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UniProtKB - Q9Y4A5 (TRRAP_HUMAN)

Entry version 208 (25 May 2022)
Sequence version 3 (17 Oct 2006)
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Protein

Transformation/transcription domain-associated protein

Gene

TRRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity).

By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y4A5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-3214847, HATs acetylate histones
R-HSA-5689880, Ub-specific processing proteases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y4A5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y4A5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transformation/transcription domain-associated protein
Alternative name(s):
350/400 kDa PCAF-associated factor
Short name:
PAF350/400
STAF40
Tra1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRRAP
Synonyms:PAF400
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12347, TRRAP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603015, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y4A5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196367

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma.1 Publication
Developmental delay with or without dysmorphic facies and autism (DEDDFA)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant neurodevelopmental disorder apparent from infancy or early childhood. Some patients present with intellectual disability and renal, cardiac, genitourinary systems, as well as structural brain abnormalities. In some cases, the phenotype is less severe, has no systemic involvement and is characterized by autism spectrum disorder and/or intellectual disability, sometimes associated with epilepsy. Affected individuals manifest variable dysmorphic features.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082969805L → F in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562940289EnsemblClinVar.1
Natural variantiVAR_082970860F → L in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_082971893R → L in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829721031I → M in DEDDFA. 1 Publication1
Natural variantiVAR_0829731035R → Q in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829741037S → R in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829751043A → T in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562945106EnsemblClinVar.1
Natural variantiVAR_0829761104E → G in DEDDFA. 1 Publication1
Natural variantiVAR_0829771106E → K in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1584324956EnsemblClinVar.1
Natural variantiVAR_0829781111G → W in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829791159G → R in DEDDFA. 1 Publication1
Natural variantiVAR_0829801859R → C in DEDDFA. 1 Publication1
Natural variantiVAR_0829811866W → C in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562957576Ensembl.1
Natural variantiVAR_0829821866W → R in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562957569Ensembl.1
Natural variantiVAR_0829831883G → R in DEDDFA. 1 Publication1
Natural variantiVAR_0416631932P → L in DEDDFA; unknown pathological significance; also found in a colorectal adenocarcinoma sample; somatic mutation. 2 Publications1
Natural variantiVAR_0829842004R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562959030Ensembl.1
Natural variantiVAR_0829853757R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs987263983Ensembl.1
Deafness, autosomal dominant, 75 (DFNA75)1 Publication
The disease may be caused by variants affecting the gene represented in this entry.
Disease descriptionA form of non-syndromic deafness characterized by late-onset hearing loss that involves mid and high frequencies, and progresses to encompass all frequencies.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083794171R → C in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200157211EnsemblClinVar.1
Natural variantiVAR_083795394D → N in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554407965Ensembl.1

Keywords - Diseasei

Autism spectrum disorder, Deafness, Disease variant, Mental retardation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		8295

MalaCards human disease database

More...MalaCardsi		TRRAP
MIMi618454, phenotype
618778, phenotype

Open Targets

More...OpenTargetsi		ENSG00000196367

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37020

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y4A5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRRAP

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888512 – 3859Transformation/transcription domain-associated proteinAdd BLAST3858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei1628PhosphoserineCombined sources1
Modified residuei2051PhosphoserineCombined sources1
Modified residuei2077PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki2543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei3078N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y4A5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y4A5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y4A5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y4A5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y4A5

PeptideAtlas

More...PeptideAtlasi		Q9Y4A5

PRoteomics IDEntifications database

More...PRIDEi		Q9Y4A5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86142 [Q9Y4A5-1]
86143 [Q9Y4A5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y4A5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y4A5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y4A5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196367, Expressed in sural nerve and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y4A5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y4A5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196367, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MYC, E2F1 and E2F4 transcription factors.

Interacts directly with p53/TP53.

Interacts with GCN5L2.

Component of various HAT complexes.

Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP.

Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP.

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6.

Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.

Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes.

Interacts with NPAT. Interaction with TELO2 AND TTI1.

Component of a SWR1-like complex.

