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UniProtKB - Q9Y4C8 (RBM19_HUMAN)
Protein
Probable RNA-binding protein 19
Gene
RBM19
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in embryo pre-implantation development.
By similarityGO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- positive regulation of embryonic development Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, RNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4C8 |
SignaLinki | Q9Y4C8 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable RNA-binding protein 19Alternative name(s): RNA-binding motif protein 19 |
Gene namesi | Name:RBM19 Synonyms:KIAA0682 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29098, RBM19 |
MIMi | 616444, gene |
neXtProti | NX_Q9Y4C8 |
VEuPathDBi | HostDB:ENSG00000122965 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- nucleolus 2 Publications
- nucleoplasm By similarity
Other locations
- Chromosome By similarity
Note: In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB.By similarity
Nucleus
- nuclear speck Source: GO_Central
- nucleolus Source: UniProtKB
- nucleoplasm Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB
- membrane Source: UniProtKB
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9904 |
OpenTargetsi | ENSG00000122965 |
PharmGKBi | PA134886784 |
Miscellaneous databases
Pharosi | Q9Y4C8, Tbio |
Genetic variation databases
BioMutai | RBM19 |
DMDMi | 308153566 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081781 | 1 – 960 | Probable RNA-binding protein 19Add BLAST | 960 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 174 | PhosphoserineCombined sources | 1 | |
Modified residuei | 176 | PhosphoserineCombined sources | 1 | |
Modified residuei | 180 | PhosphoserineCombined sources | 1 | |
Cross-linki | 481 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 936 | PhosphoserineCombined sources | 1 | |
Modified residuei | 949 | PhosphoserineCombined sources | 1 | |
Modified residuei | 951 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y4C8 |
jPOSTi | Q9Y4C8 |
MassIVEi | Q9Y4C8 |
MaxQBi | Q9Y4C8 |
PaxDbi | Q9Y4C8 |
PeptideAtlasi | Q9Y4C8 |
PRIDEi | Q9Y4C8 |
ProteomicsDBi | 86163 |
2D gel databases
SWISS-2DPAGEi | Q9Y4C8 |
PTM databases
GlyGeni | Q9Y4C8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y4C8 |
PhosphoSitePlusi | Q9Y4C8 |
Expressioni
Tissue specificityi
Expressed in the crypts of Lieberkuhn of the intestine and in intestinal neoplasia (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000122965, Expressed in sural nerve and 170 other tissues |
ExpressionAtlasi | Q9Y4C8, baseline and differential |
Genevisiblei | Q9Y4C8, HS |
Organism-specific databases
HPAi | ENSG00000122965, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115233, 200 interactors |
IntActi | Q9Y4C8, 27 interactors |
MINTi | Q9Y4C8 |
STRINGi | 9606.ENSP00000442053 |
Miscellaneous databases
RNActi | Q9Y4C8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y4C8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y4C8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 79 | RRM 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 294 – 369 | RRM 2PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 402 – 480 | RRM 3PROSITE-ProRule annotationAdd BLAST | 79 | |
Domaini | 587 – 659 | RRM 4PROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 730 – 811 | RRM 5PROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 832 – 912 | RRM 6PROSITE-ProRule annotationAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 119 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 149 – 294 | DisorderedSequence analysisAdd BLAST | 146 | |
Regioni | 491 – 513 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 667 – 729 | DisorderedSequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 190 | Acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 191 – 211 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 225 – 245 | Acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 271 – 287 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 674 – 689 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 690 – 727 | Acidic residuesSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Belongs to the RRM MRD1 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0110, Eukaryota |
