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UniProtKB - Q9Y483 (MTF2_HUMAN)

Entry version 175 (25 May 2022)
Sequence version 3 (28 Mar 2018)
Previous versions | rss
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Protein

Metal-response element-binding transcription factor 2

Gene

MTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557).

Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity).

Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity).

Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity).

In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity).

Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).

By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri102 – 157PHD-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri201 – 255PHD-type 2PROSITE-ProRule annotationAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y483

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212300, PRC2 methylates histones and DNA

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y483

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metal-response element-binding transcription factor 2
Alternative name(s):
Metal regulatory transcription factor 2
Metal-response element DNA-binding protein M96
Polycomb-like protein 2
Short name:
hPCl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTF2
Synonyms:PCL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29535, MTF2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609882, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y483

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143033

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi338 – 339KK → AA: Abolishes chromatin binding activity of the PRC2.1 complex. 1 Publication2
Mutagenesisi544 – 557Missing : Reduced chromatin binding activity of the PRC2.1 complex, probably due to loss of dimer stability. 1 PublicationAdd BLAST14

Organism-specific databases

DisGeNET

More...DisGeNETi		22823

Open Targets

More...OpenTargetsi		ENSG00000143033

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394586

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y483, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTF2

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000593171 – 593Metal-response element-binding transcription factor 2Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei452PhosphoserineCombined sources1
Cross-linki522Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y483

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y483

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y483

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y483

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y483

PeptideAtlas

More...PeptideAtlasi		Q9Y483

PRoteomics IDEntifications database

More...PRIDEi		Q9Y483

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3108
86123 [Q9Y483-1]
86124 [Q9Y483-2]
86125 [Q9Y483-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y483

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y483

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143033, Expressed in secondary oocyte and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y483, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y483, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143033, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the PRC2 complex, which consists of the core components EED, EZH1 or EZH2, SUZ12, and RBBP4, and various combinations of accessory subunits including AEBP2, JARID2, PHF19, MTF2 and EPOP (PubMed:31959557).

Forms a dimeric PRC2.1 (class 1, PRC-PCL) complex consisting of at least SUZ12, RBBP4, and PHF19 or MTF2; PHF19 and MTF2 stabilize the dimeric structure which enhances PRC2 interaction with chromatin (PubMed:31959557).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116499, 115 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y483, 44 interactors

Molecular INTeraction database

More...MINTi		Q9Y483

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359321

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y483, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y483

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y483

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini44 – 101TudorAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni360 – 411DisorderedSequence analysisAdd BLAST52
Regioni424 – 486DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi363 – 401Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi442 – 474Polar residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Polycomblike family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 157PHD-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri201 – 255PHD-type 2PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4323, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183180

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y483

Identification of Orthologs from Complete Genome Data

More...OMAi		IDRDKHR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y483

TreeFam database of animal gene trees

More...TreeFami		TF106420

Family and domain databases

Conserved Domains Database

More...CDDi		cd15578, PHD1_MTF2, 1 hit
cd15580, PHD2_MTF2, 1 hit
cd04508, TUDOR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR040477, KDM4_Tudor_2
IPR025894, Mtf2_C_dom
IPR042014, MTF2_PHD1
IPR042015, MTF2_PHD2
IPR002999, Tudor
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14061, Mtf2_C, 1 hit
PF00628, PHD, 1 hit
PF18104, Tudor_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00249, PHD, 2 hits
SM00333, TUDOR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y483-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ 
        60         70         80         90        100
DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS 
       110        120        130        140        150
GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL 
       160        170        180        190        200
CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE WDAGHKTNVQ 
       210        220        230        240        250
QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF GDRFYTFICS 
       260        270        280        290        300
VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW 
       310        320        330        340        350
DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV 
       360        370        380        390        400
PPVPPNVAFK AEKEPEGTSH EFKIKGRKAS KPISDSREVS NGIEKKGKKK 
       410        420        430        440        450
SVGRPPGPYT RKMIQKTAEP LLDKESISEN PTLDLPCSIG RTEGTAHSSN 
       460        470        480        490        500
TSDVDFTGAS SAKETTSSSI SRHYGLSDSR KRTRTGRSWP AAIPHLRRRR 
       510        520        530        540        550
GRLPRRALQT QNSEIVKDDE GKEDYQFDEL NTEILNNLAD QELQLNHLKN 
       560        570        580        590 
SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS
Length:593
Mass (Da):67,090
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4517B5DD61BB1AF4
GO
Isoform 2 (identifier: Q9Y483-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.

Show »
Length:262
Mass (Da):29,213
Checksum:iA631A09C112D2B1D
GO
Isoform 3 (identifier: Q9Y483-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:491
Mass (Da):55,725
Checksum:i662195D8854141CA
GO
Isoform 4 (identifier: Q9Y483-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-387: Missing.