14 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113900, 205 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6802, SAGA complex, KAT2B variant
CPX-900, SAGA complex, KAT2A variant
CPX-903, TFTC histone acetylation complex
CPX-978, NuA4 histone acetyltransferase complex
CPX-989, PCAF histone acetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y4A5

Database of interacting proteins

More...DIPi		DIP-28149N

Protein interaction database and analysis system

More...IntActi		Q9Y4A5, 81 interactors

Molecular INTeraction database

More...MINTi		Q9Y4A5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352925

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y4A5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y4A5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2692 – 3275FATPROSITE-ProRule annotationAdd BLAST584
Domaini3500 – 3823PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST324
Domaini3827 – 3859FATCPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni491 – 541DisorderedSequence analysisAdd BLAST51
Regioni2010 – 2388Interaction with TP531 PublicationAdd BLAST379
Regioni2023 – 2044DisorderedSequence analysisAdd BLAST22
Regioni2543 – 2578DisorderedSequence analysisAdd BLAST36
Regioni3506 – 3512G-loopPROSITE-ProRule annotation7
Regioni3687 – 3695Catalytic loopPROSITE-ProRule annotation9
Regioni3707 – 3732Activation loopPROSITE-ProRule annotationAdd BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2047 – 2062Bipartite nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi491 – 525Pro residuesSequence analysisAdd BLAST35
Compositional biasi2028 – 2044Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0889, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017961