GeneTreei | ENSGT00840000129953 |
HOGENOMi | CLU_008479_1_0_1 |
InParanoidi | Q9Y4C8 |
OMAi | TALIEYC |
OrthoDBi | 1428854at2759 |
PhylomeDBi | Q9Y4C8 |
TreeFami | TF105725 |
Family and domain databases
CDDi | cd12564, RRM1_RBM19, 1 hit cd12502, RRM2_RMB19, 1 hit cd12567, RRM3_RBM19, 1 hit cd12569, RRM4_RBM19, 1 hit cd12318, RRM5_RBM19_like, 1 hit cd12571, RRM6_RBM19, 1 hit |
Gene3Di | 3.30.70.330, 6 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034419, RBM19_RRM3 IPR034420, RBM19_RRM4 IPR034423, RBM19_RRM5 IPR034421, RBM19_RRM6 IPR034418, RMB19_RRM1 IPR034417, RMB19_RRM2 IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF00076, RRM_1, 6 hits |
SMARTi | View protein in SMART SM00360, RRM, 6 hits SM00361, RRM_1, 2 hits |
SUPFAMi | SSF54928, SSF54928, 5 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y4C8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRLIVKNLP NGMKEERFRQ LFAAFGTLTD CSLKFTKDGK FRKFGFIGFK
60 70 80 90 100
SEEEAQKAQK HFNKSFIDTS RITVEFCKSF GDPAKPRAWS KHAQKPSQPK
110 120 130 140 150
QPPKDSTTPE IKKDEKKKKV AGQLEKLKED TEFQEFLSVH QRRAQAATWA
160 170 180 190 200
NDGLDAEPSK GKSKPASDYL NFDSDSGQES EEEGAGEDLE EEASLEPKAA
210 220 230 240 250
VQKELSDMDY LKSKMVKAGS SSSSEEEESE DEAVHCDEGS EAEEEDSSAT
260 270 280 290 300
PVLQERDSKG AGQEQGMPAG KKRPPEARAE TEKPANQKEP TTCHTVKLRG
310 320 330 340 350
APFNVTEKNV MEFLAPLKPV AIRIVRNAHG NKTGYIFVDF SNEEEVKQAL
360 370 380 390 400
KCNREYMGGR YIEVFREKNV PTTKGAPKNT TKSWQGRILG ENEEEEDLAE
410 420 430 440 450
SGRLFVRNLP YTSTEEDLEK LFSKYGPLSE LHYPIDSLTK KPKGFAFITF
460 470 480 490 500
MFPEHAVKAY SEVDGQVFQG RMLHVLPSTI KKEASEDASA LGSSSYKKKK
510 520 530 540 550
EAQDKANSAS SHNWNTLFMG PNAVADAIAQ KYNATKSQVF DHETKGSVAV
560 570 580 590 600
RVALGETQLV QEVRRFLIDN GVSLDSFSQA AAERSKTVIL VKNLPAGTLA
610 620 630 640 650
AQLQETFGHF GSLGRVLLPE GGITAIVEFL EPLEARKAFR HLAYSKFHHV
660 670 680 690 700
PLYLEWAPVG VFSSTAPQKK KLQDTPSEPM EKDPAEPETV PDGETPEDEN
710 720 730 740 750
PTEEGADNSS AKMEEEEEEE EEEEESLPGC TLFIKNLNFD TTEEKLKEVF
760 770 780 790 800
SKVGTVKSCS ISKKKNKAGV LLSMGFGFVE YRKPEQAQKA LKQLQGHVVD
810 820 830 840 850
GHKLEVRISE RATKPAVTLA RKKQVPRKQT TSKILVRNIP FQAHSREIRE
860 870 880 890 900
LFSTFGELKT VRLPKKMTGT GTHRGFGFVD FLTKQDAKRA FNALCHSTHL
910 920 930 940 950
YGRRLVLEWA DSEVTLQALR RKTAAHFHEP PKKKRSVVLD EILEQLEGSD
960
SDSEEQTLQL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YIL2 | H0YIL2_HUMAN | Probable RNA-binding protein 19 | RBM19 | 110 | Annotation score: |
Sequence cautioni
The sequence BAA31657 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 141 | Q → R in BAA31657 (PubMed:9734811).Curated | 1 | |
Sequence conflicti | 259 | K → R in BAA31657 (PubMed:9734811).Curated | 1 | |
Sequence conflicti | 259 | K → R in AAH06137 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 259 | K → R in AAH04289 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059822 | 602 | Q → E4 PublicationsCorresponds to variant dbSNP:rs7299217Ensembl. | 1 | |
Natural variantiVAR_023114 | 609 | H → R2 PublicationsCorresponds to variant dbSNP:rs2290789Ensembl. | 1 | |
Natural variantiVAR_023115 | 623 | I → T2 PublicationsCorresponds to variant dbSNP:rs2290788Ensembl. | 1 | |
Natural variantiVAR_023116 | 665 | T → A2 PublicationsCorresponds to variant dbSNP:rs2290787Ensembl. | 1 | |
Natural variantiVAR_057246 | 821 | R → G. Corresponds to variant dbSNP:rs16943379Ensembl. | 1 | |
Natural variantiVAR_023117 | 921 | R → Q1 PublicationCorresponds to variant dbSNP:rs2075387Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014582 mRNA Translation: BAA31657.2 Different initiation. AL117547 mRNA Translation: CAB55987.1 AK291444 mRNA Translation: BAF84133.1 AK314606 mRNA Translation: BAG37176.1 AC009731 Genomic DNA No translation available. AC073863 Genomic DNA No translation available. AC090669 Genomic DNA No translation available. BC004289 mRNA Translation: AAH04289.1 BC006137 mRNA Translation: AAH06137.1 |
CCDSi | CCDS9172.1 |
PIRi | T17297 |
