UniProtKB - Q9Y4D8 (HECD4_HUMAN)
Protein
Probable E3 ubiquitin-protein ligase HECTD4
Gene
HECTD4
Organism
Homo sapiens (Human)
Status
Functioni
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 3964 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: InterPro
GO - Biological processi
- glucose homeostasis Source: UniProtKB
- glucose metabolic process Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4D8 |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable E3 ubiquitin-protein ligase HECTD4 (EC:2.3.2.26)Alternative name(s): HECT domain-containing protein 4 HECT-type E3 ubiquitin transferase HECTD4 |
Gene namesi | Name:HECTD4 Synonyms:C12orf51, KIAA0614 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26611, HECTD4 |
neXtProti | NX_Q9Y4D8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Miscellaneous databases
Pharosi | Q9Y4D8, Tbio |
Polymorphism and mutation databases
BioMutai | HECTD4 |
DMDMi | 300669718 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342681 | 1 – 3996 | Probable E3 ubiquitin-protein ligase HECTD4Add BLAST | 3996 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2080 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9Y4D8 |
MassIVEi | Q9Y4D8 |
PaxDbi | Q9Y4D8 |
PeptideAtlasi | Q9Y4D8 |
PRIDEi | Q9Y4D8 |
ProteomicsDBi | 86170 [Q9Y4D8-1] 86171 [Q9Y4D8-2] 86172 [Q9Y4D8-3] 86173 [Q9Y4D8-4] |
PTM databases
iPTMneti | Q9Y4D8 |
PhosphoSitePlusi | Q9Y4D8 |
Interactioni
Binary interactionsi
Q9Y4D8
With | #Exp. | IntAct |
---|---|---|
YWHAZ [P63104] | 2 | EBI-7195436,EBI-347088 |
Protein-protein interaction databases
IntActi | Q9Y4D8, 14 interactors |
MINTi | Q9Y4D8 |
STRINGi | 9606.ENSP00000449784 |
Miscellaneous databases
RNActi | Q9Y4D8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3627 – 3996 | HECTPROSITE-ProRule annotationAdd BLAST | 370 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2867 – 2909 | Ser-richAdd BLAST | 43 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1426, Eukaryota |
InParanoidi | Q9Y4D8 |
PhylomeDBi | Q9Y4D8 |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit cd13735, SPRY_HECT_like, 1 hit |
Gene3Di | 2.60.120.920, 1 hit |
InterProi | View protein in InterPro IPR043136, B30.2/SPRY_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR043366, HECTD4 IPR035781, SPRY_HECTD4 |
PANTHERi | PTHR46435, PTHR46435, 1 hit |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit |
SUPFAMi | SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y4D8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPANHLPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL
60 70 80 90 100
VVENGVFVAN PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA
110 120 130 140 150
LTGSTISNTL KEDQAANTSC GLPLKMLRKT PIYTCGTYLV MLVPPPGGSG
160 170 180 190 200
SSATRSLFGG TSGLSSLKRA CYDTVNNMLW TCSNDYIDQW CNPGNQAFHY
210 220 230 240 250
VCQRLGVSHI ITEPKEEAIT TNEVINQLLH HVGAMCIHQL NLLATNPNLP
260 270 280 290 300
ITSVLGKQHP IEAHHLSSIC DIMEKAMVNG DTCIIRCILV VFQVVFKFFF
310 320 330 340 350
SPQTERNRDI IRRSGLLLWQ LLMAPKDQIC PEIQKEVCLA ISSGLNILYP
360 370 380 390 400
GETEINNLLK LVLTEGERNS GLSQLRDVIL TNLAEQLQNN RFGSDEDDHY
410 420 430 440 450
RLNDELLHYI LKIVVRESCI LITKCQTVSK DDFQKLLSTV PAASSCLRYL
460 470 480 490 500
MAVQNHLLSN TILIKPDEND DSDSSLQGET LKVQELKVSI LALATQILTG
510 520 530 540 550
CDEVLEMLQQ VTTALINSDI ADREQRLKGL EQVTKATMLG HLLPVLLTSL
560 570 580 590 600
MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA EVGCSPCGAP
610 620 630 640 650
DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK
660 670 680 690 700
ETVHIPGARC LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG
710 720 730 740 750
YGSRSVLGTG WPKDLVKCIS PPSLNFKVEG DTVTFSFEMR SGREHNTPDK
760 770 780 790 800
AMWGFACTVR AQESSEDVSG GLPFLVDLAL GLSVLACSML RILYNGPEIT
810 820 830 840 850
KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP LTIEEDREFT
860 870 880 890 900
YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP
910 920 930 940 950
DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK
960 970 980 990 1000
LNAMERQLQS VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL
1010 1020 1030 1040 1050
