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Protein

DDB1- and CUL4-associated factor 1

Gene

DCAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).12 Publications
(Microbial infection) In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT.8 Publications
(Microbial infection) In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • estrogen receptor binding Source: UniProtKB
  • histone kinase activity (H2A-T120 specific) Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 1Imported
Alternative name(s):
HIV-1 Vpr-binding protein
Short name:
VprBP
Serine/threonine-protein kinase VPRBP (EC:2.7.11.1)
Vpr-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF1Imported
Synonyms:KIAA0800, RIP, VPRBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145041.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30911 DCAF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4B6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi194K → R: Abolishes serine/threonine-protein kinase kinase activity. 1 Publication1
Mutagenesisi361D → A: Abolishes serine/threonine-protein kinase kinase activity. 1 Publication1
Mutagenesisi363K → A: Abolishes serine/threonine-protein kinase kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9730

Open Targets

More...
OpenTargetsi
ENSG00000145041

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670621

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VPRBP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147742890

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874731 – 1507DDB1- and CUL4-associated factor 1Add BLAST1507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei202PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei701N6-acetyllysineBy similarity1
Modified residuei828PhosphoserineCombined sources1
Modified residuei888PhosphothreonineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei898PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1000PhosphoserineCombined sources1
Modified residuei1328PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4B6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y4B6

PeptideAtlas

More...
PeptideAtlasi
Q9Y4B6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4B6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86151
86152 [Q9Y4B6-2]
86153 [Q9Y4B6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y4B6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in a number of cancer cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145041 Expressed in 207 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

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CleanExi
HS_VPRBP

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y4B6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA036142
HPA052445
HPA053203

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. Interacts with DDB1; the interaction is direct. Also forms a ternary complex with DDA1 and DDB1. Interacts with NF2 (via FERM domain). Component of the EDVP complex, a E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1. Interacts with DYRK2; the interaction is direct. Interacts with RAG1; the interaction is direct. Interacts with LLGL1 and LLGL2. Interacts with histone H3. Interacts with ESR1 and LATS1; probably recruited by LATS1 to promote ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:28068668).13 Publications
(Microbial infection) Interacts with HIV-1 virus Vpr protein; the interaction is direct.6 Publications
(Microbial infection) Interacts with HIV-2 virus Vpx protein; the interaction is direct and the complex recruits SAMHD1 to promote its ubiquitin-dependent proteasomal degradation.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115079, 139 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y4B6

Database of interacting proteins

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DIPi
DIP-47048N

Protein interaction database and analysis system

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IntActi
Q9Y4B6, 46 interactors

Molecular INTeraction database

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MINTi
Q9Y4B6

STRING: functional protein association networks

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STRINGi
9606.ENSP00000393183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11507
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y4B6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y4B6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini562 – 593ChromoAdd BLAST32
Domaini846 – 878LisHPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1091 – 1130WD 1Add BLAST40
Repeati1133 – 1174WD 2Add BLAST42
Repeati1176 – 1213WD 3Add BLAST38
Repeati1215 – 1247WD 4Add BLAST33
Repeati1248 – 1290WD 5Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni141 – 500Protein kinase-likeAdd BLAST360
Regioni1091 – 1290WD repeat-like regionAdd BLAST200
Regioni1418 – 1507Interaction with NF2Add BLAST90

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1242 – 1249DWD box 18
Motifi1278 – 1285DWD box 28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1396 – 1500Asp/Glu-rich (acidic)Add BLAST105

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase-like region mediates the threonine-protein kinase activity.1 Publication
The DWD boxes are required for interaction with DDB1.
The chromo domain with a restricted pocket directly recognizes monomethylated substrates.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPRBP/DCAF1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1832 Eukaryota
ENOG410XR8C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000005874

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007026

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108659

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y4B6

KEGG Orthology (KO)

