UniProtKB - Q9Y4A5 (TRRAP_HUMAN)
Transformation/transcription domain-associated protein
TRRAP
Functioni
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. May play a role in the formation and maintenance of the auditory system (By similarity).
By similarity8 PublicationsGO - Molecular functioni
- transcription coregulator activity Source: UniProtKB
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- DNA repair Source: GO_Central
- histone acetylation Source: UniProtKB
- histone deubiquitination Source: UniProtKB
- histone H2A acetylation Source: UniProtKB
- histone H3 acetylation Source: ComplexPortal
- histone H4 acetylation Source: UniProtKB
- monoubiquitinated histone deubiquitination Source: ComplexPortal
- monoubiquitinated histone H2A deubiquitination Source: ComplexPortal
- positive regulation of double-strand break repair via homologous recombination Source: ComplexPortal
- positive regulation of transcription, DNA-templated Source: ComplexPortal
- regulation of apoptotic process Source: ComplexPortal
- regulation of cell cycle Source: ComplexPortal
- regulation of DNA repair Source: ComplexPortal
- regulation of double-strand break repair Source: ComplexPortal
- regulation of RNA splicing Source: ComplexPortal
- regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: ComplexPortal
Keywordsi
Molecular function | Activator, Chromatin regulator |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A5 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3214847, HATs acetylate histones R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q9Y4A5 |
SIGNORi | Q9Y4A5 |
Names & Taxonomyi
Protein namesi | Recommended name: Transformation/transcription domain-associated proteinAlternative name(s): 350/400 kDa PCAF-associated factor Short name: PAF350/400 STAF40 Tra1 homolog |
Gene namesi | Name:TRRAP Synonyms:PAF400 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12347, TRRAP |
MIMi | 603015, gene |
neXtProti | NX_Q9Y4A5 |
VEuPathDBi | HostDB:ENSG00000196367 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- NuA4 histone acetyltransferase complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- SAGA complex Source: UniProtKB
- Swr1 complex Source: UniProtKB
- transcription factor TFTC complex Source: UniProtKB
Other locations
- nucleosome Source: ComplexPortal
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Developmental delay with or without dysmorphic facies and autism (DEDDFA)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082969 | 805 | L → F in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562940289EnsemblClinVar. | 1 | |
Natural variantiVAR_082970 | 860 | F → L in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082971 | 893 | R → L in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082972 | 1031 | I → M in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082973 | 1035 | R → Q in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082974 | 1037 | S → R in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082975 | 1043 | A → T in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562945106EnsemblClinVar. | 1 | |
Natural variantiVAR_082976 | 1104 | E → G in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082977 | 1106 | E → K in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1584324956EnsemblClinVar. | 1 | |