ELLCSMKEVS FDGNDLENMV LSLREKFLQE VNSLIQKPSH PLAKTKTLVK
1060 1070 1080 1090 1100
SLMNRAELLL HVTIAAQSGL TRSISGTPAE TPACKSASET KVISHAVRQP
1110 1120 1130 1140 1150
VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF TLLQSLAIED
1160 1170 1180 1190 1200
SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV
1210 1220 1230 1240 1250
HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE
1260 1270 1280 1290 1300
TMTSVVSLCA RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS
1310 1320 1330 1340 1350
LSNQTESSSS EKQTKKQKVA TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS
1360 1370 1380 1390 1400
GLARQVSSLL TNHLARATEC CGNQAAGNDA LQDVLSLLND LSRSHIGKAI
1410 1420 1430 1440 1450
LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV EDCGNVELPP
1460 1470 1480 1490 1500
WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD
1510 1520 1530 1540 1550
TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS
1560 1570 1580 1590 1600
SSEGRPFRLG TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ
1610 1620 1630 1640 1650
SGLIVSIGPP VESINPETVS GLSTGDKKKT AQTSICRERN SELARTDPVR
1660 1670 1680 1690 1700
PFISGHVANS MAAEVIALLH SLLMAPESNA AQIWTTTAEK VLSRALMYIP
1710 1720 1730 1740 1750
QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF KETIKIGSEV
1760 1770 1780 1790 1800
QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL
1810 1820 1830 1840 1850
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV
1860 1870 1880 1890 1900
MAVVRLLAEI RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS
1910 1920 1930 1940 1950
AGERLAVVEV QCERLRMLYR DCARPPPPPL QADRRQPKEI TWSPSRVFPP
1960 1970 1980 1990 2000
VRACMFSSHL TSVTFLADPS AGGGLPRGTF IYATSPLPVQ APSFYWEIEI
2010 2020 2030 2040 2050
VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN NGRAVHYNGS
2060 2070 2080 2090 2100
SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR
2110 2120 2130 2140 2150
LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT
2160 2170 2180 2190 2200
DLAEEISANF EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ
2210 2220 2230 2240 2250
QYDSDTSCHY KVELSYENFI TSGPDPHPPP IADDESDDDD DDDIPQEDHY
2260 2270 2280 2290 2300
ALLVKAWETK VFPTIRRRFR NEAERKSGLD QIKGALQLGM VDIARQTVEF
2310 2320 2330 2340 2350
LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT RSPDSNNVAS
2360 2370 2380 2390 2400
SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY
2410 2420 2430 2440 2450
WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM
2460 2470 2480 2490 2500
ALLNIFAPKL PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS
2510 2520 2530 2540 2550
SSILLAQSLQ HCIHSQNCSA TDLFYQGNSQ TVREWLNVAI TRTLHQGEES
2560 2570 2580 2590 2600
LLELTKQICS FLQTAPEQFP SEEFPISESK VNMDVNFPGA AFVVVSCKES
2610 2620 2630 2640 2650
QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC YPRDASPANT
2660 2670 2680 2690 2700
GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF
2710 2720 2730 2740 2750
AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE
2760 2770 2780 2790 2800
LVFHLLAELL RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL
2810 2820 2830 2840 2850
YDEETQNWVS GGACGGSGGA AAGDQGRFST YFHALMEGCL AVAEVTLPTN
2860 2870 2880 2890 2900
MSVTASGVTS ATAPNLSDSS SSSSSSPGQT PQSPSLLSKR KKVKMKREKA
2910 2920 2930 2940 2950
SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI ILRHLTRKDP
2960 2970 2980 2990 3000
QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN
3010 3020 3030 3040 3050
AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS
3060 3070 3080 3090 3100
TSSSLTPAMS ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP
3110 3120 3130 3140 3150
GLLEPHAVSS QESLDISLCS TGSLGSLGSL GEPLDNAETA SVSDMGSMYT
3160 3170 3180 3190 3200
VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK IRASLFNNND LIGLSSLDGE
3210 3220 3230 3240 3250
DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK GEKLVPGARE
3260 3270 3280 3290 3300
VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT
3310 3320 3330 3340 3350
NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP
3360 3370 3380 3390 3400
ITKPPAKDKA VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ
3410 3420 3430 3440 3450
