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UniProtKB - Q9Y4D8 (HECD4_HUMAN)

Entry version 141 (12 Aug 2020)
Sequence version 5 (13 Jul 2010)
Previous versions | rss
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Protein

Probable E3 ubiquitin-protein ligase HECTD4

Gene

HECTD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3964Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y4D8

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable E3 ubiquitin-protein ligase HECTD4 (EC:2.3.2.26)
Alternative name(s):
HECT domain-containing protein 4
HECT-type E3 ubiquitin transferase HECTD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HECTD4
Synonyms:C12orf51, KIAA0614
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26611, HECTD4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y4D8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei282 – 302HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y4D8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HECTD4

Domain mapping of disease mutations (DMDM)

More...DMDMi		300669718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003426811 – 3996Probable E3 ubiquitin-protein ligase HECTD4Add BLAST3996

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2080PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y4D8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y4D8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y4D8

PeptideAtlas

More...PeptideAtlasi		Q9Y4D8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y4D8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86170 [Q9Y4D8-1]
86171 [Q9Y4D8-2]
86172 [Q9Y4D8-3]
86173 [Q9Y4D8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y4D8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y4D8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9Y4D8, 14 interactors

Molecular INTeraction database

More...MINTi		Q9Y4D8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000449784

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y4D8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y4D8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3627 – 3996HECTPROSITE-ProRule annotationAdd BLAST370

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2867 – 2909Ser-richAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1426, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y4D8

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y4D8

Family and domain databases

Conserved Domains Database

More...CDDi		cd00078, HECTc, 1 hit
cd13735, SPRY_HECT_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR043366, HECTD4
IPR035781, SPRY_HECTD4

The PANTHER Classification System

More...PANTHERi		PTHR46435, PTHR46435, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00632, HECT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00119, HECTc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50237, HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPANHLPIGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL 
        60         70         80         90        100
VVENGVFVAN PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA 
       110        120        130        140        150
LTGSTISNTL KEDQAANTSC GLPLKMLRKT PIYTCGTYLV MLVPPPGGSG 
       160        170        180        190        200
SSATRSLFGG TSGLSSLKRA CYDTVNNMLW TCSNDYIDQW CNPGNQAFHY 
       210        220        230        240        250
VCQRLGVSHI ITEPKEEAIT TNEVINQLLH HVGAMCIHQL NLLATNPNLP 
       260        270        280        290        300
ITSVLGKQHP IEAHHLSSIC DIMEKAMVNG DTCIIRCILV VFQVVFKFFF 
       310        320        330        340        350
SPQTERNRDI IRRSGLLLWQ LLMAPKDQIC PEIQKEVCLA ISSGLNILYP 
       360        370        380        390        400
GETEINNLLK LVLTEGERNS GLSQLRDVIL TNLAEQLQNN RFGSDEDDHY 
       410        420        430        440        450
RLNDELLHYI LKIVVRESCI LITKCQTVSK DDFQKLLSTV PAASSCLRYL 
       460        470        480        490        500
MAVQNHLLSN TILIKPDEND DSDSSLQGET LKVQELKVSI LALATQILTG 
       510        520        530        540        550
CDEVLEMLQQ VTTALINSDI ADREQRLKGL EQVTKATMLG HLLPVLLTSL 
       560        570        580        590        600
MHPNLQTLIM ADALMPQLVQ LVLYTSQTAL LLKTQCPVFA EVGCSPCGAP 
       610        620        630        640        650
DQKCRLFPDE RMLEEKEEPG FLTGLKIPAP WAAGKTVETV HPVRDNYKFK 
       660        670        680        690        700
ETVHIPGARC LYLRFDSRCS SQYDYDKLVI YAGPNTNSRK VAEYGGNTLG 
       710        720        730        740        750
YGSRSVLGTG WPKDLVKCIS PPSLNFKVEG DTVTFSFEMR SGREHNTPDK 
       760        770        780        790        800
AMWGFACTVR AQESSEDVSG GLPFLVDLAL GLSVLACSML RILYNGPEIT 
       810        820        830        840        850
KEEEACQELL RSKLLQRCQW QVEANGVISP ALTPSPSPLP LTIEEDREFT 
       860        870        880        890        900
YPSDVLVPPV GNYFDLPRIR LPPGIMIKLR EISGRARPQF RPSIKEVIQP 
       910        920        930        940        950
DVMEEMVVSC VIKHLNLVDA LQSLINFQYQ EEHAEEYDLL CKIMGETFKK 
       960        970        980        990       1000
LNAMERQLQS VAELEQKWQS EVDDAMQGKL ENNMPFFYDY HFNENKMKEL 
      1010       1020       1030       1040       1050
ELLCSMKEVS FDGNDLENMV LSLREKFLQE VNSLIQKPSH PLAKTKTLVK 
      1060       1070       1080       1090       1100
SLMNRAELLL HVTIAAQSGL TRSISGTPAE TPACKSASET KVISHAVRQP 
      1110       1120       1130       1140       1150
VFLRSMSAPS DLEMIGNEDL EFTRANQRRR HVTSHRSSSF TLLQSLAIED 
      1160       1170       1180       1190       1200
SRDKPTYSVL LGQLFAFIGT NPDQAVSSSS FLLAAQTRWR RGNTRKQALV 
      1210       1220       1230       1240       1250
HMRELLTAAV RVGGVTHLVG PVTMVLQGGP RIEELTCGGM VEQVQEAFGE 
      1260       1270       1280       1290       1300
TMTSVVSLCA RYPIACANSI GLLCTIPYTR SEEKCLVRSG LVQLMDRLCS 
      1310       1320       1330       1340       1350
LSNQTESSSS EKQTKKQKVA TMAWAAFQVL ANRCVEWEKE EGGSTEAVHS 
      1360       1370       1380       1390       1400
GLARQVSSLL TNHLARATEC CGNQAAGNDA LQDVLSLLND LSRSHIGKAI 
      1410       1420       1430       1440       1450
LSQPACVSKL LSLLLDQRPS PKLVLIILQL CRAALPLMSV EDCGNVELPP 
      1460       1470       1480       1490       1500
WSYSVPSLNS EQEDPSDPAS KIASLLLAKL ADYVVPGCQT VLSPTASEPD 
      1510       1520       1530       1540       1550
TTLTKTSPKN SLKGDKDPGE ESEAVDGKLS IFIHKREDQS SHEVLQPLLS 
      1560       1570       1580       1590       1600
SSEGRPFRLG TGANMEKVVK MDRDMTKGGC CEVITEEAAA ALRKATKWAQ 
      1610       1620       1630       1640       1650
SGLIVSIGPP VESINPETVS GLSTGDKKKT AQTSICRERN SELARTDPVR 
      1660       1670       1680       1690       1700
PFISGHVANS MAAEVIALLH SLLMAPESNA AQIWTTTAEK VLSRALMYIP 
      1710       1720       1730       1740       1750
QLGKYAESIL ENGSSSGRKL AKLQRIARQA VAALCALGGF KETIKIGSEV 
      1760       1770       1780       1790       1800
QVLGRGISGS IGVVASINEQ EGIATVRFPP IDCRKTSQAS DTLTIPLSRL 
      1810       1820       1830       1840       1850
CVPRSEALPL HKLSITEKVV QAVQSMLLPQ EGSLSIHTSL PATGDGSAPV 
      1860       1870       1880       1890       1900
MAVVRLLAEI RTRACLVMAQ LLEDSLFCEE FIQQCPAAVE VLNLVAQECS 
      1910       1920       1930       1940       1950
AGERLAVVEV QCERLRMLYR DCARPPPPPL QADRRQPKEI TWSPSRVFPP 
      1960       1970       1980       1990       2000
VRACMFSSHL TSVTFLADPS AGGGLPRGTF IYATSPLPVQ APSFYWEIEI 
      2010       2020       2030       2040       2050
VSYGDTDDDT GPIVSFGFTT EAEKRDGAWT NPVGTCLFHN NGRAVHYNGS 
      2060       2070       2080       2090       2100
SLLQWKSVRL DVTLSPGDVA GIGWERTEGT PPPPGQPAKG RVYFTYCGQR 
      2110       2120       2130       2140       2150
LSPYLEDVSG GMWPVVHIQK KNTKTRANFG SRPFAYAEGQ AHRNAADLCT 
      2160       2170       2180       2190       2200
DLAEEISANF EALPFAMASD SDNDAGTSIA SDPGTHGPPC RIAAVATAQQ 
      2210       2220       2230       2240       2250
QYDSDTSCHY KVELSYENFI TSGPDPHPPP IADDESDDDD DDDIPQEDHY 
      2260       2270       2280       2290       2300
ALLVKAWETK VFPTIRRRFR NEAERKSGLD QIKGALQLGM VDIARQTVEF 
      2310       2320       2330       2340       2350
LYEENGGIPR DLYLPTIEDI KDEANKFTID KVRKGLTVVT RSPDSNNVAS 
      2360       2370       2380       2390       2400
SAVGTALPKF AIRGMLKTFG LHGVVLDVDS VNELVQVETY LRSEGVLVRY 
      2410       2420       2430       2440       2450
WYPIDMLERP PAGYRRTATN GLVTLDNTNL QIHRELLRCE AALARLYCRM 
      2460       2470       2480       2490       2500
ALLNIFAPKL PHLFTRLFHI PAIRDITLEH LQLLSNQLLA PPLPDGTISS 
      2510       2520       2530       2540       2550
SSILLAQSLQ HCIHSQNCSA TDLFYQGNSQ TVREWLNVAI TRTLHQGEES 
      2560       2570       2580       2590       2600
LLELTKQICS FLQTAPEQFP SEEFPISESK VNMDVNFPGA AFVVVSCKES 
      2610       2620       2630       2640       2650
QSGFRKDSSL YKAPWARVLV YGLGHKVKRN GQLNLIEAAC YPRDASPANT 
      2660       2670       2680       2690       2700
GLAPPPTADQ YPSVVLSTDR VHIKLGVSPP PGAVLVLHSL PLEFPLAMAF 
      2710       2720       2730       2740       2750
AEQLLSWKSE DSEGKSEDEP DTIPTSVLLQ VVELLGNFLW TTDMAACVKE 
      2760       2770       2780       2790       2800
LVFHLLAELL RTVHTLEQRR HPAGLSSSIA LQLNPCLAML MALQSELHKL 
      2810       2820       2830       2840       2850
YDEETQNWVS GGACGGSGGA AAGDQGRFST YFHALMEGCL AVAEVTLPTN 
      2860       2870       2880       2890       2900
MSVTASGVTS ATAPNLSDSS SSSSSSPGQT PQSPSLLSKR KKVKMKREKA 
      2910       2920       2930       2940       2950
SSSGKRQSSR TVDSDPTVLS IGGSKPEDML WFHRALTLLI ILRHLTRKDP 
      2960       2970       2980       2990       3000
QGLGVTSDAI ADACQALVGP TAHSRLLVIS GIPTHLDEGV VRGAIRKACN 
      3010       3020       3030       3040       3050
AHGGVFKDEI YIPLQEEDTK KPKDKAEGGD GKVEPEKTLA FPGTDSMEVS 
      3060       3070       3080       3090       3100
TSSSLTPAMS ISASASTSQA SICSSQGISQ TVSDLSVDPL PAGLELPIPP 
      3110       3120       3130       3140       3150
GLLEPHAVSS QESLDISLCS TGSLGSLGSL GEPLDNAETA SVSDMGSMYT 
      3160       3170       3180       3190       3200
VTSLDNQPLA ARPIKGFAVV EIRSRAKIEK IRASLFNNND LIGLSSLDGE 
      3210       3220       3230       3240       3250
DELMEMSTEE ILTVSVVNQS LFDTQGSPGL EDYFNDKSIK GEKLVPGARE 
      3260       3270       3280       3290       3300
VLTEIFKSCA HSEQTLSLTP AKPIRVSDIY LSKEQINSQT PGNLLHLFFT 
      3310       3320       3330       3340       3350
NVRPPKKVLE DQLTQILRKY GVPKPKFDKS KYSKAGKEQH PVKVVSTKRP 
      3360       3370       3380       3390       3400
ITKPPAKDKA VLNSVSRTAL SEKKPTVKPK SPEKSKPDEK DPEKSPTKKQ 
      3410       3420       3430       3440       3450
EVPEEKYLTL EGFHKFVIDR ARQDIRSVWR AILSCGYDLH FERCACIDVR 
      3460       3470       3480       3490       3500
HAQKASRKWT LEMDVALVQY INQLCRHLAI TPARLHPHEV YLDPADAADP 
      3510       3520       3530       3540       3550
RVACLLNVPI ESLRLRFALL QSLNTTLETF FLPLVELRQT PMYTHSIAAL 
      3560       3570       3580       3590       3600
LKEAKGLIFY DTKVTVMNRV LNATVQRTAD HAAPEITLDP LEIVGGEIRA 
      3610       3620       3630       3640       3650
SENSYFCQAA RQLASVPSSQ LCVKLASGGD PTYAFNIRFT GEEVHGTSGS 
      3660       3670       3680       3690       3700
FRHFLWQVCK ELQSSSLSLL LLCPSSAVNK NKGKYILTPS PITYGEEQLL 
      3710       3720       3730       3740       3750
HFLGQLLGIA IRADVPLPLD LLPSFWKTLV GEPLDPEQDL QEADILTYNY 
      3760       3770       3780       3790       3800
VKKFESINDE TELEALCAEI ASQHLATESP DSPNKPCCRF TYLTMTGEEV 
      3810       3820       3830       3840       3850
ELCSRGRHIL VAWENKDIYA AAIRSLRLRE LQNVECVTAV RAGLGSIIPL 
      3860       3870       3880       3890       3900
QLLTMLSPLE MELRTCGLPY INLEFLKAHT MYQVGLMETD QHIEFFWGAL 
      3910       3920       3930       3940       3950
EMFTQEELCK FIKFACNQER IPFTCPCKDG GPDTAHVPPY PMKIAPPDGT 
      3960       3970       3980       3990 
AGSPDSRYIR VETCMFMIKL PQYSSLEIML EKLRCAIHYR EDPLSG
Length:3,996
Mass (Da):439,344
Last modified:July 13, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F091CA1EDD207D4
GO
Isoform 2 (identifier: Q9Y4D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2382-2386: NELVQ → SEQPF
     2387-3996: Missing.

Show »
Length:2,386
Mass (Da):262,203
Checksum:i2F062A3F80AC9BF5
GO
Isoform 3 (identifier: Q9Y4D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     717-726: Missing.
     896-899: EVIQ → YVAV
     900-3996: Missing.

Show »
Length:889
Mass (Da):98,752
Checksum:iE1CAC6DAF98832A6
GO
Isoform 4 (identifier: Q9Y4D8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     483-484: Missing.
     717-726: Missing.

Show »
Length:3,984
Mass (Da):438,030
Checksum:iECFB26B97AE232D9
GO
Isoform 5 (identifier: Q9Y4D8-5) [UniParc]FASTAAdd to basket
Also known as: POTAGE

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGSSAAAAAA...TLQVCQVVPM
     169-169: R → ILASSLVYNISDGQFTSRADLIDAAGSSLGRGALVPGLG
     717-726: Missing.
     896-899: EVIQ → YVAV
     900-3996: Missing.

Show »
Length:1,321
Mass (Da):145,076
Checksum:i794DC0E73FB9A093
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWT9F8VWT9_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
4,284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KPF0J3KPF0_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
4,416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYT9V9GYT9_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C150A0A494C150_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
1,828Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU57F8VU57_HUMAN
Probable E3 ubiquitin-protein ligas...
HECTD4
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36539 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAH65706 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH65706 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01483 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA31589 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC03671 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti170A → G in AAH65706 (PubMed:15489334).Curated1
Sequence conflicti681Y → C in BAC03671 (PubMed:14702039).Curated1
Sequence conflicti801K → E in AAH65706 (PubMed:15489334).Curated1
Sequence conflicti2019T → I in AK054654 (PubMed:14702039).Curated1
Sequence conflicti2702E → G in AAF36539 (Ref. 7) Curated1
Sequence conflicti2867S → T in AAF36539 (Ref. 7) Curated1
Sequence conflicti2896 – 2897KR → NA in AAF36539 (Ref. 7) Curated2
Sequence conflicti2902S → C in AAF36539 (Ref. 7) Curated1
Sequence conflicti3153S → P in AAF36539 (Ref. 7) Curated1
Sequence conflicti3182R → Q in AAF36539 (Ref. 7) Curated1
Sequence conflicti3191L → F in AAF36539 (Ref. 7) Curated1
Sequence conflicti3419 – 3420DR → YQ in AAF36539 (Ref. 7) Curated2
Sequence conflicti3665S → A in AAF36539 (Ref. 7) Curated1
Sequence conflicti3723P → T in AAH06270 (PubMed:15489334).Curated1
Sequence conflicti3726W → R in AAH06270 (PubMed:15489334).Curated1
Sequence conflicti3732 – 3733EP → DA in AAF36539 (Ref. 7) Curated2
Sequence conflicti3798E → R in AAF36539 (Ref. 7) Curated1
Sequence conflicti3830E → A in AAF36539 (Ref. 7) Curated1
Sequence conflicti3985C → G in AAF36539 (Ref. 7) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0474651M → MGSSAAAAAAAAAAADSAQW LSVKEETIFLHDGLIRVTDL AELPSEILGAPEAADTDLEI LTFETKNPSELAERLRSVCG NQSNAYARLLEYRLNALRGL WNAQRQLALEEQHERESSGD EETLALLKRQGLLQQPEQAP FTSRMGLLLVFPLIQSQSRT DPSLCNITAEVLLNCLRDCQ PLSLTKEPADCLNGIETLLC SWLEETSDTGRHIPHKQKEN AAAALVALACARGSLKTFVH TVHLLQKQTDLGSLPVADVL YRLLLLEGGPGSPSCLLGGK HIVSWGYEDMLPAPDSNTGS SSENKDADLGRCLTADGLYL YTTNSVGRGVSKLGSGLHGT LRGFVYCRNEELEPGWVAFG SGSLLHRPVSFDNKPHSLFQ VIDQNTLQVCQVVPM in isoform 5. 1 Publication1
Alternative sequenceiVSP_047466169R → ILASSLVYNISDGQFTSRAD LIDAAGSSLGRGALVPGLG in isoform 5. 1 Publication1
Alternative sequenceiVSP_039451483 – 484Missing in isoform 4. 1 Publication2
Alternative sequenceiVSP_039452717 – 726Missing in isoform 3, isoform 4 and isoform 5. 3 Publications10
Alternative sequenceiVSP_039453896 – 899EVIQ → YVAV in isoform 3 and isoform 5. 3 Publications4
Alternative sequenceiVSP_039454900 – 3996Missing in isoform 3 and isoform 5. 3 PublicationsAdd BLAST3097
Alternative sequenceiVSP_0345292382 – 2386NELVQ → SEQPF in isoform 2. 1 Publication5
Alternative sequenceiVSP_0345302387 – 3996Missing in isoform 2. 1 PublicationAdd BLAST1610

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB777655 mRNA Translation: BAM76724.1
AC073575 Genomic DNA No translation available.
AC004031 Genomic DNA No translation available.
AC004217 Genomic DNA No translation available.
BC006270 mRNA Translation: AAH06270.2
BC021144 mRNA Translation: AAH21144.1
BC065706 mRNA Translation: AAH65706.1 Sequence problems.
BC101482 mRNA Translation: AAI01483.1 Different initiation.
AK054654 mRNA No translation available.
AK091473 mRNA Translation: BAC03671.1 Different initiation.
AB014514 mRNA Translation: BAA31589.3 Sequence problems.
AF174498 mRNA Translation: AAF36539.1 Sequence problems.
AL117469 mRNA Translation: CAB55944.1

Protein sequence database of the Protein Information Resource

More...PIRi		T00390

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000430131; ENSP00000404379; ENSG00000173064

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB777655 mRNA Translation: BAM76724.1
AC073575 Genomic DNA No translation available.
AC004031 Genomic DNA No translation available.
AC004217 Genomic DNA No translation available.
BC006270 mRNA Translation: AAH06270.2
BC021144 mRNA Translation: AAH21144.1
BC065706 mRNA Translation: AAH65706.1 Sequence problems.
BC101482 mRNA Translation: AAI01483.1 Different initiation.
AK054654 mRNA No translation available.
AK091473 mRNA Translation: BAC03671.1 Different initiation.
AB014514 mRNA Translation: BAA31589.3 Sequence problems.
AF174498 mRNA Translation: AAF36539.1 Sequence problems.
AL117469 mRNA Translation: CAB55944.1
PIRiT00390

3D structure databases

SMRiQ9Y4D8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9Y4D8, 14 interactors
MINTiQ9Y4D8
STRINGi9606.ENSP00000449784

PTM databases

iPTMnetiQ9Y4D8
PhosphoSitePlusiQ9Y4D8

Polymorphism and mutation databases

BioMutaiHECTD4
DMDMi300669718

Proteomic databases

jPOSTiQ9Y4D8
MassIVEiQ9Y4D8
PaxDbiQ9Y4D8
PeptideAtlasiQ9Y4D8
PRIDEiQ9Y4D8
ProteomicsDBi86170 [Q9Y4D8-1]
86171 [Q9Y4D8-2]
86172 [Q9Y4D8-3]
86173 [Q9Y4D8-4]

Genome annotation databases

EnsembliENST00000430131; ENSP00000404379; ENSG00000173064

Organism-specific databases

GeneCards: human genes, protein and diseases

More...GeneCardsi		HECTD4
HGNCiHGNC:26611, HECTD4
neXtProtiNX_Q9Y4D8

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
InParanoidiQ9Y4D8
PhylomeDBiQ9Y4D8

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9Y4D8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HECTD4, human
PharosiQ9Y4D8, Tbio

Protein Ontology

More...PROi		PR:Q9Y4D8
RNActiQ9Y4D8, protein

Family and domain databases

CDDicd00078, HECTc, 1 hit
cd13735, SPRY_HECT_like, 1 hit
Gene3Di2.60.120.920, 1 hit
InterProiView protein in InterPro
IPR043136, B30.2/SPRY_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR043366, HECTD4
IPR035781, SPRY_HECTD4
PANTHERiPTHR46435, PTHR46435, 1 hit
PfamiView protein in Pfam
PF00632, HECT, 1 hit
SMARTiView protein in SMART
SM00119, HECTc, 1 hit
SUPFAMiSSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237, HECT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECD4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4D8
Secondary accession number(s): L8B0P6
, Q3MJD5, Q6P0A0, Q7L530, Q8NB70, Q8WU73, Q96NT9, Q9NZS4, Q9UFT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 13, 2010
Last modified: August 12, 2020
This is version 141 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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