Natural variantiVAR_082978 | 1111 | G → W in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082979 | 1159 | G → R in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082980 | 1859 | R → C in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082981 | 1866 | W → C in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562957576Ensembl. | 1 | |
Natural variantiVAR_082982 | 1866 | W → R in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562957569Ensembl. | 1 | |
Natural variantiVAR_082983 | 1883 | G → R in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_041663 | 1932 | P → L in DEDDFA; unknown pathological significance; also found in a colorectal adenocarcinoma sample; somatic mutation. 2 Publications | 1 | |
Natural variantiVAR_082984 | 2004 | R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562959030Ensembl. | 1 | |
Natural variantiVAR_082985 | 3757 | R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs987263983Ensembl. | 1 |
Deafness, autosomal dominant, 75 (DFNA75)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083794 | 171 | R → C in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200157211EnsemblClinVar. | 1 | |
Natural variantiVAR_083795 | 394 | D → N in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554407965Ensembl. | 1 |
Keywords - Diseasei
Autism spectrum disorder, Deafness, Disease variant, Mental retardation, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 8295 |
MalaCardsi | TRRAP |
MIMi | 618454, phenotype 618778, phenotype |
OpenTargetsi | ENSG00000196367 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA |
PharmGKBi | PA37020 |
Miscellaneous databases
Pharosi | Q9Y4A5, Tbio |
Genetic variation databases
BioMutai | TRRAP |
DMDMi | 116242829 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000088851 | 2 – 3859 | Transformation/transcription domain-associated proteinAdd BLAST | 3858 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 1628 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2051 | PhosphoserineCombined sources | 1 | |
Modified residuei | 2077 | PhosphoserineCombined sources | 1 | |
Cross-linki | 2543 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 3078 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y4A5 |
jPOSTi | Q9Y4A5 |
MassIVEi | Q9Y4A5 |
MaxQBi | Q9Y4A5 |
PaxDbi | Q9Y4A5 |
PeptideAtlasi | Q9Y4A5 |
PRIDEi | Q9Y4A5 |
ProteomicsDBi | 86142 [Q9Y4A5-1] 86143 [Q9Y4A5-2] |
PTM databases
iPTMneti | Q9Y4A5 |
MetOSitei | Q9Y4A5 |
PhosphoSitePlusi | Q9Y4A5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196367, Expressed in sural nerve and 197 other tissues |
ExpressionAtlasi | Q9Y4A5, baseline and differential |
Genevisiblei | Q9Y4A5, HS |
Organism-specific databases
HPAi | ENSG00000196367, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MYC, E2F1 and E2F4 transcription factors.
Interacts directly with p53/TP53.
Interacts with GCN5L2.
Component of various HAT complexes.
Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP.
Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP.
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6.
Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.
Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes.
Interacts with NPAT. Interaction with TELO2 AND TTI1.
Component of a SWR1-like complex.
14 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 113900, 205 interactors |
