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Entry version 152 (12 Aug 2020)
Sequence version 2 (30 Aug 2005)
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Protein

WD repeat-containing protein 7

Gene

WDR7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y4E6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y4E6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 7
Alternative name(s):
Rabconnectin-3 beta
TGF-beta resistance-associated protein TRAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR7
Synonyms:KIAA0541, TRAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000091157.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13490, WDR7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613473, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4E6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23335

Open Targets

More...
OpenTargetsi
ENSG00000091157

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y4E6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73920974

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513531 – 1490WD repeat-containing protein 7Add BLAST1490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei935PhosphoserineCombined sources1
Modified residuei1456PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4E6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4E6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y4E6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4E6

PeptideAtlas

More...
PeptideAtlasi
Q9Y4E6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4E6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86181 [Q9Y4E6-1]
86182 [Q9Y4E6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4E6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4E6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091157, Expressed in corpus callosum and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4E6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4E6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000091157, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116922, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4E6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254442

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y4E6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati17 – 56WD 1Add BLAST40
Repeati62 – 104WD 2Add BLAST43
Repeati156 – 199WD 3Add BLAST44
Repeati324 – 366WD 4Add BLAST43
Repeati404 – 443WD 5Add BLAST40
Repeati462 – 507WD 6Add BLAST46
Repeati558 – 597WD 7Add BLAST40
Repeati1351 – 1390WD 8Add BLAST40
Repeati1392 – 1432WD 9Add BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4155, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155301

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004362_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4E6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEGKAVP

Database of Orthologous Groups

More...
OrthoDBi
84170at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4E6

TreeFam database of animal gene trees

More...
TreeFami
TF313196

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV
60 70 80 90 100
ELQINPRALL FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR
110 120 130 140 150
CIEFTKLACT HTGIQFYQFS VGNQREGRLL CHGHYPEILV VDATSLEVLY
160 170 180 190 200
SLVSKISPDW ISSMSIIRSH RTQEDTVVAL SVTGILKVWI VTSEISDMQD
210 220 230 240 250
TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV FDAGDYSLLC
260 270 280 290 300
SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
310 320 330 340 350
GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS
360 370 380 390 400
GRLNIWNISD TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI
410 420 430 440 450
PNSNEPLKVT ASVYIPAHGR LVCGREDGSI VIVPATQTAI VQLLQGEHML
460 470 480 490 500
RRGWPPHRTL RGHRNKVTCL LYPHQVSARY DQRYLISGGV DFSVIIWDIF
510 520 530 540 550
SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH SVGLLSLREK
560 570 580 590 600
KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
610 620 630 640 650
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT
660 670 680 690 700
LATNLLASEA SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII
710 720 730 740 750
QLLTEEASRP NTALISPENL QKASGSSDKG GSFLTGKRAA VLFQQVKETI
760 770 780 790 800
KENIKEHLLD DEEEDEEIMR QRREESDPEY RSSKSKPLTL LEYNLTMDTA
810 820 830 840 850
KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR GGHMSLMLPG
860 870 880 890 900
YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
910 920 930 940 950
LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV
960 970 980 990 1000
AAPVVSARSD ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG
1010 1020 1030 1040 1050
LDKFRPPLLE MLARRWQDRC LEVREAAQAL LLAELRRIEQ AGRKEAIDAW
1060 1070 1080 1090 1100
APYLPQYIDH VISPGVTSEA AQTITTAPDA SGPEAKVQEE EHDLVDDDIT
1110 1120 1130 1140 1150
TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE IEPPKLLTRP
1160 1170 1180 1190 1200
RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
1210 1220 1230 1240 1250
AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD
1260 1270 1280 1290 1300
SARSARHALS LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA
1310 1320 1330 1340 1350
RAKGEILRVI EILIEKMPTD VVDLLVEVMD IIMYCLEGSL VKKKGLQECF
1360 1370 1380 1390 1400
PAICRFYMVS YYERNHRIAV GARHGSVALY DIRTGKCQTI HGHKGPITAV
1410 1420 1430 1440 1450
AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ LRCIKTYQVP
1460 1470 1480 1490
PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
Length:1,490
Mass (Da):163,810
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i626E876245696A1F
GO
Isoform 2 (identifier: Q9Y4E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     950-982: Missing.

