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Entry version 149 (08 May 2019)
Sequence version 6 (16 May 2012)
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Protein

Meiosis regulator and mRNA stability factor 1

Gene

MARF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processDifferentiation, Meiosis, Oogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Meiosis regulator and mRNA stability factor 1Imported
Alternative name(s):
Limkain-b11 Publication
Meiosis arrest female protein 1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARF1Imported
Synonyms:KIAA0430, LKAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29562 MARF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614593 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4F3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000166783

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148631

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MARF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
387912929

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002768461 – 1742Meiosis regulator and mRNA stability factor 1Add BLAST1742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineCombined sources1
Modified residuei699PhosphotyrosineBy similarity1
Modified residuei760PhosphoserineCombined sources1
Modified residuei1091PhosphoserineCombined sources1
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1571PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4F3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4F3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4F3

PeptideAtlas

More...
PeptideAtlasi
Q9Y4F3

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4F3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86189
86190 [Q9Y4F3-3]
86191 [Q9Y4F3-4]
86192 [Q9Y4F3-5]
86193 [Q9Y4F3-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4F3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4F3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166783 Expressed in 235 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4F3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4F3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017992

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LIMK2.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
WDR5P619644EBI-5235902,EBI-540834

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115020, 36 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4F3, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379654

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4F3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y4F3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini353 – 490NYNAdd BLAST138
Domaini791 – 870RRMPROSITE-ProRule annotationAdd BLAST80
Domaini875 – 949HTH OST-type 1PROSITE-ProRule annotationAdd BLAST75
Domaini1003 – 1079HTH OST-type 2PROSITE-ProRule annotationAdd BLAST77
Domaini1099 – 1173HTH OST-type 3PROSITE-ProRule annotationAdd BLAST75
Domaini1175 – 1250HTH OST-type 4PROSITE-ProRule annotationAdd BLAST76
Domaini1259 – 1334HTH OST-type 5PROSITE-ProRule annotationAdd BLAST76
Domaini1335 – 1410HTH OST-type 6PROSITE-ProRule annotationAdd BLAST76
Domaini1411 – 1485HTH OST-type 7PROSITE-ProRule annotationAdd BLAST75
Domaini1486 – 1560HTH OST-type 8PROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi117 – 125Poly-Gly9
Compositional biasi1079 – 1082Poly-Pro4
Compositional biasi1685 – 1690Poly-Ser6

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF58 Eukaryota
ENOG410XQFX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002393

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4F3

KEGG Orthology (KO)

More...
KOi
K17573

Identification of Orthologs from Complete Genome Data

More...
OMAi
TKDYMEN

Database of Orthologous Groups

More...
OrthoDBi
187067at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4F3

