UniProtKB - Q9Y4D1 (DAAM1_HUMAN)
Disheveled-associated activator of morphogenesis 1
DAAM1
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- Rho GTPase binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Keywordsi
Molecular function | Actin-binding |
Biological process | Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4D1 |
Reactomei | R-HSA-4086400, PCP/CE pathway R-HSA-5663220, RHO GTPases Activate Formins |
SignaLinki | Q9Y4D1 |
SIGNORi | Q9Y4D1 |
Names & Taxonomyi
Protein namesi | Recommended name: Disheveled-associated activator of morphogenesis 1 |
Gene namesi | Name:DAAM1 Synonyms:KIAA0666 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18142, DAAM1 |
MIMi | 606626, gene |
neXtProti | NX_Q9Y4D1 |
VEuPathDBi | HostDB:ENSG00000100592.15 |
Subcellular locationi
Cytoskeleton
- cilium basal body 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Perinuclear.
Cytoskeleton
- ciliary basal body Source: UniProtKB
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- membrane Source: UniProtKB
- motile cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 698 | I → A: Abolishes actin-binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23002 |
OpenTargetsi | ENSG00000100592 |
PharmGKBi | PA27129 |
Miscellaneous databases
Pharosi | Q9Y4D1, Tbio |
Genetic variation databases
BioMutai | DAAM1 |
DMDMi | 34098767 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194907 | 1 – 1078 | Disheveled-associated activator of morphogenesis 1Add BLAST | 1078 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 34 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1027 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1030 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y4D1 |
jPOSTi | Q9Y4D1 |
MassIVEi | Q9Y4D1 |
PaxDbi | Q9Y4D1 |
PeptideAtlasi | Q9Y4D1 |
PRIDEi | Q9Y4D1 |
ProteomicsDBi | 86164 [Q9Y4D1-1] 86165 [Q9Y4D1-2] 86166 [Q9Y4D1-3] |
PTM databases
iPTMneti | Q9Y4D1 |
PhosphoSitePlusi | Q9Y4D1 |
SwissPalmi | Q9Y4D1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100592, Expressed in neocortex and 243 other tissues |
ExpressionAtlasi | Q9Y4D1, baseline and differential |
Genevisiblei | Q9Y4D1, HS |
Organism-specific databases
HPAi | ENSG00000100592, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with CIP4, FNBP1 and FNBP1L.
Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.
Interacts with INTU; INTU mediates the indirect interaction between DAAM1 and NPHP4.
2 PublicationsBinary interactionsi
Hide detailsQ9Y4D1
DAAM1 - isoform 1 [Q9Y4D1-1]
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-15677700,EBI-15677700 |
Dvl2 [Q60838] from Mus musculus. | 4 | EBI-15677700,EBI-641940 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- Rho GTPase binding Source: InterPro
Protein-protein interaction databases
BioGRIDi | 116648, 36 interactors |
DIPi | DIP-29641N |
IntActi | Q9Y4D1, 37 interactors |
MINTi | Q9Y4D1 |
STRINGi | 9606.ENSP00000378557 |
Miscellaneous databases
RNActi | Q9Y4D1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y4D1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y4D1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 420 | GBD/FH3PROSITE-ProRule annotationAdd BLAST | 376 | |
Domaini | 528 – 599 | FH1Add BLAST | 72 | |
Domaini | 600 – 1009 | FH2PROSITE-ProRule annotationAdd BLAST | 410 | |
