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UniProtKB - Q9Y4D1 (DAAM1_HUMAN)

Entry version 184 (02 Jun 2021)
Sequence version 2 (15 Aug 2003)
Previous versions | rss
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Protein

Disheveled-associated activator of morphogenesis 1

Gene

DAAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208).

Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).

Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processWnt signaling pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y4D1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4086400, PCP/CE pathway
R-HSA-5663220, RHO GTPases Activate Formins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y4D1

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y4D1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disheveled-associated activator of morphogenesis 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAAM1
Synonyms:KIAA0666
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18142, DAAM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606626, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y4D1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100592.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi698I → A: Abolishes actin-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		23002

Open Targets

More...OpenTargetsi		ENSG00000100592

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27129

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y4D1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DAAM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		34098767

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949071 – 1078Disheveled-associated activator of morphogenesis 1Add BLAST1078

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei34PhosphoserineCombined sources1
Modified residuei1027PhosphoserineCombined sources1
Modified residuei1030PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y4D1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y4D1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y4D1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y4D1

PeptideAtlas

More...PeptideAtlasi		Q9Y4D1

PRoteomics IDEntifications database

More...PRIDEi		Q9Y4D1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86164 [Q9Y4D1-1]
86165 [Q9Y4D1-2]
86166 [Q9Y4D1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y4D1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y4D1

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y4D1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100592, Expressed in neocortex and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y4D1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y4D1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100592, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with CIP4, FNBP1 and FNBP1L.

Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.

Interacts with INTU; INTU mediates the indirect interaction between DAAM1 and NPHP4.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116648, 37 interactors

Database of interacting proteins

More...DIPi		DIP-29641N

Protein interaction database and analysis system

More...IntActi		Q9Y4D1, 37 interactors

Molecular INTeraction database

More...MINTi		Q9Y4D1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378557

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y4D1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11078
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y4D1

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y4D1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 420GBD/FH3PROSITE-ProRule annotationAdd BLAST376
Domaini528 – 599FH1Add BLAST72
Domaini600 – 1009FH2PROSITE-ProRule annotationAdd BLAST410
Domaini1027 – 1058DADPROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni456 – 480DisorderedSequence analysisAdd BLAST25
Regioni524 – 585DisorderedSequence analysisAdd BLAST62
Regioni693 – 702Actin-binding10
Regioni987 – 1034DisorderedSequence analysisAdd BLAST48
Regioni1055 – 1078DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili437 – 526Sequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi532 – 585Pro residuesSequence analysisAdd BLAST54
Compositional biasi988 – 1034Basic and acidic residuesSequence analysisAdd BLAST47

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1922, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156452

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002356_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y4D1

Identification of Orthologs from Complete Genome Data

More...OMAi		KMPVFRG

Database of Orthologous Groups

More...OrthoDBi		1204639at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y4D1

