UniProtKB - Q9Y4F4 (TGRM1_HUMAN)
Protein
TOG array regulator of axonemal microtubules protein 1
Gene
TOGARAM1
Organism
Homo sapiens (Human)
Status
Functioni
Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).By similarity
GO - Molecular functioni
- microtubule binding Source: GO_Central
GO - Biological processi
- axoneme assembly Source: UniProtKB
- microtubule cytoskeleton organization Source: GO_Central
- mitotic spindle assembly Source: GO_Central
- non-motile cilium assembly Source: UniProtKB
- positive regulation of microtubule polymerization Source: UniProtKB
Keywordsi
Biological process | Cilium biogenesis/degradation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4F4 |
Names & Taxonomyi
Protein namesi | Recommended name: TOG array regulator of axonemal microtubules protein 1ImportedAlternative name(s): Crescerin-1Curated Protein FAM179B |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19959, TOGARAM1 |
MIMi | 617618, gene |
neXtProti | NX_Q9Y4F4 |
VEuPathDBi | HostDB:ENSG00000198718.12 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- cilium By similarity
Note: Detected along the length of primary cilia and at the basal body. Colocalization with the cytoplasmic microtubule cytoskeleton upon heterologous expression is most likely an artifact.By similarity
Cytoskeleton
- ciliary basal body Source: UniProtKB
- cytoplasmic microtubule Source: GO_Central
- microtubule organizing center Source: GO_Central
- mitotic spindle Source: GO_Central
- spindle microtubule Source: GO_Central
Other locations
- cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Organism-specific databases
DisGeNETi | 23116 |
OpenTargetsi | ENSG00000198718 |
PharmGKBi | PA162387516 |
Miscellaneous databases
Pharosi | Q9Y4F4, Tdark |
Genetic variation databases
BioMutai | TOGARAM1 |
DMDMi | 296439476 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251952 | 1 – 1720 | TOG array regulator of axonemal microtubules protein 1Add BLAST | 1720 |
Proteomic databases
jPOSTi | Q9Y4F4 |
MassIVEi | Q9Y4F4 |
PaxDbi | Q9Y4F4 |
PeptideAtlasi | Q9Y4F4 |
PRIDEi | Q9Y4F4 |
ProteomicsDBi | 86194 [Q9Y4F4-1] 86195 [Q9Y4F4-2] 86196 [Q9Y4F4-3] |
PTM databases
iPTMneti | Q9Y4F4 |
PhosphoSitePlusi | Q9Y4F4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198718, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q9Y4F4, baseline and differential |
Genevisiblei | Q9Y4F4, HS |
Organism-specific databases
HPAi | ENSG00000198718, Low tissue specificity |
Interactioni
GO - Molecular functioni
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116738, 7 interactors |
IntActi | Q9Y4F4, 5 interactors |
STRINGi | 9606.ENSP00000355045 |
Miscellaneous databases
RNActi | Q9Y4F4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 175 – 212 | HEAT 1Sequence analysisAdd BLAST | 38 | |
Repeati | 214 – 247 | HEAT 2Sequence analysisAdd BLAST | 34 | |
Repeati | 251 – 289 | HEAT 3Sequence analysisAdd BLAST | 39 | |
Repeati | 345 – 384 | HEAT 4Sequence analysisAdd BLAST | 40 | |
Repeati | 390 – 427 | HEAT 5Sequence analysisAdd BLAST | 38 | |
