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Protein

Jerky protein homolog-like

Gene

JRKL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifBy similarityAdd BLAST21
DNA bindingi100 – 132H-T-H motifBy similarityAdd BLAST33

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: ProtInc

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Jerky protein homolog-like
Alternative name(s):
Human homolog of mouse jerky gene protein
Short name:
HHMJG
Gene namesi
Name:JRKL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000183340.6
HGNCiHGNC:6200 JRKL
MIMi603211 gene
neXtProtiNX_Q9Y4A0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183340
PharmGKBiPA30002

Polymorphism and mutation databases

BioMutaiJRKL
DMDMi254763306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001261301 – 524Jerky protein homolog-likeAdd BLAST524

Proteomic databases

EPDiQ9Y4A0
MaxQBiQ9Y4A0
PaxDbiQ9Y4A0
PeptideAtlasiQ9Y4A0
PRIDEiQ9Y4A0
ProteomicsDBi86140

PTM databases

iPTMnetiQ9Y4A0
PhosphoSitePlusiQ9Y4A0

Expressioni

Tissue specificityi

Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.

Gene expression databases

BgeeiENSG00000183340 Expressed in 219 organ(s), highest expression level in amniotic fluid
CleanExiHS_JRKL
GenevisibleiQ9Y4A0 HS

Organism-specific databases

HPAiHPA046184
HPA060341

Interactioni

Protein-protein interaction databases

BioGridi114237, 5 interactors
IntActiQ9Y4A0, 6 interactors
STRINGi9606.ENSP00000333350

Structurei

3D structure databases

ProteinModelPortaliQ9Y4A0
SMRiQ9Y4A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 52HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini67 – 139HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini168 – 385DDE-1Sequence analysisAdd BLAST218

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00760000119149
HOGENOMiHOG000130798
HOVERGENiHBG101551
InParanoidiQ9Y4A0
OMAiVSGPICA
OrthoDBiEOG091G05QK
PhylomeDBiQ9Y4A0
TreeFamiTF101131

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y4A0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE
60 70 80 90 100
KIITYASSSD STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP
110 120 130 140 150
ICAKRAEFFF YALGMDGDFN PSAGWLTRFK QRHSIREINI RNERLNGDET
160 170 180 190 200
AVEDFCNNFR DFIERENLQP EQIYNADETG LFWKCLPSRI SVIKGKCTVP
210 220 230 240 250
GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST DTLNLPVSYF
260 270 280 290 300
SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
310 320 330 340 350
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG
360 370 380 390 400
NDLKSFWKKL TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF
410 420 430 440 450
DVEDISVATV AAILQHTKGL ENVTTENLEK WLEVDSTEPG YEVLTDSEII
460 470 480 490 500
RRAQGQADES SENEEEEIEL IPEKHINHAA ALQWTENLLD YLEQQGDMIL
510 520
PDRLVIRKLR ATIRNKQKMT KSSQ
Length:524
Mass (Da):59,912
Last modified:July 28, 2009 - v2
Checksum:i81FEC7468DCBBF47
GO

Sequence cautioni

The sequence AAB65833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59S → F in BAF83268 (PubMed:14702039).Curated1
Sequence conflicti109F → S in BAG36890 (PubMed:14702039).Curated1
Sequence conflicti380T → I in BAG36890 (PubMed:14702039).Curated1
Sequence conflicti433E → K in BAG36890 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290579 mRNA Translation: BAF83268.1
AK314216 mRNA Translation: BAG36890.1
AP003781 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66986.1
BC109202 mRNA Translation: AAI09203.1
AF004715 mRNA Translation: AAB65833.1 Different initiation.
CCDSiCCDS8308.1
PIRiJC5594
RefSeqiNP_001248762.1, NM_001261833.1
NP_003763.2, NM_003772.3
UniGeneiHs.105940
Hs.745352

Genome annotation databases

EnsembliENST00000332349; ENSP00000333350; ENSG00000183340
GeneIDi8690
KEGGihsa:8690
UCSCiuc009ywu.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290579 mRNA Translation: BAF83268.1
AK314216 mRNA Translation: BAG36890.1
AP003781 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66986.1
BC109202 mRNA Translation: AAI09203.1
AF004715 mRNA Translation: AAB65833.1 Different initiation.
CCDSiCCDS8308.1
PIRiJC5594
RefSeqiNP_001248762.1, NM_001261833.1
NP_003763.2, NM_003772.3
UniGeneiHs.105940
Hs.745352

3D structure databases

ProteinModelPortaliQ9Y4A0
SMRiQ9Y4A0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114237, 5 interactors
IntActiQ9Y4A0, 6 interactors
STRINGi9606.ENSP00000333350

PTM databases

iPTMnetiQ9Y4A0
PhosphoSitePlusiQ9Y4A0

Polymorphism and mutation databases

BioMutaiJRKL
DMDMi254763306

Proteomic databases

EPDiQ9Y4A0
MaxQBiQ9Y4A0
PaxDbiQ9Y4A0
PeptideAtlasiQ9Y4A0
PRIDEiQ9Y4A0
ProteomicsDBi86140

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332349; ENSP00000333350; ENSG00000183340
GeneIDi8690
KEGGihsa:8690
UCSCiuc009ywu.5 human

Organism-specific databases

CTDi8690
EuPathDBiHostDB:ENSG00000183340.6
GeneCardsiJRKL
H-InvDBiHIX0035846
HGNCiHGNC:6200 JRKL
HPAiHPA046184
HPA060341
MIMi603211 gene
neXtProtiNX_Q9Y4A0
OpenTargetsiENSG00000183340
PharmGKBiPA30002
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00760000119149
HOGENOMiHOG000130798
HOVERGENiHBG101551
InParanoidiQ9Y4A0
OMAiVSGPICA
OrthoDBiEOG091G05QK
PhylomeDBiQ9Y4A0
TreeFamiTF101131

Miscellaneous databases

ChiTaRSiJRKL human
GenomeRNAii8690
PROiPR:Q9Y4A0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183340 Expressed in 219 organ(s), highest expression level in amniotic fluid
CleanExiHS_JRKL
GenevisibleiQ9Y4A0 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJERKL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y4A0
Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: July 28, 2009
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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