JRKL

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	28 – 48	H-T-H motifBy similarityAdd BLAST		21
DNA bindingⁱ	100 – 132	H-T-H motifBy similarityAdd BLAST		33

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

central nervous system development
Source: ProtInc
Traceable author statementⁱ
- 9240447

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Jerky protein homolog-like Alternative name(s): Human homolog of mouse jerky gene protein Short name: HHMJG
Gene namesⁱ	Name:JRKL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183340.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6200 JRKL
MIMⁱ	603211 gene
neXtProtⁱ	NX_Q9Y4A0

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000183340
PharmGKBⁱ	PA30002

Polymorphism and mutation databases

BioMutaⁱ	JRKL
DMDMⁱ	254763306

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000126130	1 – 524	Jerky protein homolog-likeAdd BLAST		524

Proteomic databases

EPDⁱ	Q9Y4A0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y4A0
PaxDbⁱ	Q9Y4A0
PeptideAtlas More...PeptideAtlasⁱ	Q9Y4A0
PRIDEⁱ	Q9Y4A0
ProteomicsDBⁱ	86140

PTM databases

iPTMnetⁱ	Q9Y4A0
PhosphoSitePlusⁱ	Q9Y4A0

Expressionⁱ

Tissue specificityⁱ

Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000183340 Expressed in 219 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_JRKL
Genevisibleⁱ	Q9Y4A0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046184 HPA060341

HPAⁱ

HPA046184
HPA060341

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	114237, 5 interactors
IntActⁱ	Q9Y4A0, 6 interactors
STRINGⁱ	9606.ENSP00000333350

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y4A0
SMRⁱ	Q9Y4A0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 52	HTH psq-typePROSITE-ProRule annotationAdd BLAST	52
Domainⁱ	67 – 139	HTH CENPB-typePROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	168 – 385	DDE-1Sequence analysisAdd BLAST	218

Sequence similaritiesⁱ

Belongs to the tigger transposable element derived protein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3105 Eukaryota ENOG4110CDI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119149
HOGENOMⁱ	HOG000130798
HOVERGENⁱ	HBG101551
InParanoidⁱ	Q9Y4A0
OMAⁱ	VSGPICA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05QK
PhylomeDBⁱ	Q9Y4A0
TreeFamⁱ	TF101131

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit
SMARTⁱ	View protein in SMART SM00674 CENPB, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Y4A0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE 
        60         70         80         90        100
KIITYASSSD STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP 
       110        120        130        140        150
ICAKRAEFFF YALGMDGDFN PSAGWLTRFK QRHSIREINI RNERLNGDET 
       160        170        180        190        200
AVEDFCNNFR DFIERENLQP EQIYNADETG LFWKCLPSRI SVIKGKCTVP 
       210        220        230        240        250
GHKSIEERVT IMCCANATGL HKLKLCVVGK AKKPRSFKST DTLNLPVSYF 
       260        270        280        290        300
SQKGAWMDLS IFRQWFDKIF VPQVREYLRS KGLQEKAVLL LDNSPTHPNE 
       310        320        330        340        350
NVLRSDDGQI FAKYLPPNVA SLIQPSDQGV IATMKRNYRA GLLQNNLEEG 
       360        370        380        390        400
NDLKSFWKKL TLLDALYEIA MAWNLVKPVT ISRAWKKILP MVEEKESLDF 
       410        420        430        440        450
DVEDISVATV AAILQHTKGL ENVTTENLEK WLEVDSTEPG YEVLTDSEII 
       460        470        480        490        500
RRAQGQADES SENEEEEIEL IPEKHINHAA ALQWTENLLD YLEQQGDMIL 
       510        520 
PDRLVIRKLR ATIRNKQKMT KSSQ

Length:524

Mass (Da):59,912

Last modified:July 28, 2009 - v2

Checksum:ⁱ81FEC7468DCBBF47

GO

Sequence cautionⁱ

The sequence AAB65833 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	59	S → F in BAF83268 (PubMed:14702039).Curated	1
Sequence conflictⁱ	109	F → S in BAG36890 (PubMed:14702039).Curated	1
Sequence conflictⁱ	380	T → I in BAG36890 (PubMed:14702039).Curated	1
Sequence conflictⁱ	433	E → K in BAG36890 (PubMed:14702039).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290579 mRNA Translation: BAF83268.1 AK314216 mRNA Translation: BAG36890.1 AP003781 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66986.1 BC109202 mRNA Translation: AAI09203.1 AF004715 mRNA Translation: AAB65833.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8308.1
PIRⁱ	JC5594
NCBI Reference Sequences More...RefSeqⁱ	NP_001248762.1, NM_001261833.1 NP_003763.2, NM_003772.3
UniGeneⁱ	Hs.105940 Hs.745352

