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UniProtKB - Q9Y4A8 (NF2L3_HUMAN)
Protein
Nuclear factor erythroid 2-related factor 3
Gene
NFE2L3
Organism
Homo sapiens (Human)
Status
Functioni
Activates erythroid-specific, globin gene expression.
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- integrated stress response signaling Source: ComplexPortal
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A8 |
SignaLinki | Q9Y4A8 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear factor erythroid 2-related factor 3Short name: NF-E2-related factor 3 Short name: NFE2-related factor 3 Alternative name(s): Nuclear factor, erythroid derived 2, like 3 |
Gene namesi | Name:NFE2L3 Synonyms:NRF3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7783, NFE2L3 |
MIMi | 604135, gene |
neXtProti | NX_Q9Y4A8 |
VEuPathDBi | HostDB:ENSG00000050344 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
- RNA polymerase II transcription regulator complex Source: ComplexPortal
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 9603 |
OpenTargetsi | ENSG00000050344 |
PharmGKBi | PA31589 |
Miscellaneous databases
Pharosi | Q9Y4A8, Tbio |
Genetic variation databases
BioMutai | NFE2L3 |
DMDMi | 56404677 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076452 | 1 – 694 | Nuclear factor erythroid 2-related factor 3Add BLAST | 694 |
Proteomic databases
EPDi | Q9Y4A8 |
MassIVEi | Q9Y4A8 |
PaxDbi | Q9Y4A8 |
PeptideAtlasi | Q9Y4A8 |
PRIDEi | Q9Y4A8 |
ProteomicsDBi | 86144 |
PTM databases
iPTMneti | Q9Y4A8 |
PhosphoSitePlusi | Q9Y4A8 |
Expressioni
Tissue specificityi
Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000050344, Expressed in placenta and 168 other tissues |
ExpressionAtlasi | Q9Y4A8, baseline and differential |
Genevisiblei | Q9Y4A8, HS |
Organism-specific databases
HPAi | ENSG00000050344, Tissue enhanced (brain, placenta) |
Interactioni
Subunit structurei
Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
2 PublicationsBinary interactionsi
Q9Y4A8
With | #Exp. | IntAct |
---|---|---|
MAFF [Q9ULX9] | 3 | EBI-10890629,EBI-721128 |
MAFG [O15525] | 5 | EBI-10890629,EBI-713514 |
NFE2 [Q16621] | 4 | EBI-10890629,EBI-726369 |
Protein-protein interaction databases
BioGRIDi | 114967, 16 interactors |
ComplexPortali | CPX-6572, bZIP transcription factor complex, ATF4-NFE2L3 |
IntActi | Q9Y4A8, 13 interactors |
STRINGi | 9606.ENSP00000056233 |
Miscellaneous databases
RNActi | Q9Y4A8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 578 – 641 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 133 – 256 | DisorderedSequence analysisAdd BLAST | 124 | |
Regioni | 330 – 357 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 580 – 599 | Basic motifPROSITE-ProRule annotationAdd BLAST | 20 | |
Regioni | 606 – 620 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 192 – 253 | Basic and acidic residuesSequence analysisAdd BLAST | 62 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q9Y4A8 |
OMAi | LKRWWSA |
OrthoDBi | 1095280at2759 |
PhylomeDBi | Q9Y4A8 |
TreeFami | TF337360 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y4A8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHLKRWWSA GGGLLHLTLL LSLAGLRVDL DLYLLLPPPT LLQDELLFLG
60 70 80 90 100
GPASSAYALS PFSASGGWGR AGHLHPKGRE LDPAAPPEGQ LLREVRALGV
110 120 130 140 150
PFVPRTSVDA WLVHSVAAGS ADEAHGLLGA AAASSTGGAG ASVDGGSQAV
160 170 180 190 200
QGGGGDPRAA RSGPLDAGEE EKAPAEPTAQ VPDAGGCASE ENGVLREKHE
210 220 230 240 250
AVDHSSQHEE NEERVSAQKE NSLQQNDDDE NKIAEKPDWE AEKTTESRNE
260 270 280 290 300
RHLNGTDTSF SLEDLFQLLS SQPENSLEGI SLGDIPLPGS ISDGMNSSAH
310 320 330 340 350
YHVNFSQAIS QDVNLHEAIL LCPNNTFRRD PTARTSQSQE PFLQLNSHTT
360 370 380 390 400
NPEQTLPGTN LTGFLSPVDN HMRNLTSQDL LYDLDINIFD EINLMSLATE
410 420 430 440 450
DNFDPIDVSQ LFDEPDSDSG LSLDSSHNNT SVIKSNSSHS VCDEGAIGYC
460 470 480 490 500
TDHESSSHHD LEGAVGGYYP EPSKLCHLDQ SDSDFHGDLT FQHVFHNHTY
510 520 530 540 550
HLQPTAPEST SEPFPWPGKS QKIRSRYLED TDRNLSRDEQ RAKALHIPFS
560 570 580 590 600
VDEIVGMPVD SFNSMLSRYY LTDLQVSLIR DIRRRGKNKV AAQNCRKRKL
610 620 630 640 650
DIILNLEDDV CNLQAKKETL KREQAQCNKA INIMKQKLHD LYHDIFSRLR
