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UniProtKB - Q9Y4A5 (TRRAP_HUMAN)

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Protein

Transformation/transcription domain-associated protein

Gene

TRRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.8 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • beta-catenin-TCF complex assembly Source: Reactome
  • DNA repair Source: GO_Central
  • histone acetylation Source: UniProtKB
  • histone deubiquitination Source: UniProtKB
  • histone H2A acetylation Source: UniProtKB
  • histone H4 acetylation Source: UniProtKB
  • protein deubiquitination Source: Reactome
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3214847 HATs acetylate histones
R-HSA-5689880 Ub-specific processing proteases
SIGNORiQ9Y4A5

Names & Taxonomyi

Protein namesi
Recommended name:
Transformation/transcription domain-associated protein
Alternative name(s):
350/400 kDa PCAF-associated factor
Short name:
PAF350/400
STAF40
Tra1 homolog
Gene namesi
Name:TRRAP
Synonyms:PAF400
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000196367.12
HGNCiHGNC:12347 TRRAP
MIMi603015 gene
neXtProtiNX_Q9Y4A5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

TRRAP mutation Phe-722 has been frequently found in cutaneous malignant melanoma, suggesting that TRRAP may play a role in the pathogenesis of melanoma.1 Publication

Organism-specific databases

DisGeNETi8295
OpenTargetsiENSG00000196367
PharmGKBiPA37020

Polymorphism and mutation databases

BioMutaiTRRAP
DMDMi116242829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000888512 – 3859Transformation/transcription domain-associated proteinAdd BLAST3858

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei1628PhosphoserineCombined sources1
Modified residuei2051PhosphoserineCombined sources1
Modified residuei2077PhosphoserineCombined sources1
Cross-linki2543Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei3078N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y4A5
PaxDbiQ9Y4A5
PeptideAtlasiQ9Y4A5
PRIDEiQ9Y4A5
ProteomicsDBi86142
86143 [Q9Y4A5-2]

PTM databases

iPTMnetiQ9Y4A5
PhosphoSitePlusiQ9Y4A5

Expressioni

Gene expression databases

BgeeiENSG00000196367
CleanExiHS_TRRAP
ExpressionAtlasiQ9Y4A5 baseline and differential
GenevisibleiQ9Y4A5 HS

Organism-specific databases

HPAiHPA054376

Interactioni

Subunit structurei

Interacts with MYC, E2F1 and E2F4 transcription factors. Interacts directly with p53/TP53. Interacts with GCN5L2. Component of various HAT complexes. Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of the STAGA complex, at least composed of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Component of the BAF53 complex, at least composed of BAF53A, RUVBL1, SMARCA4/BRG1, and TRRAP, which preferentially acetylates histone H4 (and H2A) within nucleosomes. Interacts with NPAT. Interaction with TELO2 AND TTI1. Component of a SWR1-like complex.14 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113900, 118 interactors
ComplexPortaliCPX-900 SAGA complex
CPX-903 TFTC histone acetylation complex
CPX-978 NuA4 histone acetyltransferase complex
CPX-989 PCAF histone acetylase complex
CORUMiQ9Y4A5
DIPiDIP-28149N
IntActiQ9Y4A5, 53 interactors
MINTiQ9Y4A5
STRINGi9606.ENSP00000347733

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2704 – 3275FATPROSITE-ProRule annotationAdd BLAST572
Domaini3528 – 3826PI3K/PI4KPROSITE-ProRule annotationAdd BLAST299
Domaini3827 – 3859FATCPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2010 – 2388Interaction with TP531 PublicationAdd BLAST379

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2047 – 2062Bipartite nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi485 – 526Pro-richAdd BLAST42

Domaini

The PI3K/PI4K domain is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.1 Publication

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. TRA1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0889 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00390000017961
HOGENOMiHOG000252997
HOVERGENiHBG079283
InParanoidiQ9Y4A5
KOiK08874
OMAiDYLDPIM
OrthoDBiEOG091G0024
PhylomeDBiQ9Y4A5
TreeFamiTF106414

