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UniProtKB - Q9Y4D8 (HECD4_HUMAN)

Protein

Probable E3 ubiquitin-protein ligase HECTD4

Gene

HECTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3964Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • glucose homeostasis Source: UniProtKB
  • glucose metabolic process Source: UniProtKB
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HECTD4 (EC:2.3.2.26)
Alternative name(s):
HECT domain-containing protein 4
HECT-type E3 ubiquitin transferase HECTD4
Gene namesi
Name:HECTD4
Synonyms:C12orf51, KIAA0614
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26611 HECTD4
neXtProtiNX_Q9Y4D8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi283450

Polymorphism and mutation databases

DMDMi300669718

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003426811 – 3996Probable E3 ubiquitin-protein ligase HECTD4Add BLAST3996

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2080PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Y4D8
PeptideAtlasiQ9Y4D8
PRIDEiQ9Y4D8
ProteomicsDBi86170
86171 [Q9Y4D8-2]
86172 [Q9Y4D8-3]
86173 [Q9Y4D8-4]

PTM databases

iPTMnetiQ9Y4D8
PhosphoSitePlusiQ9Y4D8

Expressioni

Organism-specific databases

HPAiHPA041062
HPA045473

Interactioni

Protein-protein interaction databases

IntActiQ9Y4D8, 2 interactors
MINTiQ9Y4D8
STRINGi9606.ENSP00000449784

Structurei

3D structure databases

ProteinModelPortaliQ9Y4D8
SMRiQ9Y4D8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3627 – 3996HECTPROSITE-ProRule annotationAdd BLAST370

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2867 – 2909Ser-richAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
HOVERGENiHBG106580
InParanoidiQ9Y4D8
PhylomeDBiQ9Y4D8