Repeati | 431 – 466 | HEAT 6Sequence analysisAdd BLAST | 36 | |
Repeati | 467 – 504 | HEAT 7Sequence analysisAdd BLAST | 38 | |
Repeati | 506 – 543 | HEAT 8Sequence analysisAdd BLAST | 38 | |
Repeati | 1294 – 1331 | HEAT 9Sequence analysisAdd BLAST | 38 | |
Repeati | 1335 – 1372 | HEAT 10Sequence analysisAdd BLAST | 38 | |
Repeati | 1485 – 1522 | HEAT 11Sequence analysisAdd BLAST | 38 | |
Repeati | 1526 – 1563 | HEAT 12Sequence analysisAdd BLAST | 38 | |
Repeati | 1567 – 1605 | HEAT 13Sequence analysisAdd BLAST | 39 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 312 | TOG 1By similarityAdd BLAST | 219 | |
Regioni | 352 – 596 | TOG 2By similarityAdd BLAST | 245 | |
Regioni | 1256 – 1425 | TOG 3By similarityAdd BLAST | 170 | |
Regioni | 1484 – 1720 | TOG 4By similarityAdd BLAST | 237 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 971 – 1129 | Ser-richAdd BLAST | 159 |
Domaini
The TOG regions are composed of HEAT-type repeats that assemble into a solenoid structure. They mediate interaction with microtubules.By similarity
Sequence similaritiesi
Belongs to the Crescerin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2933, Eukaryota |
GeneTreei | ENSGT00940000158712 |
HOGENOMi | CLU_275329_0_0_1 |
InParanoidi | Q9Y4F4 |
PhylomeDBi | Q9Y4F4 |
TreeFami | TF315518 |
Family and domain databases
Gene3Di | 1.25.10.10, 4 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR028401, Crescerin-1 IPR034085, TOG |
PANTHERi | PTHR21567:SF6, PTHR21567:SF6, 3 hits |
SMARTi | View protein in SMART SM01349, TOG, 2 hits |
SUPFAMi | SSF48371, SSF48371, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y4F4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAPSALLL LPPFPVLSTY RLQSRSRPSA PETDDSRVGG IMRGEKNYYF
60 70 80 90 100
RGAAGDHGSC PTTTSPLASA LLMPSEAVSS SWSESGGGLS GGDEEDTRLL
110 120 130 140 150
QLLRTARDPS EAFQALQAAL PRRGGRLGFP RRKEALYRAL GRVLVEGGSD
160 170 180 190 200
EKRLCLQLLS DVLRGQGEAG QLEEAFSLAL LPQLVVSLRE ENPALRKDAL
210 220 230 240 250
QILHICLKRS PGEVLRTLIQ QGLESTDARL RASTALLLPI LLTTEDLLLG
260 270 280 290 300
LDLTEVIISL ARKLGDQETE EESETAFSAL QQIGERLGQD RFQSYISRLP
310 320 330 340 350
SALRRHYNRR LESQFGSQVP YYLELEASGF PEDPLPCAVT LSNSNLKFGI
360 370 380 390 400
IPQELHSRLL DQEDYKNRTQ AVEELKQVLG KFNPSSTPHS SLVGFISLLY
410 420 430 440 450
NLLDDSNFKV VHGTLEVLHL LVIRLGEQVQ QFLGPVIAAS VKVLADNKLV
460 470 480 490 500
IKQEYMKIFL KLMKEVGPQQ VLCLLLEHLK HKHSRVREEV VNICICSLLT
510 520 530 540 550
YPSEDFDLPK LSFDLAPALV DSKRRVRQAA LEAFAVLASS MGSGKTSILF
560 570 580 590 600
KAVDTVELQD NGDGVMNAVQ ARLARKTLPR LTEQGFVEYA VLMPSSAGGR
610 620 630 640 650
SNHLAHGADT DWLLAGNRTQ SAHCHCGDHV RDSMHIYGSY SPTICTRRVL
660 670 680 690 700
SAGKGKNKLP WENEQPGIMG ENQTSTSKDI EQFSTYDFIP SAKLKLSQGM
710 720 730 740 750
PVNDDLCFSR KRVSRNLFQN SRDFNPDCLP LCAAGTTGTH QTNLSGKCAQ
760 770 780 790 800
LGFSQICGKT GSVGSDLQFL GTTSSHQEKV YASLNFGSKT QQTFGSQTEC
810 820 830 840 850
TSSNGQNPSP GAYILPSYPV SSPRTSPKHT SPLIISPKKS QDNSVNFSNS
860 870 880 890 900
WPLKSFEGLS KPSPQKKLVS QKSSDPTGRN HGENSQEKPP VQLTPALVRS
910 920 930 940 950