Show »
Length:1,457
Mass (Da):160,510
Checksum:i4F0D743D9A38F0B9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2RRE0A2RRE0_HUMAN
WD repeat-containing protein 7
WDR7
815Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMB8K7EMB8_HUMAN
WD repeat-containing protein 7
WDR7
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPQ4K7EPQ4_HUMAN
WD repeat-containing protein 7
WDR7
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMF3K7EMF3_HUMAN
WD repeat-containing protein 7
WDR7
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPY9K7EPY9_HUMAN
WD repeat-containing protein 7
WDR7
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25467 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54I → V in AAL03983 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_015274950 – 982Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY099325 mRNA Translation: AAM33134.1
AF188125 mRNA Translation: AAL03983.1
AB011113 mRNA Translation: BAA25467.2 Different initiation.
CH471096 Genomic DNA Translation: EAW63038.1
BC050352 mRNA Translation: AAH50352.1
BC150282 mRNA Translation: AAI50283.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11962.1 [Q9Y4E6-1]
CCDS11963.1 [Q9Y4E6-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T00272

NCBI Reference Sequences

More...
RefSeqi
NP_056100.2, NM_015285.2 [Q9Y4E6-1]
NP_443066.2, NM_052834.2 [Q9Y4E6-2]
XP_006722494.1, XM_006722431.2 [Q9Y4E6-1]
XP_016881171.1, XM_017025682.1 [Q9Y4E6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254442; ENSP00000254442; ENSG00000091157 [Q9Y4E6-1]
ENST00000357574; ENSP00000350187; ENSG00000091157 [Q9Y4E6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23335

UCSC genome browser

More...
UCSCi
uc002lgk.2, human [Q9Y4E6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY099325 mRNA Translation: AAM33134.1
AF188125 mRNA Translation: AAL03983.1
AB011113 mRNA Translation: BAA25467.2 Different initiation.
CH471096 Genomic DNA Translation: EAW63038.1
BC050352 mRNA Translation: AAH50352.1
BC150282 mRNA Translation: AAI50283.1
CCDSiCCDS11962.1 [Q9Y4E6-1]
CCDS11963.1 [Q9Y4E6-2]
PIRiT00272
RefSeqiNP_056100.2, NM_015285.2 [Q9Y4E6-1]
NP_443066.2, NM_052834.2 [Q9Y4E6-2]
XP_006722494.1, XM_006722431.2 [Q9Y4E6-1]
XP_016881171.1, XM_017025682.1 [Q9Y4E6-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi116922, 39 interactors
IntActiQ9Y4E6, 4 interactors
STRINGi9606.ENSP00000254442

PTM databases

iPTMnetiQ9Y4E6
PhosphoSitePlusiQ9Y4E6

Polymorphism and mutation databases

BioMutaiWDR7
DMDMi73920974

Proteomic databases

EPDiQ9Y4E6
jPOSTiQ9Y4E6
MassIVEiQ9Y4E6
PaxDbiQ9Y4E6
PeptideAtlasiQ9Y4E6
PRIDEiQ9Y4E6
ProteomicsDBi86181 [Q9Y4E6-1]
86182 [Q9Y4E6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
62690, 17 antibodies

Genome annotation databases

EnsembliENST00000254442; ENSP00000254442; ENSG00000091157 [Q9Y4E6-1]
ENST00000357574; ENSP00000350187; ENSG00000091157 [Q9Y4E6-2]
GeneIDi23335
KEGGihsa:23335
UCSCiuc002lgk.2, human [Q9Y4E6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23335
DisGeNETi23335
EuPathDBiHostDB:ENSG00000091157.13

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR7
HGNCiHGNC:13490, WDR7
HPAiENSG00000091157, Low tissue specificity
MIMi613473, gene
neXtProtiNX_Q9Y4E6
OpenTargetsiENSG00000091157
PharmGKBiPA37784

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4155, Eukaryota
GeneTreeiENSGT00940000155301
HOGENOMiCLU_004362_1_0_1
InParanoidiQ9Y4E6
OMAiCEGKAVP
OrthoDBi84170at2759
PhylomeDBiQ9Y4E6
TreeFamiTF313196

Enzyme and pathway databases

PathwayCommonsiQ9Y4E6
SignaLinkiQ9Y4E6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23335, 565 hits in 888 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR7, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23335
PharosiQ9Y4E6, Tbio

Protein Ontology

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PROi
PR:Q9Y4E6
RNActiQ9Y4E6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000091157, Expressed in corpus callosum and 237 other tissues
ExpressionAtlasiQ9Y4E6, baseline and differential
GenevisibleiQ9Y4E6, HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR011047, Quinoprotein_ADH-like_supfam
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 5 hits
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
SSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4E6
Secondary accession number(s): A7E2C8
, Q86UX5, Q86VP2, Q96PS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: August 30, 2005
Last modified: August 12, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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