UniProtKB - Q9Y4E6 (WDR7_HUMAN)
Protein
WD repeat-containing protein 7
Gene
WDR7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- hematopoietic progenitor cell differentiation Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9Y4E6 |
SignaLinki | Q9Y4E6 |
Names & Taxonomyi
Protein namesi | Recommended name: WD repeat-containing protein 7Alternative name(s): Rabconnectin-3 beta TGF-beta resistance-associated protein TRAG |
Gene namesi | Name:WDR7 Synonyms:KIAA0541, TRAG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13490, WDR7 |
MIMi | 613473, gene |
neXtProti | NX_Q9Y4E6 |
VEuPathDBi | HostDB:ENSG00000091157.13 |
Subcellular locationi
Other locations
- synaptic vesicle Source: Ensembl
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 23335 |
OpenTargetsi | ENSG00000091157 |
PharmGKBi | PA37784 |
Miscellaneous databases
Pharosi | Q9Y4E6, Tbio |
Genetic variation databases
BioMutai | WDR7 |
DMDMi | 73920974 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051353 | 1 – 1490 | WD repeat-containing protein 7Add BLAST | 1490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 935 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1456 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y4E6 |
jPOSTi | Q9Y4E6 |
MassIVEi | Q9Y4E6 |
PaxDbi | Q9Y4E6 |
PeptideAtlasi | Q9Y4E6 |
PRIDEi | Q9Y4E6 |
ProteomicsDBi | 86181 [Q9Y4E6-1] 86182 [Q9Y4E6-2] |
PTM databases
iPTMneti | Q9Y4E6 |
PhosphoSitePlusi | Q9Y4E6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000091157, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q9Y4E6, baseline and differential |
Genevisiblei | Q9Y4E6, HS |
Organism-specific databases
HPAi | ENSG00000091157, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116922, 45 interactors |
IntActi | Q9Y4E6, 4 interactors |
STRINGi | 9606.ENSP00000254442 |
Miscellaneous databases
RNActi | Q9Y4E6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 17 – 56 | WD 1Add BLAST | 40 | |
Repeati | 62 – 104 | WD 2Add BLAST | 43 | |
Repeati | 156 – 199 | WD 3Add BLAST | 44 | |
Repeati | 324 – 366 | WD 4Add BLAST | 43 | |
Repeati | 404 – 443 | WD 5Add BLAST | 40 | |
Repeati | 462 – 507 | WD 6Add BLAST | 46 | |
Repeati | 558 – 597 | WD 7Add BLAST | 40 | |
Repeati | 1351 – 1390 | WD 8Add BLAST | 40 | |
Repeati | 1392 – 1432 | WD 9Add BLAST | 41 |
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG4155, Eukaryota |
GeneTreei | ENSGT00940000155301 |
HOGENOMi | CLU_004362_1_0_1 |
InParanoidi | Q9Y4E6 |
OMAi | CEGKAVP |
OrthoDBi | 84170at2759 |
PhylomeDBi | Q9Y4E6 |
TreeFami | TF313196 |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y4E6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGNSLVLPI VLWGRKAPTH CISAVLLTDD GATIVTGCHD GQICLWDLSV
60 70 80 90 100
ELQINPRALL FGHTASITCL SKACASSDKQ YIVSASESGE MCLWDVSDGR
110 120 130 140 150
CIEFTKLACT HTGIQFYQFS VGNQREGRLL CHGHYPEILV VDATSLEVLY
160 170 180 190 200
SLVSKISPDW ISSMSIIRSH RTQEDTVVAL SVTGILKVWI VTSEISDMQD
210 220 230 240 250
TEPIFEEESK PIYCQNCQSI SFCAFTQRSL LVVCSKYWRV FDAGDYSLLC
260 270 280 290 300
SGPSENGQTW TGGDFVSSDK VIIWTENGQS YIYKLPASCL PASDSFRSDV
