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UniProtKB - Q9Y4F4 (TGRM1_HUMAN)

Entry version 146 (17 Jun 2020)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

TOG array regulator of axonemal microtubules protein 1

Gene

TOGARAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TOG array regulator of axonemal microtubules protein 1Imported
Alternative name(s):
Crescerin-1Curated
Protein FAM179B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOGARAM1Imported
Synonyms:FAM179B, KIAA0423
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000198718.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:19959 TOGARAM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617618 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y4F4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000198718

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162387516

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y4F4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TOGARAM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439476

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519521 – 1720TOG array regulator of axonemal microtubules protein 1Add BLAST1720

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y4F4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y4F4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y4F4

PeptideAtlas

More...PeptideAtlasi		Q9Y4F4

PRoteomics IDEntifications database

More...PRIDEi		Q9Y4F4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86194 [Q9Y4F4-1]
86195 [Q9Y4F4-2]
86196 [Q9Y4F4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y4F4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y4F4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198718 Expressed in corpus callosum and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y4F4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y4F4 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198718 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116738, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y4F4, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355045

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y4F4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 212HEAT 1Sequence analysisAdd BLAST38
Repeati214 – 247HEAT 2Sequence analysisAdd BLAST34
Repeati251 – 289HEAT 3Sequence analysisAdd BLAST39
Repeati345 – 384HEAT 4Sequence analysisAdd BLAST40
Repeati390 – 427HEAT 5Sequence analysisAdd BLAST38
Repeati431 – 466HEAT 6Sequence analysisAdd BLAST36
Repeati467 – 504HEAT 7Sequence analysisAdd BLAST38
Repeati506 – 543HEAT 8Sequence analysisAdd BLAST38
Repeati1294 – 1331HEAT 9Sequence analysisAdd BLAST38
Repeati1335 – 1372HEAT 10Sequence analysisAdd BLAST38
Repeati1485 – 1522HEAT 11Sequence analysisAdd BLAST38
Repeati1526 – 1563HEAT 12Sequence analysisAdd BLAST38
Repeati1567 – 1605HEAT 13Sequence analysisAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 312TOG 1By similarityAdd BLAST219
Regioni352 – 596TOG 2By similarityAdd BLAST245
Regioni1256 – 1425TOG 3By similarityAdd BLAST170
Regioni1484 – 1720TOG 4By similarityAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi971 – 1129Ser-richAdd BLAST159

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Crescerin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2933 Eukaryota
ENOG410XSBP LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_275329_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y4F4

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y4F4

TreeFam database of animal gene trees

More...TreeFami		TF315518

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028401 Crescerin-1
IPR034085 TOG

The PANTHER Classification System

More...PANTHERi		PTHR21567:SF6 PTHR21567:SF6, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01349 TOG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF 
        60         70         80         90        100
RGAAGDHGSC PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL 
       110        120        130        140        150
QLLRTARDPS EAFQALQAAL PRRGGRLGFP RRKEALYRAL GRVLVEGGSD 
       160        170        180        190        200
EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL LPQLVVSLRE ENPALRKDAL 
       210        220        230        240        250
QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI LLTTEDLLLG 
       260        270        280        290        300
LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP 
       310        320        330        340        350
SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI 
       360        370        380        390        400
IPQELHSRLL DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY 
       410        420        430        440        450
NLLDDSNFKV VHGTLEVLHL LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV 
       460        470        480        490        500
IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK HKHSRVREEV VNICICSLLT 
       510        520        530        540        550
YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS MGSGKTSILF 
       560        570        580        590        600
KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR 
       610        620        630        640        650
SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL 
       660        670        680        690        700
SAGKGKNKLP WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM 
       710        720        730        740        750
PVNDDLCFSR KRVSRNLFQN SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ 
       760        770        780        790        800
LGFSQICGKT GSVGSDLQFL GTTSSHQEKV YASLNFGSKT QQTFGSQTEC 
       810        820        830        840        850
TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS QDNSVNFSNS 
       860        870        880        890        900
WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS 
       910        920        930        940        950
PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL 
       960        970        980        990       1000
PIDLSELNFK DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA 
      1010       1020       1030       1040       1050
MKLDLTMDSP SLSSSPNINS YSESGVYSQE SLTSSLSTTP QGKRIMSDIF 
      1060       1070       1080       1090       1100
PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG SSSNPQQISS FDFTTTKALS 
      1110       1120       1130       1140       1150
EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ SIEPPSGIYG 
      1160       1170       1180       1190       1200
RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK 
      1210       1220       1230       1240       1250
EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR 
      1260       1270       1280       1290       1300
PFSKPEIALT EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN 
      1310       1320       1330       1340       1350
FAVVQEVKNL RSGVSRAAVV CLSDLFTYLK KSMDQELDTT VKVLLHKAGE 
      1360       1370       1380       1390       1400
SNTFIREDVD KALRAMVNNV TPARAVVSLI NGGQRYYGRK MLFFMMCHPN 
      1410       1420       1430       1440       1450
FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK GRRSHTGSVG 
      1460       1470       1480       1490       1500
NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA 
      1510       1520       1530       1540       1550
KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA 
      1560       1570       1580       1590       1600
LETMHKMIPL LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS 
      1610       1620       1630       1640       1650
QHVDNYLLLQ PFCTKAQFLN GKAKQDMTEK LADIVTELYQ RKPHATEQKV 
      1660       1670       1680       1690       1700
LVVLWHLLGN MTNSGSLPGA GGNIRTATAK LSKALFAQMG QNLLNQAASQ 
      1710       1720
PPHIKKSLEE LLDMTILNEL
Length:1,720
Mass (Da):189,360
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB07E731FDE69EE7D
GO
Isoform 2 (identifier: Q9Y4F4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-974: MHSSLR → VRTKYF
     975-1720: Missing.