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y4A5

Database of Orthologous Groups

More...OrthoDBi		7189at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y4A5

TreeFam database of animal gene trees

More...TreeFami		TF106414

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR033317, TRA1/TRRAP

The PANTHER Classification System

More...PANTHERi		PTHR11139:SF1, PTHR11139:SF1, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02259, FAT, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 3 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y4A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE 
        60         70         80         90        100
NVTSSPQYST FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI 
       110        120        130        140        150
PTNEHLRPHT KNVLSVMFRF LETENEENVL ICLRIIIELH KQFRPPITQE 
       160        170        180        190        200
IHHFLDFVKQ IYKELPKVVN RYFENPQVIP ENTVPPPEMV GMITTIAVKV 
       210        220        230        240        250
NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK LNIHNVVAEF 
       260        270        280        290        300
VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE 
       310        320        330        340        350
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC 
       360        370        380        390        400
MDKLFDESIL IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ 
       410        420        430        440        450
LFAKNIDDES LPSSIQTMSC KLLLNLVDCI RSKSEQESGN GRDVLMRMLE 
       460        470        480        490        500
VFVLKFHTIA RYQLSAIFKK CKPQSELGAV EAALPGVPTA PAAPGPAPSP 
       510        520        530        540        550
APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT FQVTDCRSLV 
       560        570        580        590        600
KTLVCGVKTI TWGITSCKAP GEAQFIPNKQ LQPKETQIYI KLVKYAMQAL 
       610        620        630        640        650
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI 
       660        670        680        690        700
FQTTVPYMVE RISKNYALQI VANSFLANPT TSALFATILV EYLLDRLPEM 
       710        720        730        740        750
GSNVELSNLY LKLFKLVFGS VSLFAAENEQ MLKPHLHKIV NSSMELAQTA 
       760        770        780        790        800
KEPYNYFLLL RALFRSIGGG SHDLLYQEFL PLLPNLLQGL NMLQSGLHKQ 
       810        820        830        840        850
HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT LVSQGLRTLE 
       860        870        880        890        900
LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG 
       910        920        930        940        950
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL 
       960        970        980        990       1000
KSANTEPYYR RQAWEVIKCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN 
      1010       1020       1030       1040       1050
VIISHRYKAQ DTPARKTFEQ ALTGAFMSAV IKDLRPSALP FVASLIRHYT 
      1060       1070       1080       1090       1100
MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE ENGSKGMDPL VLIDAIAICM 
      1110       1120       1130       1140       1150
AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY IVERLCACCY 
      1160       1170       1180       1190       1200
EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN 
      1210       1220       1230       1240       1250
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VAAQEKSFHH VTHDLVREVT 
      1260       1270       1280       1290       1300
SPNSTVRKQA MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ 
      1310       1320       1330       1340       1350
PANAQIGLME GNTFCTTLQP RLFTMDLNVV EHKVFYTELL NLCEAEDSAL 
      1360       1370       1380       1390       1400
TKLPCYKSLP SLVPLRIAAL NALAACNYLP QSREKIIAAL FKALNSTNSE 
      1410       1420       1430       1440       1450
LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL TLNVVNRLTS 
      1460       1470       1480       1490       1500
VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESISECGRC 
      1510       1520       1530       1540       1550
PLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA 
      1560       1570       1580       1590       1600
GSPFREPLIK FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL 
      1610       1620       1630       1640       1650
RDVLAANPNR FITLLLPGGA QTAVRPGSPS TSTMRLDLQF QAIKIISIIV 
      1660       1670       1680       1690       1700
KNDDSWLASQ HSLVSQLRRV WVSENFQERH RKENMAATNW KEPKLLAYCL 
      1710       1720       1730       1740       1750
LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI PKNYSIAQKR 
      1760       1770       1780       1790       1800
ALFFRFVDFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE 
      1810       1820       1830       1840       1850
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN 
      1860       1870       1880       1890       1900
NKNRNSKLRR LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI 
      1910       1920       1930       1940       1950
VLQVFHSLLK AHAMEARAIV RQAMAILTPA VPARMEDGHQ MLTHWTRKII 
      1960       1970       1980       1990       2000
VEEGHTVPQL VHILHLIVQH FKVYYPVRHH LVQHMVSAMQ RLGFTPSVTI 
      2010       2020       2030       2040       2050
EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN SVSSSIKRGL 
      2060       2070       2080       2090       2100
SVDSAQEVKR FRTATGAISA VFGRSQSLPG ADSLLAKPID KQHTDTVVNF 
      2110       2120       2130       2140       2150
LIRVACQVND NTNTAGSPGE VLSRRCVNLL KTALRPDMWP KSELKLQWFD 
      2160       2170       2180       2190       2200
KLLMTVEQPN QVNYGNICTG LEVLSFLLTV LQSPAILSSF KPLQRGIAAC 
      2210       2220       2230       2240       2250
MTCGNTKVLR AVHSLLSRLM SIFPTEPSTS SVASKYEELE CLYAAVGKVI 
      2260       2270       2280       2290       2300
YEGLTNYEKA TNANPSQLFG TLMILKSACS NNPSYIDRLI SVFMRSLQKM 
      2310       2320       2330       2340       2350
VREHLNPQAA SGSTEATSGT SELVMLSLEL VKTRLAVMSM EMRKNFIQAI 
      2360       2370       2380       2390       2400
LTSLIEKSPD AKILRAVVKI VEEWVKNNSP MAANQTPTLR EKSILLVKMM 
      2410       2420       2430       2440       2450
TYIEKRFPED LELNAQFLDL VNYVYRDETL SGSELTAKLE PAFLSGLRCA 
      2460       2470       2480       2490       2500
QPLIRAKFFE VFDNSMKRRV YERLLYVTCS QNWEAMGNHF WIKQCIELLL 
      2510       2520       2530       2540       2550
AVCEKSTPIG TSCQGAMLPS ITNVINLADS HDRAAFAMVT HVKQEPRERE 
      2560       2570       2580       2590       2600
NSESKEEDVE IDIELAPGDQ TSTPKTKELS EKDIGNQLHM LTNRHDKFLD 
      2610       2620       2630       2640       2650
TLREVKTGAL LSAFVQLCHI STTLAEKTWV QLFPRLWKIL SDRQQHALAG 
      2660       2670       2680       2690       2700
EISPFLCSGS HQVQRDCQPS ALNCFVEAMS QCVPPIPIRP CVLKYLGKTH 
      2710       2720       2730       2740       2750
NLWFRSTLML EHQAFEKGLS LQIKPKQTTE FYEQESITPP QQEILDSLAE 
      2760       2770       2780       2790       2800
LYSLLQEEDM WAGLWQKRCK YSETATAIAY EQHGFFEQAQ ESYEKAMDKA 
      2810       2820       2830       2840       2850
KKEHERSNAS PAIFPEYQLW EDHWIRCSKE LNQWEALTEY GQSKGHINPY 
      2860       2870       2880       2890       2900
LVLECAWRVS NWTAMKEALV QVEVSCPKEM AWKVNMYRGY LAICHPEEQQ 
      2910       2920       2930       2940       2950
LSFIERLVEM ASSLAIREWR RLPHVVSHVH TPLLQAAQQI IELQEAAQIN 
      2960       2970       2980       2990       3000
AGLQPTNLGR NNSLHDMKTV VKTWRNRLPI VSDDLSHWSS IFMWRQHHYQ 
      3010       3020       3030       3040       3050
GKPTWSGMHS SSIVTAYENS SQHDPSSNNA MLGVHASASA IIQYGKIARK 
      3060       3070       3080       3090       3100
QGLVNVALDI LSRIHTIPTV PIVDCFQKIR QQVKCYLQLA GVMGKNECMQ 
      3110       3120       3130       3140       3150
GLEVIESTNL KYFTKEMTAE FYALKGMFLA QINKSEEANK AFSAAVQMHD 
      3160       3170       3180       3190       3200
VLVKAWAMWG DYLENIFVKE RQLHLGVSAI TCYLHACRHQ NESKSRKYLA 
      3210       3220       3230       3240       3250
KVLWLLSFDD DKNTLADAVD KYCIGVPPIQ WLAWIPQLLT CLVGSEGKLL 
      3260       3270       3280       3290       3300
LNLISQVGRV YPQAVYFPIR TLYLTLKIEQ RERYKSDPGP IRATAPMWRC 
      3310       3320       3330       3340       3350
SRIMHMQREL HPTLLSSLEG IVDQMVWFRE NWHEEVLRQL QQGLAKCYSV 
      3360       3370       3380       3390       3400
AFEKSGAVSD AKITPHTLNF VKKLVSTFGV GLENVSNVST MFSSAASESL 
      3410       3420       3430       3440       3450
ARRAQATAQD PVFQKLKGQF TTDFDFSVPG SMKLHNLISK LKKWIKILEA 
      3460       3470       3480       3490       3500
KTKQLPKFFL IEEKCRFLSN FSAQTAEVEI PGEFLMPKPT HYYIKIARFM 
      3510       3520       3530       3540       3550
PRVEIVQKHN TAARRLYIRG HNGKIYPYLV MNDACLTESR REERVLQLLR 
      3560       3570       3580       3590       3600
LLNPCLEKRK ETTKRHLFFT VPRVVAVSPQ MRLVEDNPSS LSLVEIYKQR 
      3610       3620       3630       3640       3650
CAKKGIEHDN PISRYYDRLA TVQARGTQAS HQVLRDILKE VQSNMVPRSM 
      3660       3670       3680       3690       3700
LKEWALHTFP NATDYWTFRK MFTIQLALIG FAEFVLHLNR LNPEMLQIAQ 
      3710       3720       3730       3740       3750
DTGKLNVAYF RFDINDATGD LDANRPVPFR LTPNISEFLT TIGVSGPLTA 
      3760       3770       3780       3790       3800
SMIAVARCFA QPNFKVDGIL KTVLRDEIIA WHKKTQEDTS SPLSAAGQPE 
      3810       3820       3830       3840       3850
NMDSQQLVSL VQKAVTAIMT RLHNLAQFEG GESKVNTLVA AANSLDNLCR 