TreeFam database of animal gene trees

More...TreeFami		TF314602

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4D1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV 
        60         70         80         90        100
EELDVMFSEL VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT 
       110        120        130        140        150
SWPEFYIDQL NSMAARKSLL ALEKEEEEER SKTIESLKTA LRTKPMRFVT 
       160        170        180        190        200
RFIDLDGLSC ILNFLKTMDY ETSESRIHTS LIGCIKALMN NSQGRAHVLA 
       210        220        230        240        250
HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV LQAMLHYQKY 
       260        270        280        290        300
ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 
       310        320        330        340        350
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF 
       360        370        380        390        400
ELVHIDTKSA TQMFELTRKR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ 
       410        420        430        440        450
YWLLLDRIIQ QIVIQNDKGQ DPDSTPLENF NIKNVVRMLV NENEVKQWKE 
       460        470        480        490        500
QAEKMRKEHN ELQQKLEKKE RECDAKTQEK EEMMQTLNKM KEKLEKETTE 
       510        520        530        540        550
HKQVKQQVAD LTAQLHELSR RAVCASIPGG PSPGAPGGPF PSSVPGSLLP 
       560        570        580        590        600
PPPPPPLPGG MLPPPPPPLP PGGPPPPPGP PPLGAIMPPP GAPMGLALKK 
       610        620        630        640        650
KSIPQPTNAL KSFNWSKLPE NKLEGTVWTE IDDTKVFKIL DLEDLERTFS 
       660        670        680        690        700
AYQRQQDFFV NSNSKQKEAD AIDDTLSSKL KVKELSVIDG RRAQNCNILL 
       710        720        730        740        750
SRLKLSNDEI KRAILTMDEQ EDLPKDMLEQ LLKFVPEKSD IDLLEEHKHE 
       760        770        780        790        800
LDRMAKADRF LFEMSRINHY QQRLQSLYFK KKFAERVAEV KPKVEAIRSG 
       810        820        830        840        850
SEEVFRSGAL KQLLEVVLAF GNYMNKGQRG NAYGFKISSL NKIADTKSSI 
       860        870        880        890        900
DKNITLLHYL ITIVENKYPS VLNLNEELRD IPQAAKVNMT ELDKEISTLR 
       910        920        930        940        950
SGLKAVETEL EYQKSQPPQP GDKFVSVVSQ FITVASFSFS DVEDLLAEAK 
       960        970        980        990       1000
DLFTKAVKHF GEEAGKIQPD EFFGIFDQFL QAVSEAKQEN ENMRKKKEEE 
      1010       1020       1030       1040       1050
ERRARMEAQL KEQRERERKM RKAKENSEES GEFDDLVSAL RSGEVFDKDL 
      1060       1070 
SKLKRNRKRI TNQMTDSSRE RPITKLNF
Length:1,078
Mass (Da):123,473
Last modified:August 15, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE82D9892390254B6
GO
Isoform 2 (identifier: Q9Y4D1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     656-665: Missing.

Show »
Length:1,068
Mass (Da):122,306
Checksum:iC58B1A7445080313
GO
Isoform 3 (identifier: Q9Y4D1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     788-818: Missing.
     888-916: NMTELDKEISTLRSGLKAVETELEYQKSQ → KSWNIRSLSPHSPEISLCLLSASSSQ
     917-1078: Missing.

Show »
Length:882
Mass (Da):100,745
Checksum:i1BB2D1876B212852
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V275G3V275_HUMAN
Disheveled-associated activator of ...
DAAM1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31641 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04230 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti940S → F in AAH24781 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008000656 – 665Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_008001788 – 818Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_008002888 – 916NMTEL…YQKSQ → KSWNIRSLSPHSPEISLCLL SASSSQ in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_008003917 – 1078Missing in isoform 3. 1 PublicationAdd BLAST162

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB014566 mRNA Translation: BAA31641.1 Different initiation.
AL133502 Genomic DNA No translation available.
BC024781 mRNA Translation: AAH24781.1
BC038428 mRNA Translation: AAH38428.1
BC064999 mRNA Translation: AAH64999.1
BX247986 mRNA Translation: CAD62320.1
AK093813 mRNA Translation: BAC04230.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58323.1 [Q9Y4D1-2]
CCDS9737.1 [Q9Y4D1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001257449.1, NM_001270520.1 [Q9Y4D1-2]
NP_055807.1, NM_014992.2 [Q9Y4D1-1]
XP_005267487.1, XM_005267430.1 [Q9Y4D1-1]
XP_005267488.1, XM_005267431.1 [Q9Y4D1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360909; ENSP00000354162; ENSG00000100592 [Q9Y4D1-2]
ENST00000395125; ENSP00000378557; ENSG00000100592 [Q9Y4D1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23002