TreeFam database of animal gene trees

More...
TreeFami
TF329117

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12255 RRM1_LKAP, 1 hit
cd12256 RRM2_LKAP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1880, 6 hits
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041966 LOTUS-like
IPR024768 Marf1
IPR024582 Marf1_cons_dom
IPR034189 Marf1_RRM1
IPR034191 Marf1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR021139 NYN_limkain-b1
IPR025605 OST-HTH/LOTUS_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14379 PTHR14379, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11608 Limkain-b1, 1 hit
PF01936 NYN, 1 hit
PF12872 OST-HTH, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51644 HTH_OST, 8 hits
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4F3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEGNGTENS CSRTRGWLQQ DNDAKPWLWK FSNCFSRPEQ TLPHSPQTKE
60 70 80 90 100
YMENKKVAVE LKDVPSPLHA GSKLFPAVPL PDIRSLQQPK IQLSSVPKVS
110 120 130 140 150
CCAHCPNEPS TSPMRFGGGG GGSGGTSSLI HPGALLDSQS TRTITCQVGS
160 170 180 190 200
GFAFQSASSL QNASARNNLA GIASDFPSMC LESNLSSCKH LPCCGKLHFQ
210 220 230 240 250
SCHGNVHKLH QFPSLQGCTS AGYFPCSDFT SGAPGHLEEH ISQSELTPHL
260 270 280 290 300
CTNSLHLNVV PPVCLKGSLY CEDCLNKPAR NSIIDAAKVW PNIPPPNTQP
310 320 330 340 350
APLAVPLCNG CGTKGTGKET TLLLATSLGK AASKFGSPEV AVAGQVLENL
360 370 380 390 400
PPIGVFWDIE NCSVPSGRSA TAVVQRIREK FFKGHREAEF ICVCDISKEN
410 420 430 440 450
KEVIQELNNC QVTVAHINAT AKNAADDKLR QSLRRFANTH TAPATVVLVS
460 470 480 490 500
TDVNFALELS DLRHRHGFHI ILVHKNQASE ALLHHANELI RFEEFISDLP
510 520 530 540 550
PRLPLKMPQC HTLLYVYNLP ANKDGKSVSN RLRRLSDNCG GKVLSITGCS
560 570 580 590 600
AILRFINQDS AERAQKRMEN EDVFGNRIIV SFTPKNRELC ETKSSNAIAD
610 620 630 640 650
KVKSPKKLKN PKLCLIKDAS EQSSSAKATP GKGSQANSGS ATKNTNVKSL
660 670 680 690 700
QELCRMESKT GHRNSEHQQG HLRLVVPTHG NSSAAVSTPK NSGVAEPVYK
710 720 730 740 750
TSQKKENLSA RSVTSSPVEK KDKEETVFQV SYPSAFSKLV ASRQVSPLLA
760 770 780 790 800
SQSWSSRSMS PNLLNRASPL AFNIANSSSE ADCPDPFANG ADVQVSNIDY
810 820 830 840 850
RLSRKELQQL LQEAFARHGK VKSVELSPHT DYQLKAVVQM ENLQDAIGAV
860 870 880 890 900
NSLHRYKIGS KKILVSLATG AASKSLSLLS AETMSVLQDA PACCLPLFKF
910 920 930 940 950
TDIYEKKFGH KLNVSDLYKL TDTVAIREQG NGRLVCLLPS SQARQSPLGS
960 970 980 990 1000
SQSHDGSSTN CSPIIFEELE YHEPVCRQHC SNKDFSEHEF DPDSYKIPFV
1010 1020 1030 1040 1050
ILSLKTFAPQ VHSLLQTHEG TVPLLSFPDC YIAEFGDLEV VQENQGGVPL
1060 1070 1080 1090 1100
EHFITCVPGV NIATAQNGIK VVKWIHNKPP PPNTDPWLLR SKSPVGNPQL
1110 1120 1130 1140 1150
IQFSREVIDL LKSQPSCVIP ISHFIPSYHH HFAKQCRVSD YGYSKLIELL
1160 1170 1180 1190 1200
EAVPHVLQIL GMGSKRLLTL THRAQVKRFT QDLLKLLKSQ ASKQVIVREF
1210 1220 1230 1240 1250
SQAYHWCFSK DWDVTEYGVC ELIDIVSEIP DTTICLSQQD NEMVICIPKR
1260 1270 1280 1290 1300
ERTQDEIERT KQFSKDVVDL LRHQPHFRMP FNKFIPSYHH HFGRQCKLAY
1310 1320 1330 1340 1350
YGFTKLLELF EAIPDTLQVL ECGEEKILTL TEVERFKALA AQFVKLLRSQ
1360 1370 1380 1390 1400
KDNCLMMTDL LTEYAKTFGY TFRLQDYDVS SISALTQKLC HVVKVADIES
1410 1420 1430 1440 1450
GRQIQLINRK SLRSLTAQLL VLLMSWEGTT HLSVEELKRH YESTHNTPLN
1460 1470 1480 1490 1500
PCEYGFMTLT ELLKSLPYLV EVFTNDKMEE CVKLTSLYLF AKNVRSLLHT
1510 1520 1530 1540 1550
YHYQQIFLHE FSMAYTKYVG ETLQPKTYGH SSVEELLGAI PQVVWIKGHG
1560 1570 1580 1590 1600
HKRIVVLKND MKSRLSSLSL SPANHENQPS EGERILEVPE SHTASELKLG
1610 1620 1630 1640 1650
ADGSGPSHTE QELLRLTDDS PVDLLCAPVP SCLPSPQLRP DPVILQSADL
1660 1670 1680 1690 1700
IQFEERPQEP SEIMILNQEE KMEIPIPGKS KTLTSDSSSS CISAAVPVPP
1710 1720 1730 1740
CPSSETSESL LSKDPVESPA KKQPKNRVKL AANFSLAPIT KL
Length:1,742
Mass (Da):192,859
Last modified:May 16, 2012 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A0C0687B93A6A4B
GO
Isoform 2 (identifier: Q9Y4F3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1026-1084: Missing.

