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Protein

Metal-response element-binding transcription factor 2

Gene

MTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 157PHD-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri201 – 255PHD-type 2PROSITE-ProRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA

Names & Taxonomyi

Protein namesi
Recommended name:
Metal-response element-binding transcription factor 2
Alternative name(s):
Metal regulatory transcription factor 2
Metal-response element DNA-binding protein M96
Polycomb-like protein 2
Short name:
hPCl2
Gene namesi
Name:MTF2
Synonyms:PCL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143033.17
HGNCiHGNC:29535 MTF2
MIMi609882 gene
neXtProtiNX_Q9Y483

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143033
PharmGKBiPA128394586

Polymorphism and mutation databases

BioMutaiMTF2
DMDMi317373393

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593171 – 593Metal-response element-binding transcription factor 2Add BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphothreonineCombined sources1
Cross-linki360Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei452PhosphoserineCombined sources1
Cross-linki522Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y483
PaxDbiQ9Y483
PeptideAtlasiQ9Y483
PRIDEiQ9Y483
ProteomicsDBi86123
86124 [Q9Y483-2]
86125 [Q9Y483-3]

PTM databases

iPTMnetiQ9Y483
PhosphoSitePlusiQ9Y483

Expressioni

Gene expression databases

BgeeiENSG00000143033 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExiHS_MTF2
ExpressionAtlasiQ9Y483 baseline and differential
GenevisibleiQ9Y483 HS

Organism-specific databases

HPAiHPA069047
HPA069066

Interactioni

Subunit structurei

Associated component of the PRC2 complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116499, 21 interactors
IntActiQ9Y483, 24 interactors
MINTiQ9Y483
STRINGi9606.ENSP00000359321

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y483
SMRiQ9Y483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 101TudorAdd BLAST58

Domaini

The Tudor domain recognizes and binds H3K36me3 (PubMed:23142980, PubMed:23228662).2 Publications

Sequence similaritiesi

Belongs to the Polycomblike family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri102 – 157PHD-type 1PROSITE-ProRule annotationAdd BLAST56
Zinc fingeri201 – 255PHD-type 2PROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000009222
HOGENOMiHOG000010307
HOVERGENiHBG004755
InParanoidiQ9Y483
KOiK11485
OMAiVKKPACK
OrthoDBiEOG091G01JL
PhylomeDBiQ9Y483
TreeFamiTF106420

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR025894 Mtf2_C_dom
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF14061 Mtf2_C, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SM00333 TUDOR, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y483-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ
60 70 80 90 100
DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS
110 120 130 140 150
GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL
160 170 180 190 200
CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE WDAGHKTNVQ
210 220 230 240 250
QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF GDRFYTFICS
260 270 280 290 300
VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW
310 320 330 340 350
DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV
360 370 380 390 400
PPVPPNVAFK AEKEPEGTSH EFKIKGRKAS KPISDSREVS NGIEKKGKKK
410 420 430 440 450
SVGRPPGPYT RKMIQKTAEP LLDKESISEN PTLDLPCSIG RTEGTAHSSN
460 470 480 490 500
TSDVDFTGAS SAKETTSSSI SRHYGLSDSR KRTRTGRSWP AAIPHLRRRR
510 520 530 540 550
GRLPRRALQT QNSEIVKDDE GKEDYQFDEL NTEILNNLAD QELQLNHLKN
560 570 580 590
SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS
Length:593
Mass (Da):67,090
Last modified:March 28, 2018 - v3
Checksum:i4517B5DD61BB1AF4
GO
Isoform 2 (identifier: Q9Y483-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-331: Missing.

Show »
Length:262
Mass (Da):29,213
Checksum:iA631A09C112D2B1D
GO
Isoform 3 (identifier: Q9Y483-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:491
Mass (Da):55,725
Checksum:i662195D8854141CA
GO
Isoform 4 (identifier: Q9Y483-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-387: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,649
Checksum:iD8ED11FC52648AF9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DZG1B4DZG1_HUMAN
Metal response element binding tran...
MTF2 hCG_31944
491Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054765140S → C. Corresponds to variant dbSNP:rs2815427Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0046961 – 331Missing in isoform 2. 1 PublicationAdd BLAST331
Alternative sequenceiVSP_0403291 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_053348331 – 387Missing in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072814 mRNA Translation: AAC27618.1
AF073293 mRNA Translation: AAC27080.1
AJ010014 mRNA Translation: CAA08970.1
AK290318 mRNA Translation: BAF83007.1
AC093577 Genomic DNA No translation available.
AL117354 Genomic DNA No translation available.
KF459519 Genomic DNA No translation available.
BC010013 mRNA Translation: AAH10013.1
CCDSiCCDS53340.1 [Q9Y483-4]
CCDS53341.1 [Q9Y483-3]
CCDS742.1 [Q9Y483-1]
RefSeqiNP_001157863.1, NM_001164391.1 [Q9Y483-3]
NP_001157864.1, NM_001164392.1 [Q9Y483-4]
NP_001157865.1, NM_001164393.1 [Q9Y483-3]
NP_031384.1, NM_007358.3 [Q9Y483-1]
XP_011539318.1, XM_011541016.1
XP_016856165.1, XM_017000676.1 [Q9Y483-3]
UniGeneiHs.31016

Genome annotation databases

EnsembliENST00000370298; ENSP00000359321; ENSG00000143033 [Q9Y483-1]
ENST00000370303; ENSP00000359326; ENSG00000143033 [Q9Y483-4]
ENST00000540243; ENSP00000443295; ENSG00000143033 [Q9Y483-3]
ENST00000545708; ENSP00000444962; ENSG00000143033 [Q9Y483-3]
GeneIDi22823
KEGGihsa:22823
UCSCiuc009wdj.4 human [Q9Y483-1]
uc009wdk.4 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072814 mRNA Translation: AAC27618.1
AF073293 mRNA Translation: AAC27080.1
AJ010014 mRNA Translation: CAA08970.1
AK290318 mRNA Translation: BAF83007.1
AC093577 Genomic DNA No translation available.
AL117354 Genomic DNA No translation available.
KF459519 Genomic DNA No translation available.
BC010013 mRNA Translation: AAH10013.1
CCDSiCCDS53340.1 [Q9Y483-4]
CCDS53341.1 [Q9Y483-3]
CCDS742.1 [Q9Y483-1]
RefSeqiNP_001157863.1, NM_001164391.1 [Q9Y483-3]
NP_001157864.1, NM_001164392.1 [Q9Y483-4]
NP_001157865.1, NM_001164393.1 [Q9Y483-3]
NP_031384.1, NM_007358.3 [Q9Y483-1]
XP_011539318.1, XM_011541016.1
XP_016856165.1, XM_017000676.1 [Q9Y483-3]
UniGeneiHs.31016

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XFRX-ray2.25A/B43-358[»]
ProteinModelPortaliQ9Y483
SMRiQ9Y483
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116499, 21 interactors
IntActiQ9Y483, 24 interactors
MINTiQ9Y483
STRINGi9606.ENSP00000359321

PTM databases

iPTMnetiQ9Y483
PhosphoSitePlusiQ9Y483

Polymorphism and mutation databases

BioMutaiMTF2
DMDMi317373393

Proteomic databases

EPDiQ9Y483
PaxDbiQ9Y483
PeptideAtlasiQ9Y483
PRIDEiQ9Y483
ProteomicsDBi86123
86124 [Q9Y483-2]
86125 [Q9Y483-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370298; ENSP00000359321; ENSG00000143033 [Q9Y483-1]
ENST00000370303; ENSP00000359326; ENSG00000143033 [Q9Y483-4]
ENST00000540243; ENSP00000443295; ENSG00000143033 [Q9Y483-3]
ENST00000545708; ENSP00000444962; ENSG00000143033 [Q9Y483-3]
GeneIDi22823
KEGGihsa:22823
UCSCiuc009wdj.4 human [Q9Y483-1]
uc009wdk.4 human

Organism-specific databases

CTDi22823
EuPathDBiHostDB:ENSG00000143033.17
GeneCardsiMTF2
HGNCiHGNC:29535 MTF2
HPAiHPA069047
HPA069066
MIMi609882 gene
neXtProtiNX_Q9Y483
OpenTargetsiENSG00000143033
PharmGKBiPA128394586
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4323 Eukaryota
ENOG410XQ6E LUCA
GeneTreeiENSGT00390000009222
HOGENOMiHOG000010307
HOVERGENiHBG004755
InParanoidiQ9Y483
KOiK11485
OMAiVKKPACK
OrthoDBiEOG091G01JL
PhylomeDBiQ9Y483
TreeFamiTF106420

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA

Miscellaneous databases

ChiTaRSiMTF2 human
GenomeRNAii22823
PROiPR:Q9Y483
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143033 Expressed in 236 organ(s), highest expression level in secondary oocyte
CleanExiHS_MTF2
ExpressionAtlasiQ9Y483 baseline and differential
GenevisibleiQ9Y483 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR025894 Mtf2_C_dom
IPR002999 Tudor
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF14061 Mtf2_C, 1 hit
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SM00333 TUDOR, 1 hit
SUPFAMiSSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 2 hits
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTF2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y483
Secondary accession number(s): A6NGQ9
, A8K2Q3, B1AKT5, B1AKT6, Q96G26, Q9UES9, Q9UP40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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