MDPAWHPWL
Length:3,859
Mass (Da):437,600
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i391E467C0047B00B
GO
Isoform 2 (identifier: Q9Y4A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1492-1509: Missing.
     3001-3012: GKPTWSGMHSSS → A

Show »
Length:3,830
Mass (Da):434,414
Checksum:i5740D4E21629560B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2U4F2Z2U4_HUMAN
Transformation/transcription domain...
TRRAP
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4W2H0Y4W2_HUMAN
Transformation/transcription domain...
TRRAP
3,873Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFJ4A0A2R8YFJ4_HUMAN
Transformation/transcription domain...
TRRAP
1,344Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0N1C9K0N1_HUMAN
Transformation/transcription domain...
TRRAP
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC62433 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti660E → D in AAD04629 (PubMed:9885574).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083794171R → C in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200157211EnsemblClinVar.1
Natural variantiVAR_083795394D → N in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554407965Ensembl.1
Natural variantiVAR_067754722S → F Found in a cutaneous malignant melanoma sample; somatic mutation; induces cell transformation and confers resistance to apoptosis. 1 PublicationCorresponds to variant dbSNP:rs147405090Ensembl.1
Natural variantiVAR_082969805L → F in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562940289EnsemblClinVar.1
Natural variantiVAR_082970860F → L in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_028359878R → L. Corresponds to variant dbSNP:rs17161510Ensembl.1
Natural variantiVAR_041658893R → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_082971893R → L in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829721031I → M in DEDDFA. 1 Publication1
Natural variantiVAR_0829731035R → Q in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829741037S → R in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829751043A → T in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562945106EnsemblClinVar.1
Natural variantiVAR_0416591070S → G1 PublicationCorresponds to variant dbSNP:rs55920979Ensembl.1
Natural variantiVAR_0829761104E → G in DEDDFA. 1 Publication1
Natural variantiVAR_0829771106E → K in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1584324956EnsemblClinVar.1
Natural variantiVAR_0829781111G → W in DEDDFA; unknown pathological significance. 1 Publication1
Natural variantiVAR_0829791159G → R in DEDDFA. 1 Publication1
Natural variantiVAR_0416601669R → H in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373632999Ensembl.1
Natural variantiVAR_0416611724R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs782203759Ensembl.1
Natural variantiVAR_0829801859R → C in DEDDFA. 1 Publication1
Natural variantiVAR_0829811866W → C in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562957576Ensembl.1
Natural variantiVAR_0829821866W → R in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562957569Ensembl.1
Natural variantiVAR_0829831883G → R in DEDDFA. 1 Publication1
Natural variantiVAR_0416621925A → V1 PublicationCorresponds to variant dbSNP:rs56197298Ensembl.1
Natural variantiVAR_0416631932P → L in DEDDFA; unknown pathological significance; also found in a colorectal adenocarcinoma sample; somatic mutation. 2 Publications1
Natural variantiVAR_0416641947R → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0829842004R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562959030Ensembl.1
Natural variantiVAR_0416652139W → G1 PublicationCorresponds to variant dbSNP:rs34185633Ensembl.1
Natural variantiVAR_0416662302R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs528967912Ensembl.1
Natural variantiVAR_0416672433S → G1 PublicationCorresponds to variant dbSNP:rs35634065Ensembl.1
Natural variantiVAR_0416682690P → L in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs753661271Ensembl.1
Natural variantiVAR_0416692750E → D2 PublicationsCorresponds to variant dbSNP:rs55755466Ensembl.1
Natural variantiVAR_0416702801K → E1 PublicationCorresponds to variant dbSNP:rs56341061Ensembl.1
Natural variantiVAR_0416712931T → M in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1294404368Ensembl.1
Natural variantiVAR_0829853757R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs987263983Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0091021492 – 1509Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0091033001 – 3012GKPTW…MHSSS → A in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF076974 mRNA Translation: AAD09420.1
AF110377 mRNA Translation: AAD04629.1
AC004893 Genomic DNA Translation: AAC62433.1 Sequence problems.
AC004991 Genomic DNA Translation: AAC27675.2
CH471091 Genomic DNA Translation: EAW76694.1
CH236956 Genomic DNA Translation: EAL23887.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5659.1 [Q9Y4A5-2]
CCDS59066.1 [Q9Y4A5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T02632

NCBI Reference Sequences

More...RefSeqi		NP_001231509.1, NM_001244580.1 [Q9Y4A5-1]
NP_003487.1, NM_003496.3 [Q9Y4A5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355540.7; ENSP00000347733.3; ENSG00000196367.14 [Q9Y4A5-2]
ENST00000359863.8; ENSP00000352925.4; ENSG00000196367.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8295