660 670 680 690
DDQGRPVNPN HYALQCTHDG SILIVPKELV ASGHKKETQK GKRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketU3KQ19 | U3KQ19_HUMAN | Nuclear factor erythroid 2-related ... | NFE2L3 | 83 | Annotation score: |
Sequence cautioni
The sequence AAP22344 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA76288 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 286 | P → L in AAH68455 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055562 | 441 | V → E. Corresponds to variant dbSNP:rs2072129Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133059 mRNA Translation: AAG43275.1 AF134891 mRNA Translation: AAF61404.1 AF135116 Genomic DNA Translation: AAF61415.1 AC004520 Genomic DNA Translation: AAP22344.1 Sequence problems. BC049219 mRNA Translation: AAH49219.1 BC056142 mRNA Translation: AAH56142.1 BC068455 mRNA Translation: AAH68455.1 AB010812 mRNA Translation: BAA76288.1 Different initiation. |
CCDSi | CCDS5396.1 |
RefSeqi | NP_004280.5, NM_004289.6 |
Genome annotation databases
Ensembli | ENST00000056233.4; ENSP00000056233.3; ENSG00000050344.9 |
GeneIDi | 9603 |
KEGGi | hsa:9603 |
MANE-Selecti | ENST00000056233.4; ENSP00000056233.3; NM_004289.7; NP_004280.5 |
UCSCi | uc003sxq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF133059 mRNA Translation: AAG43275.1 AF134891 mRNA Translation: AAF61404.1 AF135116 Genomic DNA Translation: AAF61415.1 AC004520 Genomic DNA Translation: AAP22344.1 Sequence problems. BC049219 mRNA Translation: AAH49219.1 BC056142 mRNA Translation: AAH56142.1 BC068455 mRNA Translation: AAH68455.1 AB010812 mRNA Translation: BAA76288.1 Different initiation. |
CCDSi | CCDS5396.1 |
RefSeqi | NP_004280.5, NM_004289.6 |
3D structure databases
AlphaFoldDBi | Q9Y4A8 |
SMRi | Q9Y4A8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114967, 16 interactors |
ComplexPortali | CPX-6572, bZIP transcription factor complex, ATF4-NFE2L3 |
IntActi | Q9Y4A8, 13 interactors |
STRINGi | 9606.ENSP00000056233 |
PTM databases
iPTMneti | Q9Y4A8 |
PhosphoSitePlusi | Q9Y4A8 |
Genetic variation databases
BioMutai | NFE2L3 |
DMDMi | 56404677 |
Proteomic databases
EPDi | Q9Y4A8 |
MassIVEi | Q9Y4A8 |
PaxDbi | Q9Y4A8 |
PeptideAtlasi | Q9Y4A8 |
PRIDEi | Q9Y4A8 |
ProteomicsDBi | 86144 |
Protocols and materials databases
Antibodypediai | 12307, 183 antibodies from 27 providers |
DNASUi | 9603 |
Genome annotation databases
Ensembli | ENST00000056233.4; ENSP00000056233.3; ENSG00000050344.9 |
GeneIDi | 9603 |
KEGGi | hsa:9603 |
MANE-Selecti | ENST00000056233.4; ENSP00000056233.3; NM_004289.7; NP_004280.5 |
UCSCi | uc003sxq.4, human |
Organism-specific databases
CTDi | 9603 |
DisGeNETi | 9603 |
GeneCardsi | NFE2L3 |
HGNCi | HGNC:7783, NFE2L3 |
HPAi | ENSG00000050344, Tissue enhanced (brain, placenta) |
MIMi | 604135, gene |
neXtProti | NX_Q9Y4A8 |
OpenTargetsi | ENSG00000050344 |
PharmGKBi | PA31589 |
VEuPathDBi | HostDB:ENSG00000050344 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3863, Eukaryota |
GeneTreei | ENSGT00950000182892 |
HOGENOMi | CLU_024173_1_0_1 |
InParanoidi | Q9Y4A8 |
OMAi | LKRWWSA |
OrthoDBi | 1095280at2759 |
PhylomeDBi | Q9Y4A8 |
TreeFami | TF337360 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A8 |
SignaLinki | Q9Y4A8 |
Miscellaneous databases
BioGRID-ORCSi | 9603, 88 hits in 1100 CRISPR screens |
ChiTaRSi | NFE2L3, human |
GeneWikii | NFE2L3 |
GenomeRNAii | 9603 |
Pharosi | Q9Y4A8, Tbio |
PROi | PR:Q9Y4A8 |
RNActi | Q9Y4A8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000050344, Expressed in placenta and 168 other tissues |
ExpressionAtlasi | Q9Y4A8, baseline and differential |
Genevisiblei | Q9Y4A8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR004826, bZIP_Maf IPR046347, bZIP_sf IPR008917, TF_DNA-bd_sf |
Pfami | View protein in Pfam PF03131, bZIP_Maf, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NF2L3_HUMAN | |
Accessioni | Q9Y4A8Primary (citable) accession number: Q9Y4A8 Secondary accession number(s): Q6NUS0 Q9UQA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 7, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families