Domaini | 1027 – 1058 | DADPROSITE-ProRule annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 693 – 702 | Actin-binding | 10 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 437 – 526 | Sequence analysisAdd BLAST | 90 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 528 – 593 | Pro-richAdd BLAST | 66 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1922, Eukaryota |
GeneTreei | ENSGT00940000156452 |
HOGENOMi | CLU_002356_1_0_1 |
InParanoidi | Q9Y4D1 |
OMAi | KMPVFRG |
OrthoDBi | 1204639at2759 |
PhylomeDBi | Q9Y4D1 |
TreeFami | TF314602 |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV
60 70 80 90 100
EELDVMFSEL VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT
110 120 130 140 150
SWPEFYIDQL NSMAARKSLL ALEKEEEEER SKTIESLKTA LRTKPMRFVT
160 170 180 190 200
RFIDLDGLSC ILNFLKTMDY ETSESRIHTS LIGCIKALMN NSQGRAHVLA
210 220 230 240 250
HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV LQAMLHYQKY
260 270 280 290 300
ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF
310 320 330 340 350
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF
360 370 380 390 400
ELVHIDTKSA TQMFELTRKR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ
410 420 430 440 450
YWLLLDRIIQ QIVIQNDKGQ DPDSTPLENF NIKNVVRMLV NENEVKQWKE
460 470 480 490 500
QAEKMRKEHN ELQQKLEKKE RECDAKTQEK EEMMQTLNKM KEKLEKETTE
510 520 530 540 550
HKQVKQQVAD LTAQLHELSR RAVCASIPGG PSPGAPGGPF PSSVPGSLLP
560 570 580 590 600
PPPPPPLPGG MLPPPPPPLP PGGPPPPPGP PPLGAIMPPP GAPMGLALKK
610 620 630 640 650
KSIPQPTNAL KSFNWSKLPE NKLEGTVWTE IDDTKVFKIL DLEDLERTFS
660 670 680 690 700
AYQRQQDFFV NSNSKQKEAD AIDDTLSSKL KVKELSVIDG RRAQNCNILL
710 720 730 740 750
SRLKLSNDEI KRAILTMDEQ EDLPKDMLEQ LLKFVPEKSD IDLLEEHKHE
760 770 780 790 800
LDRMAKADRF LFEMSRINHY QQRLQSLYFK KKFAERVAEV KPKVEAIRSG
810 820 830 840 850
SEEVFRSGAL KQLLEVVLAF GNYMNKGQRG NAYGFKISSL NKIADTKSSI
860 870 880 890 900
DKNITLLHYL ITIVENKYPS VLNLNEELRD IPQAAKVNMT ELDKEISTLR
910 920 930 940 950
SGLKAVETEL EYQKSQPPQP GDKFVSVVSQ FITVASFSFS DVEDLLAEAK
960 970 980 990 1000
DLFTKAVKHF GEEAGKIQPD EFFGIFDQFL QAVSEAKQEN ENMRKKKEEE
1010 1020 1030 1040 1050
ERRARMEAQL KEQRERERKM RKAKENSEES GEFDDLVSAL RSGEVFDKDL
1060 1070
SKLKRNRKRI TNQMTDSSRE RPITKLNF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V275 | G3V275_HUMAN | Disheveled-associated activator of ... | DAAM1 | 96 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 940 | S → F in AAH24781 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008000 | 656 – 665 | Missing in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_008001 | 788 – 818 | Missing in isoform 3. 1 PublicationAdd BLAST | 31 | |
Alternative sequenceiVSP_008002 | 888 – 916 | NMTEL…YQKSQ → KSWNIRSLSPHSPEISLCLL SASSSQ in isoform 3. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_008003 | 917 – 1078 | Missing in isoform 3. 1 PublicationAdd BLAST | 162 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014566 mRNA Translation: BAA31641.1 Different initiation. AL133502 Genomic DNA No translation available. BC024781 mRNA Translation: AAH24781.1 BC038428 mRNA Translation: AAH38428.1 BC064999 mRNA Translation: AAH64999.1 BX247986 mRNA Translation: CAD62320.1 AK093813 mRNA Translation: BAC04230.1 Different initiation. |
CCDSi | CCDS58323.1 [Q9Y4D1-2] CCDS9737.1 [Q9Y4D1-1] |
RefSeqi | NP_001257449.1, NM_001270520.1 [Q9Y4D1-2] NP_055807.1, NM_014992.2 [Q9Y4D1-1] XP_005267487.1, XM_005267430.1 [Q9Y4D1-1] XP_005267488.1, XM_005267431.1 [Q9Y4D1-1] |
Genome annotation databases
