PRKAB1

Functionⁱ

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

GO - Molecular functionⁱ

AMP-activated protein kinase activity Source: Ensembl
protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17028174
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: Reactome
fatty acid biosynthetic process Source: UniProtKB-KW
macroautophagy Source: Reactome
nail development Source: Ensembl
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 27411013
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 17028174
protein heterooligomerization Source: Ensembl
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 17028174
regulation of catalytic activity Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9575201

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Biological process

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1632852 Macroautophagy R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SignaLinkⁱ	Q9Y478
SIGNORⁱ	Q9Y478

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	CBM48 Carbohydrate-Binding Module Family 48

CAZyⁱ

CBM48 Carbohydrate-Binding Module Family 48

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5'-AMP-activated protein kinase subunit beta-1 Short name: AMPK subunit beta-1 Short name: AMPKb
Gene namesⁱ	Name:PRKAB1 Synonyms:AMPK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111725.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9378 PRKAB1
MIMⁱ	602740 gene
neXtProtⁱ	NX_Q9Y478

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	2	G → A: Abolishes myristoylation and AMP-enhanced phosphorylation of PRKAA1 or PRKAA2. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5564
Open Targets More...OpenTargetsⁱ	ENSG00000111725
PharmGKBⁱ	PA33746

Chemistry databases

ChEMBLⁱ	CHEMBL3847
Drug and drug target database More...DrugBankⁱ	DB00945 Acetylsalicylic acid DB00131 Adenosine monophosphate DB00331 Metformin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1543

Polymorphism and mutation databases

BioMutaⁱ	PRKAB1
DMDMⁱ	14194425

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000204363	2 – 270	5'-AMP-activated protein kinase subunit beta-1Add BLAST		269

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Modified residueⁱ	4	PhosphothreonineCombined sources	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	6	PhosphoserineCombined sources	1
Modified residueⁱ	19	PhosphothreonineCombined sources	1
Modified residueⁱ	24	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	25	Phosphoserine; by autocatalysisBy similarity	1
Modified residueⁱ	40	PhosphoserineCombined sources	1
Modified residueⁱ	96	PhosphoserineCombined sources	1
Modified residueⁱ	101	PhosphoserineBy similarity	1
Modified residueⁱ	108	PhosphoserineCombined sources	1
Modified residueⁱ	148	PhosphothreonineCombined sources	1
Modified residueⁱ	182	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y478
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y478
PaxDbⁱ	Q9Y478
PeptideAtlas More...PeptideAtlasⁱ	Q9Y478
PRIDEⁱ	Q9Y478
ProteomicsDBⁱ	86122

PTM databases

iPTMnetⁱ	Q9Y478
PhosphoSitePlusⁱ	Q9Y478
SwissPalmⁱ	Q9Y478

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111725 Expressed in 198 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_PRKAB1
ExpressionAtlasⁱ	Q9Y478 baseline and differential
Genevisibleⁱ	Q9Y478 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005058 HPA004247

HPAⁱ

CAB005058
HPA004247

Interactionⁱ

Subunit structureⁱ

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Cidea	O70302	4	EBI-719769,EBI-7927848	From Mus musculus.
GRB2	P62993	2	EBI-719769,EBI-401755
PRKAA1	Q13131	8	EBI-719769,EBI-1181405
PRKAA2	P54646	3	EBI-719769,EBI-1383852
PRKAG1	P54619	8	EBI-719769,EBI-1181439

GO - Molecular functionⁱ

protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111551, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-39736N
IntActⁱ	Q9Y478, 19 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y478
STRINGⁱ	9606.ENSP00000229328