UCSC genome browser

More...UCSCi		uc003upp.3, human [Q9Y4A5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076974 mRNA Translation: AAD09420.1
AF110377 mRNA Translation: AAD04629.1
AC004893 Genomic DNA Translation: AAC62433.1 Sequence problems.
AC004991 Genomic DNA Translation: AAC27675.2
CH471091 Genomic DNA Translation: EAW76694.1
CH236956 Genomic DNA Translation: EAL23887.1
CCDSiCCDS5659.1 [Q9Y4A5-2]
CCDS59066.1 [Q9Y4A5-1]
PIRiT02632
RefSeqiNP_001231509.1, NM_001244580.1 [Q9Y4A5-1]
NP_003487.1, NM_003496.3 [Q9Y4A5-2]

3D structure databases

SMRiQ9Y4A5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113900, 205 interactors
ComplexPortaliCPX-6802, SAGA complex, KAT2B variant
CPX-900, SAGA complex, KAT2A variant
CPX-903, TFTC histone acetylation complex
CPX-978, NuA4 histone acetyltransferase complex
CPX-989, PCAF histone acetylase complex
CORUMiQ9Y4A5
DIPiDIP-28149N
IntActiQ9Y4A5, 81 interactors
MINTiQ9Y4A5
STRINGi9606.ENSP00000352925

PTM databases

iPTMnetiQ9Y4A5
MetOSiteiQ9Y4A5
PhosphoSitePlusiQ9Y4A5

Genetic variation databases

BioMutaiTRRAP
DMDMi116242829

Proteomic databases

EPDiQ9Y4A5
jPOSTiQ9Y4A5
MassIVEiQ9Y4A5
MaxQBiQ9Y4A5
PaxDbiQ9Y4A5
PeptideAtlasiQ9Y4A5
PRIDEiQ9Y4A5
ProteomicsDBi86142 [Q9Y4A5-1]
86143 [Q9Y4A5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16027, 182 antibodies from 23 providers

The DNASU plasmid repository

More...DNASUi		8295

Genome annotation databases

EnsembliENST00000355540.7; ENSP00000347733.3; ENSG00000196367.14 [Q9Y4A5-2]
ENST00000359863.8; ENSP00000352925.4; ENSG00000196367.14
GeneIDi8295
KEGGihsa:8295
UCSCiuc003upp.3, human [Q9Y4A5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8295
DisGeNETi8295

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRRAP
HGNCiHGNC:12347, TRRAP
HPAiENSG00000196367, Low tissue specificity
MalaCardsiTRRAP
MIMi603015, gene
618454, phenotype
618778, phenotype
neXtProtiNX_Q9Y4A5
OpenTargetsiENSG00000196367
Orphaneti90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA37020
VEuPathDBiHostDB:ENSG00000196367

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0889, Eukaryota
GeneTreeiENSGT00390000017961
InParanoidiQ9Y4A5
OrthoDBi7189at2759
PhylomeDBiQ9Y4A5
TreeFamiTF106414

Enzyme and pathway databases

PathwayCommonsiQ9Y4A5
ReactomeiR-HSA-201722, Formation of the beta-catenin:TCF transactivating complex
R-HSA-3214847, HATs acetylate histones
R-HSA-5689880, Ub-specific processing proteases
SignaLinkiQ9Y4A5
SIGNORiQ9Y4A5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8295, 742 hits in 1119 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRRAP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8295
PharosiQ9Y4A5, Tbio

Protein Ontology

More...PROi		PR:Q9Y4A5
RNActiQ9Y4A5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196367, Expressed in sural nerve and 197 other tissues
ExpressionAtlasiQ9Y4A5, baseline and differential
GenevisibleiQ9Y4A5, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR033317, TRA1/TRRAP
PANTHERiPTHR11139:SF1, PTHR11139:SF1, 2 hits
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 3 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRRAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y4A5
Secondary accession number(s): A4D265
, O75218, Q9Y631, Q9Y6H4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 17, 2006
Last modified: May 25, 2022
This is version 208 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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