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Entry version 151 (13 Feb 2019)
Sequence version 1 (01 Nov 1999)
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Protein

WD repeat domain phosphoinositide-interacting protein 4

Gene

WDR45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).2 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated upon amino-acid starvation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol-3,5-bisphosphate binding Source: GO_Central
  • phosphatidylinositol-3-phosphate binding Source: GO_Central
  • phosphatidylinositol phosphate binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1632852 Macroautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y484

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 4
Short name:
WIPI-4
Alternative name(s):
WD repeat-containing protein 45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR45
Synonyms:WDRX1, WDRXI4, WIPI4
ORF Names:JM5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196998.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28912 WDR45

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300526 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y484

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodegeneration with brain iron accumulation 5 (NBIA5)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. NBIA5 is characterized by global developmental delay in early childhood that is essentially static, with slow motor and cognitive gains until adolescence or early adulthood. In young adulthood, affected individuals develop progressive dystonia, parkinsonism, extrapyramidal signs, and dementia resulting in severe disability.
See also OMIM:300894
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0786457 – 360Missing in NBIA5. 1 PublicationAdd BLAST354
Natural variantiVAR_080430208A → D in NBIA5; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi15N → A: Decreased interaction with ATG2A. Loss of interaction with ATG2A; when associated with A-17. 1 Publication1
Mutagenesisi16Q → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi17D → A: Decreased interaction with ATG2A. Loss of interaction with ATG2A; when associated with A-15. 1 Publication1
Mutagenesisi55E → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi109R → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi111R → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi112H → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi113D → A: Loss of interaction with AMPK. No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi114K → A: No effect on interaction with ATG2A. 1 Publication1
Mutagenesisi232 – 233RR → AA: No effect on interaction with ATG2A. 1 Publication2

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
11152

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
WDR45

MalaCards human disease database

More...
MalaCardsi
WDR45
MIMi300894 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196998

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
329284 Beta-propeller protein-associated neurodegeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927673

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR45

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762056

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000514521 – 360WD repeat domain phosphoinositide-interacting protein 4Add BLAST360

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y484

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y484

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y484

PeptideAtlas

More...
PeptideAtlasi
Q9Y484

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y484

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86126
86127 [Q9Y484-2]
86128 [Q9Y484-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y484

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y484

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y484

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196998 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y484 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y484 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027562

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WIPI1 (PubMed:28561066). Interacts with WIPI2 (PubMed:28561066). Interacts with ATG2A and probably ATG2B (PubMed:28561066). Interacts with ULK1 (PubMed:28561066). May interact with the PRKAA1, PRKAA2, PRKAB1 and PRKAG1 subunits of the AMPK kinase (PubMed:28561066). May interact with NUDC (PubMed:28561066).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116323, 20 interactors

Protein interaction database and analysis system

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IntActi
Q9Y484, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348848

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y484

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 34WD 1Add BLAST34
Repeati40 – 84WD 2Add BLAST45
Repeati92 – 128WD 3Add BLAST37
Repeati133 – 174WD 4Add BLAST42
Repeati183 – 222WD 5Add BLAST40
Repeati227 – 266WD 6Add BLAST40
Repeati284 – 329WD 7Add BLAST46

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2111 Eukaryota
ENOG410XQZ6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155657

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217543

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053275

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y484

KEGG Orthology (KO)

More...
KOi
K22991

Identification of Orthologs from Complete Genome Data

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OMAi
CICAFGK

Database of Orthologous Groups

More...
OrthoDBi
966922at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y484

TreeFam database of animal gene trees

More...
TreeFami
TF314859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
IPR032910 WIPI4

The PANTHER Classification System

More...
PANTHERi
PTHR11227:SF44 PTHR11227:SF44, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 25 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y484-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLDHEQVGS
60 70 80 90 100
MGLVEMLHRS NLLALVGGGS SPKFSEISVL IWDDAREGKD SKEKLVLEFT
110 120 130 140 150
FTKPVLSVRM RHDKIVIVLK NRIYVYSFPD NPRKLFEFDT RDNPKGLCDL
160 170 180 190 200
CPSLEKQLLV FPGHKCGSLQ LVDLASTKPG TSSAPFTINA HQSDIACVSL
210 220 230 240 250
NQPGTVVASA SQKGTLIRLF DTQSKEKLVE LRRGTDPATL YCINFSHDSS
260 270 280 290 300
FLCASSDKGT VHIFALKDTR LNRRSALARV GKVGPMIGQY VDSQWSLASF
310 320 330 340 350
TVPAESACIC AFGRNTSKNV NSVIAICVDG TFHKYVFTPD GNCNREAFDV
360
YLDICDDDDF
Length:360
Mass (Da):39,868
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1A6746277182AF9
GO
Isoform 2 (identifier: Q9Y484-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-145: K → KAAHPTPHLHTL

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):41,044
Checksum:i2837B845913E4BD1
GO
Isoform 3 (identifier: Q9Y484-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: S → SA