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003152 FATC_dom
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR003151 PIK-rel_kinase_FAT
IPR014009 PIK_FAT
IPR033317 TRA1/TRRAP
PANTHERiPTHR11139:SF1 PTHR11139:SF1, 1 hit
PfamiView protein in Pfam
PF02259 FAT, 1 hit
PF00454 PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343 FATC, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 13 hits
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51189 FAT, 1 hit
PS51190 FATC, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y4A5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVATQGAT VVDQTTLMKK YLQFVAALTD VNTPDETKLK MMQEVSENFE 
        60         70         80         90        100
NVTSSPQYST FLEHIIPRFL TFLQDGEVQF LQEKPAQQLR KLVLEIIHRI 
       110        120        130        140        150
PTNEHLRPHT KNVLSVMFRF LETENEENVL ICLRIIIELH KQFRPPITQE 
       160        170        180        190        200
IHHFLDFVKQ IYKELPKVVN RYFENPQVIP ENTVPPPEMV GMITTIAVKV 
       210        220        230        240        250
NPEREDSETR THSIIPRGSL SLKVLAELPI IVVLMYQLYK LNIHNVVAEF 
       260        270        280        290        300
VPLIMNTIAI QVSAQARQHK LYNKELYADF IAAQIKTLSF LAYIIRIYQE 
       310        320        330        340        350
LVTKYSQQMV KGMLQLLSNC PAETAHLRKE LLIAAKHILT TELRNQFIPC 
       360        370        380        390        400
MDKLFDESIL IGSGYTARET LRPLAYSTLA DLVHHVRQHL PLSDLSLAVQ 
       410        420        430        440        450
LFAKNIDDES LPSSIQTMSC KLLLNLVDCI RSKSEQESGN GRDVLMRMLE 
       460        470        480        490        500
VFVLKFHTIA RYQLSAIFKK CKPQSELGAV EAALPGVPTA PAAPGPAPSP 
       510        520        530        540        550
APVPAPPPPP PPPPPATPVT PAPVPPFEKQ GEKDKEDKQT FQVTDCRSLV 
       560        570        580        590        600
KTLVCGVKTI TWGITSCKAP GEAQFIPNKQ LQPKETQIYI KLVKYAMQAL 
       610        620        630        640        650
DIYQVQIAGN GQTYIRVANC QTVRMKEEKE VLEHFAGVFT MMNPLTFKEI 
       660        670        680        690        700
FQTTVPYMVE RISKNYALQI VANSFLANPT TSALFATILV EYLLDRLPEM 
       710        720        730        740        750
GSNVELSNLY LKLFKLVFGS VSLFAAENEQ MLKPHLHKIV NSSMELAQTA 
       760        770        780        790        800
KEPYNYFLLL RALFRSIGGG SHDLLYQEFL PLLPNLLQGL NMLQSGLHKQ 
       810        820        830        840        850
HMKDLFVELC LTVPVRLSSL LPYLPMLMDP LVSALNGSQT LVSQGLRTLE 
       860        870        880        890        900
LCVDNLQPDF LYDHIQPVRA ELMQALWRTL RNPADSISHV AYRVLGKFGG 
       910        920        930        940        950
SNRKMLKESQ KLHYVVTEVQ GPSITVEFSD CKASLQLPME KAIETALDCL 
       960        970        980        990       1000
KSANTEPYYR RQAWEVIKCF LVAMMSLEDN KHALYQLLAH PNFTEKTIPN 
      1010       1020       1030       1040       1050
VIISHRYKAQ DTPARKTFEQ ALTGAFMSAV IKDLRPSALP FVASLIRHYT 
      1060       1070       1080       1090       1100
MVAVAQQCGP FLLPCYQVGS QPSTAMFHSE ENGSKGMDPL VLIDAIAICM 
      1110       1120       1130       1140       1150
