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Protein

Kinesin-like protein KIF3A

Gene

KIF3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitement of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: BHF-UCL
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: GO_Central
  • protein phosphatase binding Source: BHF-UCL
  • Rab GTPase binding Source: ParkinsonsUK-UCL
  • spectrin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5620924 Intraflagellar transport
R-HSA-5635838 Activation of SMO
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins
SIGNORiQ9Y496

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF3A
Alternative name(s):
Microtubule plus end-directed kinesin motor 3A
Gene namesi
Name:KIF3A
Synonyms:KIF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000131437.15
HGNCiHGNC:6319 KIF3A
MIMi604683 gene
neXtProtiNX_Q9Y496

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi11127
OpenTargetsiENSG00000131437
PharmGKBiPA30102

Chemistry databases

ChEMBLiCHEMBL5544

Polymorphism and mutation databases

BioMutaiKIF3A
DMDMi296439481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253931 – 699Kinesin-like protein KIF3AAdd BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei687PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y496
MaxQBiQ9Y496
PaxDbiQ9Y496
PeptideAtlasiQ9Y496
PRIDEiQ9Y496
ProteomicsDBi86139

PTM databases

iPTMnetiQ9Y496
PhosphoSitePlusiQ9Y496

Expressioni

Gene expression databases

BgeeiENSG00000131437 Expressed in 209 organ(s), highest expression level in forebrain
CleanExiHS_KIF3A
ExpressionAtlasiQ9Y496 baseline and differential
GenevisibleiQ9Y496 HS

Organism-specific databases

HPAiCAB037085

Interactioni

Subunit structurei

Heterodimer of KIF3A and KIF3B (By similarity). Interacts with PIFO (PubMed:20643351). Interacts with CLN3 (PubMed:22261744). Interacts with DCTN1 (By similarity).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116300, 82 interactors
ComplexPortaliCPX-3138 KIF3 complex variant AB
CPX-3199 KIF3 complex variant AC
CPX-3200 KIF3 complex variant AC-KAP3
CPX-3201 KIF3 complex variant AB-KAP3
CORUMiQ9Y496
DIPiDIP-33237N
IntActiQ9Y496, 27 interactors
MINTiQ9Y496
STRINGi9606.ENSP00000368020

Chemistry databases

BindingDBiQ9Y496

Structurei

3D structure databases

ProteinModelPortaliQ9Y496
SMRiQ9Y496
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 345Kinesin motorPROSITE-ProRule annotationAdd BLAST332

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni697 – 699Globular3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 590Sequence analysisAdd BLAST236

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOGENOMiHOG000116164
HOVERGENiHBG052255
InParanoidiQ9Y496
KOiK10394
PhylomeDBiQ9Y496
TreeFamiTF105223

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9Y496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYKQAVSVD EMRGTITVHK
60 70 80 90 100
TDSSNEPPKT FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG
110 120 130 140 150
QTGTGKTFTM EGVRAIPELR GIIPNSFAHI FGHIAKAEGD TRFLVRVSYL
160 170 180 190 200
EIYNEEVRDL LGKDQTQRLE VKERPDVGVY IKDLSAYVVN NADDMDRIMT
210 220 230 240 250
LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGIDGNMH VRMGKLHLVD
260 270 280 290 300
LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS
310 320 330 340 350
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR
360 370 380 390 400
INEDPKDALL RQFQKEIEEL KKKLEEGEEI SGSDISGSEE DDDEEGEVGE
410 420 430 440 450
DGEKRKKRRG KKKVSPDKMI EMQAKIDEER KALETKLDME EEERNKARAE
460 470 480 490 500
LEKREKDLLK AQQEHQSLLE KLSALEKKVI VGGVDLLAKA EEQEKLLEES
510 520 530 540 550
NMELEERRKR AEQLRRELEE KEQERLDIEE KYTSLQEEAQ GKTKKLKKVW
560 570 580 590 600
TMLMAAKSEM ADLQQEHQRE IEGLLENIRQ LSRELRLQML IIDNFIPRDY
610 620 630 640 650
QEMIENYVHW NEDIGEWQLK CVAYTGNNMR KQTPVPDKKE KDPFEVDLSH
660 670 680 690
VYLAYTEESL RQSLMKLERP RTSKGKARPK TGRRKRSAKP ETVIDSLLQ
Length:699
Mass (Da):80,041
Last modified:May 18, 2010 - v4
Checksum:iA0BF5BB1F699DF12
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PES4E9PES4_HUMAN
Kinesin-like protein
KIF3A
726Annotation score:
J3KPF9J3KPF9_HUMAN
Kinesin-like protein
KIF3A
702Annotation score:
A0A087X011A0A087X011_HUMAN
Kinesin-like protein
KIF3A
725Annotation score:
C9J9X2C9J9X2_HUMAN
Kinesin-like protein KIF3A
KIF3A
169Annotation score:
H7C2F6H7C2F6_HUMAN
Kinesin-like protein KIF3A
KIF3A
185Annotation score:

Sequence cautioni

The sequence AAC04475 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD93017 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151E → G in AAH45542 (PubMed:15489334).Curated1
Sequence conflicti170E → A in AAC72294 (PubMed:10548469).Curated1
Sequence conflicti409R → RDQA in BAD93017 (Ref. 2) Curated1
Sequence conflicti409R → RDQT in AAH45542 (PubMed:15489334).Curated1
Sequence conflicti409R → RIQI in AAC72294 (PubMed:10548469).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055319172K → I1 PublicationCorresponds to variant dbSNP:rs17854353Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041853 mRNA Translation: AAC72294.1
AB209780 mRNA Translation: BAD93017.1 Different initiation.
AC004039 Genomic DNA No translation available.
AC004237 Genomic DNA Translation: AAC04475.1 Sequence problems.
BC045542 mRNA Translation: AAH45542.1
CCDSiCCDS34235.1
RefSeqiNP_001287720.1, NM_001300791.1
NP_001287721.1, NM_001300792.1
NP_008985.3, NM_007054.6
UniGeneiHs.43670

Genome annotation databases

EnsembliENST00000378746; ENSP00000368020; ENSG00000131437
GeneIDi11127
KEGGihsa:11127
UCSCiuc003kxo.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041853 mRNA Translation: AAC72294.1
AB209780 mRNA Translation: BAD93017.1 Different initiation.
AC004039 Genomic DNA No translation available.
AC004237 Genomic DNA Translation: AAC04475.1 Sequence problems.
BC045542 mRNA Translation: AAH45542.1
CCDSiCCDS34235.1
RefSeqiNP_001287720.1, NM_001300791.1
NP_001287721.1, NM_001300792.1
NP_008985.3, NM_007054.6
UniGeneiHs.43670

3D structure databases

ProteinModelPortaliQ9Y496
SMRiQ9Y496
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116300, 82 interactors
ComplexPortaliCPX-3138 KIF3 complex variant AB
CPX-3199 KIF3 complex variant AC
CPX-3200 KIF3 complex variant AC-KAP3
CPX-3201 KIF3 complex variant AB-KAP3
CORUMiQ9Y496
DIPiDIP-33237N
IntActiQ9Y496, 27 interactors
MINTiQ9Y496
STRINGi9606.ENSP00000368020

Chemistry databases

BindingDBiQ9Y496
ChEMBLiCHEMBL5544

PTM databases

iPTMnetiQ9Y496
PhosphoSitePlusiQ9Y496

Polymorphism and mutation databases

BioMutaiKIF3A
DMDMi296439481

Proteomic databases

EPDiQ9Y496
MaxQBiQ9Y496
PaxDbiQ9Y496
PeptideAtlasiQ9Y496
PRIDEiQ9Y496
ProteomicsDBi86139

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378746; ENSP00000368020; ENSG00000131437
GeneIDi11127
KEGGihsa:11127
UCSCiuc003kxo.4 human

Organism-specific databases

CTDi11127
DisGeNETi11127
EuPathDBiHostDB:ENSG00000131437.15
GeneCardsiKIF3A
H-InvDBiHIX0024788
HGNCiHGNC:6319 KIF3A
HPAiCAB037085
MIMi604683 gene
neXtProtiNX_Q9Y496
OpenTargetsiENSG00000131437
PharmGKBiPA30102
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150817
HOGENOMiHOG000116164
HOVERGENiHBG052255
InParanoidiQ9Y496
KOiK10394
PhylomeDBiQ9Y496
TreeFamiTF105223

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2132295 MHC class II antigen presentation
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5620924 Intraflagellar transport
R-HSA-5635838 Activation of SMO
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189 Kinesins
SIGNORiQ9Y496

Miscellaneous databases

ChiTaRSiKIF3A human
GeneWikiiKIF3A
GenomeRNAii11127
PROiPR:Q9Y496
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131437 Expressed in 209 organ(s), highest expression level in forebrain
CleanExiHS_KIF3A
ExpressionAtlasiQ9Y496 baseline and differential
GenevisibleiQ9Y496 HS

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y496
Secondary accession number(s): A8MSW9
, Q59EN1, Q86XE9, Q9Y6V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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