ComplexPortali | CPX-6802, SAGA complex, KAT2B variant CPX-900, SAGA complex, KAT2A variant CPX-903, TFTC histone acetylation complex CPX-978, NuA4 histone acetyltransferase complex CPX-989, PCAF histone acetylase complex |
CORUMi | Q9Y4A5 |
DIPi | DIP-28149N |
IntActi | Q9Y4A5, 81 interactors |
MINTi | Q9Y4A5 |
STRINGi | 9606.ENSP00000352925 |
Miscellaneous databases
RNActi | Q9Y4A5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2692 – 3275 | FATPROSITE-ProRule annotationAdd BLAST | 584 | |
Domaini | 3500 – 3823 | PI3K/PI4K catalyticPROSITE-ProRule annotationAdd BLAST | 324 | |
Domaini | 3827 – 3859 | FATCPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 491 – 541 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 2010 – 2388 | Interaction with TP531 PublicationAdd BLAST | 379 | |
Regioni | 2023 – 2044 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 2543 – 2578 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 3506 – 3512 | G-loopPROSITE-ProRule annotation | 7 | |
Regioni | 3687 – 3695 | Catalytic loopPROSITE-ProRule annotation | 9 | |
Regioni | 3707 – 3732 | Activation loopPROSITE-ProRule annotationAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2047 – 2062 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 491 – 525 | Pro residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 2028 – 2044 | Polar residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0889, Eukaryota |
GeneTreei | ENSGT00390000017961 |
InParanoidi | Q9Y4A5 |
OrthoDBi | 7189at2759 |
PhylomeDBi | Q9Y4A5 |
TreeFami | TF106414 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR033317, TRA1/TRRAP |
PANTHERi | PTHR11139:SF1, PTHR11139:SF1, 2 hits |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE
60 70 80 90 100
NVTSSPQYST FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI
110 120 130 140 150
PTNEHLRPHT KNVLSVMFRF LETENEENVL ICLRIIIELH KQFRPPITQE
160 170 180 190 200
IHHFLDFVKQ IYKELPKVVN RYFENPQVIP ENTVPPPEMV GMITTIAVKV
210 220 230 240 250
NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK LNIHNVVAEF
260 270 280 290 300
VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE
310 320 330 340 350
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC
360 370 380 390 400
MDKLFDESIL IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ
410 420 430 440 450
LFAKNIDDES LPSSIQTMSC KLLLNLVDCI RSKSEQESGN GRDVLMRMLE
460 470 480 490 500
VFVLKFHTIA RYQLSAIFKK CKPQSELGAV EAALPGVPTA PAAPGPAPSP
510 520 530 540 550
APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT FQVTDCRSLV
560 570 580 590 600
KTLVCGVKTI TWGITSCKAP GEAQFIPNKQ LQPKETQIYI KLVKYAMQAL
610 620 630 640 650
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI
660 670 680 690 700
FQTTVPYMVE RISKNYALQI VANSFLANPT TSALFATILV EYLLDRLPEM
710 720 730 740 750
GSNVELSNLY LKLFKLVFGS VSLFAAENEQ MLKPHLHKIV NSSMELAQTA
760 770 780 790 800
KEPYNYFLLL RALFRSIGGG SHDLLYQEFL PLLPNLLQGL NMLQSGLHKQ
810 820 830 840 850
HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT LVSQGLRTLE
860 870 880 890 900
LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG
910 920 930 940 950
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL
960 970 980 990 1000
KSANTEPYYR RQAWEVIKCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN
1010 1020 1030 1040 1050
VIISHRYKAQ DTPARKTFEQ ALTGAFMSAV IKDLRPSALP FVASLIRHYT
1060 1070 1080 1090 1100
MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE ENGSKGMDPL VLIDAIAICM
1110 1120 1130 1140 1150
AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY IVERLCACCY
1160 1170 1180 1190 1200
EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN
1210 1220 1230 1240 1250
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VAAQEKSFHH VTHDLVREVT
1260 1270 1280 1290 1300
SPNSTVRKQA MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ
1310 1320 1330 1340 1350
PANAQIGLME GNTFCTTLQP RLFTMDLNVV EHKVFYTELL NLCEAEDSAL
1360 1370 1380 1390 1400
TKLPCYKSLP SLVPLRIAAL NALAACNYLP QSREKIIAAL FKALNSTNSE
1410 1420 1430 1440 1450
LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL TLNVVNRLTS
1460 1470 1480 1490 1500
VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESISECGRC
1510 1520 1530 1540 1550
PLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA
1560 1570 1580 1590 1600
GSPFREPLIK FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL
1610 1620 1630 1640 1650
RDVLAANPNR FITLLLPGGA QTAVRPGSPS TSTMRLDLQF QAIKIISIIV
1660 1670 1680 1690 1700
KNDDSWLASQ HSLVSQLRRV WVSENFQERH RKENMAATNW KEPKLLAYCL
1710 1720 1730 1740 1750
LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI PKNYSIAQKR
1760 1770 1780 1790 1800
ALFFRFVDFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE
1810 1820 1830 1840 1850
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN
1860 1870 1880 1890 1900
NKNRNSKLRR LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI
1910 1920 1930 1940 1950
VLQVFHSLLK AHAMEARAIV RQAMAILTPA VPARMEDGHQ MLTHWTRKII
1960 1970 1980 1990 2000
VEEGHTVPQL VHILHLIVQH FKVYYPVRHH LVQHMVSAMQ RLGFTPSVTI
2010 2020 2030 2040 2050
EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN SVSSSIKRGL
2060 2070 2080 2090 2100
SVDSAQEVKR FRTATGAISA VFGRSQSLPG ADSLLAKPID KQHTDTVVNF
2110 2120 2130 2140 2150
LIRVACQVND NTNTAGSPGE VLSRRCVNLL KTALRPDMWP KSELKLQWFD
2160 2170 2180 2190 2200
KLLMTVEQPN QVNYGNICTG LEVLSFLLTV LQSPAILSSF KPLQRGIAAC
2210 2220 2230 2240 2250
MTCGNTKVLR AVHSLLSRLM SIFPTEPSTS SVASKYEELE CLYAAVGKVI
2260 2270 2280 2290 2300
YEGLTNYEKA TNANPSQLFG TLMILKSACS NNPSYIDRLI SVFMRSLQKM
2310 2320 2330 2340 2350
VREHLNPQAA SGSTEATSGT SELVMLSLEL VKTRLAVMSM EMRKNFIQAI
2360 2370 2380 2390 2400
LTSLIEKSPD AKILRAVVKI VEEWVKNNSP MAANQTPTLR EKSILLVKMM
2410 2420 2430 2440 2450
TYIEKRFPED LELNAQFLDL VNYVYRDETL SGSELTAKLE PAFLSGLRCA
2460 2470 2480 2490 2500
QPLIRAKFFE VFDNSMKRRV YERLLYVTCS QNWEAMGNHF WIKQCIELLL
2510 2520 2530 2540 2550
AVCEKSTPIG TSCQGAMLPS ITNVINLADS HDRAAFAMVT HVKQEPRERE
2560 2570 2580 2590 2600
NSESKEEDVE IDIELAPGDQ TSTPKTKELS EKDIGNQLHM LTNRHDKFLD
2610 2620 2630 2640 2650
TLREVKTGAL LSAFVQLCHI STTLAEKTWV QLFPRLWKIL SDRQQHALAG
2660 2670 2680 2690 2700
EISPFLCSGS HQVQRDCQPS ALNCFVEAMS QCVPPIPIRP CVLKYLGKTH
2710 2720 2730 2740 2750
NLWFRSTLML EHQAFEKGLS LQIKPKQTTE FYEQESITPP QQEILDSLAE
2760 2770 2780 2790 2800
LYSLLQEEDM WAGLWQKRCK YSETATAIAY EQHGFFEQAQ ESYEKAMDKA
2810 2820 2830 2840 2850
KKEHERSNAS PAIFPEYQLW EDHWIRCSKE LNQWEALTEY GQSKGHINPY
2860 2870 2880 2890 2900
LVLECAWRVS NWTAMKEALV QVEVSCPKEM AWKVNMYRGY LAICHPEEQQ
2910 2920 2930 2940 2950
LSFIERLVEM ASSLAIREWR RLPHVVSHVH TPLLQAAQQI IELQEAAQIN
2960 2970 2980 2990 3000
AGLQPTNLGR NNSLHDMKTV VKTWRNRLPI VSDDLSHWSS IFMWRQHHYQ
3010 3020 3030 3040 3050
GKPTWSGMHS SSIVTAYENS SQHDPSSNNA MLGVHASASA IIQYGKIARK
3060 3070 3080 3090 3100
QGLVNVALDI LSRIHTIPTV PIVDCFQKIR QQVKCYLQLA GVMGKNECMQ
3110 3120 3130 3140 3150
GLEVIESTNL KYFTKEMTAE FYALKGMFLA QINKSEEANK AFSAAVQMHD
3160 3170 3180 3190 3200