AYEEKELCKI GEVALAVIFD VASIILGSKE RACQLPLFSY IVERLCACCY 
      1160       1170       1180       1190       1200
EQAWYAKLGG VVSIKFLMER LPLTWVLQNQ QTFLKALLFV MMDLTGEVSN 
      1210       1220       1230       1240       1250
GAVAMAKTTL EQLLMRCATP LKDEERAEEI VAAQEKSFHH VTHDLVREVT 
      1260       1270       1280       1290       1300
SPNSTVRKQA MHSLQVLAQV TGKSVTVIME PHKEVLQDMV PPKKHLLRHQ 
      1310       1320       1330       1340       1350
PANAQIGLME GNTFCTTLQP RLFTMDLNVV EHKVFYTELL NLCEAEDSAL 
      1360       1370       1380       1390       1400
TKLPCYKSLP SLVPLRIAAL NALAACNYLP QSREKIIAAL FKALNSTNSE 
      1410       1420       1430       1440       1450
LQEAGEACMR KFLEGATIEV DQIHTHMRPL LMMLGDYRSL TLNVVNRLTS 
      1460       1470       1480       1490       1500
VTRLFPNSFN DKFCDQMMQH LRKWMEVVVI THKGGQRSDG NESISECGRC 
      1510       1520       1530       1540       1550
PLSPFCQFEE MKICSAIINL FHLIPAAPQT LVKPLLEVVM KTERAMLIEA 
      1560       1570       1580       1590       1600
GSPFREPLIK FLTRHPSQTV ELFMMEATLN DPQWSRMFMS FLKHKDARPL 
      1610       1620       1630       1640       1650
RDVLAANPNR FITLLLPGGA QTAVRPGSPS TSTMRLDLQF QAIKIISIIV 
      1660       1670       1680       1690       1700
KNDDSWLASQ HSLVSQLRRV WVSENFQERH RKENMAATNW KEPKLLAYCL 
      1710       1720       1730       1740       1750
LNYCKRNYGD IELLFQLLRA FTGRFLCNMT FLKEYMEEEI PKNYSIAQKR 
      1760       1770       1780       1790       1800
ALFFRFVDFN DPNFGDELKA KVLQHILNPA FLYSFEKGEG EQLLGPPNPE 
      1810       1820       1830       1840       1850
GDNPESITSV FITKVLDPEK QADMLDSLRI YLLQYATLLV EHAPHHIHDN 
      1860       1870       1880       1890       1900
NKNRNSKLRR LMTFAWPCLL SKACVDPACK YSGHLLLAHI IAKFAIHKKI 
      1910       1920       1930       1940       1950
VLQVFHSLLK AHAMEARAIV RQAMAILTPA VPARMEDGHQ MLTHWTRKII 
      1960       1970       1980       1990       2000
VEEGHTVPQL VHILHLIVQH FKVYYPVRHH LVQHMVSAMQ RLGFTPSVTI 
      2010       2020       2030       2040       2050
EQRRLAVDLS EVVIKWELQR IKDQQPDSDM DPNSSGEGVN SVSSSIKRGL 
      2060       2070       2080       2090       2100
SVDSAQEVKR FRTATGAISA VFGRSQSLPG ADSLLAKPID KQHTDTVVNF 
      2110       2120       2130       2140       2150
LIRVACQVND NTNTAGSPGE VLSRRCVNLL KTALRPDMWP KSELKLQWFD 
      2160       2170       2180       2190       2200
KLLMTVEQPN QVNYGNICTG LEVLSFLLTV LQSPAILSSF KPLQRGIAAC 
      2210       2220       2230       2240       2250
MTCGNTKVLR AVHSLLSRLM SIFPTEPSTS SVASKYEELE CLYAAVGKVI 
      2260       2270       2280       2290       2300
YEGLTNYEKA TNANPSQLFG TLMILKSACS NNPSYIDRLI SVFMRSLQKM 
      2310       2320       2330       2340       2350
VREHLNPQAA SGSTEATSGT SELVMLSLEL VKTRLAVMSM EMRKNFIQAI 
      2360       2370       2380       2390       2400
LTSLIEKSPD AKILRAVVKI VEEWVKNNSP MAANQTPTLR EKSILLVKMM 
      2410       2420       2430       2440       2450
TYIEKRFPED LELNAQFLDL VNYVYRDETL SGSELTAKLE PAFLSGLRCA 
      2460       2470       2480       2490       2500
