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Entry version 144 (13 Feb 2019)
Sequence version 4 (18 May 2010)
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Protein

Helicase ARIP4

Gene

RAD54L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi305 – 312ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Y4B4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase ARIP4 (EC:3.6.4.12)
Alternative name(s):
Androgen receptor-interacting protein 4
RAD54-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAD54L2
Synonyms:ARIP4, KIAA0809
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000164080.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29123 RAD54L2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y4B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23132

Open Targets

More...
OpenTargetsi
ENSG00000164080

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485591

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAD54L2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439458

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003157811 – 1467Helicase ARIP4Add BLAST1467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki115Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki272Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki665Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki682Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki759Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki901Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1014Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1018Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1169PhosphoserineCombined sources1
Modified residuei1172PhosphoserineCombined sources1
Modified residuei1260PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y4B4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y4B4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y4B4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y4B4

PeptideAtlas

More...
PeptideAtlasi
Q9Y4B4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y4B4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86146

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9Y4B4

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y4B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y4B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164080 Expressed in 201 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y4B4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y4B4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035004
HPA039992

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AR via its N-terminus. Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not seem to form large multiprotein complexes (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116750, 28 interactors

Database of interacting proteins

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DIPi
DIP-47284N

Protein interaction database and analysis system

More...
IntActi
Q9Y4B4, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9Y4B4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y4B4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini292 – 512Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST221
Domaini728 – 896Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi463 – 466DEAH box4
Motifi551 – 555LXXLL motif 15
Motifi1329 – 1333LXXLL motif 25

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1015 Eukaryota
COG0553 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155763

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168429

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG104283

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y4B4

KEGG Orthology (KO)

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KOi
K10876

Identification of Orthologs from Complete Genome Data

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OMAi
PINEWSS

Database of Orthologous Groups

More...
OrthoDBi
815681at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y4B4

TreeFam database of animal gene trees

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TreeFami
TF313172

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y4B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDESASGSD PDLDPDVELE DAEEEEEEEE VAVEECDRDD EEDLLDDPSL
60 70 80 90 100
EGMCGTEHAQ LGEDGQQPPR CTSTTSSQSE PSEQLRRHQG KNLASEDPKK
110 120 130 140 150
KRAQKPSHMR RNIRKLLRED QLEPVTKAAQ QEELERRKRL EQQRKDYAAP
160 170 180 190 200
IPTVPLEFLP EEIALRASDG PQLPPRVLAQ EVICLDSSSG SEDEKSSRDE
210 220 230 240 250
VIELSSGEED TLHIVDSSES VSEDDEEEEK GGTHVNDVLN QRDALGRVLV
260 270 280 290 300
NLNHPPEEEN VFLAPQLARA VKPHQIGGIR FLYDNLVESL ERFKTSSGFG
310 320 330 340 350
CILAHSMGLG KTLQVISFID VLFRHTPAKT VLAIVPVNTL QNWLAEFNMW
360 370 380 390 400
LPPPEALPAD NKPEEVQPRF FKVHILNDEH KTMASRAKVM ADWVSEGGVL
410 420 430 440 450
LMGYEMYRLL TLKKSFATGR PKKTKKRSHP VIIDLDEEDR QQEFRREFEK
460 470 480 490 500
ALCRPGPDVV ICDEGHRIKN CQASTSQALK NIRSRRRVVL TGYPLQNNLI
510 520 530 540 550
EYWCMVDFVR PDFLGTRQEF SNMFERPILN GQCIDSTPQD VRLMRYRSHV
560 570 580 590 600
LHSLLEGFVQ RRGHTVLKIH LPAKEENVIL VRLSKIQRDL YTQFMDRFRD
610 620 630 640 650
CGSSGWLGLN PLKAFCVCCK IWNHPDVLYE ALQKESLANE QDLDVEELGS
660 670 680 690 700
AGTSARCPPQ GTKGKGEDST LASSMGEATN SKFLQGVGFN PFQERGNNIV
710 720 730 740 750
TYEWAKDLLT NYQTGVLENS PKMVLLFHLI EESVKLGDKI LVFSQSLSTL
760 770 780 790 800
ALIEEFLGKR EVPCPPGTEG QGAQKWVRNI SYFRLDGSTP AFERERLINQ
810 820 830 840 850
FNDPSNLTTW LFLLSTRAGC LGVNLIGANR VVVFDASWNP CHDAQAVCRV
860 870 880 890 900
YRYGQKKPCY IYRLVADYTL EKKIYDRQIS KQGMSDRVVD DLNPMLNFTR
910 920 930 940 950
KEVENLLHFV EKEPAPQVSL NVKGIKESVL QLACLKYPHL ITKEPFEHES
960 970 980 990 1000
LLLNRKDHKL TKAEKKAAKK SYEEDKRTSV PYTRPSYAQY YPASDQSLTS
1010 1020 1030 1040 1050
IPAFSQRNWQ PTLKGDEKPV ASVRPVQSTP IPMMPRHVPL GGSVSSASST
1060 1070 1080 1090 1100
NPSMNFPINY LQRAGVLVQK VVTTTDIVIP GLNSSTDVQA RINAGESIHI
1110 1120 1130 1140 1150
IRGTKGTYIR TSDGRIFAVR ATGKPKVPED GRMAASGSQG PSCESTSNGR
1160 1170 1180 1190 1200
HSASSPKAPD PEGLARPVSP DSPEIISELQ QYADVAAARE SRQSSPSTNA
1210 1220 1230 1240 1250
ALPGPPAQLM DSSAVPGTAL GTEPRLGGHC LNSSLLVTGQ PCGDRHPVLD
1260 1270 1280 1290 1300
LRGHKRKLAT PPAAQESSRR RSRKGHLPAP VQPYEHGYPV SGGFAMPPVS
1310 1320 1330 1340 1350
LNHNLTTPFT SQAGENSLFM GSTPSYYQLS NLLADARLVF PVTTDPLVPA
1360 1370 1380 1390 1400
GPVSSSSTAT SVTASNPSFM LNPSVPGILP SYSLPFSQPL LSEPRMFAPF
1410 1420 1430 1440 1450
PSPVLPSNLS RGMSIYPGYM SPHAGYPAGG LLRSQVPPFD SHEVAEVGFS
1460
SNDDEDKDDD VIEVTGK
Length:1,467
Mass (Da):162,769
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B4144B6BBC4C3B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y760H0Y760_HUMAN
Helicase ARIP4
RAD54L2
1,296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24298 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti123E → Q in BAA34529 (PubMed:9872452).Curated1
Sequence conflicti249L → F in AAH24298 (PubMed:15489334).Curated1
Sequence conflicti328A → V in BAA34529 (PubMed:9872452).Curated1
Sequence conflicti860Y → F in AAH01474 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0383021369F → L. Corresponds to variant dbSNP:rs35712917Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC099050 Genomic DNA No translation available.
AC113933 Genomic DNA No translation available.
AB018352 mRNA Translation: BAA34529.2
BC001474 mRNA Translation: AAH01474.2
BC024298 mRNA Translation: AAH24298.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33765.2

