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Entry version 140 (31 Jul 2019)
Sequence version 4 (18 May 2010)
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Protein

TOG array regulator of axonemal microtubules protein 1

Gene

TOGARAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TOG array regulator of axonemal microtubules protein 1Imported
Alternative name(s):
Crescerin-1Curated
Protein FAM179B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOGARAM1Imported
Synonyms:FAM179B, KIAA0423
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:19959 TOGARAM1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617618 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y4F4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000198718

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162387516

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TOGARAM1

Domain mapping of disease mutations (DMDM)

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DMDMi
296439476

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002519521 – 1720TOG array regulator of axonemal microtubules protein 1Add BLAST1720

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y4F4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y4F4

PeptideAtlas

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PeptideAtlasi
Q9Y4F4

PRoteomics IDEntifications database

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PRIDEi
Q9Y4F4

ProteomicsDB human proteome resource

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ProteomicsDBi
86194 [Q9Y4F4-1]
86195 [Q9Y4F4-2]
86196 [Q9Y4F4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4F4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y4F4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198718 Expressed in 226 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y4F4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y4F4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050849
HPA053559

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116738, 2 interactors

Protein interaction database and analysis system

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IntActi
Q9Y4F4, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355045

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati175 – 212HEAT 1Sequence analysisAdd BLAST38
Repeati214 – 247HEAT 2Sequence analysisAdd BLAST34
Repeati251 – 289HEAT 3Sequence analysisAdd BLAST39
Repeati345 – 384HEAT 4Sequence analysisAdd BLAST40
Repeati390 – 427HEAT 5Sequence analysisAdd BLAST38
Repeati431 – 466HEAT 6Sequence analysisAdd BLAST36
Repeati467 – 504HEAT 7Sequence analysisAdd BLAST38
Repeati506 – 543HEAT 8Sequence analysisAdd BLAST38
Repeati1294 – 1331HEAT 9Sequence analysisAdd BLAST38
Repeati1335 – 1372HEAT 10Sequence analysisAdd BLAST38
Repeati1485 – 1522HEAT 11Sequence analysisAdd BLAST38
Repeati1526 – 1563HEAT 12Sequence analysisAdd BLAST38
Repeati1567 – 1605HEAT 13Sequence analysisAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 312TOG 1By similarityAdd BLAST219
Regioni352 – 596TOG 2By similarityAdd BLAST245
Regioni1256 – 1425TOG 3By similarityAdd BLAST170
Regioni1484 – 1720TOG 4By similarityAdd BLAST237

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi971 – 1129Ser-richAdd BLAST159

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Crescerin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2933 Eukaryota
ENOG410XSBP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112454

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y4F4

Database of Orthologous Groups

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OrthoDBi
476837at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y4F4

TreeFam database of animal gene trees

More...
TreeFami
TF315518

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028401 Crescerin-1
IPR034085 TOG

The PANTHER Classification System

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PANTHERi
PTHR21567:SF6 PTHR21567:SF6, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01349 TOG, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF
60 70 80 90 100
RGAAGDHGSC PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL
110 120 130 140 150
QLLRTARDPS EAFQALQAAL PRRGGRLGFP RRKEALYRAL GRVLVEGGSD
160 170 180 190 200
EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL LPQLVVSLRE ENPALRKDAL
210 220 230 240 250
QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI LLTTEDLLLG
260 270 280 290 300
LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP
310 320 330 340 350
SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI
360 370 380 390 400
IPQELHSRLL DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY
410 420 430 440 450
NLLDDSNFKV VHGTLEVLHL LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV
460 470 480 490 500
IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK HKHSRVREEV VNICICSLLT
510 520 530 540 550
YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS MGSGKTSILF
560 570 580 590 600
KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR
610 620 630 640 650
SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL
660 670 680 690 700
SAGKGKNKLP WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM
710 720 730 740 750
PVNDDLCFSR KRVSRNLFQN SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ
760 770 780 790 800
LGFSQICGKT GSVGSDLQFL GTTSSHQEKV YASLNFGSKT QQTFGSQTEC
810 820 830 840 850
TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS QDNSVNFSNS
860 870 880 890 900
WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS
910 920 930 940 950
PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL
960 970 980 990 1000
PIDLSELNFK DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA
1010 1020 1030 1040 1050
MKLDLTMDSP SLSSSPNINS YSESGVYSQE SLTSSLSTTP QGKRIMSDIF
1060 1070 1080 1090 1100
PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG SSSNPQQISS FDFTTTKALS
1110 1120 1130 1140 1150
EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ SIEPPSGIYG
1160 1170 1180 1190 1200
RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK
1210 1220 1230 1240 1250
EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR
1260 1270 1280 1290 1300
PFSKPEIALT EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN
1310 1320 1330 1340 1350
FAVVQEVKNL RSGVSRAAVV CLSDLFTYLK KSMDQELDTT VKVLLHKAGE
1360 1370 1380 1390 1400
SNTFIREDVD KALRAMVNNV TPARAVVSLI NGGQRYYGRK MLFFMMCHPN
1410 1420 1430 1440 1450
FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK GRRSHTGSVG
1460 1470 1480 1490 1500
NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA
1510 1520 1530 1540 1550
KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA
1560 1570 1580 1590 1600
LETMHKMIPL LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS
1610 1620 1630 1640 1650
QHVDNYLLLQ PFCTKAQFLN GKAKQDMTEK LADIVTELYQ RKPHATEQKV
1660 1670 1680 1690 1700
LVVLWHLLGN MTNSGSLPGA GGNIRTATAK LSKALFAQMG QNLLNQAASQ
1710 1720
PPHIKKSLEE LLDMTILNEL
Length:1,720
Mass (Da):189,360
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB07E731FDE69EE7D
GO
Isoform 2 (identifier: Q9Y4F4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-974: MHSSLR → VRTKYF
     975-1720: Missing.