Genome annotation databases

Ensemblⁱ	ENST00000332349; ENSP00000333350; ENSG00000183340
GeneIDⁱ	8690
KEGGⁱ	hsa:8690
UCSC genome browser More...UCSCⁱ	uc009ywu.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y4A0	Jerky protein homolog-like		MOUSE		523	UniRef90_Q9Y4A0
Putative dde superfamily endonuclease		DESRO		525
jerky protein homolog-like		URSMA		525
JRK like		PANTR		524
Uncharacterized protein		PANPA		524
+92

Protein	Similar proteins		Species	Score	Length	Source
Q9Y4A0	Jerky protein homolog-like		MOUSE		523	UniRef50_Q9Y4A0
jerky protein homolog-like		URSMA		525
Putative dde superfamily endonuclease		DESRO		525
jerky protein homolog-like		Florida manatee		524
jerky protein homolog-like		Enhydra lutris kenyoni		524
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK290579 mRNA Translation: BAF83268.1 AK314216 mRNA Translation: BAG36890.1 AP003781 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66986.1 BC109202 mRNA Translation: AAI09203.1 AF004715 mRNA Translation: AAB65833.1 Different initiation.
CCDSⁱ	CCDS8308.1
PIRⁱ	JC5594
RefSeqⁱ	NP_001248762.1, NM_001261833.1 NP_003763.2, NM_003772.3
UniGeneⁱ	Hs.105940 Hs.745352

3D structure databases

ProteinModelPortalⁱ	Q9Y4A0
SMRⁱ	Q9Y4A0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114237, 5 interactors
IntActⁱ	Q9Y4A0, 6 interactors
STRINGⁱ	9606.ENSP00000333350

PTM databases

iPTMnetⁱ	Q9Y4A0
PhosphoSitePlusⁱ	Q9Y4A0

Polymorphism and mutation databases

BioMutaⁱ	JRKL
DMDMⁱ	254763306

Proteomic databases

EPDⁱ	Q9Y4A0
MaxQBⁱ	Q9Y4A0
PaxDbⁱ	Q9Y4A0
PeptideAtlasⁱ	Q9Y4A0
PRIDEⁱ	Q9Y4A0
ProteomicsDBⁱ	86140

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000332349; ENSP00000333350; ENSG00000183340
GeneIDⁱ	8690
KEGGⁱ	hsa:8690
UCSCⁱ	uc009ywu.5 human

Organism-specific databases

CTDⁱ	8690
EuPathDBⁱ	HostDB:ENSG00000183340.6
GeneCardsⁱ	JRKL
H-InvDBⁱ	HIX0035846
HGNCⁱ	HGNC:6200 JRKL
HPAⁱ	HPA046184 HPA060341
MIMⁱ	603211 gene
neXtProtⁱ	NX_Q9Y4A0
OpenTargetsⁱ	ENSG00000183340
PharmGKBⁱ	PA30002
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3105 Eukaryota ENOG4110CDI LUCA
GeneTreeⁱ	ENSGT00760000119149
HOGENOMⁱ	HOG000130798
HOVERGENⁱ	HBG101551
InParanoidⁱ	Q9Y4A0
OMAⁱ	VSGPICA
OrthoDBⁱ	EOG091G05QK
PhylomeDBⁱ	Q9Y4A0
TreeFamⁱ	TF101131

Miscellaneous databases

ChiTaRSⁱ	JRKL human
GenomeRNAiⁱ	8690
Protein Ontology More...PROⁱ	PR:Q9Y4A0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183340 Expressed in 219 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_JRKL
Genevisibleⁱ	Q9Y4A0 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit
SMARTⁱ	View protein in SMART SM00674 CENPB, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	JERKL_HUMAN
Accessionⁱ	Q9Y4A0Primary (citable) accession number: Q9Y4A0 Secondary accession number(s): A8K3G4, B2RAJ3, Q32MC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
	Last sequence update:	July 28, 2009
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y4A0 (JERKL_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Jerky protein homolog-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