NCBI Reference Sequences

More...
RefSeqi
NP_001309182.1, NM_001322253.1
NP_001309185.1, NM_001322256.1
NP_055921.2, NM_015106.3
XP_006713125.1, XM_006713062.3
XP_016861476.1, XM_017005987.1
XP_016861477.1, XM_017005988.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.105399
Hs.655185
Hs.659486

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000409535; ENSP00000386520; ENSG00000164080

Database of genes from NCBI RefSeq genomes

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GeneIDi
23132

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23132

UCSC genome browser

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UCSCi
uc011bdt.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC099050 Genomic DNA No translation available.
AC113933 Genomic DNA No translation available.
AB018352 mRNA Translation: BAA34529.2
BC001474 mRNA Translation: AAH01474.2
BC024298 mRNA Translation: AAH24298.1 Different initiation.
CCDSiCCDS33765.2
RefSeqiNP_001309182.1, NM_001322253.1
NP_001309185.1, NM_001322256.1
NP_055921.2, NM_015106.3
XP_006713125.1, XM_006713062.3
XP_016861476.1, XM_017005987.1
XP_016861477.1, XM_017005988.1
UniGeneiHs.105399
Hs.655185
Hs.659486

3D structure databases

ProteinModelPortaliQ9Y4B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116750, 28 interactors
DIPiDIP-47284N
IntActiQ9Y4B4, 37 interactors
MINTiQ9Y4B4
STRINGi9606.ENSP00000386520

PTM databases

CarbonylDBiQ9Y4B4
iPTMnetiQ9Y4B4
PhosphoSitePlusiQ9Y4B4

Polymorphism and mutation databases

BioMutaiRAD54L2
DMDMi296439458

Proteomic databases

EPDiQ9Y4B4
jPOSTiQ9Y4B4
MaxQBiQ9Y4B4
PaxDbiQ9Y4B4
PeptideAtlasiQ9Y4B4
PRIDEiQ9Y4B4
ProteomicsDBi86146

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409535; ENSP00000386520; ENSG00000164080
GeneIDi23132
KEGGihsa:23132
UCSCiuc011bdt.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23132
DisGeNETi23132
EuPathDBiHostDB:ENSG00000164080.13

GeneCards: human genes, protein and diseases

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GeneCardsi
RAD54L2
HGNCiHGNC:29123 RAD54L2
HPAiHPA035004
HPA039992
neXtProtiNX_Q9Y4B4
OpenTargetsiENSG00000164080
PharmGKBiPA143485591

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1015 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00940000155763
HOGENOMiHOG000168429
HOVERGENiHBG104283
InParanoidiQ9Y4B4
KOiK10876
OMAiPINEWSS
OrthoDBi815681at2759
PhylomeDBiQ9Y4B4
TreeFamiTF313172

Enzyme and pathway databases

SABIO-RKiQ9Y4B4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RAD54L2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23132

Protein Ontology

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PROi
PR:Q9Y4B4

Gene expression databases

BgeeiENSG00000164080 Expressed in 201 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9Y4B4 baseline and differential
GenevisibleiQ9Y4B4 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARIP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4B4
Secondary accession number(s): Q8TB57, Q9BV54
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 144 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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