Note: No experimental confirmation available.
Show »
Length:974
Mass (Da):106,960
Checksum:i243AD70C87AB776A
GO
Isoform 3 (identifier: Q9Y4F4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     969-995: MHSSLRSLRNSAAKKRAKLSGSTSDLE → VRHISNIWVKTLSNKTFFCKEKNFSYC
     996-1720: Missing.

Note: No experimental confirmation available.
Show »
Length:995
Mass (Da):109,440
Checksum:iB0A3F68CFF984DCF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAE9G3XAE9_HUMAN
KIAA0423, isoform CRA_a
TOGARAM1 KIAA0423, hCG_20876
1,773Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ89H0YJ89_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3B1G3V3B1_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIY7H0YIY7_HUMAN
TOG array regulator of axonemal mic...
TOGARAM1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA24853 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18354 differs from that shown. Reason: Frameshift at positions 1069 and 1506.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191E → G in CAH18354 (PubMed:12508121).Curated1
Sequence conflicti477E → K in BAA24853 (PubMed:9455477).Curated1
Sequence conflicti992S → L in BAA24853 (PubMed:9455477).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027739416E → Q. Corresponds to variant dbSNP:rs3825629Ensembl.1
Natural variantiVAR_027740511L → V. Corresponds to variant dbSNP:rs3742591Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020821969 – 995MHSSL…TSDLE → VRHISNIWVKTLSNKTFFCK EKNFSYC in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_020822969 – 974MHSSLR → VRTKYF in isoform 2. 1 Publication6
Alternative sequenceiVSP_020823975 – 1720Missing in isoform 2. 1 PublicationAdd BLAST746
Alternative sequenceiVSP_020824996 – 1720Missing in isoform 3. 1 PublicationAdd BLAST725

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007883 mRNA Translation: BAA24853.2 Different initiation.
CR749557 mRNA Translation: CAH18354.1 Frameshift.
AL049870 Genomic DNA No translation available.
AL121809 Genomic DNA No translation available.
BC057255 mRNA Translation: AAH57255.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9681.1 [Q9Y4F4-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00057

NCBI Reference Sequences

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RefSeqi
NP_055906.2, NM_015091.3 [Q9Y4F4-1]
XP_016876589.1, XM_017021100.1 [Q9Y4F4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1]
ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23116

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23116

UCSC genome browser

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UCSCi
uc001wvv.4 human [Q9Y4F4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007883 mRNA Translation: BAA24853.2 Different initiation.
CR749557 mRNA Translation: CAH18354.1 Frameshift.
AL049870 Genomic DNA No translation available.
AL121809 Genomic DNA No translation available.
BC057255 mRNA Translation: AAH57255.1
CCDSiCCDS9681.1 [Q9Y4F4-1]
PIRiT00057
RefSeqiNP_055906.2, NM_015091.3 [Q9Y4F4-1]
XP_016876589.1, XM_017021100.1 [Q9Y4F4-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116738, 2 interactors
IntActiQ9Y4F4, 5 interactors
STRINGi9606.ENSP00000355045

PTM databases

iPTMnetiQ9Y4F4
PhosphoSitePlusiQ9Y4F4

Polymorphism and mutation databases

BioMutaiTOGARAM1
DMDMi296439476

Proteomic databases

jPOSTiQ9Y4F4
PaxDbiQ9Y4F4
PeptideAtlasiQ9Y4F4
PRIDEiQ9Y4F4
ProteomicsDBi86194 [Q9Y4F4-1]
86195 [Q9Y4F4-2]
86196 [Q9Y4F4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1]
ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3]
GeneIDi23116
KEGGihsa:23116
UCSCiuc001wvv.4 human [Q9Y4F4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23116

GeneCards: human genes, protein and diseases

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GeneCardsi
TOGARAM1
HGNCiHGNC:19959 TOGARAM1
HPAiHPA050849
HPA053559
MIMi617618 gene
neXtProtiNX_Q9Y4F4
OpenTargetsiENSG00000198718
PharmGKBiPA162387516

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2933 Eukaryota
ENOG410XSBP LUCA
GeneTreeiENSGT00940000158712
HOGENOMiHOG000112454
InParanoidiQ9Y4F4
OrthoDBi476837at2759
PhylomeDBiQ9Y4F4
TreeFamiTF315518

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM179B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23116

Protein Ontology

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PROi
PR:Q9Y4F4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198718 Expressed in 226 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9Y4F4 baseline and differential
GenevisibleiQ9Y4F4 HS

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028401 Crescerin-1
IPR034085 TOG
PANTHERiPTHR21567:SF6 PTHR21567:SF6, 3 hits
SMARTiView protein in SMART
SM01349 TOG, 2 hits
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTGRM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4F4
Secondary accession number(s): Q68D66, Q6PG27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: July 31, 2019
This is version 140 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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