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd13735 SPRY_HECT_like, 1 hit
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR035781 SPRY_HECTD4
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPANHLPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL 
        60         70         80         90        100
VVENGVFVAN PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA 
       110        120        130        140        150
LTGSTISNTL KEDQAANTSC GLPLKMLRKT PIYTCGTYLV MLVPPPGGSG 
       160        170        180        190        200
SSATRSLFGG TSGLSSLKRA CYDTVNNMLW TCSNDYIDQW CNPGNQAFHY 
       210        220        230        240        250
VCQRLGVSHI ITEPKEEAIT TNEVINQLLH HVGAMCIHQL NLLATNPNLP 
       260        270        280        290        300
ITSVLGKQHP IEAHHLSSIC DIMEKAMVNG DTCIIRCILV VFQVVFKFFF 
       310        320        330        340        350
SPQTERNRDI IRRSGLLLWQ LLMAPKDQIC PEIQKEVCLA ISSGLNILYP 
       360        370        380        390        400
GETEINNLLK LVLTEGERNS GLSQLRDVIL TNLAEQLQNN RFGSDEDDHY 
       410        420        430        440        450
RLNDELLHYI LKIVVRESCI LITKCQTVSK DDFQKLLSTV PAASSCLRYL 
       460        470        480        490        500
MAVQNHLLSN TILIKPDEND DSDSSLQGET LKVQELKVSI LALATQILTG 
       510        520        530        540        550
CDEVLEMLQQ VTTALINSDI ADREQRLKGL EQVTKATMLG HLLPVLLTSL 
       560        570        580        590        600
MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA EVGCSPCGAP 
       610        620        630        640        650
DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK 
       660        670        680        690        700
ETVHIPGARC LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG 
       710        720        730        740        750
YGSRSVLGTG WPKDLVKCIS PPSLNFKVEG DTVTFSFEMR SGREHNTPDK 
       760        770        780        790        800
AMWGFACTVR AQESSEDVSG GLPFLVDLAL GLSVLACSML RILYNGPEIT 
       810        820        830        840        850
KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP LTIEEDREFT 
       860        870        880        890        900
YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP 
       910        920        930        940        950
DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK 
       960        970        980        990       1000
LNAMERQLQS VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL 
      1010       1020       1030       1040       1050
ELLCSMKEVS FDGNDLENMV LSLREKFLQE VNSLIQKPSH PLAKTKTLVK 
      1060       1070       1080       1090       1100
SLMNRAELLL HVTIAAQSGL TRSISGTPAE TPACKSASET KVISHAVRQP 
      1110       1120       1130       1140       1150
VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF TLLQSLAIED 
      1160       1170       1180       1190       1200
SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV 
      1210       1220       1230       1240       1250
HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE 
      1260       1270       1280       1290       1300
TMTSVVSLCA RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS 
      1310       1320       1330       1340       1350
LSNQTESSSS EKQTKKQKVA TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS 
      1360       1370       1380       1390       1400
GLARQVSSLL TNHLARATEC CGNQAAGNDA LQDVLSLLND LSRSHIGKAI 
      1410       1420       1430       1440       1450
LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV EDCGNVELPP 
      1460       1470       1480       1490       1500
WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD 
      1510       1520       1530       1540       1550
TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS 
      1560       1570       1580       1590       1600
SSEGRPFRLG TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ 
      1610       1620       1630       1640       1650
SGLIVSIGPP VESINPETVS GLSTGDKKKT AQTSICRERN SELARTDPVR 
      1660       1670       1680       1690       1700
PFISGHVANS MAAEVIALLH SLLMAPESNA AQIWTTTAEK VLSRALMYIP 
      1710       1720       1730       1740       1750
QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF KETIKIGSEV 
      1760       1770       1780       1790       1800
QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL 
      1810       1820       1830       1840       1850
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV 
      1860       1870       1880       1890       1900
MAVVRLLAEI RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS 
      1910       1920       1930       1940       1950
AGERLAVVEV QCERLRMLYR DCARPPPPPL QADRRQPKEI TWSPSRVFPP 
      1960       1970       1980       1990       2000
VRACMFSSHL TSVTFLADPS AGGGLPRGTF IYATSPLPVQ APSFYWEIEI 
      2010       2020       2030       2040       2050
VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN NGRAVHYNGS 
      2060       2070       2080       2090       2100
SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR 
      2110       2120       2130       2140       2150
LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT 
      2160       2170       2180       2190       2200
DLAEEISANF EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ 
      2210       2220       2230       2240       2250
QYDSDTSCHY KVELSYENFI TSGPDPHPPP IADDESDDDD DDDIPQEDHY 
      2260       2270       2280       2290       2300
ALLVKAWETK VFPTIRRRFR NEAERKSGLD QIKGALQLGM VDIARQTVEF 
      2310       2320       2330       2340       2350
LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT RSPDSNNVAS 
      2360       2370       2380       2390       2400
SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY 
      2410       2420       2430       2440       2450
WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM 
      2460       2470       2480       2490       2500
ALLNIFAPKL PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS 
      2510       2520       2530       2540       2550
SSILLAQSLQ HCIHSQNCSA TDLFYQGNSQ TVREWLNVAI TRTLHQGEES 
      2560       2570       2580       2590       2600
LLELTKQICS FLQTAPEQFP SEEFPISESK VNMDVNFPGA AFVVVSCKES 
      2610       2620       2630       2640       2650
QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC YPRDASPANT 
      2660       2670       2680       2690       2700
GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF 
      2710       2720       2730       2740       2750
AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE 
      2760       2770       2780       2790       2800
LVFHLLAELL RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL 
      2810       2820       2830       2840       2850
YDEETQNWVS GGACGGSGGA AAGDQGRFST YFHALMEGCL AVAEVTLPTN 
      2860       2870       2880       2890       2900
MSVTASGVTS ATAPNLSDSS SSSSSSPGQT PQSPSLLSKR KKVKMKREKA 
      2910       2920       2930       2940       2950
SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI ILRHLTRKDP 
      2960       2970       2980       2990       3000
QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN 
      3010       3020       3030       3040       3050
AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS 
      3060       3070       3080       3090       3100
TSSSLTPAMS ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP 
      3110       3120       3130       3140       3150
GLLEPHAVSS QESLDISLCS TGSLGSLGSL GEPLDNAETA SVSDMGSMYT 
      3160       3170       3180       3190       3200
VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK IRASLFNNND LIGLSSLDGE 
      3210       3220       3230       3240       3250
DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK GEKLVPGARE 
      3260       3270       3280       3290       3300
VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT 
      3310       3320       3330       3340       3350
NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP 
      3360       3370       3380       3390       3400
ITKPPAKDKA VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ 
      3410       3420       3430       3440       3450
EVPEEKYLTL EGFHKFVIDR ARQDIRSVWR AILSCGYDLH FERCACIDVR 
      3460       3470       3480       3490       3500
HAQKASRKWT LEMDVALVQY INQLCRHLAI TPARLHPHEV YLDPADAADP 
      3510       3520       3530       3540       3550
RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT PMYTHSIAAL 
      3560       3570       3580       3590       3600
LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA 
      3610       3620       3630       3640       3650
SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS 
      3660       3670       3680       3690       3700
FRHFLWQVCK ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL 
      3710       3720       3730       3740       3750
HFLGQLLGIA IRADVPLPLD LLPSFWKTLV GEPLDPEQDL QEADILTYNY 
      3760       3770       3780       3790       3800
VKKFESINDE TELEALCAEI ASQHLATESP DSPNKPCCRF TYLTMTGEEV 
      3810       3820       3830       3840       3850
ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV RAGLGSIIPL 
      3860       3870       3880       3890       3900
QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL 
      3910       3920       3930       3940       3950
EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT 
      3960       3970       3980       3990 
AGSPDSRYIR VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG
Length:3,996
Mass (Da):439,344
Last modified:July 13, 2010 - v5
Checksum:i5F091CA1EDD207D4
GO
Isoform 2 (identifier: Q9Y4D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2382-2386: NELVQ → SEQPF
     2387-3996: Missing.