Show »
Length:974
Mass (Da):106,960
Checksum:i243AD70C87AB776A
GO
Isoform 3 (identifier: Q9Y4F4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-995: MHSSLRSLRNSAAKKRAKLSGSTSDLE → VRHISNIWVKTLSNKTFFCKEKNFSYC
     996-1720: Missing.

Show »
Length:995
Mass (Da):109,440
Checksum:iB0A3F68CFF984DCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAE9G3XAE9_HUMAN
KIAA0423, isoform CRA_a
TOGARAM1 KIAA0423, hCG_20876
1,773Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3B1G3V3B1_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ89H0YJ89_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIY7H0YIY7_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA24853 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAH18354 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191E → G in CAH18354 (PubMed:12508121).Curated1
Sequence conflicti477E → K in BAA24853 (PubMed:9455477).Curated1
Sequence conflicti992S → L in BAA24853 (PubMed:9455477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027739416E → Q. Corresponds to variant dbSNP:rs3825629Ensembl.1
Natural variantiVAR_027740511L → V. Corresponds to variant dbSNP:rs3742591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020821969 – 995MHSSL…TSDLE → VRHISNIWVKTLSNKTFFCK EKNFSYC in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_020822969 – 974MHSSLR → VRTKYF in isoform 2. 1 Publication6
Alternative sequenceiVSP_020823975 – 1720Missing in isoform 2. 1 PublicationAdd BLAST746
Alternative sequenceiVSP_020824996 – 1720Missing in isoform 3. 1 PublicationAdd BLAST725

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB007883 mRNA Translation: BAA24853.2 Different initiation.
CR749557 mRNA Translation: CAH18354.1 Frameshift.
AL049870 Genomic DNA No translation available.
AL121809 Genomic DNA No translation available.
BC057255 mRNA Translation: AAH57255.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9681.1 [Q9Y4F4-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T00057

NCBI Reference Sequences

More...RefSeqi		NP_055906.2, NM_015091.3 [Q9Y4F4-1]
XP_016876589.1, XM_017021100.1 [Q9Y4F4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1]
ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23116

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23116

UCSC genome browser

More...UCSCi		uc001wvv.4 human [Q9Y4F4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007883 mRNA Translation: BAA24853.2 Different initiation.
CR749557 mRNA Translation: CAH18354.1 Frameshift.
AL049870 Genomic DNA No translation available.
AL121809 Genomic DNA No translation available.
BC057255 mRNA Translation: AAH57255.1
CCDSiCCDS9681.1 [Q9Y4F4-1]
PIRiT00057
RefSeqiNP_055906.2, NM_015091.3 [Q9Y4F4-1]
XP_016876589.1, XM_017021100.1 [Q9Y4F4-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116738, 3 interactors
IntActiQ9Y4F4, 5 interactors
STRINGi9606.ENSP00000355045

PTM databases

iPTMnetiQ9Y4F4
PhosphoSitePlusiQ9Y4F4

Polymorphism and mutation databases

BioMutaiTOGARAM1
DMDMi296439476

Proteomic databases

jPOSTiQ9Y4F4
MassIVEiQ9Y4F4
PaxDbiQ9Y4F4
PeptideAtlasiQ9Y4F4
PRIDEiQ9Y4F4
ProteomicsDBi86194 [Q9Y4F4-1]
86195 [Q9Y4F4-2]
86196 [Q9Y4F4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23425 13 antibodies

Genome annotation databases

EnsembliENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1]
ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3]
GeneIDi23116
KEGGihsa:23116
UCSCiuc001wvv.4 human [Q9Y4F4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23116
EuPathDBiHostDB:ENSG00000198718.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		TOGARAM1
HGNCiHGNC:19959 TOGARAM1
HPAiENSG00000198718 Low tissue specificity
MIMi617618 gene
neXtProtiNX_Q9Y4F4
OpenTargetsiENSG00000198718
PharmGKBiPA162387516

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2933 Eukaryota
ENOG410XSBP LUCA
GeneTreeiENSGT00940000158712
HOGENOMiCLU_275329_0_0_1
InParanoidiQ9Y4F4
PhylomeDBiQ9Y4F4
TreeFamiTF315518

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23116 1 hit in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM179B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23116
PharosiQ9Y4F4 Tdark

Protein Ontology

More...PROi		PR:Q9Y4F4
RNActiQ9Y4F4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198718 Expressed in corpus callosum and 225 other tissues
ExpressionAtlasiQ9Y4F4 baseline and differential
GenevisibleiQ9Y4F4 HS

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028401 Crescerin-1
IPR034085 TOG
PANTHERiPTHR21567:SF6 PTHR21567:SF6, 3 hits
SMARTiView protein in SMART
SM01349 TOG, 2 hits
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGRM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4F4
Secondary accession number(s): Q68D66, Q6PG27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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