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KOi
K11789

Identification of Orthologs from Complete Genome Data

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OMAi
VWESVCS

Database of Orthologous Groups

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OrthoDBi
EOG091G0128

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y4B6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR006594 LisH
IPR033270 VPRBP/DCAF1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR13129 PTHR13129, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00667 LisH, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50896 LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y4B6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTVVVHVDS KAELTTLLEQ WEKEHGSGQD MVPILTRMSQ LIEKETEEYR
60 70 80 90 100
KGDPDPFDDR HPGRADPECM LGHLLRILFK NDDFMNALVN AYVMTSREPP
110 120 130 140 150
LNTAACRLLL DIMPGLETAV VFQEKEGIVE NLFKWAREAD QPLRTYSTGL
160 170 180 190 200
LGGAMENQDI AANYRDENSQ LVAIVLRRLR ELQLQEVALR QENKRPSPRK
210 220 230 240 250
LSSEPLLPLD EEAVDMDYGD MAVDVVDGDQ EEASGDMEIS FHLDSGHKTS
260 270 280 290 300
SRVNSTTKPE DGGLKKNKSA KQGDRENFRK AKQKLGFSSS DPDRMFVELS
310 320 330 340 350
NSSWSEMSPW VIGTNYTLYP MTPAIEQRLI LQYLTPLGEY QELLPIFMQL
360 370 380 390 400
GSRELMMFYI DLKQTNDVLL TFEALKHLAS LLLHNKFATE FVAHGGVQKL
410 420 430 440 450
LEIPRPSMAA TGVSMCLYYL SYNQDAMERV CMHPHNVLSD VVNYTLWLME
460 470 480 490 500
CSHASGCCHA TMFFSICFSF RAVLELFDRY DGLRRLVNLI STLEILNLED
510 520 530 540 550
QGALLSDDEI FASRQTGKHT CMALRKYFEA HLAIKLEQVK QSLQRTEGGI
560 570 580 590 600
LVHPQPPYKA CSYTHEQIVE MMEFLIEYGP AQLYWEPAEV FLKLSCVQLL
610 620 630 640 650
LQLISIACNW KTYYARNDTV RFALDVLAIL TVVPKIQLQL AESVDVLDEA
660 670 680 690 700
GSTVSTVGIS IILGVAEGEF FIHDAEIQKS ALQIIINCVC GPDNRISSIG
710 720 730 740 750
KFISGTPRRK LPQNPKSSEH TLAKMWNVVQ SNNGIKVLLS LLSIKMPITD
760 770 780 790 800
ADQIRALACK ALVGLSRSST VRQIISKLPL FSSCQIQQLM KEPVLQDKRS
810 820 830 840 850
DHVKFCKYAA ELIERVSGKP LLIGTDVSLA RLQKADVVAQ SRISFPEKEL
860 870 880 890 900
LLLIRNHLIS KGLGETATVL TKEADLPMTA ASHSSAFTPV TAAASPVSLP
910 920 930 940 950
RTPRIANGIA TRLGSHAAVG ASAPSAPTAH PQPRPPQGPL ALPGPSYAGN
960 970 980 990 1000
SPLIGRISFI RERPSPCNGR KIRVLRQKSD HGAYSQSPAI KKQLDRHLPS
1010 1020 1030 1040 1050
PPTLDSIITE YLREQHARCK NPVATCPPFS LFTPHQCPEP KQRRQAPINF
1060 1070 1080 1090 1100
TSRLNRRASF PKYGGVDGGC FDRHLIFSRF RPISVFREAN EDESGFTCCA
1110 1120 1130 1140 1150
FSARERFLML GTCTGQLKLY NVFSGQEEAS YNCHNSAITH LEPSRDGSLL
1160 1170 1180 1190 1200
LTSATWSQPL SALWGMKSVF DMKHSFTEDH YVEFSKHSQD RVIGTKGDIA
1210 1220 1230 1240 1250
HIYDIQTGNK LLTLFNPDLA NNYKRNCATF NPTDDLVLND GVLWDVRSAQ
1260 1270 1280 1290 1300
AIHKFDKFNM NISGVFHPNG LEVIINTEIW DLRTFHLLHT VPALDQCRVV
1310 1320 1330 1340 1350
FNHTGTVMYG AMLQADDEDD LMEERMKSPF GSSFRTFNAT DYKPIATIDV
1360 1370 1380 1390 1400
KRNIFDLCTD TKDCYLAVIE NQGSMDALNM DTVCRLYEVG RQRLAEDEDE
1410 1420 1430 1440 1450
EEDQEEEEQE EEDDDEDDDD TDDLDELDTD QLLEAELEED DNNENAGEDG
1460 1470 1480 1490 1500
DNDFSPSDEE LANLLEEGED GEDEDSDADE EVELILGDTD SSDNSDLEDD