Ensembli | ENST00000360909; ENSP00000354162; ENSG00000100592 [Q9Y4D1-2] ENST00000395125; ENSP00000378557; ENSG00000100592 [Q9Y4D1-1] |
GeneIDi | 23002 |
KEGGi | hsa:23002 |
UCSCi | uc001xea.3, human [Q9Y4D1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014566 mRNA Translation: BAA31641.1 Different initiation. AL133502 Genomic DNA No translation available. BC024781 mRNA Translation: AAH24781.1 BC038428 mRNA Translation: AAH38428.1 BC064999 mRNA Translation: AAH64999.1 BX247986 mRNA Translation: CAD62320.1 AK093813 mRNA Translation: BAC04230.1 Different initiation. |
CCDSi | CCDS58323.1 [Q9Y4D1-2] CCDS9737.1 [Q9Y4D1-1] |
RefSeqi | NP_001257449.1, NM_001270520.1 [Q9Y4D1-2] NP_055807.1, NM_014992.2 [Q9Y4D1-1] XP_005267487.1, XM_005267430.1 [Q9Y4D1-1] XP_005267488.1, XM_005267431.1 [Q9Y4D1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J1D | X-ray | 2.55 | G | 596-1078 | [»] | |
2Z6E | X-ray | 2.80 | A/B/C/D | 594-1012 | [»] | |
SMRi | Q9Y4D1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116648, 36 interactors |
DIPi | DIP-29641N |
IntActi | Q9Y4D1, 37 interactors |
MINTi | Q9Y4D1 |
STRINGi | 9606.ENSP00000378557 |
PTM databases
iPTMneti | Q9Y4D1 |
PhosphoSitePlusi | Q9Y4D1 |
SwissPalmi | Q9Y4D1 |
Genetic variation databases
BioMutai | DAAM1 |
DMDMi | 34098767 |
Proteomic databases
EPDi | Q9Y4D1 |
jPOSTi | Q9Y4D1 |
MassIVEi | Q9Y4D1 |
PaxDbi | Q9Y4D1 |
PeptideAtlasi | Q9Y4D1 |
PRIDEi | Q9Y4D1 |
ProteomicsDBi | 86164 [Q9Y4D1-1] 86165 [Q9Y4D1-2] 86166 [Q9Y4D1-3] |
Protocols and materials databases
Antibodypediai | 11379, 343 antibodies |
Genome annotation databases
Ensembli | ENST00000360909; ENSP00000354162; ENSG00000100592 [Q9Y4D1-2] ENST00000395125; ENSP00000378557; ENSG00000100592 [Q9Y4D1-1] |
GeneIDi | 23002 |
KEGGi | hsa:23002 |
UCSCi | uc001xea.3, human [Q9Y4D1-1] |
Organism-specific databases
CTDi | 23002 |
DisGeNETi | 23002 |
GeneCardsi | DAAM1 |
HGNCi | HGNC:18142, DAAM1 |
HPAi | ENSG00000100592, Low tissue specificity |
MIMi | 606626, gene |
neXtProti | NX_Q9Y4D1 |
OpenTargetsi | ENSG00000100592 |
PharmGKBi | PA27129 |
VEuPathDBi | HostDB:ENSG00000100592.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1922, Eukaryota |
GeneTreei | ENSGT00940000156452 |
HOGENOMi | CLU_002356_1_0_1 |
InParanoidi | Q9Y4D1 |
OMAi | KMPVFRG |
OrthoDBi | 1204639at2759 |
PhylomeDBi | Q9Y4D1 |
TreeFami | TF314602 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4D1 |
Reactomei | R-HSA-4086400, PCP/CE pathway R-HSA-5663220, RHO GTPases Activate Formins |
SignaLinki | Q9Y4D1 |
SIGNORi | Q9Y4D1 |
Miscellaneous databases
BioGRID-ORCSi | 23002, 3 hits in 874 CRISPR screens |
ChiTaRSi | DAAM1, human |
EvolutionaryTracei | Q9Y4D1 |
GeneWikii | DAAM1 |
GenomeRNAii | 23002 |
Pharosi | Q9Y4D1, Tbio |
PROi | PR:Q9Y4D1 |
RNActi | Q9Y4D1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100592, Expressed in neocortex and 243 other tissues |
ExpressionAtlasi | Q9Y4D1, baseline and differential |
Genevisiblei | Q9Y4D1, HS |
Family and domain databases
Gene3Di | 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR014768, GBD/FH3_dom IPR010473, GTPase-bd |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DAAM1_HUMAN | |
Accessioni | Q9Y4D1Primary (citable) accession number: Q9Y4D1 Secondary accession number(s): Q86U34, Q8N1Z8, Q8TB39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 15, 2003 |
Last sequence update: | August 15, 2003 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families