QPLIRAKFFE VFDNSMKRRV YERLLYVTCS QNWEAMGNHF WIKQCIELLL 
      2510       2520       2530       2540       2550
AVCEKSTPIG TSCQGAMLPS ITNVINLADS HDRAAFAMVT HVKQEPRERE 
      2560       2570       2580       2590       2600
NSESKEEDVE IDIELAPGDQ TSTPKTKELS EKDIGNQLHM LTNRHDKFLD 
      2610       2620       2630       2640       2650
TLREVKTGAL LSAFVQLCHI STTLAEKTWV QLFPRLWKIL SDRQQHALAG 
      2660       2670       2680       2690       2700
EISPFLCSGS HQVQRDCQPS ALNCFVEAMS QCVPPIPIRP CVLKYLGKTH 
      2710       2720       2730       2740       2750
NLWFRSTLML EHQAFEKGLS LQIKPKQTTE FYEQESITPP QQEILDSLAE 
      2760       2770       2780       2790       2800
LYSLLQEEDM WAGLWQKRCK YSETATAIAY EQHGFFEQAQ ESYEKAMDKA 
      2810       2820       2830       2840       2850
KKEHERSNAS PAIFPEYQLW EDHWIRCSKE LNQWEALTEY GQSKGHINPY 
      2860       2870       2880       2890       2900
LVLECAWRVS NWTAMKEALV QVEVSCPKEM AWKVNMYRGY LAICHPEEQQ 
      2910       2920       2930       2940       2950
LSFIERLVEM ASSLAIREWR RLPHVVSHVH TPLLQAAQQI IELQEAAQIN 
      2960       2970       2980       2990       3000
AGLQPTNLGR NNSLHDMKTV VKTWRNRLPI VSDDLSHWSS IFMWRQHHYQ 
      3010       3020       3030       3040       3050
GKPTWSGMHS SSIVTAYENS SQHDPSSNNA MLGVHASASA IIQYGKIARK 
      3060       3070       3080       3090       3100
QGLVNVALDI LSRIHTIPTV PIVDCFQKIR QQVKCYLQLA GVMGKNECMQ 
      3110       3120       3130       3140       3150
GLEVIESTNL KYFTKEMTAE FYALKGMFLA QINKSEEANK AFSAAVQMHD 
      3160       3170       3180       3190       3200
VLVKAWAMWG DYLENIFVKE RQLHLGVSAI TCYLHACRHQ NESKSRKYLA 
      3210       3220       3230       3240       3250
KVLWLLSFDD DKNTLADAVD KYCIGVPPIQ WLAWIPQLLT CLVGSEGKLL 
      3260       3270       3280       3290       3300
LNLISQVGRV YPQAVYFPIR TLYLTLKIEQ RERYKSDPGP IRATAPMWRC 
      3310       3320       3330       3340       3350
SRIMHMQREL HPTLLSSLEG IVDQMVWFRE NWHEEVLRQL QQGLAKCYSV 
      3360       3370       3380       3390       3400
AFEKSGAVSD AKITPHTLNF VKKLVSTFGV GLENVSNVST MFSSAASESL 
      3410       3420       3430       3440       3450
ARRAQATAQD PVFQKLKGQF TTDFDFSVPG SMKLHNLISK LKKWIKILEA 
      3460       3470       3480       3490       3500
KTKQLPKFFL IEEKCRFLSN FSAQTAEVEI PGEFLMPKPT HYYIKIARFM 
      3510       3520       3530       3540       3550
PRVEIVQKHN TAARRLYIRG HNGKIYPYLV MNDACLTESR REERVLQLLR 
      3560       3570       3580       3590       3600
LLNPCLEKRK ETTKRHLFFT VPRVVAVSPQ MRLVEDNPSS LSLVEIYKQR 
      3610       3620       3630       3640       3650
CAKKGIEHDN PISRYYDRLA TVQARGTQAS HQVLRDILKE VQSNMVPRSM 
      3660       3670       3680       3690       3700
LKEWALHTFP NATDYWTFRK MFTIQLALIG FAEFVLHLNR LNPEMLQIAQ 
      3710       3720       3730       3740       3750
DTGKLNVAYF RFDINDATGD LDANRPVPFR LTPNISEFLT TIGVSGPLTA 
      3760       3770       3780       3790       3800
SMIAVARCFA QPNFKVDGIL KTVLRDEIIA WHKKTQEDTS SPLSAAGQPE 
      3810       3820       3830       3840       3850
NMDSQQLVSL VQKAVTAIMT RLHNLAQFEG GESKVNTLVA AANSLDNLCR 

