UniProtKB - Q9Y463 (DYR1B_HUMAN)
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
DYRK1B
Functioni
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661).
During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815).
Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
5 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 140 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 239 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 117 – 125 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 190 – 193 | ATPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- protein tyrosine kinase activity Source: UniProtKB-KW
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- adipose tissue development Source: UniProtKB
- myoblast fusion Source: Ensembl
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein autophosphorylation Source: InterPro
- protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase |
Biological process | DNA damage, DNA repair |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q9Y463 |
SignaLinki | Q9Y463 |
SIGNORi | Q9Y463 |
Names & Taxonomyi
Protein namesi | Recommended name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC:2.7.12.11 Publication)Alternative name(s): Minibrain-related kinase Mirk protein kinase |
Gene namesi | Name:DYRK1B Synonyms:MIRK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3092, DYRK1B |
MIMi | 604556, gene |
neXtProti | NX_Q9Y463 |
VEuPathDBi | HostDB:ENSG00000105204 |
Subcellular locationi
Nucleus
Other locations
- Chromosome 1 Publication
Note: Localizes to sites of double-strand breaks (DSBs) following DNA damage.1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromosome Source: HPA
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Involvement in diseasei
Abdominal obesity-metabolic syndrome 3 (AOMS3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071773 | 90 | H → P in AOMS3; expression of glucose-6-phosphatase is significantly higher than wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777380EnsemblClinVar. | 1 | |
Natural variantiVAR_071774 | 102 | R → C in AOMS3; accumulation of intracellular lipid is significantly greater than with wild-type protein; cells expressing the variant are able to transform into mature adipocytes without requiring adipogenic medium; expression levels of CEBPA, PPARG forms 1 and 2 and PPARGC1A are higher and those of GLI1 and CDKN1B are lower in cells transfected with the mutant protein compared to wild-type; WNT1 signaling activity is lower in mutant cells compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs367643250EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 140 | K → R: Abolishes kinase activity. 1 Publication | 1 | |
Mutagenesisi | 239 | D → A: Abolishes kinase activity. 1 Publication | 1 | |
Mutagenesisi | 271 | Y → F: Abolishes kinase activity; when associated with F-273. 1 Publication | 1 | |
Mutagenesisi | 273 | Y → F: Abolishes kinase activity; when associated with F-271. 1 Publication | 1 |
Keywords - Diseasei
Diabetes mellitus, ObesityOrganism-specific databases
DisGeNETi | 9149 |
MalaCardsi | DYRK1B |
MIMi | 615812, phenotype |
OpenTargetsi | ENSG00000105204 |
Orphaneti | 411969, NON RARE IN EUROPE: Metabolic syndrome |
PharmGKBi | PA27549 |
Miscellaneous databases
Pharosi | Q9Y463, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5543 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y463 |
GuidetoPHARMACOLOGYi | 2010 |
Genetic variation databases
BioMutai | DYRK1B |
DMDMi | 9296963 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085934 | 1 – 629 | Dual specificity tyrosine-phosphorylation-regulated kinase 1BAdd BLAST | 629 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 63 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 92 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 111 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 129 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 171 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 262 | PhosphoserineBy similarity | 1 | |
Modified residuei | 271 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 273 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 401 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 624 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y463 |
jPOSTi | Q9Y463 |
MassIVEi | Q9Y463 |
MaxQBi | Q9Y463 |
PaxDbi | Q9Y463 |
PeptideAtlasi | Q9Y463 |
PRIDEi | Q9Y463 |
ProteomicsDBi | 86110 [Q9Y463-1] 86111 [Q9Y463-2] 86112 [Q9Y463-3] |
PTM databases
iPTMneti | Q9Y463 |
PhosphoSitePlusi | Q9Y463 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105204, Expressed in right adrenal gland and 174 other tissues |
ExpressionAtlasi | Q9Y463, baseline and differential |
Genevisiblei | Q9Y463, HS |
Organism-specific databases
HPAi | ENSG00000105204, Tissue enhanced (skeletal muscle, testis) |
Interactioni
Subunit structurei
Binary interactionsi
Q9Y463
Protein-protein interaction databases
BioGRIDi | 114596, 74 interactors |
ELMi | Q9Y463 |
IntActi | Q9Y463, 72 interactors |
MINTi | Q9Y463 |
STRINGi | 9606.ENSP00000469863 |
Chemistry databases
BindingDBi | Q9Y463 |
Miscellaneous databases
RNActi | Q9Y463, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 111 – 431 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 321 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 67 – 89 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 380 – 399 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 436 – 629 | DisorderedSequence analysisAdd BLAST | 194 | |
Regioni | 480 – 520 | Interaction with RANBP91 PublicationAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 69 – 86 | Bipartite nuclear localization signalSequence analysisAdd BLAST | 18 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 439 – 485 | Polar residuesSequence analysisAdd BLAST | 47 | |
Compositional biasi | 546 – 562 | Pro residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000160345 |
HOGENOMi | CLU_000288_5_6_1 |
InParanoidi | Q9Y463 |
OMAi | GHSTADY |
OrthoDBi | 1219474at2759 |
PhylomeDBi | Q9Y463 |
TreeFami | TF314624 |
Family and domain databases
CDDi | cd14226, PKc_DYRK1, 1 hit |
InterProi | View protein in InterPro IPR028318, DYRK1A/B_MNB IPR011009, Kinase-like_dom_sf IPR044131, PKc_DYR1A/1B IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24058:SF12, PTHR24058:SF12, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV
60 70 80 90 100
DLIKTYKHIN EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI
110 120 130 140 150
VRSGERWLER YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN
160 170 180 190 200
QAQIELRLLE LMNQHDTEMK YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL
210 220 230 240 250
LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL KPENILLCNP
260 270 280 290 300
KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG
310 320 330 340 350
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL
360 370 380 390 400
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD
410 420 430 440 450
YLRFQDLVLR MLEYEPAARI SPLGALQHGF FRRTADEATN TGPAGSSAST
460 470 480 490 500
SPAPLDTCPS SSTASSISSS GGSSGSSSDN RTYRYSNRYC GGPGPPITDC
510 520 530 540 550
EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA QLPPQPRYLG
560 570 580 590 600
RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR
610 620
PPLPPPDDPA TLGPHLGLRG VPQSTAASS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R131 | M0R131_HUMAN | Dual-specificity kinase | DYRK1B | 172 | Annotation score: | ||
M0R2X3 | M0R2X3_HUMAN | Dual-specificity kinase | DYRK1B | 137 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_040454 | 28 | L → P1 PublicationCorresponds to variant dbSNP:rs34587974EnsemblClinVar. | 1 | |
Natural variantiVAR_071773 | 90 | H → P in AOMS3; expression of glucose-6-phosphatase is significantly higher than wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777380EnsemblClinVar. | 1 | |
Natural variantiVAR_071774 | 102 | R → C in AOMS3; accumulation of intracellular lipid is significantly greater than with wild-type protein; cells expressing the variant are able to transform into mature adipocytes without requiring adipogenic medium; expression levels of CEBPA, PPARG forms 1 and 2 and PPARGC1A are higher and those of GLI1 and CDKN1B are lower in cells transfected with the mutant protein compared to wild-type; WNT1 signaling activity is lower in mutant cells compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs367643250EnsemblClinVar. | 1 | |
Natural variantiVAR_040455 | 102 | R → H1 PublicationCorresponds to variant dbSNP:rs55687541Ensembl. | 1 | |
Natural variantiVAR_040456 | 234 | S → G1 PublicationCorresponds to variant dbSNP:rs35858874Ensembl. | 1 | |
Natural variantiVAR_040457 | 275 | Q → R in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004925 | 366 – 405 | Missing in isoform 2. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_004926 | 378 – 405 | Missing in isoform 3. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17999 mRNA Translation: CAA76991.1 Y17999 mRNA Translation: CAA76990.1 Y17999 mRNA Translation: CAA76989.1 AF205861 mRNA Translation: AAF15893.1 AC005393 Genomic DNA Translation: AAC28914.1 Sequence problems. BC018751 mRNA Translation: AAH18751.1 BC025291 mRNA Translation: AAH25291.1 |
CCDSi | CCDS12543.1 [Q9Y463-1] CCDS12544.1 [Q9Y463-3] CCDS46075.1 [Q9Y463-2] |
PIRi | JG0195 |
RefSeqi | NP_004705.1, NM_004714.2 [Q9Y463-1] NP_006474.1, NM_006483.2 [Q9Y463-2] NP_006475.1, NM_006484.2 [Q9Y463-3] XP_005259455.1, XM_005259398.4 [Q9Y463-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y17999 mRNA Translation: CAA76991.1 Y17999 mRNA Translation: CAA76990.1 Y17999 mRNA Translation: CAA76989.1 AF205861 mRNA Translation: AAF15893.1 AC005393 Genomic DNA Translation: AAC28914.1 Sequence problems. BC018751 mRNA Translation: AAH18751.1 BC025291 mRNA Translation: AAH25291.1 |
CCDSi | CCDS12543.1 [Q9Y463-1] CCDS12544.1 [Q9Y463-3] CCDS46075.1 [Q9Y463-2] |
PIRi | JG0195 |
RefSeqi | NP_004705.1, NM_004714.2 [Q9Y463-1] NP_006474.1, NM_006483.2 [Q9Y463-2] NP_006475.1, NM_006484.2 [Q9Y463-3] XP_005259455.1, XM_005259398.4 [Q9Y463-1] |
3D structure databases
AlphaFoldDBi | Q9Y463 |
SMRi | Q9Y463 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114596, 74 interactors |
ELMi | Q9Y463 |
IntActi | Q9Y463, 72 interactors |
MINTi | Q9Y463 |
STRINGi | 9606.ENSP00000469863 |
Chemistry databases
BindingDBi | Q9Y463 |
ChEMBLi | CHEMBL5543 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y463 |
GuidetoPHARMACOLOGYi | 2010 |
PTM databases
iPTMneti | Q9Y463 |
PhosphoSitePlusi | Q9Y463 |
Genetic variation databases
BioMutai | DYRK1B |
DMDMi | 9296963 |
Proteomic databases
EPDi | Q9Y463 |
jPOSTi | Q9Y463 |
MassIVEi | Q9Y463 |
MaxQBi | Q9Y463 |
PaxDbi | Q9Y463 |
PeptideAtlasi | Q9Y463 |
PRIDEi | Q9Y463 |
ProteomicsDBi | 86110 [Q9Y463-1] 86111 [Q9Y463-2] 86112 [Q9Y463-3] |
Protocols and materials databases
Antibodypediai | 30414, 357 antibodies from 36 providers |
DNASUi | 9149 |
Genome annotation databases
Organism-specific databases
CTDi | 9149 |
DisGeNETi | 9149 |
GeneCardsi | DYRK1B |
HGNCi | HGNC:3092, DYRK1B |
HPAi | ENSG00000105204, Tissue enhanced (skeletal muscle, testis) |
MalaCardsi | DYRK1B |
MIMi | 604556, gene 615812, phenotype |
neXtProti | NX_Q9Y463 |
OpenTargetsi | ENSG00000105204 |
Orphaneti | 411969, NON RARE IN EUROPE: Metabolic syndrome |
PharmGKBi | PA27549 |
VEuPathDBi | HostDB:ENSG00000105204 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0667, Eukaryota |
GeneTreei | ENSGT00940000160345 |
HOGENOMi | CLU_000288_5_6_1 |
InParanoidi | Q9Y463 |
OMAi | GHSTADY |
OrthoDBi | 1219474at2759 |
PhylomeDBi | Q9Y463 |
TreeFami | TF314624 |
Enzyme and pathway databases
BRENDAi | 2.7.12.1, 2681 |
PathwayCommonsi | Q9Y463 |
SignaLinki | Q9Y463 |
SIGNORi | Q9Y463 |
Miscellaneous databases
BioGRID-ORCSi | 9149, 14 hits in 1112 CRISPR screens |
ChiTaRSi | DYRK1B, human |
GeneWikii | DYRK1B |
GenomeRNAii | 9149 |
Pharosi | Q9Y463, Tchem |
PROi | PR:Q9Y463 |
RNActi | Q9Y463, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105204, Expressed in right adrenal gland and 174 other tissues |
ExpressionAtlasi | Q9Y463, baseline and differential |
Genevisiblei | Q9Y463, HS |
Family and domain databases
CDDi | cd14226, PKc_DYRK1, 1 hit |
InterProi | View protein in InterPro IPR028318, DYRK1A/B_MNB IPR011009, Kinase-like_dom_sf IPR044131, PKc_DYR1A/1B IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24058:SF12, PTHR24058:SF12, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DYR1B_HUMAN | |
Accessioni | Q9Y463Primary (citable) accession number: Q9Y463 Secondary accession number(s): O75258, O75788, O75789 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families