PSSRRGLNGT KPVPPIPRGI SLLPDKADLS TVGHKKKEPD DIWKCEKDSL
960 970 980 990 1000
PIDLSELNFK DKDLDQEEMH SSLRSLRNSA AKKRAKLSGS TSDLESPDSA
1010 1020 1030 1040 1050
MKLDLTMDSP SLSSSPNINS YSESGVYSQE SLTSSLSTTP QGKRIMSDIF
1060 1070 1080 1090 1100
PTFGSKPCPT RLSSAKKKIS HIAEQSPSAG SSSNPQQISS FDFTTTKALS
1110 1120 1130 1140 1150
EDSVVVVGKG VFGSLSSAPA TCSQSVISSV ENGDTFSIKQ SIEPPSGIYG
1160 1170 1180 1190 1200
RSVQQNISSY LDVENEKDAK VSISKSTYNK MRQKRKEEKE LFHNKDCEKK
1210 1220 1230 1240 1250
EKNSWERMRH TGTEKMASES ETPTGAISQY KERMPSVTHS PEIMDLSELR
1260 1270 1280 1290 1300
PFSKPEIALT EALRLLADED WEKKIEGLNF IRCLAAFHSE ILNTKLHETN
1310 1320 1330 1340 1350
FAVVQEVKNL RSGVSRAAVV CLSDLFTYLK KSMDQELDTT VKVLLHKAGE
1360 1370 1380 1390 1400
SNTFIREDVD KALRAMVNNV TPARAVVSLI NGGQRYYGRK MLFFMMCHPN
1410 1420 1430 1440 1450
FEKMLEKYVP SKDLPYIKDS VRNLQQKGLG EIPLDTPSAK GRRSHTGSVG
1460 1470 1480 1490 1500
NTRSSSVSRD AFNSAERAVT EVREVTRKSV PRNSLESAEY LKLITGLLNA
1510 1520 1530 1540 1550
KDFRDRINGI KQLLSDTENN QDLVVGNIVK IFDAFKSRLH DSNSKVNLVA
1560 1570 1580 1590 1600
LETMHKMIPL LRDHLSPIIN MLIPAIVDNN LNSKNPGIYA AATNVVQALS
1610 1620 1630 1640 1650
QHVDNYLLLQ PFCTKAQFLN GKAKQDMTEK LADIVTELYQ RKPHATEQKV
1660 1670 1680 1690 1700
LVVLWHLLGN MTNSGSLPGA GGNIRTATAK LSKALFAQMG QNLLNQAASQ
1710 1720
PPHIKKSLEE LLDMTILNEL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAE9 | G3XAE9_HUMAN | KIAA0423, isoform CRA_a | TOGARAM1 KIAA0423, hCG_20876 | 1,773 | Annotation score: | ||
G3V3B1 | G3V3B1_HUMAN | TOG array regulator of axonemal mic... | TOGARAM1 | 174 | Annotation score: | ||
H0YJ89 | H0YJ89_HUMAN | TOG array regulator of axonemal mic... | TOGARAM1 | 160 | Annotation score: | ||
H0YIY7 | H0YIY7_HUMAN | TOG array regulator of axonemal mic... | TOGARAM1 | 155 | Annotation score: |
Sequence cautioni
The sequence BAA24853 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAH18354 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | E → G in CAH18354 (PubMed:12508121).Curated | 1 | |
Sequence conflicti | 477 | E → K in BAA24853 (PubMed:9455477).Curated | 1 | |
Sequence conflicti | 992 | S → L in BAA24853 (PubMed:9455477).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027739 | 416 | E → Q. Corresponds to variant dbSNP:rs3825629Ensembl. | 1 | |
Natural variantiVAR_027740 | 511 | L → V. Corresponds to variant dbSNP:rs3742591Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020821 | 969 – 995 | MHSSL…TSDLE → VRHISNIWVKTLSNKTFFCK EKNFSYC in isoform 3. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_020822 | 969 – 974 | MHSSLR → VRTKYF in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_020823 | 975 – 1720 | Missing in isoform 2. 1 PublicationAdd BLAST | 746 | |
Alternative sequenceiVSP_020824 | 996 – 1720 | Missing in isoform 3. 1 PublicationAdd BLAST | 725 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007883 mRNA Translation: BAA24853.2 Different initiation. CR749557 mRNA Translation: CAH18354.1 Frameshift. AL049870 Genomic DNA No translation available. AL121809 Genomic DNA No translation available. BC057255 mRNA Translation: AAH57255.1 |
CCDSi | CCDS9681.1 [Q9Y4F4-1] |