Show »
Length:1,683
Mass (Da):186,447
Checksum:iFBB6FE3DF3E14D75
GO
Isoform 3 (identifier: Q9Y4F3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-338: Missing.

Show »
Length:1,739
Mass (Da):192,618
Checksum:iAE0825D8F42C7200
GO
Isoform 4 (identifier: Q9Y4F3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     509-509: Missing.
     754-754: W → WS

Show »
Length:1,742
Mass (Da):192,818
Checksum:i68D45929E9D4BB88
GO
Isoform 5 (identifier: Q9Y4F3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-291: PARNSIIDAAKVWP → VRIFLFLKLGAAED
     293-1742: Missing.

Note: May be due to an intron retention.
Show »
Length:292
Mass (Da):31,458
Checksum:iA36DF5EF146267CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JLP4G8JLP4_HUMAN
Meiosis regulator and mRNA stabilit...
MARF1
1,577Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVB8F8VVB8_HUMAN
Meiosis regulator and mRNA stabilit...
MARF1
1,037Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRS5F8VRS5_HUMAN
Meiosis regulator and mRNA stabilit...
MARF1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIB6H0YIB6_HUMAN
Meiosis regulator and mRNA stabilit...
MARF1
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC31662 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH64914 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence EAW53920 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti451T → A in AC026401 (PubMed:15616553).Curated1
Sequence conflicti941S → R in BAA24860 (PubMed:9455477).Curated1
Sequence conflicti1541P → S in AAI44516 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037755278 – 291PARNS…AKVWP → VRIFLFLKLGAAED in isoform 5. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_037756293 – 1742Missing in isoform 5. 1 PublicationAdd BLAST1450
Alternative sequenceiVSP_037757336 – 338Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_037758509Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_037759754W → WS in isoform 4. 1 Publication1
Alternative sequenceiVSP_0229881026 – 1084Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK302667 mRNA Translation: BAG63901.1
U95740 Genomic DNA Translation: AAC31662.1 Sequence problems.
AC026401 Genomic DNA No translation available.
CH471226 Genomic DNA Translation: EAW53920.1 Sequence problems.
BC064914 mRNA Translation: AAH64914.2 Sequence problems.
BC137165 mRNA Translation: AAI37166.1
BC137170 mRNA Translation: AAI37171.1
BC144514 mRNA Translation: AAI44515.1
BC144515 mRNA Translation: AAI44516.1
AB007890 mRNA Translation: BAA24860.3
AB012134 mRNA Translation: BAB82433.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10562.2 [Q9Y4F3-1]
CCDS53990.1 [Q9Y4F3-5]
CCDS55991.1 [Q9Y4F3-4]

Protein sequence database of the Protein Information Resource

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PIRi
T00060

NCBI Reference Sequences

More...
RefSeqi
NP_001171927.1, NM_001184998.1 [Q9Y4F3-5]
NP_001171928.1, NM_001184999.1 [Q9Y4F3-4]
NP_055462.2, NM_014647.3 [Q9Y4F3-1]
XP_005255764.1, XM_005255707.1
XP_016879390.1, XM_017023901.1 [Q9Y4F3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000396368; ENSP00000379654; ENSG00000166783 [Q9Y4F3-1]
ENST00000548025; ENSP00000449376; ENSG00000166783 [Q9Y4F3-4]
ENST00000551742; ENSP00000450309; ENSG00000166783 [Q9Y4F3-5]
ENST00000621511; ENSP00000479383; ENSG00000277140 [Q9Y4F3-1]
ENST00000632465; ENSP00000487685; ENSG00000277140 [Q9Y4F3-4]
ENST00000632628; ENSP00000488025; ENSG00000277140 [Q9Y4F3-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9665

