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Protein

Centrosomal protein of 170 kDa protein B

Gene

CEP170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in microtubule organization.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 170 kDa protein B
Alternative name(s):
Centrosomal protein 170B
Short name:
Cep170B
Gene namesi
Name:CEP170B
Synonyms:FAM68C, KIAA0284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000099814.15
HGNCiHGNC:20362 CEP170B
neXtProtiNX_Q9Y4F5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi283638
OpenTargetsiENSG00000099814
PharmGKBiPA134863153

Polymorphism and mutation databases

BioMutaiCEP170B
DMDMi143342098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828891 – 1589Centrosomal protein of 170 kDa protein BAdd BLAST1589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei480PhosphoserineBy similarity1
Modified residuei492PhosphoserineCombined sources1
Modified residuei536PhosphoserineBy similarity1
Modified residuei542PhosphothreonineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei711PhosphoserineBy similarity1
Modified residuei721PhosphoserineCombined sources1
Modified residuei746PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei753PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei829PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei954PhosphoserineCombined sources1
Modified residuei972PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei988PhosphoserineCombined sources1
Modified residuei1135PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1199PhosphoserineBy similarity1
Modified residuei1304PhosphothreonineCombined sources1
Modified residuei1356PhosphoserineBy similarity1
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1545PhosphoserineCombined sources1
Modified residuei1548PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y4F5
PaxDbiQ9Y4F5
PeptideAtlasiQ9Y4F5
PRIDEiQ9Y4F5
ProteomicsDBi86197
86198 [Q9Y4F5-2]
86199 [Q9Y4F5-3]

PTM databases

iPTMnetiQ9Y4F5
PhosphoSitePlusiQ9Y4F5

Expressioni

Gene expression databases

BgeeiENSG00000099814 Expressed in 231 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_KIAA0284
ExpressionAtlasiQ9Y4F5 baseline and differential
GenevisibleiQ9Y4F5 HS

Organism-specific databases

HPAiHPA000871
HPA059017

Interactioni

Protein-protein interaction databases

BioGridi129628, 20 interactors
IntActiQ9Y4F5, 17 interactors
STRINGi9606.ENSP00000404151

Structurei

3D structure databases

ProteinModelPortaliQ9Y4F5
SMRiQ9Y4F5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

Sequence similaritiesi

Belongs to the CEP170 family.Curated

Phylogenomic databases

eggNOGiENOG410IJXX Eukaryota
ENOG410XQU2 LUCA
GeneTreeiENSGT00640000091476
HOGENOMiHOG000111524
HOVERGENiHBG108016
InParanoidiQ9Y4F5
KOiK16463
PhylomeDBiQ9Y4F5
TreeFamiTF328469