PIRi | T00057 |
RefSeqi | NP_055906.2, NM_015091.3 [Q9Y4F4-1] XP_016876589.1, XM_017021100.1 [Q9Y4F4-3] |
Genome annotation databases
Ensembli | ENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1] ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3] |
GeneIDi | 23116 |
KEGGi | hsa:23116 |
UCSCi | uc001wvv.4, human [Q9Y4F4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB007883 mRNA Translation: BAA24853.2 Different initiation. CR749557 mRNA Translation: CAH18354.1 Frameshift. AL049870 Genomic DNA No translation available. AL121809 Genomic DNA No translation available. BC057255 mRNA Translation: AAH57255.1 |
CCDSi | CCDS9681.1 [Q9Y4F4-1] |
PIRi | T00057 |
RefSeqi | NP_055906.2, NM_015091.3 [Q9Y4F4-1] XP_016876589.1, XM_017021100.1 [Q9Y4F4-3] |
3D structure databases
SMRi | Q9Y4F4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116738, 7 interactors |
IntActi | Q9Y4F4, 5 interactors |
STRINGi | 9606.ENSP00000355045 |
PTM databases
iPTMneti | Q9Y4F4 |
PhosphoSitePlusi | Q9Y4F4 |
Genetic variation databases
BioMutai | TOGARAM1 |
DMDMi | 296439476 |
Proteomic databases
jPOSTi | Q9Y4F4 |
MassIVEi | Q9Y4F4 |
PaxDbi | Q9Y4F4 |
PeptideAtlasi | Q9Y4F4 |
PRIDEi | Q9Y4F4 |
ProteomicsDBi | 86194 [Q9Y4F4-1] 86195 [Q9Y4F4-2] 86196 [Q9Y4F4-3] |
Protocols and materials databases
Antibodypediai | 23425, 13 antibodies |
Genome annotation databases
Ensembli | ENST00000361577; ENSP00000355045; ENSG00000198718 [Q9Y4F4-1] ENST00000557423; ENSP00000451829; ENSG00000198718 [Q9Y4F4-3] |
GeneIDi | 23116 |
KEGGi | hsa:23116 |
UCSCi | uc001wvv.4, human [Q9Y4F4-1] |
Organism-specific databases
CTDi | 23116 |
DisGeNETi | 23116 |
GeneCardsi | TOGARAM1 |
HGNCi | HGNC:19959, TOGARAM1 |
HPAi | ENSG00000198718, Low tissue specificity |
MIMi | 617618, gene |
neXtProti | NX_Q9Y4F4 |
OpenTargetsi | ENSG00000198718 |
PharmGKBi | PA162387516 |
VEuPathDBi | HostDB:ENSG00000198718.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2933, Eukaryota |
GeneTreei | ENSGT00940000158712 |
HOGENOMi | CLU_275329_0_0_1 |
InParanoidi | Q9Y4F4 |
PhylomeDBi | Q9Y4F4 |
TreeFami | TF315518 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4F4 |
Miscellaneous databases
BioGRID-ORCSi | 23116, 8 hits in 995 CRISPR screens |
ChiTaRSi | FAM179B, human |
GenomeRNAii | 23116 |
Pharosi | Q9Y4F4, Tdark |
PROi | PR:Q9Y4F4 |
RNActi | Q9Y4F4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198718, Expressed in corpus callosum and 236 other tissues |
ExpressionAtlasi | Q9Y4F4, baseline and differential |
Genevisiblei | Q9Y4F4, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 4 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR028401, Crescerin-1 IPR034085, TOG |
PANTHERi | PTHR21567:SF6, PTHR21567:SF6, 3 hits |
SMARTi | View protein in SMART SM01349, TOG, 2 hits |
SUPFAMi | SSF48371, SSF48371, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGRM1_HUMAN | |
Accessioni | Q9Y4F4Primary (citable) accession number: Q9Y4F4 Secondary accession number(s): Q68D66, Q6PG27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families