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Entry version 142 (07 Oct 2020)
Sequence version 4 (03 Apr 2007)
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Protein

Centrosomal protein of 170 kDa protein B

Gene

CEP170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in microtubule organization.By similarity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y4F5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 170 kDa protein B
Alternative name(s):
Centrosomal protein 170B
Short name:
Cep170B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP170B
Synonyms:FAM68C, KIAA0284
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000099814.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20362, CEP170B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4F5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283638

Open Targets

More...
OpenTargetsi
ENSG00000099814

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134863153

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y4F5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP170B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143342098

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828891 – 1589Centrosomal protein of 170 kDa protein BAdd BLAST1589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei360PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei480PhosphoserineBy similarity1
Modified residuei492PhosphoserineCombined sources1
Modified residuei536PhosphoserineBy similarity1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei711PhosphoserineBy similarity1
Modified residuei721PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1
Modified residuei972PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1135PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1304PhosphothreonineCombined sources1
Modified residuei1356PhosphoserineBy similarity1
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1545PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4F5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4F5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y4F5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4F5

PeptideAtlas

More...
PeptideAtlasi
Q9Y4F5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4F5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86197 [Q9Y4F5-1]
86198 [Q9Y4F5-2]
86199 [Q9Y4F5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4F5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4F5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000099814, Expressed in Brodmann (1909) area 10 and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4F5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4F5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000099814, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
129628, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4F5, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404151

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y4F5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4F5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP170 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSH8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157058

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4F5

KEGG Orthology (KO)

More...
KOi
K16463

Database of Orthologous Groups

More...
OrthoDBi
83451at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4F5

TreeFam database of animal gene trees

More...
TreeFami
TF328469

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029300, CEP170_C
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15308, CEP170_C, 1 hit
PF00498, FHA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240, FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ
60 70 80 90 100
DRDEHWVKDL GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER
110 120 130 140 150
VQHRVPEEAL KHEKYTSQLQ VSVKGLAPKR SEALPEHTPY CEASNPRPEK
160 170 180 190 200
GDRRPGTEAA SYRTPLYGQP SWWGEDDGST LPDAQRQGEP YPERPKGPVQ
210 220 230 240 250
QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP EVPAHEMPTK
260 270 280 290 300
DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK
310 320 330 340 350
EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK
360 370 380 390 400
GHKHEDGTQS DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN
410 420 430 440 450
QQAFVIEFFD EDTPRKKRSQ SFTHSPSGDP KADKRRGPTP ADRDRPSVPA
460 470 480 490 500
PVQAGGRSSG PQRAGSLKRE KTEERLGSPS PASRTPARPF GSVGRRSRLA
510 520 530 540 550
QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP PTPPPAPTDP
560 570 580 590 600
QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL
610 620 630 640 650
SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL
660 670 680 690 700
PVPGSPGGQK WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR
710 720 730 740 750
LPQLPSERAD SPAGPESSRR SGPGPPELDS EQPSRLFGQE ELDPDSLSDA
760 770 780 790 800
SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS RGRRSPRAPG EPTPASFFIG
810 820 830 840 850
DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA NGRMVIQLRP
860 870 880 890 900
GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA
910 920 930 940 950
ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL
960 970 980 990 1000
SGDSDVDTAS TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL
1010 1020 1030 1040 1050
VSAREQSSER QHHPLGPTDM GRGEPVRRSA IRRGHRPRGS LDWPSEERGP
1060 1070 1080 1090 1100
VLAHLPSSDV MASNHETPEA TGAGRLGSRR KPAAPPPSPA AREEQSRSSA
1110 1120 1130 1140 1150
SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA DGERGSLGNP
1160 1170 1180 1190 1200
EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV
1210 1220 1230 1240 1250
ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR
1260 1270 1280 1290 1300
RQQGSDYTST SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG
1310 1320 1330 1340 1350
PRDTDDDEEE PDPYGFIVQT AEIAEIARLS QTLVKDVAIL AQEIHDVAGD
1360 1370 1380 1390 1400
GDTLGSSEPA HSASLSNMPS TPASTISARE ELVQRIPEAS LNFQKVPPGS
1410 1420 1430 1440 1450
LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV SQLSQAIREN
1460 1470 1480 1490 1500
TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR
1510 1520 1530 1540 1550
RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA
1560 1570 1580
SAEALLPALP LRNFPQRASC GPPSLPDPTF LPDAERFLI
Length:1,589
Mass (Da):171,688
Last modified:April 3, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB232960C12A81244
GO
Isoform 2 (identifier: Q9Y4F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1247-1282: NTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTA → T