EVPEEKYLTL EGFHKFVIDR ARQDIRSVWR AILSCGYDLH FERCACIDVR
3460 3470 3480 3490 3500
HAQKASRKWT LEMDVALVQY INQLCRHLAI TPARLHPHEV YLDPADAADP
3510 3520 3530 3540 3550
RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT PMYTHSIAAL
3560 3570 3580 3590 3600
LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA
3610 3620 3630 3640 3650
SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS
3660 3670 3680 3690 3700
FRHFLWQVCK ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL
3710 3720 3730 3740 3750
HFLGQLLGIA IRADVPLPLD LLPSFWKTLV GEPLDPEQDL QEADILTYNY
3760 3770 3780 3790 3800
VKKFESINDE TELEALCAEI ASQHLATESP DSPNKPCCRF TYLTMTGEEV
3810 3820 3830 3840 3850
ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV RAGLGSIIPL
3860 3870 3880 3890 3900
QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL
3910 3920 3930 3940 3950
EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT
3960 3970 3980 3990
AGSPDSRYIR VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG
Isoform 5 (identifier: Q9Y4D8-5) [UniParc]FASTAAdd to basket
Also known as: POTAGE
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MGSSAAAAAA...TLQVCQVVPM
169-169: R → ILASSLVYNISDGQFTSRADLIDAAGSSLGRGALVPGLG
717-726: Missing.
896-899: EVIQ → YVAV
900-3996: Missing.
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VWT9 | F8VWT9_HUMAN | Probable E3 ubiquitin-protein ligas... | HECTD4 | 4,284 | Annotation score: | ||
J3KPF0 | J3KPF0_HUMAN | Probable E3 ubiquitin-protein ligas... | HECTD4 | 4,416 | Annotation score: | ||
V9GYT9 | V9GYT9_HUMAN | Probable E3 ubiquitin-protein ligas... | HECTD4 | 262 | Annotation score: | ||
A0A494C150 | A0A494C150_HUMAN | Probable E3 ubiquitin-protein ligas... | HECTD4 | 1,828 | Annotation score: | ||
F8VU57 | F8VU57_HUMAN | Probable E3 ubiquitin-protein ligas... | HECTD4 | 109 | Annotation score: |
Sequence cautioni
The sequence AAF36539 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH65706 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH65706 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01483 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA31589 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC03671 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 170 | A → G in AAH65706 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 681 | Y → C in BAC03671 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 801 | K → E in AAH65706 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 2019 | T → I in AK054654 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2702 | E → G in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 2867 | S → T in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 2896 – 2897 | KR → NA in AAF36539 (Ref. 7) Curated | 2 | |
Sequence conflicti | 2902 | S → C in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3153 | S → P in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3182 | R → Q in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3191 | L → F in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3419 – 3420 | DR → YQ in AAF36539 (Ref. 7) Curated | 2 | |
Sequence conflicti | 3665 | S → A in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3723 | P → T in AAH06270 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3726 | W → R in AAH06270 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 3732 – 3733 | EP → DA in AAF36539 (Ref. 7) Curated | 2 | |
Sequence conflicti | 3798 | E → R in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3830 | E → A in AAF36539 (Ref. 7) Curated | 1 | |
Sequence conflicti | 3985 | C → G in AAF36539 (Ref. 7) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047465 | 1 | M → MGSSAAAAAAAAAAADSAQW LSVKEETIFLHDGLIRVTDL AELPSEILGAPEAADTDLEI LTFETKNPSELAERLRSVCG NQSNAYARLLEYRLNALRGL WNAQRQLALEEQHERESSGD EETLALLKRQGLLQQPEQAP FTSRMGLLLVFPLIQSQSRT DPSLCNITAEVLLNCLRDCQ PLSLTKEPADCLNGIETLLC SWLEETSDTGRHIPHKQKEN AAAALVALACARGSLKTFVH TVHLLQKQTDLGSLPVADVL YRLLLLEGGPGSPSCLLGGK HIVSWGYEDMLPAPDSNTGS SSENKDADLGRCLTADGLYL YTTNSVGRGVSKLGSGLHGT LRGFVYCRNEELEPGWVAFG SGSLLHRPVSFDNKPHSLFQ VIDQNTLQVCQVVPM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_047466 | 169 | R → ILASSLVYNISDGQFTSRAD LIDAAGSSLGRGALVPGLG in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_039451 | 483 – 484 | Missing in isoform 4. 1 Publication | 2 | |
