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UniProtKB - Q9Y478 (AAKB1_HUMAN)

Entry version 200 (07 Apr 2021)
Sequence version 4 (23 Jan 2007)
Previous versions | rss
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Protein

5'-AMP-activated protein kinase subunit beta-1

Gene

PRKAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y478

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852, Macroautophagy
R-HSA-2151209, Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-9613354, Lipophagy
R-HSA-9619483, Activation of AMPK downstream of NMDARs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y478

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y478

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		CBM48, Carbohydrate-Binding Module Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-AMP-activated protein kinase subunit beta-1
Short name:
AMPK subunit beta-1
Short name:
AMPKb
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKAB1
Synonyms:AMPK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9378, PRKAB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602740, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y478

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111725.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Abolishes myristoylation and AMP-enhanced phosphorylation of PRKAA1 or PRKAA2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5564

Open Targets

More...OpenTargetsi		ENSG00000111725

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33746

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y478, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3847

Drug and drug target database

More...DrugBanki		DB00945, Acetylsalicylic acid
DB00131, Adenosine phosphate
DB12010, Fostamatinib
DB00331, Metformin
DB00273, Topiramate

DrugCentral

More...DrugCentrali		Q9Y478

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1543

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRKAB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		14194425

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002043632 – 2705'-AMP-activated protein kinase subunit beta-1Add BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphothreonineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei19PhosphothreonineCombined sources1
Modified residuei24Phosphoserine; by autocatalysisBy similarity1
Modified residuei25Phosphoserine; by autocatalysisBy similarity1
Modified residuei40PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei101PhosphoserineBy similarity1
Modified residuei108PhosphoserineCombined sources1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei182PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y478

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y478

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y478

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y478

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y478

PeptideAtlas

More...PeptideAtlasi		Q9Y478

PRoteomics IDEntifications database

More...PRIDEi		Q9Y478

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86122

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y478

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y478

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y478

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111725, Expressed in adult mammalian kidney and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y478, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y478, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111725, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).

Interacts with FNIP1 and FNIP2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111551, 84 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5633, AMPK complex, alpha1-beta1-gamma1 variant
CPX-5786, AMPK complex, alpha1-beta1-gamma2 variant
CPX-5787, AMPK complex, alpha2-beta1-gamma1 variant
CPX-5842, AMPK complex, alpha1-beta1-gamma3 variant
CPX-5843, AMPK complex, alpha2-beta1-gamma3 variant
CPX-5844, AMPK complex, alpha2-beta1-gamma2 variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y478

Database of interacting proteins

More...DIPi		DIP-39736N

Protein interaction database and analysis system

More...IntActi		Q9Y478, 35 interactors

Molecular INTeraction database

More...MINTi		Q9Y478

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000229328

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y478

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y478, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y478

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 163Glycogen-binding domainBy similarityAdd BLAST96

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-AMP-activated protein kinase beta subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1616, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070949_2_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GEDMKAP

Database of Orthologous Groups

More...OrthoDBi		956412at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y478

TreeFam database of animal gene trees

More...TreeFami		TF313827

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00686

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032640, AMPK1_CBM
IPR039160, AMPKB
IPR006828, ASC_dom
IPR037256, ASC_dom_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set

