dbSNP:rs34016544EnsemblClinVar.1
Natural variantiVAR_032575452S → C. Corresponds to variant dbSNP:rs34298086EnsemblClinVar.1
Natural variantiVAR_032576495E → K. Corresponds to variant dbSNP:rs35514577EnsemblClinVar.1
Natural variantiVAR_032577520R → C. Corresponds to variant dbSNP:rs35780910EnsemblClinVar.1
Natural variantiVAR_062193868R → Q1 PublicationCorresponds to variant dbSNP:rs9461073EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025904360 – 409Missing in isoform 2. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_025905641C → K in isoform 2. 2 Publications1
Alternative sequenceiVSP_025906642 – 1068Missing in isoform 2. 2 PublicationsAdd BLAST427

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U49187 mRNA Translation: AAC51134.1 Frameshift.
AB002384 mRNA Translation: BAA20840.2 Different initiation.
AL512428 Genomic DNA No translation available.
AL078584 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55470.1
BC001232 mRNA Translation: AAH01232.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47383.1 [Q9Y4F9-1]
CCDS47384.1 [Q9Y4F9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273375.1, NM_001286446.2
NP_001273376.1, NM_001286447.1
NP_055537.2, NM_014722.4 [Q9Y4F9-1]
NP_056948.2, NM_015864.3 [Q9Y4F9-2]
XP_016867015.1, XM_017011526.1 [Q9Y4F9-2]
XP_016867016.1, XM_017011527.1 [Q9Y4F9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259698; ENSP00000259698; ENSG00000111913 [Q9Y4F9-1]
ENST00000378023; ENSP00000367262; ENSG00000111913 [Q9Y4F9-2]
ENST00000613507; ENSP00000482957; ENSG00000111913 [Q9Y4F9-1]
ENST00000643623; ENSP00000495245; ENSG00000111913 [Q9Y4F9-2]
ENST00000644621; ENSP00000495914; ENSG00000111913 [Q9Y4F9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9750

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9750

UCSC genome browser

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UCSCi
uc003neo.3 human [Q9Y4F9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49187 mRNA Translation: AAC51134.1 Frameshift.
AB002384 mRNA Translation: BAA20840.2 Different initiation.
AL512428 Genomic DNA No translation available.
AL078584 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55470.1
BC001232 mRNA Translation: AAH01232.1
CCDSiCCDS47383.1 [Q9Y4F9-1]
CCDS47384.1 [Q9Y4F9-2]
RefSeqiNP_001273375.1, NM_001286446.2
NP_001273376.1, NM_001286447.1
NP_055537.2, NM_014722.4 [Q9Y4F9-1]
NP_056948.2, NM_015864.3 [Q9Y4F9-2]
XP_016867015.1, XM_017011526.1 [Q9Y4F9-2]
XP_016867016.1, XM_017011527.1 [Q9Y4F9-2]

3D structure databases

SMRiQ9Y4F9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115098, 10 interactors
IntActiQ9Y4F9, 10 interactors
STRINGi9606.ENSP00000482957

PTM databases

iPTMnetiQ9Y4F9
PhosphoSitePlusiQ9Y4F9

Polymorphism and mutation databases

BioMutaiRIPOR2
DMDMi296439477

Proteomic databases

EPDiQ9Y4F9
jPOSTiQ9Y4F9
MassIVEiQ9Y4F9
PaxDbiQ9Y4F9
PeptideAtlasiQ9Y4F9
PRIDEiQ9Y4F9
ProteomicsDBi86200 [Q9Y4F9-1]
86201 [Q9Y4F9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9750
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259698; ENSP00000259698; ENSG00000111913 [Q9Y4F9-1]
ENST00000378023; ENSP00000367262; ENSG00000111913 [Q9Y4F9-2]
ENST00000613507; ENSP00000482957; ENSG00000111913 [Q9Y4F9-1]
ENST00000643623; ENSP00000495245; ENSG00000111913 [Q9Y4F9-2]
ENST00000644621; ENSP00000495914; ENSG00000111913 [Q9Y4F9-2]
GeneIDi9750
KEGGihsa:9750
UCSCiuc003neo.3 human [Q9Y4F9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9750
DisGeNETi9750

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RIPOR2
HGNCiHGNC:13872 RIPOR2
MalaCardsiRIPOR2
MIMi611410 gene
616515 phenotype
neXtProtiNX_Q9Y4F9
OpenTargetsiENSG00000111913
Orphaneti90636 Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA162387677

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEN6 Eukaryota
ENOG410XR7R LUCA
GeneTreeiENSGT00940000153717
HOGENOMiHOG000112476
InParanoidiQ9Y4F9
OMAiVKGLATH
OrthoDBi1121546at2759
PhylomeDBiQ9Y4F9
TreeFamiTF329332

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM65B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9750

Pharos

More...
Pharosi
Q9Y4F9

Protein Ontology

More...
PROi
PR:Q9Y4F9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111913 Expressed in 197 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ9Y4F9 baseline and differential
GenevisibleiQ9Y4F9 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031780 FAM65_N
IPR033035 FAM65B
IPR026136 RIPOR3
PANTHERiPTHR15829 PTHR15829, 1 hit
PTHR15829:SF2 PTHR15829:SF2, 1 hit
PfamiView protein in Pfam
PF15903 PL48, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIPR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4F9
Secondary accession number(s): A6NHP2
, Q13529, Q5VV37, Q5VV38, Q9BQ28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 139 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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