Show »
Length:1,554
Mass (Da):167,714
Checksum:i1EBC4872698A20BF
GO
Isoform 3 (identifier: Q9Y4F5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:1,519
Mass (Da):163,627
Checksum:i240FDF3FC1A9D934
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQR7J3KQR7_HUMAN
Centrosomal protein of 170 kDa prot...
CEP170B
1,590Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH47913 differs from that shown. Reason: Frameshift.Curated
The sequence BAA22953 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti315A → T in BAA22953 (PubMed:9179496).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0242471 – 70Missing in isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0242481247 – 1282NTRRR…HTSTA → T in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB006622 mRNA Translation: BAA22953.3 Different initiation.
AL583810 Genomic DNA No translation available.
BC047913 mRNA Translation: AAH47913.1 Frameshift.
BC112928 mRNA Translation: AAI12929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45175.1 [Q9Y4F5-2]
CCDS45176.2 [Q9Y4F5-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00037

NCBI Reference Sequences

More...
RefSeqi
NP_001106197.1, NM_001112726.2 [Q9Y4F5-2]
NP_055820.2, NM_015005.2 [Q9Y4F5-3]
XP_005267607.1, XM_005267550.3 [Q9Y4F5-1]
XP_011534967.1, XM_011536665.2 [Q9Y4F5-1]
XP_011534968.1, XM_011536666.2 [Q9Y4F5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000414716; ENSP00000404151; ENSG00000099814 [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814 [Q9Y4F5-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
283638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283638

UCSC genome browser

More...
UCSCi
uc001yps.4, human [Q9Y4F5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006622 mRNA Translation: BAA22953.3 Different initiation.
AL583810 Genomic DNA No translation available.
BC047913 mRNA Translation: AAH47913.1 Frameshift.
BC112928 mRNA Translation: AAI12929.1
CCDSiCCDS45175.1 [Q9Y4F5-2]
CCDS45176.2 [Q9Y4F5-3]
PIRiT00037
RefSeqiNP_001106197.1, NM_001112726.2 [Q9Y4F5-2]
NP_055820.2, NM_015005.2 [Q9Y4F5-3]
XP_005267607.1, XM_005267550.3 [Q9Y4F5-1]
XP_011534967.1, XM_011536665.2 [Q9Y4F5-1]
XP_011534968.1, XM_011536666.2 [Q9Y4F5-1]

3D structure databases

SMRiQ9Y4F5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129628, 28 interactors
IntActiQ9Y4F5, 22 interactors
STRINGi9606.ENSP00000404151

PTM databases

iPTMnetiQ9Y4F5
PhosphoSitePlusiQ9Y4F5

Polymorphism and mutation databases

BioMutaiCEP170B
DMDMi143342098

Proteomic databases

EPDiQ9Y4F5
jPOSTiQ9Y4F5
MassIVEiQ9Y4F5
PaxDbiQ9Y4F5
PeptideAtlasiQ9Y4F5
PRIDEiQ9Y4F5
ProteomicsDBi86197 [Q9Y4F5-1]
86198 [Q9Y4F5-2]
86199 [Q9Y4F5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
54848, 41 antibodies

The DNASU plasmid repository

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DNASUi
283638

Genome annotation databases

EnsembliENST00000414716; ENSP00000404151; ENSG00000099814 [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814 [Q9Y4F5-3]
GeneIDi283638
KEGGihsa:283638
UCSCiuc001yps.4, human [Q9Y4F5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
283638
DisGeNETi283638
EuPathDBiHostDB:ENSG00000099814.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CEP170B
HGNCiHGNC:20362, CEP170B
HPAiENSG00000099814, Low tissue specificity
neXtProtiNX_Q9Y4F5
OpenTargetsiENSG00000099814
PharmGKBiPA134863153

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QSH8, Eukaryota
GeneTreeiENSGT00940000157058
InParanoidiQ9Y4F5
KOiK16463
OrthoDBi83451at2759
PhylomeDBiQ9Y4F5
TreeFamiTF328469

Enzyme and pathway databases

PathwayCommonsiQ9Y4F5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
283638, 7 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CEP170B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
283638
PharosiQ9Y4F5, Tdark

Protein Ontology

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PROi
PR:Q9Y4F5
RNActiQ9Y4F5, protein

Gene expression databases

BgeeiENSG00000099814, Expressed in Brodmann (1909) area 10 and 243 other tissues
ExpressionAtlasiQ9Y4F5, baseline and differential
GenevisibleiQ9Y4F5, HS

Family and domain databases

CDDicd00060, FHA, 1 hit
InterProiView protein in InterPro
IPR029300, CEP170_C
IPR000253, FHA_dom
IPR008984, SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF15308, CEP170_C, 1 hit
PF00498, FHA, 1 hit
SMARTiView protein in SMART
SM00240, FHA, 1 hit
SUPFAMiSSF49879, SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006, FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC170B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4F5
Secondary accession number(s): Q2KHR7, Q86TI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: October 7, 2020
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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