Note: No experimental confirmation available.
Show »
Length:2,386
Mass (Da):262,203
Checksum:i2F062A3F80AC9BF5
GO
Isoform 3 (identifier: Q9Y4D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     717-726: Missing.
     896-899: EVIQ → YVAV
     900-3996: Missing.

Note: No experimental confirmation available.
Show »
Length:889
Mass (Da):98,752
Checksum:iE1CAC6DAF98832A6
GO
Isoform 4 (identifier: Q9Y4D8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-484: Missing.
     717-726: Missing.

Note: No experimental confirmation available.
Show »
Length:3,984
Mass (Da):438,030
Checksum:iECFB26B97AE232D9
GO
Isoform 5 (identifier: Q9Y4D8-5) [UniParc]FASTAAdd to basket
Also known as: POTAGE

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGSSAAAAAA...TLQVCQVVPM
     169-169: R → ILASSLVYNISDGQFTSRADLIDAAGSSLGRGALVPGLG
     717-726: Missing.
     896-899: EVIQ → YVAV
     900-3996: Missing.

Show »
Length:1,321
Mass (Da):145,076
Checksum:i794DC0E73FB9A093
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWT9F8VWT9_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
4,284Annotation score:
J3KPF0J3KPF0_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
4,416Annotation score:
F8VU57F8VU57_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
109Annotation score:
V9GYT9V9GYT9_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
262Annotation score:

Sequence cautioni

The sequence AAF36539 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH65706 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH65706 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI01483 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA31589 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC03671 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti170A → G in AAH65706 (PubMed:15489334).Curated1
Sequence conflicti681Y → C in BAC03671 (PubMed:14702039).Curated1
Sequence conflicti801K → E in AAH65706 (PubMed:15489334).Curated1
Sequence conflicti2019T → I in AK054654 (PubMed:14702039).Curated1
Sequence conflicti2702E → G in AAF36539 (Ref. 7) Curated1
Sequence conflicti2867S → T in AAF36539 (Ref. 7) Curated1
Sequence conflicti2896 – 2897KR → NA in AAF36539 (Ref. 7) Curated2
Sequence conflicti2902S → C in AAF36539 (Ref. 7) Curated1
Sequence conflicti3153S → P in AAF36539 (Ref. 7) Curated1
Sequence conflicti3182R → Q in AAF36539 (Ref. 7) Curated1
Sequence conflicti3191L → F in AAF36539 (Ref. 7) Curated1
Sequence conflicti3419 – 3420DR → YQ in AAF36539 (Ref. 7) Curated2
Sequence conflicti3665S → A in AAF36539 (Ref. 7) Curated1
Sequence conflicti3723P → T in AAH06270 (PubMed:15489334).Curated1
Sequence conflicti3726W → R in AAH06270 (PubMed:15489334).Curated1
Sequence conflicti3732 – 3733EP → DA in AAF36539 (Ref. 7) Curated2
Sequence conflicti3798E → R in AAF36539 (Ref. 7) Curated1
Sequence conflicti3830E → A in AAF36539 (Ref. 7) Curated1
Sequence conflicti3985C → G in AAF36539 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474651M → MGSSAAAAAAAAAAADSAQW LSVKEETIFLHDGLIRVTDL AELPSEILGAPEAADTDLEI LTFETKNPSELAERLRSVCG NQSNAYARLLEYRLNALRGL WNAQRQLALEEQHERESSGD EETLALLKRQGLLQQPEQAP FTSRMGLLLVFPLIQSQSRT DPSLCNITAEVLLNCLRDCQ PLSLTKEPADCLNGIETLLC SWLEETSDTGRHIPHKQKEN AAAALVALACARGSLKTFVH TVHLLQKQTDLGSLPVADVL YRLLLLEGGPGSPSCLLGGK HIVSWGYEDMLPAPDSNTGS SSENKDADLGRCLTADGLYL YTTNSVGRGVSKLGSGLHGT LRGFVYCRNEELEPGWVAFG SGSLLHRPVSFDNKPHSLFQ VIDQNTLQVCQVVPM in isoform 5. 1 Publication1
Alternative sequenceiVSP_047466169R → ILASSLVYNISDGQFTSRAD LIDAAGSSLGRGALVPGLG in isoform 5. 1 Publication1
Alternative sequenceiVSP_039451483 – 484Missing in isoform 4. 1 Publication2
Alternative sequenceiVSP_039452717 – 726Missing in isoform 3, isoform 4 and isoform 5. 3 Publications10
Alternative sequenceiVSP_039453896 – 899EVIQ → YVAV in isoform 3 and isoform 5. 3 Publications4
Alternative sequenceiVSP_039454900 – 3996Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST3097
Alternative sequenceiVSP_0345292382 – 2386NELVQ → SEQPF in isoform 2. 1 Publication5
Alternative sequenceiVSP_0345302387 – 3996Missing in isoform 2. 1 PublicationAdd BLAST1610

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB777655 mRNA Translation: BAM76724.1
AC073575 Genomic DNA No translation available.
AC004031 Genomic DNA No translation available.
AC004217 Genomic DNA No translation available.
BC006270 mRNA Translation: AAH06270.2
BC021144 mRNA Translation: AAH21144.1
BC065706 mRNA Translation: AAH65706.1 Sequence problems.
BC101482 mRNA Translation: AAI01483.1 Different initiation.
AK054654 mRNA No translation available.
AK091473 mRNA Translation: BAC03671.1 Different initiation.
AB014514 mRNA Translation: BAA31589.3 Sequence problems.
AF174498 mRNA Translation: AAF36539.1 Sequence problems.
AL117469 mRNA Translation: CAB55944.1
PIRiT00390
UniGeneiHs.530943

Genome annotation databases

EnsembliENST00000430131; ENSP00000404379; ENSG00000173064

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB777655 mRNA Translation: BAM76724.1
AC073575 Genomic DNA No translation available.
AC004031 Genomic DNA No translation available.
AC004217 Genomic DNA No translation available.
BC006270 mRNA Translation: AAH06270.2
BC021144 mRNA Translation: AAH21144.1
BC065706 mRNA Translation: AAH65706.1 Sequence problems.
BC101482 mRNA Translation: AAI01483.1 Different initiation.
AK054654 mRNA No translation available.
AK091473 mRNA Translation: BAC03671.1 Different initiation.
AB014514 mRNA Translation: BAA31589.3 Sequence problems.
AF174498 mRNA Translation: AAF36539.1 Sequence problems.
AL117469 mRNA Translation: CAB55944.1
PIRiT00390
UniGeneiHs.530943

3D structure databases

ProteinModelPortaliQ9Y4D8
SMRiQ9Y4D8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y4D8, 2 interactors
MINTiQ9Y4D8
STRINGi9606.ENSP00000449784

PTM databases

iPTMnetiQ9Y4D8
PhosphoSitePlusiQ9Y4D8

Polymorphism and mutation databases

DMDMi300669718

Proteomic databases

PaxDbiQ9Y4D8
PeptideAtlasiQ9Y4D8
PRIDEiQ9Y4D8
ProteomicsDBi86170
86171 [Q9Y4D8-2]
86172 [Q9Y4D8-3]
86173 [Q9Y4D8-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430131; ENSP00000404379; ENSG00000173064

Organism-specific databases

DisGeNETi283450
GeneCardsiHECTD4
HGNCiHGNC:26611 HECTD4
HPAiHPA041062
HPA045473
neXtProtiNX_Q9Y4D8
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5184 LUCA
HOVERGENiHBG106580
InParanoidiQ9Y4D8
PhylomeDBiQ9Y4D8

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiHECTD4 human
PROiPR:Q9Y4D8

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd13735 SPRY_HECT_like, 1 hit
InterProiView protein in InterPro
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR035781 SPRY_HECTD4
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHECD4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4D8
Secondary accession number(s): L8B0P6
, Q3MJD5, Q6P0A0, Q7L530, Q8NB70, Q8WU73, Q96NT9, Q9NZS4, Q9UFT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 13, 2010
Last modified: June 20, 2018
This is version 129 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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