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UniProtKB - Q9Y4A0 (JERKL_HUMAN)
Protein
Jerky protein homolog-like
Gene
JRKL
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 48 | H-T-H motifBy similarityAdd BLAST | 21 | |
DNA bindingi | 100 – 132 | H-T-H motifBy similarityAdd BLAST | 33 |
GO - Molecular functioni
- DNA binding Source: GO_Central
GO - Biological processi
- central nervous system development Source: ProtInc
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A0 |
SignaLinki | Q9Y4A0 |
Names & Taxonomyi
Protein namesi | Recommended name: Jerky protein homolog-likeAlternative name(s): Human homolog of mouse jerky gene protein Short name: HHMJG |
Gene namesi | Name:JRKL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6200, JRKL |
MIMi | 603211, gene |
neXtProti | NX_Q9Y4A0 |
VEuPathDBi | HostDB:ENSG00000183340 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000183340 |
PharmGKBi | PA30002 |
Miscellaneous databases
Pharosi | Q9Y4A0, Tdark |
Genetic variation databases
BioMutai | JRKL |
DMDMi | 254763306 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000126130 | 1 – 524 | Jerky protein homolog-likeAdd BLAST | 524 |
Proteomic databases
EPDi | Q9Y4A0 |
jPOSTi | Q9Y4A0 |
MassIVEi | Q9Y4A0 |
MaxQBi | Q9Y4A0 |
PaxDbi | Q9Y4A0 |
PeptideAtlasi | Q9Y4A0 |
PRIDEi | Q9Y4A0 |
ProteomicsDBi | 86140 |
PTM databases
iPTMneti | Q9Y4A0 |
PhosphoSitePlusi | Q9Y4A0 |
Expressioni
Tissue specificityi
Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000183340, Expressed in amniotic fluid and 235 other tissues |
Genevisiblei | Q9Y4A0, HS |
Organism-specific databases
HPAi | ENSG00000183340, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 114237, 7 interactors |
IntActi | Q9Y4A0, 7 interactors |
STRINGi | 9606.ENSP00000333350 |
Miscellaneous databases
RNActi | Q9Y4A0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 52 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 67 – 139 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 168 – 385 | DDE-1Sequence analysisAdd BLAST | 218 |
Sequence similaritiesi
Belongs to the tigger transposable element derived protein family.Curated
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000161513 |
HOGENOMi | CLU_018294_1_1_1 |
InParanoidi | Q9Y4A0 |
OMAi | VSGPICA |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q9Y4A0 |
TreeFami | TF101131 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y4A0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE
60 70 80 90 100
KIITYASSSD STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP
110 120 130 140 150
ICAKRAEFFF YALGMDGDFN PSAGWLTRFK QRHSIREINI RNERLNGDET
160 170 180 190 200
AVEDFCNNFR DFIERENLQP EQIYNADETG LFWKCLPSRI SVIKGKCTVP
210 220 230 240 250
GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST DTLNLPVSYF
260 270 280 290 300
SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE
310 320 330 340 350
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG
360 370 380 390 400
NDLKSFWKKL TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF
410 420 430 440 450
DVEDISVATV AAILQHTKGL ENVTTENLEK WLEVDSTEPG YEVLTDSEII
460 470 480 490 500
RRAQGQADES SENEEEEIEL IPEKHINHAA ALQWTENLLD YLEQQGDMIL
510 520
PDRLVIRKLR ATIRNKQKMT KSSQ
Sequence cautioni
The sequence AAB65833 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | S → F in BAF83268 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 109 | F → S in BAG36890 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 380 | T → I in BAG36890 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 433 | E → K in BAG36890 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290579 mRNA Translation: BAF83268.1 AK314216 mRNA Translation: BAG36890.1 AP003781 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66986.1 BC109202 mRNA Translation: AAI09203.1 AF004715 mRNA Translation: AAB65833.1 Different initiation. |
CCDSi | CCDS8308.1 |
PIRi | JC5594 |
RefSeqi | NP_001248762.1, NM_001261833.1 NP_003763.2, NM_003772.3 |
Genome annotation databases
Ensembli | ENST00000332349; ENSP00000333350; ENSG00000183340 |
GeneIDi | 8690 |
KEGGi | hsa:8690 |
MANE-Selecti | ENST00000332349.5; ENSP00000333350.4; NM_001261833.2; NP_001248762.1 |
UCSCi | uc009ywu.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290579 mRNA Translation: BAF83268.1 AK314216 mRNA Translation: BAG36890.1 AP003781 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66986.1 BC109202 mRNA Translation: AAI09203.1 AF004715 mRNA Translation: AAB65833.1 Different initiation. |
CCDSi | CCDS8308.1 |
PIRi | JC5594 |
RefSeqi | NP_001248762.1, NM_001261833.1 NP_003763.2, NM_003772.3 |
3D structure databases
SMRi | Q9Y4A0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114237, 7 interactors |
IntActi | Q9Y4A0, 7 interactors |
STRINGi | 9606.ENSP00000333350 |
PTM databases
iPTMneti | Q9Y4A0 |
PhosphoSitePlusi | Q9Y4A0 |
Genetic variation databases
BioMutai | JRKL |
DMDMi | 254763306 |
Proteomic databases
EPDi | Q9Y4A0 |
jPOSTi | Q9Y4A0 |
MassIVEi | Q9Y4A0 |
MaxQBi | Q9Y4A0 |
PaxDbi | Q9Y4A0 |
PeptideAtlasi | Q9Y4A0 |
PRIDEi | Q9Y4A0 |
ProteomicsDBi | 86140 |
Protocols and materials databases
Antibodypediai | 31694, 114 antibodies from 19 providers |
DNASUi | 8690 |
Genome annotation databases
Ensembli | ENST00000332349; ENSP00000333350; ENSG00000183340 |
GeneIDi | 8690 |
KEGGi | hsa:8690 |
MANE-Selecti | ENST00000332349.5; ENSP00000333350.4; NM_001261833.2; NP_001248762.1 |
UCSCi | uc009ywu.5, human |
Organism-specific databases
CTDi | 8690 |
GeneCardsi | JRKL |
HGNCi | HGNC:6200, JRKL |
HPAi | ENSG00000183340, Low tissue specificity |
MIMi | 603211, gene |
neXtProti | NX_Q9Y4A0 |
OpenTargetsi | ENSG00000183340 |
PharmGKBi | PA30002 |
VEuPathDBi | HostDB:ENSG00000183340 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000161513 |
HOGENOMi | CLU_018294_1_1_1 |
InParanoidi | Q9Y4A0 |
OMAi | VSGPICA |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q9Y4A0 |
TreeFami | TF101131 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y4A0 |
SignaLinki | Q9Y4A0 |
Miscellaneous databases
BioGRID-ORCSi | 8690, 8 hits in 1054 CRISPR screens |
GenomeRNAii | 8690 |
Pharosi | Q9Y4A0, Tdark |
PROi | PR:Q9Y4A0 |
RNActi | Q9Y4A0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183340, Expressed in amniotic fluid and 235 other tissues |
Genevisiblei | Q9Y4A0, HS |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq IPR036397, RNaseH_sf |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JERKL_HUMAN | |
Accessioni | Q9Y4A0Primary (citable) accession number: Q9Y4A0 Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2002 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families