IILSLNE
Length:1,507
Mass (Da):169,007
Last modified:May 15, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E71AB2CAC4962C5
GO
Isoform 2 (identifier: Q9Y4B6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-87: Missing.

Note: No experimental confirmation available.
Show »
Length:1,506
Mass (Da):168,936
Checksum:i016CF082F1239B17
GO
Isoform 3 (identifier: Q9Y4B6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-673: Missing.

Note: No experimental confirmation available.
Show »
Length:1,058
Mass (Da):118,235
Checksum:iA5A53818C128F546
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34520 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051486267N → D. Corresponds to variant dbSNP:rs3749318Ensembl.1
Natural variantiVAR_051487378L → F Does not affect serine/threonine-protein kinase kinase activity. 1 PublicationCorresponds to variant dbSNP:rs17712228Ensembl.1
Natural variantiVAR_0514881031L → P. Corresponds to variant dbSNP:rs9835229Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02549887Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_025499225 – 673Missing in isoform 3. 1 PublicationAdd BLAST449

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018343 mRNA Translation: BAA34520.2 Different initiation.
AC092037 Genomic DNA No translation available.
BC022792 mRNA Translation: AAH22792.1
BC110371 mRNA Translation: AAI10372.1
AL080145 mRNA Translation: CAB45738.1
AF061935 mRNA Translation: AAG27134.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74943.1 [Q9Y4B6-1]
CCDS74944.1 [Q9Y4B6-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T12529

NCBI Reference Sequences

More...
RefSeqi
NP_001165375.1, NM_001171904.1 [Q9Y4B6-2]
NP_055518.1, NM_014703.2 [Q9Y4B6-1]
XP_005276810.1, XM_005276753.4 [Q9Y4B6-1]
XP_005276812.1, XM_005276755.4 [Q9Y4B6-1]
XP_011532575.1, XM_011534273.2 [Q9Y4B6-1]
XP_011532576.1, XM_011534274.2
XP_011532577.1, XM_011534275.2 [Q9Y4B6-1]
XP_011532578.1, XM_011534276.2
XP_011532579.1, XM_011534277.2
XP_016863035.1, XM_017007546.1 [Q9Y4B6-1]
XP_016863036.1, XM_017007547.1 [Q9Y4B6-1]
XP_016863037.1, XM_017007548.1
XP_016863038.1, XM_017007549.1 [Q9Y4B6-1]
XP_016863039.1, XM_017007550.1 [Q9Y4B6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.716623

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000335891; ENSP00000338857; ENSG00000145041 [Q9Y4B6-3]
ENST00000423656; ENSP00000393183; ENSG00000145041 [Q9Y4B6-1]
ENST00000504652; ENSP00000421724; ENSG00000145041 [Q9Y4B6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9730