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSATSWFLVS SSGARHRLPR ELIFVGREEC ELMLQSRSVD KQHAVINYDQ
60 70 80 90 100
DRDEHWVKDL GSLNGTFVND MRIPDQKYVT LKLNDVIRFG YDSNMYVLER
110 120 130 140 150
VQHRVPEEAL KHEKYTSQLQ VSVKGLAPKR SEALPEHTPY CEASNPRPEK
160 170 180 190 200
GDRRPGTEAA SYRTPLYGQP SWWGEDDGST LPDAQRQGEP YPERPKGPVQ
210 220 230 240 250
QDGELHGFRA PAEPQGCSFR REPSYFEIPT KETPQPSQPP EVPAHEMPTK
260 270 280 290 300
DAEAGGGGAA PVVQSHASFT IEFDDCSPGK MKIKDHITKF SLRQRRPPGK
310 320 330 340 350
EATPGEMVSA ETKVADWLVQ NDPSLLHRVG PGDDRHSTKS DLPVHTRTLK
360 370 380 390 400
GHKHEDGTQS DSEDPLAKAA SAAGVPLEAS GEQVRLQRQI KRDPQELLHN
410 420 430 440 450
QQAFVIEFFD EDTPRKKRSQ SFTHSPSGDP KADKRRGPTP ADRDRPSVPA
460 470 480 490 500
PVQAGGRSSG PQRAGSLKRE KTEERLGSPS PASRTPARPF GSVGRRSRLA
510 520 530 540 550
QDFMAQCLRE SSPAARPSPE KVPPVLPAPL TPHGTSPVGP PTPPPAPTDP
560 570 580 590 600
QLTKARKQEE DDSLSDAGTY TIETEAQDTE VEEARKMIDQ VFGVLESPEL
610 620 630 640 650
SRASSATFRP VIRGDRDESD DGGVAQRMAL LQEFASRPLG AAPQAEHQGL
660 670 680 690 700
PVPGSPGGQK WVSRWASLAD SYSDPGLTED GLGRRGGEPE GSLPVRMRRR
710 720 730 740 750
LPQLPSERAD SPAGPESSRR SGPGPPELDS EQPSRLFGQE ELDPDSLSDA
760 770 780 790 800
SGSDGGRGPE PGVEPQDSRR RSPQEGPTWS RGRRSPRAPG EPTPASFFIG
810 820 830 840 850
DQNGDAVLSR KPLAAPGDGE GLGQTAQPSP PARDGVYVSA NGRMVIQLRP
860 870 880 890 900
GRSPEPDGPA PAFLRQESFT KEPASGPPAP GKPPHISSHP LLQDLAATRA
910 920 930 940 950
ARMDFHSQDT HLILKETETA LAALEARLLS NSVDAECEGG STPRPPEDAL
960 970 980 990 1000
SGDSDVDTAS TVSLRSGKSG PSPTTPQPLR AQKEMSPSPP AAQDPGGTAL
1010 1020 1030 1040 1050
VSAREQSSER QHHPLGPTDM GRGEPVRRSA IRRGHRPRGS LDWPSEERGP
1060 1070 1080 1090 1100
VLAHLPSSDV MASNHETPEA TGAGRLGSRR KPAAPPPSPA AREEQSRSSA
1110 1120 1130 1140 1150
SSQKGPQALT RSNSLSTPRP TRASRLRRAR LGDASDTEAA DGERGSLGNP
1160 1170 1180 1190 1200
EPVGRPAAEQ AKKLSRLDIL AMPRKRAGSF TGTSDPEAAP ARTSFSGRSV
1210 1220 1230 1240 1250
ELCCASRKPT MAEARAVSRK AANTATTTGP RQPFSRARSG SARYTSNTRR
1260 1270 1280 1290 1300
RQQGSDYTST SEEEYGSRHG SPKHTRSHTS TATQTPRAGS SSRARSRAPG
1310 1320 1330 1340 1350
PRDTDDDEEE PDPYGFIVQT AEIAEIARLS QTLVKDVAIL AQEIHDVAGD
1360 1370 1380 1390 1400
GDTLGSSEPA HSASLSNMPS TPASTISARE ELVQRIPEAS LNFQKVPPGS
1410 1420 1430 1440 1450
LNSRDFDQNM NDSCEDALAN KTRPRNREEV IFDNLMLNPV SQLSQAIREN
1460 1470 1480 1490 1500
TEHLAEKMKI LFQNTGRAWE DLEARINAEN EVPILKTSNK EISSILKELR
1510 1520 1530 1540 1550
RVQKQLEVIN AIVDPSGSLD LLTGNRSLAS SAQPGLGKGR VAAQSPPSPA
1560 1570 1580
SAEALLPALP LRNFPQRASC GPPSLPDPTF LPDAERFLI
Length:1,589
Mass (Da):171,688
Last modified:April 3, 2007 - v4
Checksum:iB232960C12A81244
GO
Isoform 2 (identifier: Q9Y4F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1247-1282: NTRRRQQGSDYTSTSEEEYGSRHGSPKHTRSHTSTA → T

Show »
Length:1,554
Mass (Da):167,714
Checksum:i1EBC4872698A20BF
GO
Isoform 3 (identifier: Q9Y4F5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.
Show »
Length:1,519
Mass (Da):163,627
Checksum:i240FDF3FC1A9D934
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQR7J3KQR7_HUMAN
Centrosomal protein of 170 kDa prot...
CEP170B
1,590Annotation score:

Sequence cautioni

The sequence AAH47913 differs from that shown. Reason: Frameshift at position 1379.Curated
The sequence BAA22953 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti315A → T in BAA22953 (PubMed:9179496).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242471 – 70Missing in isoform 3. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0242481247 – 1282NTRRR…HTSTA → T in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006622 mRNA Translation: BAA22953.3 Different initiation.
AL583810 Genomic DNA No translation available.
BC047913 mRNA Translation: AAH47913.1 Frameshift.
BC112928 mRNA Translation: AAI12929.1
CCDSiCCDS45175.1 [Q9Y4F5-2]
CCDS45176.2 [Q9Y4F5-3]
PIRiT00037
RefSeqiNP_001106197.1, NM_001112726.2 [Q9Y4F5-2]
NP_055820.2, NM_015005.2 [Q9Y4F5-3]
XP_005267607.1, XM_005267550.3 [Q9Y4F5-1]
XP_011534967.1, XM_011536665.2 [Q9Y4F5-1]
XP_011534968.1, XM_011536666.2 [Q9Y4F5-1]
UniGeneiHs.533721

Genome annotation databases

EnsembliENST00000414716; ENSP00000404151; ENSG00000099814 [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814 [Q9Y4F5-3]
GeneIDi283638
KEGGihsa:283638
UCSCiuc001yps.4 human [Q9Y4F5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB006622 mRNA Translation: BAA22953.3 Different initiation.
AL583810 Genomic DNA No translation available.
BC047913 mRNA Translation: AAH47913.1 Frameshift.
BC112928 mRNA Translation: AAI12929.1
CCDSiCCDS45175.1 [Q9Y4F5-2]
CCDS45176.2 [Q9Y4F5-3]
PIRiT00037
RefSeqiNP_001106197.1, NM_001112726.2 [Q9Y4F5-2]
NP_055820.2, NM_015005.2 [Q9Y4F5-3]
XP_005267607.1, XM_005267550.3 [Q9Y4F5-1]
XP_011534967.1, XM_011536665.2 [Q9Y4F5-1]
XP_011534968.1, XM_011536666.2 [Q9Y4F5-1]
UniGeneiHs.533721

3D structure databases

ProteinModelPortaliQ9Y4F5
SMRiQ9Y4F5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129628, 20 interactors
IntActiQ9Y4F5, 17 interactors
STRINGi9606.ENSP00000404151

PTM databases

iPTMnetiQ9Y4F5
PhosphoSitePlusiQ9Y4F5

Polymorphism and mutation databases

BioMutaiCEP170B
DMDMi143342098

Proteomic databases

EPDiQ9Y4F5
PaxDbiQ9Y4F5
PeptideAtlasiQ9Y4F5
PRIDEiQ9Y4F5
ProteomicsDBi86197
86198 [Q9Y4F5-2]
86199 [Q9Y4F5-3]

Protocols and materials databases

DNASUi283638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000414716; ENSP00000404151; ENSG00000099814 [Q9Y4F5-2]
ENST00000556508; ENSP00000451249; ENSG00000099814 [Q9Y4F5-3]
GeneIDi283638
KEGGihsa:283638
UCSCiuc001yps.4 human [Q9Y4F5-1]

Organism-specific databases

CTDi283638
DisGeNETi283638
EuPathDBiHostDB:ENSG00000099814.15
GeneCardsiCEP170B
HGNCiHGNC:20362 CEP170B
HPAiHPA000871
HPA059017
neXtProtiNX_Q9Y4F5
OpenTargetsiENSG00000099814
PharmGKBiPA134863153
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXX Eukaryota
ENOG410XQU2 LUCA
GeneTreeiENSGT00640000091476
HOGENOMiHOG000111524
HOVERGENiHBG108016
InParanoidiQ9Y4F5
KOiK16463
PhylomeDBiQ9Y4F5
TreeFamiTF328469

Miscellaneous databases

ChiTaRSiCEP170B human
GenomeRNAii283638
PROiPR:Q9Y4F5

Gene expression databases

BgeeiENSG00000099814 Expressed in 231 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_KIAA0284
ExpressionAtlasiQ9Y4F5 baseline and differential
GenevisibleiQ9Y4F5 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PfamiView protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC170B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4F5
Secondary accession number(s): Q2KHR7, Q86TI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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