RefSeqi | NP_001140170.1, NM_001146698.1 NP_001140171.1, NM_001146699.1 NP_057280.2, NM_016196.3 |
Genome annotation databases
Ensembli | ENST00000261741; ENSP00000261741; ENSG00000122965 ENST00000392561; ENSP00000376344; ENSG00000122965 ENST00000545145; ENSP00000442053; ENSG00000122965 |
GeneIDi | 9904 |
KEGGi | hsa:9904 |
MANE-Selecti | ENST00000261741.10; ENSP00000261741.5; NM_016196.4; NP_057280.2 |
UCSCi | uc001tvm.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB014582 mRNA Translation: BAA31657.2 Different initiation. AL117547 mRNA Translation: CAB55987.1 AK291444 mRNA Translation: BAF84133.1 AK314606 mRNA Translation: BAG37176.1 AC009731 Genomic DNA No translation available. AC073863 Genomic DNA No translation available. AC090669 Genomic DNA No translation available. BC004289 mRNA Translation: AAH04289.1 BC006137 mRNA Translation: AAH06137.1 |
CCDSi | CCDS9172.1 |
PIRi | T17297 |
RefSeqi | NP_001140170.1, NM_001146698.1 NP_001140171.1, NM_001146699.1 NP_057280.2, NM_016196.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DGW | NMR | - | A | 291-368 | [»] | |
SMRi | Q9Y4C8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115233, 200 interactors |
IntActi | Q9Y4C8, 27 interactors |
MINTi | Q9Y4C8 |
STRINGi | 9606.ENSP00000442053 |
PTM databases
GlyGeni | Q9Y4C8, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y4C8 |
PhosphoSitePlusi | Q9Y4C8 |
Genetic variation databases
BioMutai | RBM19 |
DMDMi | 308153566 |
2D gel databases
SWISS-2DPAGEi | Q9Y4C8 |
Proteomic databases
EPDi | Q9Y4C8 |
jPOSTi | Q9Y4C8 |
MassIVEi | Q9Y4C8 |
MaxQBi | Q9Y4C8 |
PaxDbi | Q9Y4C8 |
PeptideAtlasi | Q9Y4C8 |
PRIDEi | Q9Y4C8 |
ProteomicsDBi | 86163 |
Protocols and materials databases
Antibodypediai | 31281, 53 antibodies from 16 providers |
DNASUi | 9904 |
Genome annotation databases
Ensembli | ENST00000261741; ENSP00000261741; ENSG00000122965 ENST00000392561; ENSP00000376344; ENSG00000122965 ENST00000545145; ENSP00000442053; ENSG00000122965 |
GeneIDi | 9904 |
KEGGi | hsa:9904 |
MANE-Selecti | ENST00000261741.10; ENSP00000261741.5; NM_016196.4; NP_057280.2 |
UCSCi | uc001tvm.4, human |
Organism-specific databases
CTDi | 9904 |
DisGeNETi | 9904 |
GeneCardsi | RBM19 |
HGNCi | HGNC:29098, RBM19 |
HPAi | ENSG00000122965, Low tissue specificity |
MIMi | 616444, gene |
neXtProti | NX_Q9Y4C8 |
OpenTargetsi | ENSG00000122965 |
PharmGKBi | PA134886784 |
VEuPathDBi | HostDB:ENSG00000122965 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0110, Eukaryota |
GeneTreei | ENSGT00840000129953 |
HOGENOMi | CLU_008479_1_0_1 |
InParanoidi | Q9Y4C8 |
OMAi | TALIEYC |
OrthoDBi | 1428854at2759 |
PhylomeDBi | Q9Y4C8 |
TreeFami | TF105725 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4C8 |
SignaLinki | Q9Y4C8 |
Miscellaneous databases
BioGRID-ORCSi | 9904, 619 hits in 1056 CRISPR screens |
ChiTaRSi | RBM19, human |
EvolutionaryTracei | Q9Y4C8 |
GeneWikii | RBM19 |
GenomeRNAii | 9904 |
Pharosi | Q9Y4C8, Tbio |
PROi | PR:Q9Y4C8 |
RNActi | Q9Y4C8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122965, Expressed in sural nerve and 170 other tissues |
ExpressionAtlasi | Q9Y4C8, baseline and differential |
Genevisiblei | Q9Y4C8, HS |
Family and domain databases
CDDi | cd12564, RRM1_RBM19, 1 hit cd12502, RRM2_RMB19, 1 hit cd12567, RRM3_RBM19, 1 hit cd12569, RRM4_RBM19, 1 hit cd12318, RRM5_RBM19_like, 1 hit cd12571, RRM6_RBM19, 1 hit |
Gene3Di | 3.30.70.330, 6 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR034419, RBM19_RRM3 IPR034420, RBM19_RRM4 IPR034423, RBM19_RRM5 IPR034421, RBM19_RRM6 IPR034418, RMB19_RRM1 IPR034417, RMB19_RRM2 IPR000504, RRM_dom IPR003954, RRM_dom_euk |
Pfami | View protein in Pfam PF00076, RRM_1, 6 hits |
SMARTi | View protein in SMART SM00360, RRM, 6 hits SM00361, RRM_1, 2 hits |
SUPFAMi | SSF54928, SSF54928, 5 hits |
PROSITEi | View protein in PROSITE PS50102, RRM, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM19_HUMAN | |
Accessioni | Q9Y4C8Primary (citable) accession number: Q9Y4C8 Secondary accession number(s): A8K5X9, Q9BPY6, Q9UFN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | October 5, 2010 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families