VLVKAWAMWG DYLENIFVKE RQLHLGVSAI TCYLHACRHQ NESKSRKYLA
3210 3220 3230 3240 3250
KVLWLLSFDD DKNTLADAVD KYCIGVPPIQ WLAWIPQLLT CLVGSEGKLL
3260 3270 3280 3290 3300
LNLISQVGRV YPQAVYFPIR TLYLTLKIEQ RERYKSDPGP IRATAPMWRC
3310 3320 3330 3340 3350
SRIMHMQREL HPTLLSSLEG IVDQMVWFRE NWHEEVLRQL QQGLAKCYSV
3360 3370 3380 3390 3400
AFEKSGAVSD AKITPHTLNF VKKLVSTFGV GLENVSNVST MFSSAASESL
3410 3420 3430 3440 3450
ARRAQATAQD PVFQKLKGQF TTDFDFSVPG SMKLHNLISK LKKWIKILEA
3460 3470 3480 3490 3500
KTKQLPKFFL IEEKCRFLSN FSAQTAEVEI PGEFLMPKPT HYYIKIARFM
3510 3520 3530 3540 3550
PRVEIVQKHN TAARRLYIRG HNGKIYPYLV MNDACLTESR REERVLQLLR
3560 3570 3580 3590 3600
LLNPCLEKRK ETTKRHLFFT VPRVVAVSPQ MRLVEDNPSS LSLVEIYKQR
3610 3620 3630 3640 3650
CAKKGIEHDN PISRYYDRLA TVQARGTQAS HQVLRDILKE VQSNMVPRSM
3660 3670 3680 3690 3700
LKEWALHTFP NATDYWTFRK MFTIQLALIG FAEFVLHLNR LNPEMLQIAQ
3710 3720 3730 3740 3750
DTGKLNVAYF RFDINDATGD LDANRPVPFR LTPNISEFLT TIGVSGPLTA
3760 3770 3780 3790 3800
SMIAVARCFA QPNFKVDGIL KTVLRDEIIA WHKKTQEDTS SPLSAAGQPE
3810 3820 3830 3840 3850
NMDSQQLVSL VQKAVTAIMT RLHNLAQFEG GESKVNTLVA AANSLDNLCR
MDPAWHPWL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF2Z2U4 | F2Z2U4_HUMAN | Transformation/transcription domain... | TRRAP | 3,848 | Annotation score: | ||
H0Y4W2 | H0Y4W2_HUMAN | Transformation/transcription domain... | TRRAP | 3,873 | Annotation score: | ||
A0A2R8YFJ4 | A0A2R8YFJ4_HUMAN | Transformation/transcription domain... | TRRAP | 1,344 | Annotation score: | ||
C9K0N1 | C9K0N1_HUMAN | Transformation/transcription domain... | TRRAP | 71 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 660 | E → D in AAD04629 (PubMed:9885574).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_083794 | 171 | R → C in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200157211EnsemblClinVar. | 1 | |
Natural variantiVAR_083795 | 394 | D → N in DFNA75; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1554407965Ensembl. | 1 | |
Natural variantiVAR_067754 | 722 | S → F Found in a cutaneous malignant melanoma sample; somatic mutation; induces cell transformation and confers resistance to apoptosis. 1 PublicationCorresponds to variant dbSNP:rs147405090Ensembl. | 1 | |
Natural variantiVAR_082969 | 805 | L → F in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562940289EnsemblClinVar. | 1 | |
Natural variantiVAR_082970 | 860 | F → L in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_028359 | 878 | R → L. Corresponds to variant dbSNP:rs17161510Ensembl. | 1 | |
Natural variantiVAR_041658 | 893 | R → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_082971 | 893 | R → L in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082972 | 1031 | I → M in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082973 | 1035 | R → Q in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082974 | 1037 | S → R in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082975 | 1043 | A → T in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562945106EnsemblClinVar. | 1 | |
Natural variantiVAR_041659 | 1070 | S → G1 PublicationCorresponds to variant dbSNP:rs55920979Ensembl. | 1 | |
Natural variantiVAR_082976 | 1104 | E → G in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082977 | 1106 | E → K in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1584324956EnsemblClinVar. | 1 | |