MDPAWHPWL
Length:3,859
Mass (Da):437,600
Last modified:October 17, 2006 - v3
Checksum:i391E467C0047B00B
GO
Isoform 2 (identifier: Q9Y4A5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1492-1509: Missing.
     3001-3012: GKPTWSGMHSSS → A

Show »
Length:3,830
Mass (Da):434,414
Checksum:i5740D4E21629560B
GO

Sequence cautioni

The sequence AAC62433 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti660E → D in AAD04629 (PubMed:9885574).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_067754722S → F Found in a cutaneous malignant melanoma sample; somatic mutation; induces cell transformation and confers resistance to apoptosis. 1 PublicationCorresponds to variant dbSNP:rs147405090Ensembl.1
Natural variantiVAR_028359878R → L. Corresponds to variant dbSNP:rs17161510Ensembl.1
Natural variantiVAR_041658893R → C in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416591070S → G1 PublicationCorresponds to variant dbSNP:rs55920979Ensembl.1
Natural variantiVAR_0416601669R → H in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373632999Ensembl.1
Natural variantiVAR_0416611724R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs782203759Ensembl.1
Natural variantiVAR_0416621925A → V1 PublicationCorresponds to variant dbSNP:rs56197298Ensembl.1
Natural variantiVAR_0416631932P → L in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416641947R → L in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0416652139W → G1 PublicationCorresponds to variant dbSNP:rs34185633Ensembl.1
Natural variantiVAR_0416662302R → W in a colorectal adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs528967912Ensembl.1
Natural variantiVAR_0416672433S → G1 PublicationCorresponds to variant dbSNP:rs35634065Ensembl.1
Natural variantiVAR_0416682690P → L in a lung large cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs753661271Ensembl.1
Natural variantiVAR_0416692750E → D1 PublicationCorresponds to variant dbSNP:rs55755466Ensembl.1
Natural variantiVAR_0416702801K → E1 PublicationCorresponds to variant dbSNP:rs56341061Ensembl.1
Natural variantiVAR_0416712931T → M in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0091021492 – 1509Missing in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_0091033001 – 3012GKPTW…MHSSS → A in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076974 mRNA Translation: AAD09420.1
AF110377 mRNA Translation: AAD04629.1
AC004893 Genomic DNA Translation: AAC62433.1 Sequence problems.
AC004991 Genomic DNA Translation: AAC27675.2
CH471091 Genomic DNA Translation: EAW76694.1
CH236956 Genomic DNA Translation: EAL23887.1
CCDSiCCDS5659.1 [Q9Y4A5-2]
CCDS59066.1 [Q9Y4A5-1]
PIRiT02632
RefSeqiNP_001231509.1, NM_001244580.1 [Q9Y4A5-1]
NP_003487.1, NM_003496.3 [Q9Y4A5-2]
UniGeneiHs.203952

Genome annotation databases

EnsembliENST00000355540; ENSP00000347733; ENSG00000196367 [Q9Y4A5-2]
ENST00000359863; ENSP00000352925; ENSG00000196367 [Q9Y4A5-1]
GeneIDi8295
KEGGihsa:8295
UCSCiuc003upp.3 human [Q9Y4A5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRRAP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A5
Secondary accession number(s): A4D265
, O75218, Q9Y631, Q9Y6H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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