Show »
Length:536
Mass (Da):60,649
Checksum:iD8ED11FC52648AF9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054765140S → C. Corresponds to variant dbSNP:rs2815427Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0046961 – 331Missing in isoform 2. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_0403291 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_053348331 – 387Missing in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF072814 mRNA Translation: AAC27618.1
AF073293 mRNA Translation: AAC27080.1
AJ010014 mRNA Translation: CAA08970.1
AK290318 mRNA Translation: BAF83007.1
AC093577 Genomic DNA No translation available.
AL117354 Genomic DNA No translation available.
KF459519 Genomic DNA No translation available.
BC010013 mRNA Translation: AAH10013.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53340.1 [Q9Y483-4]
CCDS53341.1 [Q9Y483-3]
CCDS742.1 [Q9Y483-1]

NCBI Reference Sequences

More...RefSeqi		NP_001157863.1, NM_001164391.1 [Q9Y483-3]
NP_001157864.1, NM_001164392.1 [Q9Y483-4]
NP_001157865.1, NM_001164393.1 [Q9Y483-3]
NP_031384.1, NM_007358.3 [Q9Y483-1]
XP_011539318.1, XM_011541016.1
XP_016856165.1, XM_017000676.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370298.9; ENSP00000359321.4; ENSG00000143033.18
ENST00000370303.4; ENSP00000359326.4; ENSG00000143033.18 [Q9Y483-4]
ENST00000540243.5; ENSP00000443295.1; ENSG00000143033.18 [Q9Y483-3]
ENST00000545708.5; ENSP00000444962.1; ENSG00000143033.18 [Q9Y483-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22823

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22823

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000370298.9; ENSP00000359321.4; NM_007358.4; NP_031384.1

UCSC genome browser

More...UCSCi		uc009wdj.4, human [Q9Y483-1]
uc009wdk.4, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072814 mRNA Translation: AAC27618.1
AF073293 mRNA Translation: AAC27080.1
AJ010014 mRNA Translation: CAA08970.1
AK290318 mRNA Translation: BAF83007.1
AC093577 Genomic DNA No translation available.
AL117354 Genomic DNA No translation available.
KF459519 Genomic DNA No translation available.
BC010013 mRNA Translation: AAH10013.1
CCDSiCCDS53340.1 [Q9Y483-4]
CCDS53341.1 [Q9Y483-3]
CCDS742.1 [Q9Y483-1]
RefSeqiNP_001157863.1, NM_001164391.1 [Q9Y483-3]
NP_001157864.1, NM_001164392.1 [Q9Y483-4]
NP_001157865.1, NM_001164393.1 [Q9Y483-3]
NP_031384.1, NM_007358.3 [Q9Y483-1]
XP_011539318.1, XM_011541016.1
XP_016856165.1, XM_017000676.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XFRX-ray2.25A/B43-358[»]
AlphaFoldDBiQ9Y483
SMRiQ9Y483
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116499, 115 interactors
IntActiQ9Y483, 44 interactors
MINTiQ9Y483
STRINGi9606.ENSP00000359321

PTM databases

iPTMnetiQ9Y483
PhosphoSitePlusiQ9Y483

Genetic variation databases

BioMutaiMTF2
DMDMi317373393

Proteomic databases

EPDiQ9Y483
jPOSTiQ9Y483
MassIVEiQ9Y483
MaxQBiQ9Y483
PaxDbiQ9Y483
PeptideAtlasiQ9Y483
PRIDEiQ9Y483
ProteomicsDBi3108
86123 [Q9Y483-1]
86124 [Q9Y483-2]
86125 [Q9Y483-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9Y483, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19938, 183 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		22823

Genome annotation databases

EnsembliENST00000370298.9; ENSP00000359321.4; ENSG00000143033.18
ENST00000370303.4; ENSP00000359326.4; ENSG00000143033.18 [Q9Y483-4]
ENST00000540243.5; ENSP00000443295.1; ENSG00000143033.18 [Q9Y483-3]
ENST00000545708.5; ENSP00000444962.1; ENSG00000143033.18 [Q9Y483-3]
GeneIDi22823
KEGGihsa:22823
MANE-SelectiENST00000370298.9; ENSP00000359321.4; NM_007358.4; NP_031384.1
UCSCiuc009wdj.4, human [Q9Y483-1]
uc009wdk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22823
DisGeNETi22823

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTF2
HGNCiHGNC:29535, MTF2
HPAiENSG00000143033, Low tissue specificity
MIMi609882, gene
neXtProtiNX_Q9Y483
OpenTargetsiENSG00000143033
PharmGKBiPA128394586
VEuPathDBiHostDB:ENSG00000143033

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4323, Eukaryota
GeneTreeiENSGT00950000183180
InParanoidiQ9Y483
OMAiIDRDKHR
PhylomeDBiQ9Y483
TreeFamiTF106420

Enzyme and pathway databases

PathwayCommonsiQ9Y483
ReactomeiR-HSA-212300, PRC2 methylates histones and DNA
SignaLinkiQ9Y483

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		22823, 17 hits in 1091 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTF2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22823
PharosiQ9Y483, Tbio

Protein Ontology

More...PROi		PR:Q9Y483
RNActiQ9Y483, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143033, Expressed in secondary oocyte and 248 other tissues
ExpressionAtlasiQ9Y483, baseline and differential
GenevisibleiQ9Y483, HS

Family and domain databases

CDDicd15578, PHD1_MTF2, 1 hit
cd15580, PHD2_MTF2, 1 hit
cd04508, TUDOR, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR040477, KDM4_Tudor_2
IPR025894, Mtf2_C_dom
IPR042014, MTF2_PHD1
IPR042015, MTF2_PHD2
IPR002999, Tudor
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF14061, Mtf2_C, 1 hit
PF00628, PHD, 1 hit
PF18104, Tudor_2, 1 hit
SMARTiView protein in SMART
SM00249, PHD, 2 hits
SM00333, TUDOR, 1 hit
SUPFAMiSSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS01359, ZF_PHD_1, 2 hits
PS50016, ZF_PHD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTF2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y483
Secondary accession number(s): A6NGQ9
, A8K2Q3, B1AKT5, B1AKT6, Q96G26, Q9UES9, Q9UP40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 28, 2018
Last modified: May 25, 2022
This is version 175 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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