Natural variantiVAR_082978 | 1111 | G → W in DEDDFA; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_082979 | 1159 | G → R in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_041660 | 1669 | R → H in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373632999Ensembl. | 1 | |
Natural variantiVAR_041661 | 1724 | R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs782203759Ensembl. | 1 | |
Natural variantiVAR_082980 | 1859 | R → C in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_082981 | 1866 | W → C in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562957576Ensembl. | 1 | |
Natural variantiVAR_082982 | 1866 | W → R in DEDDFA. 1 PublicationCorresponds to variant dbSNP:rs1562957569Ensembl. | 1 | |
Natural variantiVAR_082983 | 1883 | G → R in DEDDFA. 1 Publication | 1 | |
Natural variantiVAR_041662 | 1925 | A → V1 PublicationCorresponds to variant dbSNP:rs56197298Ensembl. | 1 | |
Natural variantiVAR_041663 | 1932 | P → L in DEDDFA; unknown pathological significance; also found in a colorectal adenocarcinoma sample; somatic mutation. 2 Publications | 1 | |
Natural variantiVAR_041664 | 1947 | R → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_082984 | 2004 | R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1562959030Ensembl. | 1 | |
Natural variantiVAR_041665 | 2139 | W → G1 PublicationCorresponds to variant dbSNP:rs34185633Ensembl. | 1 | |
Natural variantiVAR_041666 | 2302 | R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs528967912Ensembl. | 1 | |
Natural variantiVAR_041667 | 2433 | S → G1 PublicationCorresponds to variant dbSNP:rs35634065Ensembl. | 1 | |
Natural variantiVAR_041668 | 2690 | P → L in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs753661271Ensembl. | 1 | |
Natural variantiVAR_041669 | 2750 | E → D2 PublicationsCorresponds to variant dbSNP:rs55755466Ensembl. | 1 | |
Natural variantiVAR_041670 | 2801 | K → E1 PublicationCorresponds to variant dbSNP:rs56341061Ensembl. | 1 | |
Natural variantiVAR_041671 | 2931 | T → M in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1294404368Ensembl. | 1 | |
Natural variantiVAR_082985 | 3757 | R → Q in DEDDFA; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs987263983Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009102 | 1492 – 1509 | Missing in isoform 2. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_009103 | 3001 – 3012 | GKPTW…MHSSS → A in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076974 mRNA Translation: AAD09420.1 AF110377 mRNA Translation: AAD04629.1 AC004893 Genomic DNA Translation: AAC62433.1 Sequence problems. AC004991 Genomic DNA Translation: AAC27675.2 CH471091 Genomic DNA Translation: EAW76694.1 CH236956 Genomic DNA Translation: EAL23887.1 |
CCDSi | CCDS5659.1 [Q9Y4A5-2] CCDS59066.1 [Q9Y4A5-1] |
PIRi | T02632 |
RefSeqi | NP_001231509.1, NM_001244580.1 [Q9Y4A5-1] NP_003487.1, NM_003496.3 [Q9Y4A5-2] |
Genome annotation databases
Ensembli | ENST00000355540.7; ENSP00000347733.3; ENSG00000196367.14 [Q9Y4A5-2] ENST00000359863.8; ENSP00000352925.4; ENSG00000196367.14 |
GeneIDi | 8295 |
KEGGi | hsa:8295 |
UCSCi | uc003upp.3, human [Q9Y4A5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF076974 mRNA Translation: AAD09420.1 AF110377 mRNA Translation: AAD04629.1 AC004893 Genomic DNA Translation: AAC62433.1 Sequence problems. AC004991 Genomic DNA Translation: AAC27675.2 CH471091 Genomic DNA Translation: EAW76694.1 CH236956 Genomic DNA Translation: EAL23887.1 |