The PANTHER Classification System

More...PANTHERi		PTHR10343:SF89, PTHR10343:SF89, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16561, AMPK1_CBM, 1 hit
PF04739, AMPKBI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01010, AMPKBI, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF160219, SSF160219, 1 hit
SSF81296, SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNTSSERAA LERHGGHKTP RRDSSGGTKD GDRPKILMDS PEDADLFHSE 
        60         70         80         90        100
EIKAPEKEEF LAWQHDLEVN DKAPAQARPT VFRWTGGGKE VYLSGSFNNW 
       110        120        130        140        150
SKLPLTRSHN NFVAILDLPE GEHQYKFFVD GQWTHDPSEP IVTSQLGTVN 
       160        170        180        190        200
NIIQVKKTDF EVFDALMVDS QKCSDVSELS SSPPGPYHQE PYVCKPEERF 
       210        220        230        240        250
RAPPILPPHL LQVILNKDTG ISCDPALLPE PNHVMLNHLY ALSIKDGVMV 
       260        270
LSATHRYKKK YVTTLLYKPI
Length:270
Mass (Da):30,382
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0BCAA94D5BC15FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2X8F5H2X8_HUMAN
5'-AMP-activated protein kinase sub...
PRKAB1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H610F5H610_HUMAN
5'-AMP-activated protein kinase sub...
PRKAB1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4Y8F5H4Y8_HUMAN
5'-AMP-activated protein kinase sub...
PRKAB1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB71326 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAC98897 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10A → G in CAA73146 (PubMed:9224708).Curated1
Sequence conflicti10A → G in AAC98897 (Ref. 4) Curated1
Sequence conflicti15G → A in CAA12024 (Ref. 1) Curated1
Sequence conflicti20P → A in CAA73146 (PubMed:9224708).Curated1
Sequence conflicti20P → A in AAC98897 (Ref. 4) Curated1
Sequence conflicti22R → K in AAD09237 (Ref. 3) Curated1
Sequence conflicti22R → K in AAD00625 (Ref. 3) Curated1
Sequence conflicti56E → Y in AAD09237 (Ref. 3) Curated1
Sequence conflicti56E → Y in AAD00625 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ224515 mRNA Translation: CAA12024.1
Y12556 mRNA Translation: CAA73146.1
U83994 mRNA Translation: AAD09237.1
U87276 U87275 Genomic DNA Translation: AAD00625.1
AF022116 mRNA Translation: AAC98897.1 Frameshift.
AC002563 Genomic DNA Translation: AAB71326.1 Sequence problems.
BC001007 mRNA Translation: AAH01007.1
BC001056 mRNA Translation: AAH01056.1
BC001823 mRNA Translation: AAH01823.1
BC017671 mRNA Translation: AAH17671.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9191.1

Protein sequence database of the Protein Information Resource

More...PIRi		T09514

NCBI Reference Sequences

More...RefSeqi		NP_006244.2, NM_006253.4
XP_005253966.1, XM_005253909.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229328; ENSP00000229328; ENSG00000111725
ENST00000541640; ENSP00000441369; ENSG00000111725

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5564

UCSC genome browser

More...UCSCi		uc001txg.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224515 mRNA Translation: CAA12024.1
Y12556 mRNA Translation: CAA73146.1
U83994 mRNA Translation: AAD09237.1
U87276 U87275 Genomic DNA Translation: AAD00625.1
AF022116 mRNA Translation: AAC98897.1 Frameshift.
AC002563 Genomic DNA Translation: AAB71326.1 Sequence problems.
BC001007 mRNA Translation: AAH01007.1
BC001056 mRNA Translation: AAH01056.1
BC001823 mRNA Translation: AAH01823.1
BC017671 mRNA Translation: AAH17671.1
CCDSiCCDS9191.1
PIRiT09514
RefSeqiNP_006244.2, NM_006253.4
XP_005253966.1, XM_005253909.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CFEX-ray3.02B/D1-270[»]
4CFFX-ray3.92B/D1-270[»]
4ZHXX-ray2.99B/D1-270[»]
5EZVX-ray2.99B/D1-270[»]
5ISOX-ray2.63B/D1-270[»]
6B1UX-ray2.77B/D1-270[»]
6C9FX-ray2.92B68-270[»]
6C9GX-ray2.70B67-270[»]
6C9HX-ray2.65B68-270[»]
6C9JX-ray3.05B68-270[»]
SMRiQ9Y478
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111551, 84 interactors
ComplexPortaliCPX-5633, AMPK complex, alpha1-beta1-gamma1 variant
CPX-5786, AMPK complex, alpha1-beta1-gamma2 variant
CPX-5787, AMPK complex, alpha2-beta1-gamma1 variant
CPX-5842, AMPK complex, alpha1-beta1-gamma3 variant
CPX-5843, AMPK complex, alpha2-beta1-gamma3 variant
CPX-5844, AMPK complex, alpha2-beta1-gamma2 variant
CORUMiQ9Y478
DIPiDIP-39736N
IntActiQ9Y478, 35 interactors
MINTiQ9Y478
STRINGi9606.ENSP00000229328

Chemistry databases

BindingDBiQ9Y478
ChEMBLiCHEMBL3847
DrugBankiDB00945, Acetylsalicylic acid
DB00131, Adenosine phosphate
DB12010, Fostamatinib
DB00331, Metformin
DB00273, Topiramate
DrugCentraliQ9Y478
GuidetoPHARMACOLOGYi1543

Protein family/group databases

CAZyiCBM48, Carbohydrate-Binding Module Family 48

PTM databases

iPTMnetiQ9Y478
PhosphoSitePlusiQ9Y478
SwissPalmiQ9Y478

Genetic variation databases

BioMutaiPRKAB1
DMDMi14194425

Proteomic databases

EPDiQ9Y478
jPOSTiQ9Y478
MassIVEiQ9Y478
MaxQBiQ9Y478
PaxDbiQ9Y478
PeptideAtlasiQ9Y478
PRIDEiQ9Y478
ProteomicsDBi86122

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1328, 808 antibodies

Genome annotation databases

EnsembliENST00000229328; ENSP00000229328; ENSG00000111725
ENST00000541640; ENSP00000441369; ENSG00000111725
GeneIDi5564
KEGGihsa:5564
UCSCiuc001txg.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5564
DisGeNETi5564

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRKAB1
HGNCiHGNC:9378, PRKAB1
HPAiENSG00000111725, Low tissue specificity
MIMi602740, gene
neXtProtiNX_Q9Y478
OpenTargetsiENSG00000111725
PharmGKBiPA33746
VEuPathDBiHostDB:ENSG00000111725.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1616, Eukaryota
GeneTreeiENSGT00940000155307
HOGENOMiCLU_070949_2_0_1
OMAiGEDMKAP
OrthoDBi956412at2759
PhylomeDBiQ9Y478
TreeFamiTF313827

Enzyme and pathway databases

PathwayCommonsiQ9Y478
ReactomeiR-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852, Macroautophagy
R-HSA-2151209, Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-6804756, Regulation of TP53 Activity through Phosphorylation
R-HSA-9613354, Lipophagy
R-HSA-9619483, Activation of AMPK downstream of NMDARs
SignaLinkiQ9Y478
SIGNORiQ9Y478

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5564, 12 hits in 1000 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRKAB1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRKAB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5564
PharosiQ9Y478, Tchem

Protein Ontology

More...PROi		PR:Q9Y478
RNActiQ9Y478, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111725, Expressed in adult mammalian kidney and 210 other tissues
ExpressionAtlasiQ9Y478, baseline and differential
GenevisibleiQ9Y478, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
IDEALiIID00686
InterProiView protein in InterPro
IPR032640, AMPK1_CBM
IPR039160, AMPKB
IPR006828, ASC_dom
IPR037256, ASC_dom_sf
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
PANTHERiPTHR10343:SF89, PTHR10343:SF89, 1 hit
PfamiView protein in Pfam
PF16561, AMPK1_CBM, 1 hit
PF04739, AMPKBI, 1 hit
SMARTiView protein in SMART
SM01010, AMPKBI, 1 hit
SUPFAMiSSF160219, SSF160219, 1 hit
SSF81296, SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAKB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y478
Secondary accession number(s): Q9UBV0
, Q9UE20, Q9UEX2, Q9Y6V8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 200 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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