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Entry version 178 (26 Feb 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Probable RNA-binding protein 19

Gene

RBM19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in embryo pre-implantation development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable RNA-binding protein 19
Alternative name(s):
RNA-binding motif protein 19
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM19
Synonyms:KIAA0682
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29098 RBM19

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616444 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4C8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9904

Open Targets

More...
OpenTargetsi
ENSG00000122965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134886784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y4C8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBM19

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153566

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817811 – 960Probable RNA-binding protein 19Add BLAST960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei174PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei180PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki481Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei936PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei951PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4C8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4C8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y4C8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y4C8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4C8

PeptideAtlas

More...
PeptideAtlasi
Q9Y4C8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4C8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86163

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q9Y4C8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y4C8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4C8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122965 Expressed in left lobe of thyroid gland and 157 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4C8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4C8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038860
HPA058732

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115233, 128 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y4C8, 27 interactors

Molecular INTeraction database

More...
MINTi
Q9Y4C8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000442053

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y4C8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y4C8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y4C8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 79RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 369RRM 2PROSITE-ProRule annotationAdd BLAST76
Domaini402 – 480RRM 3PROSITE-ProRule annotationAdd BLAST79
Domaini587 – 659RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini730 – 811RRM 5PROSITE-ProRule annotationAdd BLAST82
Domaini832 – 912RRM 6PROSITE-ProRule annotationAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 232Poly-Glu8
Compositional biasi391 – 396Poly-Glu6
Compositional biasi714 – 725Poly-GluAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM MRD1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0110 Eukaryota
ENOG410XQZ5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00840000129953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008479_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y4C8

KEGG Orthology (KO)

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KOi
K14787

Identification of Orthologs from Complete Genome Data

More...
OMAi
FCYVGFK

Database of Orthologous Groups

More...
OrthoDBi
1428854at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4C8

TreeFam database of animal gene trees

More...
TreeFami
TF105725

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12564 RRM1_RBM19, 1 hit
cd12502 RRM2_RMB19, 1 hit
cd12567 RRM3_RBM19, 1 hit
cd12569 RRM4_RBM19, 1 hit
cd12318 RRM5_RBM19_like, 1 hit
cd12571 RRM6_RBM19, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034419 RBM19_RRM3
IPR034420 RBM19_RRM4
IPR034423 RBM19_RRM5
IPR034421 RBM19_RRM6
IPR034418 RMB19_RRM1
IPR034417 RMB19_RRM2
IPR000504 RRM_dom
IPR003954 RRM_dom_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 6 hits
SM00361 RRM_1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y4C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK
60 70 80 90 100
SEEEAQKAQK HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK
110 120 130 140 150
QPPKDSTTPE IKKDEKKKKV AGQLEKLKED TEFQEFLSVH QRRAQAATWA
160 170 180 190 200
NDGLDAEPSK GKSKPASDYL NFDSDSGQES EEEGAGEDLE EEASLEPKAA
210 220 230 240 250
VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS EAEEEDSSAT
260 270 280 290 300
PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
310 320 330 340 350
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL
360 370 380 390 400
KCNREYMGGR YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE
410 420 430 440 450
SGRLFVRNLP YTSTEEDLEK LFSKYGPLSE LHYPIDSLTK KPKGFAFITF
460 470 480 490 500
MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI KKEASEDASA LGSSSYKKKK
510 520 530 540 550
EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF DHETKGSVAV
560 570 580 590 600
RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
610 620 630 640 650
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV
660 670 680 690 700
PLYLEWAPVG VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN
710 720 730 740 750
PTEEGADNSS AKMEEEEEEE EEEEESLPGC TLFIKNLNFD TTEEKLKEVF
760 770 780 790 800
SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE YRKPEQAQKA LKQLQGHVVD
810 820 830 840 850
GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP FQAHSREIRE
860 870 880 890 900
LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
910 920 930 940 950
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD
960
SDSEEQTLQL
Length:960
Mass (Da):107,332
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28B6F37B18D7B9B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIL2H0YIL2_HUMAN
Probable RNA-binding protein 19
RBM19
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA31657 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti141Q → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in BAA31657 (PubMed:9734811).Curated1
Sequence conflicti259K → R in AAH06137 (PubMed:15489334).Curated1
Sequence conflicti259K → R in AAH04289 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059822602Q → E4 PublicationsCorresponds to variant dbSNP:rs7299217Ensembl.1
Natural variantiVAR_023114609H → R2 PublicationsCorresponds to variant dbSNP:rs2290789Ensembl.1
Natural variantiVAR_023115623I → T2 PublicationsCorresponds to variant dbSNP:rs2290788Ensembl.1
Natural variantiVAR_023116665T → A2 PublicationsCorresponds to variant dbSNP:rs2290787Ensembl.1
Natural variantiVAR_057246821R → G. Corresponds to variant dbSNP:rs16943379Ensembl.1
Natural variantiVAR_023117921R → Q1 PublicationCorresponds to variant dbSNP:rs2075387Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014582 mRNA Translation: BAA31657.2 Different initiation.
AL117547 mRNA Translation: CAB55987.1
AK291444 mRNA Translation: BAF84133.1
AK314606 mRNA Translation: BAG37176.1
AC009731 Genomic DNA No translation available.
AC073863 Genomic DNA No translation available.
AC090669 Genomic DNA No translation available.
BC004289 mRNA Translation: AAH04289.1
BC006137 mRNA Translation: AAH06137.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9172.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T17297