Chemistry databases

BindingDBⁱ

Q9Y478

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	79 – 84	Combined sources	6
Beta strandⁱ	91 – 95	Combined sources	5
Helixⁱ	96 – 98	Combined sources	3
Beta strandⁱ	106 – 110	Combined sources	5
Beta strandⁱ	112 – 117	Combined sources	6
Beta strandⁱ	120 – 129	Combined sources	10
Beta strandⁱ	132 – 134	Combined sources	3
Beta strandⁱ	137 – 139	Combined sources	3
Beta strandⁱ	141 – 143	Combined sources	3
Beta strandⁱ	145 – 147	Combined sources	3
Beta strandⁱ	149 – 155	Combined sources	7
Helixⁱ	157 – 159	Combined sources	3
Helixⁱ	162 – 176	Combined sources	15
Helixⁱ	208 – 211	Combined sources	4
Helixⁱ	214 – 216	Combined sources	3
Beta strandⁱ	221 – 223	Combined sources	3
Helixⁱ	233 – 235	Combined sources	3
Beta strandⁱ	238 – 241	Combined sources	4
Beta strandⁱ	248 – 257	Combined sources	10
Beta strandⁱ	260 – 269	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y478
SMRⁱ	Q9Y478
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	68 – 163	Glycogen-binding domainBy similarityAdd BLAST		96

Domainⁱ

The glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.By similarity

Sequence similaritiesⁱ

Belongs to the 5'-AMP-activated protein kinase beta subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1616 Eukaryota ENOG410XRB3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001416
HOGENOMⁱ	HOG000230597
HOVERGENⁱ	HBG050430
KEGG Orthology (KO) More...KOⁱ	K07199
OMAⁱ	QWTHDPA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DZR
PhylomeDBⁱ	Q9Y478
TreeFamⁱ	TF313827

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR032640 AMPK1_CBM IPR039160 AMPKB IPR006828 ASC_dom IPR037256 ASC_dom_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set
PANTHERⁱ	PTHR10343:SF80 PTHR10343:SF80, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16561 AMPK1_CBM, 1 hit PF04739 AMPKBI, 1 hit
SMARTⁱ	View protein in SMART SM01010 AMPKBI, 1 hit
SUPFAMⁱ	SSF160219 SSF160219, 1 hit SSF81296 SSF81296, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9Y478-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNTSSERAA LERHGGHKTP RRDSSGGTKD GDRPKILMDS PEDADLFHSE 
        60         70         80         90        100
EIKAPEKEEF LAWQHDLEVN DKAPAQARPT VFRWTGGGKE VYLSGSFNNW 
       110        120        130        140        150
SKLPLTRSHN NFVAILDLPE GEHQYKFFVD GQWTHDPSEP IVTSQLGTVN 
       160        170        180        190        200
NIIQVKKTDF EVFDALMVDS QKCSDVSELS SSPPGPYHQE PYVCKPEERF 
       210        220        230        240        250
RAPPILPPHL LQVILNKDTG ISCDPALLPE PNHVMLNHLY ALSIKDGVMV 
       260        270
LSATHRYKKK YVTTLLYKPI

Length:270

Mass (Da):30,382

Last modified:January 23, 2007 - v4

Checksum:ⁱF0BCAA94D5BC15FC

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H2X8	F5H2X8_HUMAN	5'-AMP-activated protein kinase sub... 5'-AMP-activated protein kinase subunit beta-1	PRKAB1	104	Annotation score:
F5H610	F5H610_HUMAN	5'-AMP-activated protein kinase sub... 5'-AMP-activated protein kinase subunit beta-1	PRKAB1	62	Annotation score:
F5H4Y8	F5H4Y8_HUMAN	5'-AMP-activated protein kinase sub... 5'-AMP-activated protein kinase subunit beta-1	PRKAB1	58	Annotation score:

Sequence cautionⁱ

The sequence AAB71326 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAC98897 differs from that shown. Reason: Frameshift at position 245.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10	A → G in CAA73146 (PubMed:9224708).Curated	1
Sequence conflictⁱ	10	A → G in AAC98897 (Ref. 4) Curated	1
Sequence conflictⁱ	15	G → A in CAA12024 (Ref. 1) Curated	1
Sequence conflictⁱ	20	P → A in CAA73146 (PubMed:9224708).Curated	1
Sequence conflictⁱ	20	P → A in AAC98897 (Ref. 4) Curated	1
Sequence conflictⁱ	22	R → K in AAD09237 (Ref. 3) Curated	1
Sequence conflictⁱ	22	R → K in AAD00625 (Ref. 3) Curated	1
Sequence conflictⁱ	56	E → Y in AAD09237 (Ref. 3) Curated	1
Sequence conflictⁱ	56	E → Y in AAD00625 (Ref. 3) Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224515 mRNA Translation: CAA12024.1 Y12556 mRNA Translation: CAA73146.1 U83994 mRNA Translation: AAD09237.1 U87276 U87275 Genomic DNA Translation: AAD00625.1 AF022116 mRNA Translation: AAC98897.1 Frameshift. AC002563 Genomic DNA Translation: AAB71326.1 Sequence problems. BC001007 mRNA Translation: AAH01007.1 BC001056 mRNA Translation: AAH01056.1 BC001823 mRNA Translation: AAH01823.1 BC017671 mRNA Translation: AAH17671.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9191.1
PIRⁱ	T09514
NCBI Reference Sequences More...RefSeqⁱ	NP_006244.2, NM_006253.4 XP_005253966.1, XM_005253909.1
UniGeneⁱ	Hs.741184

Genome annotation databases

Ensemblⁱ	ENST00000229328; ENSP00000229328; ENSG00000111725 ENST00000541640; ENSP00000441369; ENSG00000111725
GeneIDⁱ	5564
KEGGⁱ	hsa:5564
UCSC genome browser More...UCSCⁱ	uc001txg.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q9Y478	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, isoform CRA_a		HUMAN		270	UniRef100_Q9Y478
5'-AMP-activated protein kinase subunit beta-1		MACMU		270
5'-AMP-activated protein kinase subunit beta-1		PANTR		270
5'-AMP-activated protein kinase subunit beta-1		CALJA		270
Protein kinase AMP-activated non-catalytic subunit beta 1		MACFA		270
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9Y478	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, isoform CRA_a		HUMAN		270	UniRef90_Q9Y478
5'-AMP-activated protein kinase subunit beta-1		MACMU		270
5'-AMP-activated protein kinase subunit beta-1		PANTR		270
5'-AMP-activated protein kinase subunit beta-1		CALJA		270
Protein kinase AMP-activated non-catalytic subunit beta 1		MACFA		270
+25

Protein	Similar proteins		Species	Score	Length	Source
Q9Y478	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, isoform CRA_a		HUMAN		270	UniRef50_Q9Y478
5'-AMP-activated protein kinase subunit beta-1		MACMU		270
5'-AMP-activated protein kinase subunit beta-1		PANTR		270
5'-AMP-activated protein kinase subunit beta-1		CALJA		270
Protein kinase AMP-activated non-catalytic subunit beta 1		MACFA		270
+240

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ224515 mRNA Translation: CAA12024.1 Y12556 mRNA Translation: CAA73146.1 U83994 mRNA Translation: AAD09237.1 U87276 U87275 Genomic DNA Translation: AAD00625.1 AF022116 mRNA Translation: AAC98897.1 Frameshift. AC002563 Genomic DNA Translation: AAB71326.1 Sequence problems. BC001007 mRNA Translation: AAH01007.1 BC001056 mRNA Translation: AAH01056.1 BC001823 mRNA Translation: AAH01823.1 BC017671 mRNA Translation: AAH17671.1
CCDSⁱ	CCDS9191.1
PIRⁱ	T09514
RefSeqⁱ	NP_006244.2, NM_006253.4 XP_005253966.1, XM_005253909.1
UniGeneⁱ	Hs.741184

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4CFE	X-ray	3.02	B/D	1-270	[»]
	4CFF	X-ray	3.92	B/D	1-270	[»]
	4ZHX	X-ray	2.99	B/D	1-270	[»]
	5EZV	X-ray	2.99	B/D	1-270	[»]
	5ISO	X-ray	2.63	B/D	1-270	[»]
	6B1U	X-ray	2.77	B/D	1-270	[»]
ProteinModelPortalⁱ	Q9Y478
SMRⁱ	Q9Y478
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111551, 59 interactors
DIPⁱ	DIP-39736N
IntActⁱ	Q9Y478, 19 interactors
MINTⁱ	Q9Y478
STRINGⁱ	9606.ENSP00000229328

Chemistry databases

BindingDBⁱ	Q9Y478
ChEMBLⁱ	CHEMBL3847
DrugBankⁱ	DB00945 Acetylsalicylic acid DB00131 Adenosine monophosphate DB00331 Metformin
GuidetoPHARMACOLOGYⁱ	1543

Protein family/group databases

CAZyⁱ	CBM48 Carbohydrate-Binding Module Family 48

CAZyⁱ

CBM48 Carbohydrate-Binding Module Family 48

PTM databases

iPTMnetⁱ	Q9Y478
PhosphoSitePlusⁱ	Q9Y478
SwissPalmⁱ	Q9Y478

Polymorphism and mutation databases

BioMutaⁱ	PRKAB1
DMDMⁱ	14194425

Proteomic databases

EPDⁱ	Q9Y478
MaxQBⁱ	Q9Y478
PaxDbⁱ	Q9Y478
PeptideAtlasⁱ	Q9Y478
PRIDEⁱ	Q9Y478
ProteomicsDBⁱ	86122

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000229328; ENSP00000229328; ENSG00000111725 ENST00000541640; ENSP00000441369; ENSG00000111725
GeneIDⁱ	5564
KEGGⁱ	hsa:5564
UCSCⁱ	uc001txg.4 human

Organism-specific databases

CTDⁱ	5564
DisGeNETⁱ	5564
EuPathDBⁱ	HostDB:ENSG00000111725.10
GeneCardsⁱ	PRKAB1
HGNCⁱ	HGNC:9378 PRKAB1
HPAⁱ	CAB005058 HPA004247
MIMⁱ	602740 gene
neXtProtⁱ	NX_Q9Y478
OpenTargetsⁱ	ENSG00000111725
PharmGKBⁱ	PA33746
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1616 Eukaryota ENOG410XRB3 LUCA
GeneTreeⁱ	ENSGT00390000001416
HOGENOMⁱ	HOG000230597
HOVERGENⁱ	HBG050430
KOⁱ	K07199
OMAⁱ	QWTHDPA
OrthoDBⁱ	EOG091G0DZR
PhylomeDBⁱ	Q9Y478
TreeFamⁱ	TF313827

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1632852 Macroautophagy R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
SignaLinkⁱ	Q9Y478
SIGNORⁱ	Q9Y478

Miscellaneous databases

GeneWikiⁱ	PRKAB1
GenomeRNAiⁱ	5564
Protein Ontology More...PROⁱ	PR:Q9Y478
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111725 Expressed in 198 organ(s), highest expression level in adult mammalian kidney
CleanExⁱ	HS_PRKAB1
ExpressionAtlasⁱ	Q9Y478 baseline and differential
Genevisibleⁱ	Q9Y478 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR032640 AMPK1_CBM IPR039160 AMPKB IPR006828 ASC_dom IPR037256 ASC_dom_sf IPR013783 Ig-like_fold IPR014756 Ig_E-set
PANTHERⁱ	PTHR10343:SF80 PTHR10343:SF80, 1 hit
Pfamⁱ	View protein in Pfam PF16561 AMPK1_CBM, 1 hit PF04739 AMPKBI, 1 hit
SMARTⁱ	View protein in SMART SM01010 AMPKBI, 1 hit
SUPFAMⁱ	SSF160219 SSF160219, 1 hit SSF81296 SSF81296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AAKB1_HUMAN
Accessionⁱ	Q9Y478Primary (citable) accession number: Q9Y478 Secondary accession number(s): Q9UBV0 , Q9UE20, Q9UEX2, Q9Y6V8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 183 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y478 (AAKB1_HUMAN)

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5'-AMP-activated protein kinase subunit beta-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