CCDSi | CCDS5659.1 [Q9Y4A5-2] CCDS59066.1 [Q9Y4A5-1] |
PIRi | T02632 |
RefSeqi | NP_001231509.1, NM_001244580.1 [Q9Y4A5-1] NP_003487.1, NM_003496.3 [Q9Y4A5-2] |
3D structure databases
SMRi | Q9Y4A5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113900, 205 interactors |
ComplexPortali | CPX-6802, SAGA complex, KAT2B variant CPX-900, SAGA complex, KAT2A variant CPX-903, TFTC histone acetylation complex CPX-978, NuA4 histone acetyltransferase complex CPX-989, PCAF histone acetylase complex |
CORUMi | Q9Y4A5 |
DIPi | DIP-28149N |
IntActi | Q9Y4A5, 81 interactors |
MINTi | Q9Y4A5 |
STRINGi | 9606.ENSP00000352925 |
PTM databases
iPTMneti | Q9Y4A5 |
MetOSitei | Q9Y4A5 |
PhosphoSitePlusi | Q9Y4A5 |
Genetic variation databases
BioMutai | TRRAP |
DMDMi | 116242829 |
Proteomic databases
EPDi | Q9Y4A5 |
jPOSTi | Q9Y4A5 |
MassIVEi | Q9Y4A5 |
MaxQBi | Q9Y4A5 |
PaxDbi | Q9Y4A5 |
PeptideAtlasi | Q9Y4A5 |
PRIDEi | Q9Y4A5 |
ProteomicsDBi | 86142 [Q9Y4A5-1] 86143 [Q9Y4A5-2] |
Protocols and materials databases
Antibodypediai | 16027, 182 antibodies from 23 providers |
DNASUi | 8295 |
Genome annotation databases
Ensembli | ENST00000355540.7; ENSP00000347733.3; ENSG00000196367.14 [Q9Y4A5-2] ENST00000359863.8; ENSP00000352925.4; ENSG00000196367.14 |
GeneIDi | 8295 |
KEGGi | hsa:8295 |
UCSCi | uc003upp.3, human [Q9Y4A5-1] |
Organism-specific databases
CTDi | 8295 |
DisGeNETi | 8295 |
GeneCardsi | TRRAP |
HGNCi | HGNC:12347, TRRAP |
HPAi | ENSG00000196367, Low tissue specificity |
MalaCardsi | TRRAP |
MIMi | 603015, gene 618454, phenotype 618778, phenotype |
neXtProti | NX_Q9Y4A5 |
OpenTargetsi | ENSG00000196367 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA |
PharmGKBi | PA37020 |
VEuPathDBi | HostDB:ENSG00000196367 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0889, Eukaryota |
GeneTreei | ENSGT00390000017961 |
InParanoidi | Q9Y4A5 |
OrthoDBi | 7189at2759 |
PhylomeDBi | Q9Y4A5 |
TreeFami | TF106414 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A5 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3214847, HATs acetylate histones R-HSA-5689880, Ub-specific processing proteases |
SignaLinki | Q9Y4A5 |
SIGNORi | Q9Y4A5 |
Miscellaneous databases
BioGRID-ORCSi | 8295, 742 hits in 1119 CRISPR screens |
ChiTaRSi | TRRAP, human |
GenomeRNAii | 8295 |
Pharosi | Q9Y4A5, Tbio |
PROi | PR:Q9Y4A5 |
RNActi | Q9Y4A5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196367, Expressed in sural nerve and 197 other tissues |
ExpressionAtlasi | Q9Y4A5, baseline and differential |
Genevisiblei | Q9Y4A5, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR003152, FATC_dom IPR011009, Kinase-like_dom_sf IPR000403, PI3/4_kinase_cat_dom IPR003151, PIK-rel_kinase_FAT IPR014009, PIK_FAT IPR033317, TRA1/TRRAP |
PANTHERi | PTHR11139:SF1, PTHR11139:SF1, 2 hits |
Pfami | View protein in Pfam PF02259, FAT, 1 hit PF00454, PI3_PI4_kinase, 1 hit |
SMARTi | View protein in SMART SM01343, FATC, 1 hit SM00146, PI3Kc, 1 hit |
SUPFAMi | SSF48371, SSF48371, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51189, FAT, 1 hit PS51190, FATC, 1 hit PS50290, PI3_4_KINASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRRAP_HUMAN | |
Accessioni | Q9Y4A5Primary (citable) accession number: Q9Y4A5 Secondary accession number(s): A4D265 Q9Y6H4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2003 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families