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9730

UCSC genome browser

More...
UCSCi
uc032rnn.1 human [Q9Y4B6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018343 mRNA Translation: BAA34520.2 Different initiation.
AC092037 Genomic DNA No translation available.
BC022792 mRNA Translation: AAH22792.1
BC110371 mRNA Translation: AAI10372.1
AL080145 mRNA Translation: CAB45738.1
AF061935 mRNA Translation: AAG27134.1
CCDSiCCDS74943.1 [Q9Y4B6-1]
CCDS74944.1 [Q9Y4B6-2]
PIRiT12529
RefSeqiNP_001165375.1, NM_001171904.1 [Q9Y4B6-2]
NP_055518.1, NM_014703.2 [Q9Y4B6-1]
XP_005276810.1, XM_005276753.4 [Q9Y4B6-1]
XP_005276812.1, XM_005276755.4 [Q9Y4B6-1]
XP_011532575.1, XM_011534273.2 [Q9Y4B6-1]
XP_011532576.1, XM_011534274.2
XP_011532577.1, XM_011534275.2 [Q9Y4B6-1]
XP_011532578.1, XM_011534276.2
XP_011532579.1, XM_011534277.2
XP_016863035.1, XM_017007546.1 [Q9Y4B6-1]
XP_016863036.1, XM_017007547.1 [Q9Y4B6-1]
XP_016863037.1, XM_017007548.1
XP_016863038.1, XM_017007549.1 [Q9Y4B6-1]
XP_016863039.1, XM_017007550.1 [Q9Y4B6-1]
UniGeneiHs.716623

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WA0X-ray2.31G/H1418-1507[»]
4CC9X-ray2.47A1058-1396[»]
4P7IX-ray2.60C/D1447-1507[»]
4PXWX-ray1.72A/B1039-1401[»]
4Z8LX-ray2.60A/D1057-1396[»]
5AJAX-ray2.65A1058-1396[»]
5JK7X-ray3.49C/E1045-1396[»]
ProteinModelPortaliQ9Y4B6
SMRiQ9Y4B6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115079, 139 interactors
CORUMiQ9Y4B6
DIPiDIP-47048N
IntActiQ9Y4B6, 46 interactors
MINTiQ9Y4B6
STRINGi9606.ENSP00000393183

PTM databases

iPTMnetiQ9Y4B6
PhosphoSitePlusiQ9Y4B6

Polymorphism and mutation databases

BioMutaiVPRBP
DMDMi147742890

Proteomic databases

EPDiQ9Y4B6
PaxDbiQ9Y4B6
PeptideAtlasiQ9Y4B6
PRIDEiQ9Y4B6
ProteomicsDBi86151
86152 [Q9Y4B6-2]
86153 [Q9Y4B6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335891; ENSP00000338857; ENSG00000145041 [Q9Y4B6-3]
ENST00000423656; ENSP00000393183; ENSG00000145041 [Q9Y4B6-1]
ENST00000504652; ENSP00000421724; ENSG00000145041 [Q9Y4B6-2]
GeneIDi9730
KEGGihsa:9730
UCSCiuc032rnn.1 human [Q9Y4B6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9730
DisGeNETi9730
EuPathDBiHostDB:ENSG00000145041.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCAF1
HGNCiHGNC:30911 DCAF1
HPAiHPA036142
HPA052445
HPA053203
neXtProtiNX_Q9Y4B6
OpenTargetsiENSG00000145041
PharmGKBiPA142670621

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1832 Eukaryota
ENOG410XR8C LUCA
GeneTreeiENSGT00390000005874
HOGENOMiHOG000007026
HOVERGENiHBG108659
InParanoidiQ9Y4B6
KOiK11789
OMAiVWESVCS
OrthoDBiEOG091G0128
PhylomeDBiQ9Y4B6

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCAF1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
VPRBP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9730

Protein Ontology

More...
PROi
PR:Q9Y4B6

Gene expression databases

BgeeiENSG00000145041 Expressed in 207 organ(s), highest expression level in sperm
CleanExiHS_VPRBP
GenevisibleiQ9Y4B6 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR006594 LisH
IPR033270 VPRBP/DCAF1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13129 PTHR13129, 1 hit
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCAF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4B6
Secondary accession number(s): Q2YD74
, Q8TBD9, Q9HCA1, Q9UG37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: December 5, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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