NCBI Reference Sequences

More...
RefSeqi
NP_001140170.1, NM_001146698.1
NP_001140171.1, NM_001146699.1
NP_057280.2, NM_016196.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261741; ENSP00000261741; ENSG00000122965
ENST00000392561; ENSP00000376344; ENSG00000122965
ENST00000545145; ENSP00000442053; ENSG00000122965

Database of genes from NCBI RefSeq genomes

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GeneIDi
9904

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9904

UCSC genome browser

More...
UCSCi
uc001tvm.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014582 mRNA Translation: BAA31657.2 Different initiation.
AL117547 mRNA Translation: CAB55987.1
AK291444 mRNA Translation: BAF84133.1
AK314606 mRNA Translation: BAG37176.1
AC009731 Genomic DNA No translation available.
AC073863 Genomic DNA No translation available.
AC090669 Genomic DNA No translation available.
BC004289 mRNA Translation: AAH04289.1
BC006137 mRNA Translation: AAH06137.1
CCDSiCCDS9172.1
PIRiT17297
RefSeqiNP_001140170.1, NM_001146698.1
NP_001140171.1, NM_001146699.1
NP_057280.2, NM_016196.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DGWNMR-A291-368[»]
SMRiQ9Y4C8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115233, 128 interactors
IntActiQ9Y4C8, 27 interactors
MINTiQ9Y4C8
STRINGi9606.ENSP00000442053

PTM databases

iPTMnetiQ9Y4C8
PhosphoSitePlusiQ9Y4C8

Polymorphism and mutation databases

BioMutaiRBM19
DMDMi308153566

2D gel databases

SWISS-2DPAGEiQ9Y4C8

Proteomic databases

EPDiQ9Y4C8
jPOSTiQ9Y4C8
MassIVEiQ9Y4C8
MaxQBiQ9Y4C8
PaxDbiQ9Y4C8
PeptideAtlasiQ9Y4C8
PRIDEiQ9Y4C8
ProteomicsDBi86163

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9904

Genome annotation databases

EnsembliENST00000261741; ENSP00000261741; ENSG00000122965
ENST00000392561; ENSP00000376344; ENSG00000122965
ENST00000545145; ENSP00000442053; ENSG00000122965
GeneIDi9904
KEGGihsa:9904
UCSCiuc001tvm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9904
DisGeNETi9904

GeneCards: human genes, protein and diseases

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GeneCardsi
RBM19
HGNCiHGNC:29098 RBM19
HPAiHPA038860
HPA058732
MIMi616444 gene
neXtProtiNX_Q9Y4C8
OpenTargetsiENSG00000122965
PharmGKBiPA134886784

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0110 Eukaryota
ENOG410XQZ5 LUCA
GeneTreeiENSGT00840000129953
HOGENOMiCLU_008479_1_0_1
InParanoidiQ9Y4C8
KOiK14787
OMAiFCYVGFK
OrthoDBi1428854at2759
PhylomeDBiQ9Y4C8
TreeFamiTF105725

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RBM19 human
EvolutionaryTraceiQ9Y4C8

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RBM19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9904
PharosiQ9Y4C8 Tbio

Protein Ontology

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PROi
PR:Q9Y4C8
RNActiQ9Y4C8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000122965 Expressed in left lobe of thyroid gland and 157 other tissues
ExpressionAtlasiQ9Y4C8 baseline and differential
GenevisibleiQ9Y4C8 HS

Family and domain databases

CDDicd12564 RRM1_RBM19, 1 hit
cd12502 RRM2_RMB19, 1 hit
cd12567 RRM3_RBM19, 1 hit
cd12569 RRM4_RBM19, 1 hit
cd12318 RRM5_RBM19_like, 1 hit
cd12571 RRM6_RBM19, 1 hit
Gene3Di3.30.70.330, 6 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034419 RBM19_RRM3
IPR034420 RBM19_RRM4
IPR034423 RBM19_RRM5
IPR034421 RBM19_RRM6
IPR034418 RMB19_RRM1
IPR034417 RMB19_RRM2
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00076 RRM_1, 5 hits
SMARTiView protein in SMART
SM00360 RRM, 6 hits
SM00361 RRM_1, 2 hits
SUPFAMiSSF54928 SSF54928, 5 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM19_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4C8
Secondary accession number(s): A8K5X9, Q9BPY6, Q9UFN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 5, 2010
Last modified: February 26, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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