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9665

UCSC genome browser

More...
UCSCi
uc002ddr.4 human [Q9Y4F3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302667 mRNA Translation: BAG63901.1
U95740 Genomic DNA Translation: AAC31662.1 Sequence problems.
AC026401 Genomic DNA No translation available.
CH471226 Genomic DNA Translation: EAW53920.1 Sequence problems.
BC064914 mRNA Translation: AAH64914.2 Sequence problems.
BC137165 mRNA Translation: AAI37166.1
BC137170 mRNA Translation: AAI37171.1
BC144514 mRNA Translation: AAI44515.1
BC144515 mRNA Translation: AAI44516.1
AB007890 mRNA Translation: BAA24860.3
AB012134 mRNA Translation: BAB82433.1
CCDSiCCDS10562.2 [Q9Y4F3-1]
CCDS53990.1 [Q9Y4F3-5]
CCDS55991.1 [Q9Y4F3-4]
PIRiT00060
RefSeqiNP_001171927.1, NM_001184998.1 [Q9Y4F3-5]
NP_001171928.1, NM_001184999.1 [Q9Y4F3-4]
NP_055462.2, NM_014647.3 [Q9Y4F3-1]
XP_005255764.1, XM_005255707.1
XP_016879390.1, XM_017023901.1 [Q9Y4F3-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGXNMR-A789-871[»]
2DIUNMR-A510-592[»]
6FDLX-ray1.75A/B352-500[»]
SMRiQ9Y4F3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115020, 36 interactors
IntActiQ9Y4F3, 13 interactors
STRINGi9606.ENSP00000379654

PTM databases

iPTMnetiQ9Y4F3
PhosphoSitePlusiQ9Y4F3

Polymorphism and mutation databases

BioMutaiMARF1
DMDMi387912929

Proteomic databases

EPDiQ9Y4F3
jPOSTiQ9Y4F3
PaxDbiQ9Y4F3
PeptideAtlasiQ9Y4F3
PRIDEiQ9Y4F3
ProteomicsDBi86189
86190 [Q9Y4F3-3]
86191 [Q9Y4F3-4]
86192 [Q9Y4F3-5]
86193 [Q9Y4F3-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396368; ENSP00000379654; ENSG00000166783 [Q9Y4F3-1]
ENST00000548025; ENSP00000449376; ENSG00000166783 [Q9Y4F3-4]
ENST00000551742; ENSP00000450309; ENSG00000166783 [Q9Y4F3-5]
ENST00000621511; ENSP00000479383; ENSG00000277140 [Q9Y4F3-1]
ENST00000632465; ENSP00000487685; ENSG00000277140 [Q9Y4F3-4]
ENST00000632628; ENSP00000488025; ENSG00000277140 [Q9Y4F3-5]
GeneIDi9665
KEGGihsa:9665
UCSCiuc002ddr.4 human [Q9Y4F3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9665

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MARF1
HGNCiHGNC:29562 MARF1
HPAiHPA017992
MIMi614593 gene
neXtProtiNX_Q9Y4F3
OpenTargetsiENSG00000166783
PharmGKBiPA145148631

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF58 Eukaryota
ENOG410XQFX LUCA
GeneTreeiENSGT00390000002393
InParanoidiQ9Y4F3
KOiK17573
OMAiTKDYMEN
OrthoDBi187067at2759
PhylomeDBiQ9Y4F3
TreeFamiTF329117

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0430 human
EvolutionaryTraceiQ9Y4F3

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KIAA0430

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9665

Protein Ontology

More...
PROi
PR:Q9Y4F3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166783 Expressed in 235 organ(s), highest expression level in blood
ExpressionAtlasiQ9Y4F3 baseline and differential
GenevisibleiQ9Y4F3 HS

Family and domain databases

CDDicd12255 RRM1_LKAP, 1 hit
cd12256 RRM2_LKAP, 1 hit
Gene3Di1.10.10.1880, 6 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR041966 LOTUS-like
IPR024768 Marf1
IPR024582 Marf1_cons_dom
IPR034189 Marf1_RRM1
IPR034191 Marf1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR021139 NYN_limkain-b1
IPR025605 OST-HTH/LOTUS_dom
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR14379 PTHR14379, 1 hit
PfamiView protein in Pfam
PF11608 Limkain-b1, 1 hit
PF01936 NYN, 1 hit
PF12872 OST-HTH, 5 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS51644 HTH_OST, 8 hits
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4F3
Secondary accession number(s): A8MSK2
, B2RNX2, B4DYY9, B7ZMG1, B7ZMG2, F8VV09, Q6P1R6, Q8WYR2, Q9Y4J9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 16, 2012
Last modified: May 8, 2019
This is version 149 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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