310 320 330 340 350
GKAVENLIPP VQHILLDRKD KELLICPPVT RFFYGCREYF HKLLIQGDSS
360 370 380 390 400
GRLNIWNISD TADKQGSEEG LAMTTSISLQ EAFDKLNPCP AGIIDQLSVI
410 420 430 440 450
PNSNEPLKVT ASVYIPAHGR LVCGREDGSI VIVPATQTAI VQLLQGEHML
460 470 480 490 500
RRGWPPHRTL RGHRNKVTCL LYPHQVSARY DQRYLISGGV DFSVIIWDIF
510 520 530 540 550
SGEMKHIFCV HGGEITQLLV PPENCSARVQ HCICSVASDH SVGLLSLREK
560 570 580 590 600
KCIMLASRHL FPIQVIKWRP SDDYLVVGCS DGSVYVWQMD TGALDRCVMG
610 620 630 640 650
ITAVEILNAC DEAVPAAVDS LSHPAVNLKQ AMTRRSLAAL KNMAHHKLQT
660 670 680 690 700
LATNLLASEA SDKGNLPKYS HNSLMVQAIK TNLTDPDIHV LFFDVEALII
710 720 730 740 750
QLLTEEASRP NTALISPENL QKASGSSDKG GSFLTGKRAA VLFQQVKETI
760 770 780 790 800
KENIKEHLLD DEEEDEEIMR QRREESDPEY RSSKSKPLTL LEYNLTMDTA
810 820 830 840 850
KLFMSCLHAW GLNEVLDEVC LDRLGMLKPH CTVSFGLLSR GGHMSLMLPG
860 870 880 890 900
YNQPACKLSH GKTEVGRKLP ASEGVGKGTY GVSRAVTTQH LLSIISLANT
910 920 930 940 950
LMSMTNATFI GDHMKKGPTR PPRPSTPDLS KARGSPPTSS NIVQGQIKQV
960 970 980 990 1000
AAPVVSARSD ADHSGSDPPS APALHTCFLV NEGWSQLAAM HCVMLPDLLG
1010 1020 1030 1040 1050
LDKFRPPLLE MLARRWQDRC LEVREAAQAL LLAELRRIEQ AGRKEAIDAW
1060 1070 1080 1090 1100
APYLPQYIDH VISPGVTSEA AQTITTAPDA SGPEAKVQEE EHDLVDDDIT
1110 1120 1130 1140 1150
TGCLSSVPQM KKISTSYEER RKQATAIVLL GVIGAEFGAE IEPPKLLTRP
1160 1170 1180 1190 1200
RSSSQIPEGF GLTSGGSNYS LARHTCKALT FLLLQPPSPK LPPHSTIRRT
1210 1220 1230 1240 1250
AIDLIGRGFT VWEPYMDVSA VLMGLLELCA DAEKQLANIT MGLPLSPAAD
1260 1270 1280 1290 1300
SARSARHALS LIATARPPAF ITTIAKEVHR HTALAANTQS QQNMHTTTLA
1310 1320 1330 1340 1350
RAKGEILRVI EILIEKMPTD VVDLLVEVMD IIMYCLEGSL VKKKGLQECF
1360 1370 1380 1390 1400
PAICRFYMVS YYERNHRIAV GARHGSVALY DIRTGKCQTI HGHKGPITAV
1410 1420 1430 1440 1450
AFAPDGRYLA TYSNTDSHIS FWQMNTSLLG SIGMLNSAPQ LRCIKTYQVP
1460 1470 1480 1490
PVQPASPGSH NALKLARLIW TSNRNVILMA HDGKEHRFMV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2RRE0 | A2RRE0_HUMAN | WD repeat-containing protein 7 | WDR7 | 815 | Annotation score: | ||
K7EMB8 | K7EMB8_HUMAN | WD repeat-containing protein 7 | WDR7 | 169 | Annotation score: | ||
K7EPQ4 | K7EPQ4_HUMAN | WD repeat-containing protein 7 | WDR7 | 67 | Annotation score: | ||
K7EMF3 | K7EMF3_HUMAN | WD repeat-containing protein 7 | WDR7 | 40 | Annotation score: | ||
K7EPY9 | K7EPY9_HUMAN | WD repeat-containing protein 7 | WDR7 | 62 | Annotation score: |
Sequence cautioni
The sequence BAA25467 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | I → V in AAL03983 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015274 | 950 – 982 | Missing in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY099325 mRNA Translation: AAM33134.1 AF188125 mRNA Translation: AAL03983.1 AB011113 mRNA Translation: BAA25467.2 Different initiation. CH471096 Genomic DNA Translation: EAW63038.1 BC050352 mRNA Translation: AAH50352.1 BC150282 mRNA Translation: AAI50283.1 |
CCDSi | CCDS11962.1 [Q9Y4E6-1] CCDS11963.1 [Q9Y4E6-2] |
PIRi | T00272 |
RefSeqi | NP_056100.2, NM_015285.2 [Q9Y4E6-1] NP_443066.2, NM_052834.2 [Q9Y4E6-2] XP_006722494.1, XM_006722431.2 XP_016881171.1, XM_017025682.1 |