Note: No experimental confirmation available.
Show »
Length:361
Mass (Da):39,939
Checksum:i780640AF2B1D2A63
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 25 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NM71A6NM71_HUMAN
PRA1 family protein
WDR45
292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J471C9J471_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G8JLI5G8JLI5_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYH8C9JYH8_HUMAN
WD repeat domain 45, isoform CRA_e
WDR45 hCG_1986580
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y329H0Y329_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JE01C9JE01_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVT3C9JVT3_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JBX7C9JBX7_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0A8C9J0A8_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5L0C9J5L0_HUMAN
WD repeat domain phosphoinositide-i...
WDR45
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti217I → T in CAG33006 (Ref. 3) Curated1
Sequence conflicti300 – 302FTV → YTA in AAV80764 (PubMed:15602573).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0786457 – 360Missing in NBIA5. 1 PublicationAdd BLAST354
Natural variantiVAR_080430208A → D in NBIA5; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01697578S → SA in isoform 3. 1 Publication1
Alternative sequenceiVSP_016976145K → KAAHPTPHLHTL in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY691428 mRNA Translation: AAV80764.1
AJ005897 mRNA Translation: CAA06754.1
CR456725 mRNA Translation: CAG33006.1
AF196779 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50697.1
CH471224 Genomic DNA Translation: EAW50702.1
BC000464 mRNA Translation: AAH00464.1
BC003037 mRNA Translation: AAH03037.1
BC009027 mRNA Translation: AAH09027.1
BC069206 mRNA Translation: AAH69206.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14318.1 [Q9Y484-3]
CCDS35250.1 [Q9Y484-1]

NCBI Reference Sequences

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RefSeqi
NP_001025067.1, NM_001029896.1 [Q9Y484-1]
NP_009006.2, NM_007075.3 [Q9Y484-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632807

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000322995; ENSP00000365543; ENSG00000196998 [Q9Y484-2]
ENST00000356463; ENSP00000348848; ENSG00000196998 [Q9Y484-3]
ENST00000376368; ENSP00000365546; ENSG00000196998 [Q9Y484-3]
ENST00000376372; ENSP00000365551; ENSG00000196998 [Q9Y484-1]
ENST00000634944; ENSP00000488972; ENSG00000196998 [Q9Y484-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11152

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11152

UCSC genome browser

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UCSCi
uc004dmk.2 human [Q9Y484-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY691428 mRNA Translation: AAV80764.1
AJ005897 mRNA Translation: CAA06754.1
CR456725 mRNA Translation: CAG33006.1
AF196779 Genomic DNA No translation available.
CH471224 Genomic DNA Translation: EAW50697.1
CH471224 Genomic DNA Translation: EAW50702.1
BC000464 mRNA Translation: AAH00464.1
BC003037 mRNA Translation: AAH03037.1
BC009027 mRNA Translation: AAH09027.1
BC069206 mRNA Translation: AAH69206.1
CCDSiCCDS14318.1 [Q9Y484-3]
CCDS35250.1 [Q9Y484-1]
RefSeqiNP_001025067.1, NM_001029896.1 [Q9Y484-1]
NP_009006.2, NM_007075.3 [Q9Y484-3]
UniGeneiHs.632807

3D structure databases

ProteinModelPortaliQ9Y484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116323, 20 interactors
IntActiQ9Y484, 10 interactors
STRINGi9606.ENSP00000348848

PTM databases

iPTMnetiQ9Y484
PhosphoSitePlusiQ9Y484
SwissPalmiQ9Y484

Polymorphism and mutation databases

BioMutaiWDR45
DMDMi74762056

Proteomic databases

EPDiQ9Y484
jPOSTiQ9Y484
PaxDbiQ9Y484
PeptideAtlasiQ9Y484
PRIDEiQ9Y484
ProteomicsDBi86126
86127 [Q9Y484-2]
86128 [Q9Y484-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
11152
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322995; ENSP00000365543; ENSG00000196998 [Q9Y484-2]
ENST00000356463; ENSP00000348848; ENSG00000196998 [Q9Y484-3]
ENST00000376368; ENSP00000365546; ENSG00000196998 [Q9Y484-3]
ENST00000376372; ENSP00000365551; ENSG00000196998 [Q9Y484-1]
ENST00000634944; ENSP00000488972; ENSG00000196998 [Q9Y484-1]
GeneIDi11152
KEGGihsa:11152
UCSCiuc004dmk.2 human [Q9Y484-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11152
DisGeNETi11152
EuPathDBiHostDB:ENSG00000196998.16

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR45
GeneReviewsiWDR45
HGNCiHGNC:28912 WDR45
HPAiHPA027562
MalaCardsiWDR45
MIMi300526 gene
300894 phenotype
neXtProtiNX_Q9Y484
OpenTargetsiENSG00000196998
Orphaneti329284 Beta-propeller protein-associated neurodegeneration
PharmGKBiPA134927673

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2111 Eukaryota
ENOG410XQZ6 LUCA
GeneTreeiENSGT00940000155657
HOGENOMiHOG000217543
HOVERGENiHBG053275
InParanoidiQ9Y484
KOiK22991
OMAiCICAFGK
OrthoDBi966922at2759
PhylomeDBiQ9Y484
TreeFamiTF314859

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SignaLinkiQ9Y484

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR45 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WDR45

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11152

Protein Ontology

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PROi
PR:Q9Y484

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196998 Expressed in 231 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasiQ9Y484 baseline and differential
GenevisibleiQ9Y484 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
IPR032910 WIPI4
PANTHERiPTHR11227:SF44 PTHR11227:SF44, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWIPI4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y484
Secondary accession number(s): A6NGH5
, B7WPI2, Q5MNZ5, Q6IBS7, Q6NT94, Q96H03
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 1, 1999
Last modified: February 13, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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