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Protein

Nuclear factor erythroid 2-related factor 3

Gene

NFE2L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates erythroid-specific, globin gene expression.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 3
Short name:
NF-E2-related factor 3
Short name:
NFE2-related factor 3
Alternative name(s):
Nuclear factor, erythroid derived 2, like 3
Gene namesi
Name:NFE2L3
Synonyms:NRF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000050344.8
HGNCiHGNC:7783 NFE2L3
MIMi604135 gene
neXtProtiNX_Q9Y4A8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9603
OpenTargetsiENSG00000050344
PharmGKBiPA31589

Polymorphism and mutation databases

BioMutaiNFE2L3
DMDMi56404677

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764521 – 694Nuclear factor erythroid 2-related factor 3Add BLAST694

Proteomic databases

EPDiQ9Y4A8
PaxDbiQ9Y4A8
PeptideAtlasiQ9Y4A8
PRIDEiQ9Y4A8
ProteomicsDBi86144

PTM databases

iPTMnetiQ9Y4A8
PhosphoSitePlusiQ9Y4A8

Expressioni

Tissue specificityi

Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000050344
CleanExiHS_NFE2L3
ExpressionAtlasiQ9Y4A8 baseline and differential
GenevisibleiQ9Y4A8 HS

Organism-specific databases

HPAiHPA055889

Interactioni

Subunit structurei

Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114967, 15 interactors
IntActiQ9Y4A8, 3 interactors
STRINGi9606.ENSP00000056233

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A8
SMRiQ9Y4A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini578 – 641bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni580 – 599Basic motifPROSITE-ProRule annotationAdd BLAST20
Regioni606 – 620Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 49Leu-richAdd BLAST36

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00920000148991
HOGENOMiHOG000234410
HOVERGENiHBG052609
InParanoidiQ9Y4A8
KOiK09040
OMAiPFIPRTR
OrthoDBiEOG091G02EB
PhylomeDBiQ9Y4A8
TreeFamiTF337360

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR029854 NF2L3
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR24411:SF8 PTHR24411:SF8, 1 hit
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y4A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG
60 70 80 90 100
GPASSAYALS PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV
110 120 130 140 150
PFVPRTSVDA WLVHSVAAGS ADEAHGLLGA AAASSTGGAG ASVDGGSQAV
160 170 180 190 200
QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ VPDAGGCASE ENGVLREKHE
210 220 230 240 250
AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE AEKTTESRNE
260 270 280 290 300
RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH
310 320 330 340 350
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT
360 370 380 390 400
NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE
410 420 430 440 450
DNFDPIDVSQ LFDEPDSDSG LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC
460 470 480 490 500
TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ SDSDFHGDLT FQHVFHNHTY
510 520 530 540 550
HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ RAKALHIPFS
560 570 580 590 600
VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL
610 620 630 640 650
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR
660 670 680 690
DDQGRPVNPN HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK
Length:694
Mass (Da):76,154
Last modified:November 1, 1999 - v1
Checksum:iDAD6D883FCCBA982
GO

Sequence cautioni

The sequence AAP22344 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA76288 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286P → L in AAH68455 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055562441V → E. Corresponds to variant dbSNP:rs2072129Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133059 mRNA Translation: AAG43275.1
AF134891 mRNA Translation: AAF61404.1
AF135116 Genomic DNA Translation: AAF61415.1
AC004520 Genomic DNA Translation: AAP22344.1 Sequence problems.
BC049219 mRNA Translation: AAH49219.1
BC056142 mRNA Translation: AAH56142.1
BC068455 mRNA Translation: AAH68455.1
AB010812 mRNA Translation: BAA76288.1 Different initiation.
CCDSiCCDS5396.1
RefSeqiNP_004280.5, NM_004289.6
UniGeneiHs.404741
Hs.712898

Genome annotation databases

EnsembliENST00000056233; ENSP00000056233; ENSG00000050344
GeneIDi9603
KEGGihsa:9603
UCSCiuc003sxq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNF2L3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A8
Secondary accession number(s): Q6NUS0
, Q7Z498, Q86UJ4, Q86VR5, Q9UQA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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