UCSC genome browser

More...UCSCi		uc001xea.3, human [Q9Y4D1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014566 mRNA Translation: BAA31641.1 Different initiation.
AL133502 Genomic DNA No translation available.
BC024781 mRNA Translation: AAH24781.1
BC038428 mRNA Translation: AAH38428.1
BC064999 mRNA Translation: AAH64999.1
BX247986 mRNA Translation: CAD62320.1
AK093813 mRNA Translation: BAC04230.1 Different initiation.
CCDSiCCDS58323.1 [Q9Y4D1-2]
CCDS9737.1 [Q9Y4D1-1]
RefSeqiNP_001257449.1, NM_001270520.1 [Q9Y4D1-2]
NP_055807.1, NM_014992.2 [Q9Y4D1-1]
XP_005267487.1, XM_005267430.1 [Q9Y4D1-1]
XP_005267488.1, XM_005267431.1 [Q9Y4D1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1DX-ray2.55G596-1078[»]
2Z6EX-ray2.80A/B/C/D594-1012[»]
SMRiQ9Y4D1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116648, 37 interactors
DIPiDIP-29641N
IntActiQ9Y4D1, 37 interactors
MINTiQ9Y4D1
STRINGi9606.ENSP00000378557

PTM databases

iPTMnetiQ9Y4D1
PhosphoSitePlusiQ9Y4D1
SwissPalmiQ9Y4D1

Genetic variation databases

BioMutaiDAAM1
DMDMi34098767

Proteomic databases

EPDiQ9Y4D1
jPOSTiQ9Y4D1
MassIVEiQ9Y4D1
PaxDbiQ9Y4D1
PeptideAtlasiQ9Y4D1
PRIDEiQ9Y4D1
ProteomicsDBi86164 [Q9Y4D1-1]
86165 [Q9Y4D1-2]
86166 [Q9Y4D1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11379, 350 antibodies

The DNASU plasmid repository

More...DNASUi		23002

Genome annotation databases

EnsembliENST00000360909; ENSP00000354162; ENSG00000100592 [Q9Y4D1-2]
ENST00000395125; ENSP00000378557; ENSG00000100592 [Q9Y4D1-1]
GeneIDi23002
KEGGihsa:23002
UCSCiuc001xea.3, human [Q9Y4D1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23002
DisGeNETi23002

GeneCards: human genes, protein and diseases

More...GeneCardsi		DAAM1
HGNCiHGNC:18142, DAAM1
HPAiENSG00000100592, Low tissue specificity
MIMi606626, gene
neXtProtiNX_Q9Y4D1
OpenTargetsiENSG00000100592
PharmGKBiPA27129
VEuPathDBiHostDB:ENSG00000100592.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1922, Eukaryota
GeneTreeiENSGT00940000156452
HOGENOMiCLU_002356_1_0_1
InParanoidiQ9Y4D1
OMAiKMPVFRG
OrthoDBi1204639at2759
PhylomeDBiQ9Y4D1
TreeFamiTF314602

Enzyme and pathway databases

PathwayCommonsiQ9Y4D1
ReactomeiR-HSA-4086400, PCP/CE pathway
R-HSA-5663220, RHO GTPases Activate Formins
SignaLinkiQ9Y4D1
SIGNORiQ9Y4D1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23002, 5 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DAAM1, human
EvolutionaryTraceiQ9Y4D1

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DAAM1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23002
PharosiQ9Y4D1, Tbio

Protein Ontology

More...PROi		PR:Q9Y4D1
RNActiQ9Y4D1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100592, Expressed in neocortex and 244 other tissues
ExpressionAtlasiQ9Y4D1, baseline and differential
GenevisibleiQ9Y4D1, HS

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR014767, DAD_dom
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR010472, FH3_dom
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
PfamiView protein in Pfam
PF06367, Drf_FH3, 1 hit
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01139, Drf_FH3, 1 hit
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231, DAD, 1 hit
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAAM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4D1
Secondary accession number(s): Q86U34, Q8N1Z8, Q8TB39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: June 2, 2021
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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