Genome annotation databases
Ensembli | ENST00000254442; ENSP00000254442; ENSG00000091157 [Q9Y4E6-1] ENST00000357574; ENSP00000350187; ENSG00000091157 [Q9Y4E6-2] |
GeneIDi | 23335 |
KEGGi | hsa:23335 |
UCSCi | uc002lgk.2, human [Q9Y4E6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY099325 mRNA Translation: AAM33134.1 AF188125 mRNA Translation: AAL03983.1 AB011113 mRNA Translation: BAA25467.2 Different initiation. CH471096 Genomic DNA Translation: EAW63038.1 BC050352 mRNA Translation: AAH50352.1 BC150282 mRNA Translation: AAI50283.1 |
CCDSi | CCDS11962.1 [Q9Y4E6-1] CCDS11963.1 [Q9Y4E6-2] |
PIRi | T00272 |
RefSeqi | NP_056100.2, NM_015285.2 [Q9Y4E6-1] NP_443066.2, NM_052834.2 [Q9Y4E6-2] XP_006722494.1, XM_006722431.2 XP_016881171.1, XM_017025682.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116922, 45 interactors |
IntActi | Q9Y4E6, 4 interactors |
STRINGi | 9606.ENSP00000254442 |
PTM databases
iPTMneti | Q9Y4E6 |
PhosphoSitePlusi | Q9Y4E6 |
Genetic variation databases
BioMutai | WDR7 |
DMDMi | 73920974 |
Proteomic databases
EPDi | Q9Y4E6 |
jPOSTi | Q9Y4E6 |
MassIVEi | Q9Y4E6 |
PaxDbi | Q9Y4E6 |
PeptideAtlasi | Q9Y4E6 |
PRIDEi | Q9Y4E6 |
ProteomicsDBi | 86181 [Q9Y4E6-1] 86182 [Q9Y4E6-2] |
Protocols and materials databases
Antibodypediai | 62690, 18 antibodies |
Genome annotation databases
Ensembli | ENST00000254442; ENSP00000254442; ENSG00000091157 [Q9Y4E6-1] ENST00000357574; ENSP00000350187; ENSG00000091157 [Q9Y4E6-2] |
GeneIDi | 23335 |
KEGGi | hsa:23335 |
UCSCi | uc002lgk.2, human [Q9Y4E6-1] |
Organism-specific databases
CTDi | 23335 |
DisGeNETi | 23335 |
GeneCardsi | WDR7 |
HGNCi | HGNC:13490, WDR7 |
HPAi | ENSG00000091157, Low tissue specificity |
MIMi | 613473, gene |
neXtProti | NX_Q9Y4E6 |
OpenTargetsi | ENSG00000091157 |
PharmGKBi | PA37784 |
VEuPathDBi | HostDB:ENSG00000091157.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4155, Eukaryota |
GeneTreei | ENSGT00940000155301 |
HOGENOMi | CLU_004362_1_0_1 |
InParanoidi | Q9Y4E6 |
OMAi | CEGKAVP |
OrthoDBi | 84170at2759 |
PhylomeDBi | Q9Y4E6 |
TreeFami | TF313196 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4E6 |
SignaLinki | Q9Y4E6 |
Miscellaneous databases
BioGRID-ORCSi | 23335, 582 hits in 903 CRISPR screens |
ChiTaRSi | WDR7, human |
GenomeRNAii | 23335 |
Pharosi | Q9Y4E6, Tbio |
PROi | PR:Q9Y4E6 |
RNActi | Q9Y4E6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000091157, Expressed in corpus callosum and 237 other tissues |
ExpressionAtlasi | Q9Y4E6, baseline and differential |
Genevisiblei | Q9Y4E6, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 3 hits |
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF00400, WD40, 5 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF50998, SSF50998, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | WDR7_HUMAN | |
Accessioni | Q9Y4E6Primary (citable) accession number: Q9Y4E6 Secondary accession number(s): A7E2C8 Q96PS7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | August 30, 2005 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM