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Protein

Plexin-D1

Gene

PLXND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processAngiogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416700 Other semaphorin interactions
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLXND1
Synonyms:KIAA0620
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000004399.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9107 PLXND1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604282 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4D7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini47 – 1271ExtracellularSequence analysisAdd BLAST1225
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1272 – 1292HelicalSequence analysisAdd BLAST21
Topological domaini1293 – 1925CytoplasmicSequence analysisAdd BLAST633

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23129

MalaCards human disease database

More...
MalaCardsi
PLXND1

Open Targets

More...
OpenTargetsi
ENSG00000004399

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
570 Moebius syndrome
3384 Truncus arteriosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394602

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLXND1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452982

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 46Sequence analysisAdd BLAST46
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002467647 – 1925Plexin-D1Add BLAST1879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi104 ↔ 114PROSITE-ProRule annotation
Disulfide bondi140 ↔ 148PROSITE-ProRule annotation
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi322 ↔ 445PROSITE-ProRule annotation
Disulfide bondi345 ↔ 389PROSITE-ProRule annotation
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi549 ↔ 566PROSITE-ProRule annotation
Disulfide bondi555 ↔ 600PROSITE-ProRule annotation
Disulfide bondi558 ↔ 575PROSITE-ProRule annotation
Disulfide bondi569 ↔ 581PROSITE-ProRule annotation
Glycosylationi583N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi637 ↔ 661PROSITE-ProRule annotation
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi736N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi802N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1017N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1060N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1099N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1132N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1257N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4D7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4D7

PeptideAtlas

More...
PeptideAtlasi
Q9Y4D7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4D7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86168
86169 [Q9Y4D7-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1615

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4D7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4D7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000004399 Expressed in 229 organ(s), highest expression level in right lung

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLXND1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4D7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4D7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020819

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NRP1 and SEMA4A (By similarity). Interacts with SH3BP1; they dissociate upon SEMA3E binding to PLXND1 allowing SH3BP1 to transduce downstream signal through RAC1 inactivation (PubMed:24841563).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116747, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y4D7

Protein interaction database and analysis system

More...
IntActi
Q9Y4D7, 6 interactors

Molecular INTeraction database

More...
MINTi
Q9Y4D7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000317128

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11925
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y4D7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4D7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y4D7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 546SemaPROSITE-ProRule annotationAdd BLAST500
Domaini891 – 979IPT/TIG 1Add BLAST89
Domaini981 – 1066IPT/TIG 2Add BLAST86
Domaini1069 – 1160IPT/TIG 3Add BLAST92

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410ZUMY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153516

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231376

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053404

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4D7

KEGG Orthology (KO)

More...
KOi
K06822

Identification of Orthologs from Complete Genome Data

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OMAi
MEMACDY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00EK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4D7

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRAAGGAP LSARAAAASP PPFQTPPRCP VPLLLLLLLG AARAGALEIQ
60 70 80 90 100
RRFPSPTPTN NFALDGAAGT VYLAAVNRLY QLSGANLSLE AEAAVGPVPD
110 120 130 140 150
SPLCHAPQLP QASCEHPRRL TDNYNKILQL DPGQGLVVVC GSIYQGFCQL
160 170 180 190 200
RRRGNISAVA VRFPPAAPPA EPVTVFPSML NVAANHPNAS TVGLVLPPAA
210 220 230 240 250
GAGGSRLLVG ATYTGYGSSF FPRNRSLEDH RFENTPEIAI RSLDTRGDLA
260 270 280 290 300
KLFTFDLNPS DDNILKIKQG AKEQHKLGFV SAFLHPSDPP PGAQSYAYLA
310 320 330 340 350
LNSEARAGDK ESQARSLLAR ICLPHGAGGD AKKLTESYIQ LGLQCAGGAG
360 370 380 390 400
RGDLYSRLVS VFPARERLFA VFERPQGSPA ARAAPAALCA FRFADVRAAI
410 420 430 440 450
RAARTACFVE PAPDVVAVLD SVVQGTGPAC ERKLNIQLQP EQLDCGAAHL
460 470 480 490 500
QHPLSILQPL KATPVFRAPG LTSVAVASVN NYTAVFLGTV NGRLLKINLN
510 520 530 540 550
ESMQVVSRRV VTVAYGEPVH HVMQFDPADS GYLYLMTSHQ MARVKVAACN
560 570 580 590 600
VHSTCGDCVG AADAYCGWCA LETRCTLQQD CTNSSQQHFW TSASEGPSRC
610 620 630 640 650
PAMTVLPSEI DVRQEYPGMI LQISGSLPSL SGMEMACDYG NNIRTVARVP
660 670 680 690 700
GPAFGHQIAY CNLLPRDQFP PFPPNQDHVT VEMSVRVNGR NIVKANFTIY
710 720 730 740 750
DCSRTAQVYP HTACTSCLSA QWPCFWCSQQ HSCVSNQSRC EASPNPTSPQ
760 770 780 790 800
DCPRTLLSPL APVPTGGSQN ILVPLANTAF FQGAALECSF GLEEIFEAVW
810 820 830 840 850
VNESVVRCDQ VVLHTTRKSQ VFPLSLQLKG RPARFLDSPE PMTVMVYNCA
860 870 880 890 900
MGSPDCSQCL GREDLGHLCM WSDGCRLRGP LQPMAGTCPA PEIHAIEPLS
910 920 930 940 950
GPLDGGTLLT IRGRNLGRRL SDVAHGVWIG GVACEPLPDR YTVSEEIVCV
960 970 980 990 1000
TGPAPGPLSG VVTVNASKEG KSRDRFSYVL PLVHSLEPTM GPKAGGTRIT
1010 1020 1030 1040 1050
IHGNDLHVGS ELQVLVNDTD PCTELMRTDT SIACTMPEGA LPAPVPVCVR
1060 1070 1080 1090 1100
FERRGCVHGN LTFWYMQNPV ITAISPRRSP VSGGRTITVA GERFHMVQNV
1110 1120 1130 1140 1150
SMAVHHIGRE PTLCKVLNST LITCPSPGAL SNASAPVDFF INGRAYADEV
1160 1170 1180 1190 1200
AVAEELLDPE EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
1210 1220 1230 1240 1250
KEQDSLGLQS HEYRVKIGQV SCDIQIVSDR IIHCSVNESL GAAVGQLPIT
1260 1270 1280 1290 1300
IQVGNFNQTI ATLQLGGSET AIIVSIVICS VLLLLSVVAL FVFCTKSRRA
1310 1320 1330 1340 1350
ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE
1360 1370 1380 1390 1400
YKHFVTRTFF PKCSSLYEER YVLPSQTLNS QGSSQAQETH PLLGEWKIPE
1410 1420 1430 1440 1450
SCRPNMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI
1460 1470 1480 1490 1500
ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
1510 1520 1530 1540 1550
CMYSCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LSEEWLLREN
1560 1570 1580 1590 1600
IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW
1610 1620 1630 1640 1650
PRAEDVDLEW FASSTQSYIL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL
1660 1670 1680 1690 1700
AMSLIDKKDN TLGRVKDLDT EKYFHLVLPT DELAEPKKSH RQSHRKKVLP
1710 1720 1730 1740 1750
EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK
1760 1770 1780 1790 1800
RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIDKTDH IDACLSVIAQ
1810 1820 1830 1840 1850
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKIVQRYYK QIQDMTPLSE
1860 1870 1880 1890 1900
QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR
1910 1920
TQLQHKFEQV VALMEDNIYE CYSEA
Length:1,925
Mass (Da):212,007
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28967933B2D17CE1
GO
Isoform 2 (identifier: Q9Y4D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1766-1925: SLPLRFWVNI...DNIYECYSEA → RWRPSSPVLGEHPEEPPVCL

Show »
Length:1,785
Mass (Da):195,558
Checksum:i4CA3AE813635414A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YA64H0YA64_HUMAN
Plexin-D1
PLXND1
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9D1H0Y9D1_HUMAN
Plexin-D1
PLXND1
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAM9H0YAM9_HUMAN
Plexin-D1
PLXND1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAB2H0YAB2_HUMAN
Plexin-D1
PLXND1
380Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RH25D6RH25_HUMAN
Plexin-D1
PLXND1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31595 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti531G → V in BAA31595 (PubMed:9734811).Curated1
Sequence conflicti531G → V in AAM49063 (PubMed:12412018).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056723617P → S. Corresponds to variant dbSNP:rs2285372Ensembl.1
Natural variantiVAR_022144870M → V. Corresponds to variant dbSNP:rs2255703Ensembl.1
Natural variantiVAR_059558894H → R2 PublicationsCorresponds to variant dbSNP:rs2625962Ensembl.1
Natural variantiVAR_0567241412L → V. Corresponds to variant dbSNP:rs2625973Ensembl.1
Natural variantiVAR_0615391542S → N3 PublicationsCorresponds to variant dbSNP:rs2713625Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0115161766 – 1925SLPLR…CYSEA → RWRPSSPVLGEHPEEPPVCL in isoform 2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB014520 mRNA Translation: BAA31595.2 Different initiation.
AY116661 mRNA Translation: AAM49063.1
AC023162 Genomic DNA No translation available.
AC080007 Genomic DNA No translation available.
BC003526 mRNA Translation: AAH03526.1
BC011848 mRNA Translation: AAH11848.1
BC150280 mRNA Translation: AAI50281.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33854.1 [Q9Y4D7-1]

NCBI Reference Sequences

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RefSeqi
NP_055918.2, NM_015103.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.301685

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000324093; ENSP00000317128; ENSG00000004399 [Q9Y4D7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23129

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23129

UCSC genome browser

More...
UCSCi
uc003emx.3 human [Q9Y4D7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014520 mRNA Translation: BAA31595.2 Different initiation.
AY116661 mRNA Translation: AAM49063.1
AC023162 Genomic DNA No translation available.
AC080007 Genomic DNA No translation available.
BC003526 mRNA Translation: AAH03526.1
BC011848 mRNA Translation: AAH11848.1
BC150280 mRNA Translation: AAI50281.1
CCDSiCCDS33854.1 [Q9Y4D7-1]
RefSeqiNP_055918.2, NM_015103.2
UniGeneiHs.301685

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H6NX-ray2.00A1553-1678[»]
ProteinModelPortaliQ9Y4D7
SMRiQ9Y4D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116747, 2 interactors
CORUMiQ9Y4D7
IntActiQ9Y4D7, 6 interactors
MINTiQ9Y4D7
STRINGi9606.ENSP00000317128

PTM databases

GlyConnecti1615
iPTMnetiQ9Y4D7
PhosphoSitePlusiQ9Y4D7

Polymorphism and mutation databases

BioMutaiPLXND1
DMDMi296452982

Proteomic databases

EPDiQ9Y4D7
PaxDbiQ9Y4D7
PeptideAtlasiQ9Y4D7
PRIDEiQ9Y4D7
ProteomicsDBi86168
86169 [Q9Y4D7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324093; ENSP00000317128; ENSG00000004399 [Q9Y4D7-1]
GeneIDi23129
KEGGihsa:23129
UCSCiuc003emx.3 human [Q9Y4D7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23129
DisGeNETi23129
EuPathDBiHostDB:ENSG00000004399.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLXND1
HGNCiHGNC:9107 PLXND1
HPAiCAB020819
MalaCardsiPLXND1
MIMi604282 gene
neXtProtiNX_Q9Y4D7
OpenTargetsiENSG00000004399
Orphaneti570 Moebius syndrome
3384 Truncus arteriosus
PharmGKBiPA128394602

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410ZUMY LUCA
GeneTreeiENSGT00940000153516
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiQ9Y4D7
KOiK06822
OMAiMEMACDY
OrthoDBiEOG091G00EK
PhylomeDBiQ9Y4D7
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-416700 Other semaphorin interactions
R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLXND1 human
EvolutionaryTraceiQ9Y4D7

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PLXND1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23129

Protein Ontology

More...
PROi
PR:Q9Y4D7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000004399 Expressed in 229 organ(s), highest expression level in right lung
CleanExiHS_PLXND1
ExpressionAtlasiQ9Y4D7 baseline and differential
GenevisibleiQ9Y4D7 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4D7
Secondary accession number(s): A7E2C6
, C9JPZ6, Q6PJS9, Q8IZJ2, Q9BTQ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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