Alternative sequenceiVSP_039452 | 717 – 726 | Missing in isoform 3, isoform 4 and isoform 5. 3 Publications | 10 | |
Alternative sequenceiVSP_039453 | 896 – 899 | EVIQ → YVAV in isoform 3 and isoform 5. 3 Publications | 4 | |
Alternative sequenceiVSP_039454 | 900 – 3996 | Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST | 3097 | |
Alternative sequenceiVSP_034529 | 2382 – 2386 | NELVQ → SEQPF in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_034530 | 2387 – 3996 | Missing in isoform 2. 1 PublicationAdd BLAST | 1610 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB777655 mRNA Translation: BAM76724.1 AC073575 Genomic DNA No translation available. AC004031 Genomic DNA No translation available. AC004217 Genomic DNA No translation available. BC006270 mRNA Translation: AAH06270.2 BC021144 mRNA Translation: AAH21144.1 BC065706 mRNA Translation: AAH65706.1 Sequence problems. BC101482 mRNA Translation: AAI01483.1 Different initiation. AK054654 mRNA No translation available. AK091473 mRNA Translation: BAC03671.1 Different initiation. AB014514 mRNA Translation: BAA31589.3 Sequence problems. AF174498 mRNA Translation: AAF36539.1 Sequence problems. AL117469 mRNA Translation: CAB55944.1 |
PIRi | T00390 |
Genome annotation databases
Ensembli | ENST00000430131; ENSP00000404379; ENSG00000173064 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB777655 mRNA Translation: BAM76724.1 AC073575 Genomic DNA No translation available. AC004031 Genomic DNA No translation available. AC004217 Genomic DNA No translation available. BC006270 mRNA Translation: AAH06270.2 BC021144 mRNA Translation: AAH21144.1 BC065706 mRNA Translation: AAH65706.1 Sequence problems. BC101482 mRNA Translation: AAI01483.1 Different initiation. AK054654 mRNA No translation available. AK091473 mRNA Translation: BAC03671.1 Different initiation. AB014514 mRNA Translation: BAA31589.3 Sequence problems. AF174498 mRNA Translation: AAF36539.1 Sequence problems. AL117469 mRNA Translation: CAB55944.1 |
PIRi | T00390 |
3D structure databases
SMRi | Q9Y4D8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9Y4D8, 14 interactors |
MINTi | Q9Y4D8 |
STRINGi | 9606.ENSP00000449784 |
PTM databases
iPTMneti | Q9Y4D8 |
PhosphoSitePlusi | Q9Y4D8 |
Polymorphism and mutation databases
BioMutai | HECTD4 |
DMDMi | 300669718 |
Proteomic databases
jPOSTi | Q9Y4D8 |
MassIVEi | Q9Y4D8 |
PaxDbi | Q9Y4D8 |
PeptideAtlasi | Q9Y4D8 |
PRIDEi | Q9Y4D8 |
ProteomicsDBi | 86170 [Q9Y4D8-1] 86171 [Q9Y4D8-2] 86172 [Q9Y4D8-3] 86173 [Q9Y4D8-4] |
Genome annotation databases
Ensembli | ENST00000430131; ENSP00000404379; ENSG00000173064 |
Organism-specific databases
GeneCardsi | HECTD4 |
HGNCi | HGNC:26611, HECTD4 |
neXtProti | NX_Q9Y4D8 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1426, Eukaryota |
InParanoidi | Q9Y4D8 |
PhylomeDBi | Q9Y4D8 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9Y4D8 |
Miscellaneous databases
ChiTaRSi | HECTD4, human |
Pharosi | Q9Y4D8, Tbio |
PROi | PR:Q9Y4D8 |
RNActi | Q9Y4D8, protein |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit cd13735, SPRY_HECT_like, 1 hit |
Gene3Di | 2.60.120.920, 1 hit |
InterProi | View protein in InterPro IPR043136, B30.2/SPRY_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR043366, HECTD4 IPR035781, SPRY_HECTD4 |
PANTHERi | PTHR46435, PTHR46435, 1 hit |
Pfami | View protein in Pfam PF00632, HECT, 1 hit |
SMARTi | View protein in SMART SM00119, HECTc, 1 hit |
SUPFAMi | SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50237, HECT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HECD4_HUMAN | |
Accessioni | Q9Y4D8Primary (citable) accession number: Q9Y4D8 Secondary accession number(s): L8B0P6 Q9UFT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | July 13, 2010 | |
Last modified: | August 12, 2020 | |
This is version 141 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM