Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q9Y463 (DYR1B_HUMAN)

Entry version 204 (25 May 2022)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Add a publicationFeedback
Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

Gene

DYRK1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661).

During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815).

Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by RANBP9.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei140ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei239Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi117 – 125ATPPROSITE-ProRule annotation9
Nucleotide bindingi190 – 193ATPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.12.1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y463

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y463

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y463

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC:2.7.12.11 Publication)
Alternative name(s):
Minibrain-related kinase
Mirk protein kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DYRK1B
Synonyms:MIRK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 19, Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3092, DYRK1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604556, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y463

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105204

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Abdominal obesity-metabolic syndrome 3 (AOMS3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07177390H → P in AOMS3; expression of glucose-6-phosphatase is significantly higher than wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777380EnsemblClinVar.1
Natural variantiVAR_071774102R → C in AOMS3; accumulation of intracellular lipid is significantly greater than with wild-type protein; cells expressing the variant are able to transform into mature adipocytes without requiring adipogenic medium; expression levels of CEBPA, PPARG forms 1 and 2 and PPARGC1A are higher and those of GLI1 and CDKN1B are lower in cells transfected with the mutant protein compared to wild-type; WNT1 signaling activity is lower in mutant cells compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs367643250EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi140K → R: Abolishes kinase activity. 1 Publication1
Mutagenesisi239D → A: Abolishes kinase activity. 1 Publication1
Mutagenesisi271Y → F: Abolishes kinase activity; when associated with F-273. 1 Publication1
Mutagenesisi273Y → F: Abolishes kinase activity; when associated with F-271. 1 Publication1

Keywords - Diseasei

Diabetes mellitus, Obesity

Organism-specific databases

DisGeNET

More...DisGeNETi		9149

MalaCards human disease database

More...MalaCardsi		DYRK1B
MIMi615812, phenotype

Open Targets

More...OpenTargetsi		ENSG00000105204

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		411969, NON RARE IN EUROPE: Metabolic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27549

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y463, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5543

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q9Y463

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2010

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DYRK1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		9296963

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000859341 – 629Dual specificity tyrosine-phosphorylation-regulated kinase 1BAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei63PhosphotyrosineBy similarity1
Modified residuei92PhosphotyrosineBy similarity1
Modified residuei111PhosphotyrosineBy similarity1
Modified residuei129PhosphotyrosineBy similarity1
Modified residuei171PhosphotyrosineBy similarity1
Modified residuei262PhosphoserineBy similarity1
Modified residuei271Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei273Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei401PhosphotyrosineBy similarity1
Modified residuei624PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y463

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y463

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y463

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y463

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y463

PeptideAtlas

More...PeptideAtlasi		Q9Y463

PRoteomics IDEntifications database

More...PRIDEi		Q9Y463

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86110 [Q9Y463-1]
86111 [Q9Y463-2]
86112 [Q9Y463-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y463

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y463

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105204, Expressed in right adrenal gland and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y463, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y463, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105204, Tissue enhanced (skeletal muscle, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer.

Interacts with DCOHM, MAP2K3/MKK3, RANBP9 and TCF1/HNF1A (PubMed:11980910).

Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5 (PubMed:14500717).

Interacts with DCAF7 (PubMed:14593110).

Interacts with RNF169 (PubMed:33469661).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114596, 74 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9Y463

Protein interaction database and analysis system

More...IntActi		Q9Y463, 72 interactors

Molecular INTeraction database

More...MINTi		Q9Y463

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000469863

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y463

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y463, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y463

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y463

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini111 – 431Protein kinasePROSITE-ProRule annotationAdd BLAST321

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 89DisorderedSequence analysisAdd BLAST23
Regioni380 – 399DisorderedSequence analysisAdd BLAST20
Regioni436 – 629DisorderedSequence analysisAdd BLAST194
Regioni480 – 520Interaction with RANBP91 PublicationAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi69 – 86Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi439 – 485Polar residuesSequence analysisAdd BLAST47
Compositional biasi546 – 562Pro residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160345

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_5_6_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y463

Identification of Orthologs from Complete Genome Data

More...OMAi		GHSTADY

Database of Orthologous Groups

More...OrthoDBi		1219474at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y463

TreeFam database of animal gene trees

More...TreeFami		TF314624

Family and domain databases

Conserved Domains Database

More...CDDi		cd14226, PKc_DYRK1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028318, DYRK1A/B_MNB
IPR011009, Kinase-like_dom_sf
IPR044131, PKc_DYR1A/1B
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR24058:SF12, PTHR24058:SF12, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y463-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV 
        60         70         80         90        100
DLIKTYKHIN EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI 
       110        120        130        140        150
VRSGERWLER YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN 
       160        170        180        190        200
QAQIELRLLE LMNQHDTEMK YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL 
       210        220        230        240        250
LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL KPENILLCNP 
       260        270        280        290        300
KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 
       310        320        330        340        350
CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL 
       360        370        380        390        400
PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD 
       410        420        430        440        450
YLRFQDLVLR MLEYEPAARI SPLGALQHGF FRRTADEATN TGPAGSSAST 
       460        470        480        490        500
SPAPLDTCPS SSTASSISSS GGSSGSSSDN RTYRYSNRYC GGPGPPITDC 
       510        520        530        540        550
EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA QLPPQPRYLG 
       560        570        580        590        600
RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR 
       610        620 
PPLPPPDDPA TLGPHLGLRG VPQSTAASS
Length:629
Mass (Da):69,198
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7C354AC55943A8B
GO
Isoform 2 (identifier: Q9Y463-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-405: Missing.

Show »
Length:589
Mass (Da):64,934
Checksum:iE98BF9B257237A9D
GO
Isoform 3 (identifier: Q9Y463-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-405: Missing.

Show »
Length:601
Mass (Da):66,336
Checksum:i8601907D9652274B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R131M0R131_HUMAN
Dual-specificity kinase
DYRK1B
172Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2X3M0R2X3_HUMAN
Dual-specificity kinase
DYRK1B
137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC28914 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04045428L → P1 PublicationCorresponds to variant dbSNP:rs34587974EnsemblClinVar.1
Natural variantiVAR_07177390H → P in AOMS3; expression of glucose-6-phosphatase is significantly higher than wild-type. 1 PublicationCorresponds to variant dbSNP:rs587777380EnsemblClinVar.1
Natural variantiVAR_071774102R → C in AOMS3; accumulation of intracellular lipid is significantly greater than with wild-type protein; cells expressing the variant are able to transform into mature adipocytes without requiring adipogenic medium; expression levels of CEBPA, PPARG forms 1 and 2 and PPARGC1A are higher and those of GLI1 and CDKN1B are lower in cells transfected with the mutant protein compared to wild-type; WNT1 signaling activity is lower in mutant cells compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs367643250EnsemblClinVar.1
Natural variantiVAR_040455102R → H1 PublicationCorresponds to variant dbSNP:rs55687541Ensembl.1
Natural variantiVAR_040456234S → G1 PublicationCorresponds to variant dbSNP:rs35858874Ensembl.1
Natural variantiVAR_040457275Q → R in a metastatic melanoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004925366 – 405Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_004926378 – 405Missing in isoform 3. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y17999 mRNA Translation: CAA76991.1
Y17999 mRNA Translation: CAA76990.1
Y17999 mRNA Translation: CAA76989.1
AF205861 mRNA Translation: AAF15893.1
AC005393 Genomic DNA Translation: AAC28914.1 Sequence problems.
BC018751 mRNA Translation: AAH18751.1
BC025291 mRNA Translation: AAH25291.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12543.1 [Q9Y463-1]
CCDS12544.1 [Q9Y463-3]
CCDS46075.1 [Q9Y463-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JG0195

NCBI Reference Sequences

More...RefSeqi		NP_004705.1, NM_004714.2 [Q9Y463-1]
NP_006474.1, NM_006483.2 [Q9Y463-2]
NP_006475.1, NM_006484.2 [Q9Y463-3]
XP_005259455.1, XM_005259398.4 [Q9Y463-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000323039.10; ENSP00000312789.4; ENSG00000105204.14
ENST00000348817.7; ENSP00000221803.4; ENSG00000105204.14 [Q9Y463-3]
ENST00000430012.6; ENSP00000403182.1; ENSG00000105204.14 [Q9Y463-2]
ENST00000593685.5; ENSP00000469863.1; ENSG00000105204.14
ENST00000597639.5; ENSP00000472941.1; ENSG00000105204.14 [Q9Y463-3]
ENST00000625388.2; ENSP00000486839.1; ENSG00000281320.3 [Q9Y463-3]
ENST00000625438.2; ENSP00000487313.1; ENSG00000281320.3 [Q9Y463-3]
ENST00000625757.3; ENSP00000485915.1; ENSG00000281320.3
ENST00000627034.2; ENSP00000487539.1; ENSG00000281320.3 [Q9Y463-2]
ENST00000631090.2; ENSP00000486377.1; ENSG00000281320.3

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9149

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9149

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000323039.10; ENSP00000312789.4; NM_004714.3; NP_004705.1

UCSC genome browser

More...UCSCi		uc002omi.4, human [Q9Y463-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17999 mRNA Translation: CAA76991.1
Y17999 mRNA Translation: CAA76990.1
Y17999 mRNA Translation: CAA76989.1
AF205861 mRNA Translation: AAF15893.1
AC005393 Genomic DNA Translation: AAC28914.1 Sequence problems.
BC018751 mRNA Translation: AAH18751.1
BC025291 mRNA Translation: AAH25291.1
CCDSiCCDS12543.1 [Q9Y463-1]
CCDS12544.1 [Q9Y463-3]
CCDS46075.1 [Q9Y463-2]
PIRiJG0195
RefSeqiNP_004705.1, NM_004714.2 [Q9Y463-1]
NP_006474.1, NM_006483.2 [Q9Y463-2]
NP_006475.1, NM_006484.2 [Q9Y463-3]
XP_005259455.1, XM_005259398.4 [Q9Y463-1]

3D structure databases

AlphaFoldDBiQ9Y463
SMRiQ9Y463
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114596, 74 interactors
ELMiQ9Y463
IntActiQ9Y463, 72 interactors
MINTiQ9Y463
STRINGi9606.ENSP00000469863

Chemistry databases

BindingDBiQ9Y463
ChEMBLiCHEMBL5543
DrugBankiDB12010, Fostamatinib
DrugCentraliQ9Y463
GuidetoPHARMACOLOGYi2010

PTM databases

iPTMnetiQ9Y463
PhosphoSitePlusiQ9Y463

Genetic variation databases

BioMutaiDYRK1B
DMDMi9296963

Proteomic databases

EPDiQ9Y463
jPOSTiQ9Y463
MassIVEiQ9Y463
MaxQBiQ9Y463
PaxDbiQ9Y463
PeptideAtlasiQ9Y463
PRIDEiQ9Y463
ProteomicsDBi86110 [Q9Y463-1]
86111 [Q9Y463-2]
86112 [Q9Y463-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30414, 357 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		9149

Genome annotation databases

EnsembliENST00000323039.10; ENSP00000312789.4; ENSG00000105204.14
ENST00000348817.7; ENSP00000221803.4; ENSG00000105204.14 [Q9Y463-3]
ENST00000430012.6; ENSP00000403182.1; ENSG00000105204.14 [Q9Y463-2]
ENST00000593685.5; ENSP00000469863.1; ENSG00000105204.14
ENST00000597639.5; ENSP00000472941.1; ENSG00000105204.14 [Q9Y463-3]
ENST00000625388.2; ENSP00000486839.1; ENSG00000281320.3 [Q9Y463-3]
ENST00000625438.2; ENSP00000487313.1; ENSG00000281320.3 [Q9Y463-3]
ENST00000625757.3; ENSP00000485915.1; ENSG00000281320.3
ENST00000627034.2; ENSP00000487539.1; ENSG00000281320.3 [Q9Y463-2]
ENST00000631090.2; ENSP00000486377.1; ENSG00000281320.3
GeneIDi9149
KEGGihsa:9149
MANE-SelectiENST00000323039.10; ENSP00000312789.4; NM_004714.3; NP_004705.1
UCSCiuc002omi.4, human [Q9Y463-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9149
DisGeNETi9149

GeneCards: human genes, protein and diseases

More...GeneCardsi		DYRK1B
HGNCiHGNC:3092, DYRK1B
HPAiENSG00000105204, Tissue enhanced (skeletal muscle, testis)
MalaCardsiDYRK1B
MIMi604556, gene
615812, phenotype
neXtProtiNX_Q9Y463
OpenTargetsiENSG00000105204
Orphaneti411969, NON RARE IN EUROPE: Metabolic syndrome
PharmGKBiPA27549
VEuPathDBiHostDB:ENSG00000105204

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0667, Eukaryota
GeneTreeiENSGT00940000160345
HOGENOMiCLU_000288_5_6_1
InParanoidiQ9Y463
OMAiGHSTADY
OrthoDBi1219474at2759
PhylomeDBiQ9Y463
TreeFamiTF314624

Enzyme and pathway databases

BRENDAi2.7.12.1, 2681
PathwayCommonsiQ9Y463
SignaLinkiQ9Y463
SIGNORiQ9Y463

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9149, 14 hits in 1112 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DYRK1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DYRK1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9149
PharosiQ9Y463, Tchem

Protein Ontology

More...PROi		PR:Q9Y463
RNActiQ9Y463, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105204, Expressed in right adrenal gland and 174 other tissues
ExpressionAtlasiQ9Y463, baseline and differential
GenevisibleiQ9Y463, HS

Family and domain databases

CDDicd14226, PKc_DYRK1, 1 hit
InterProiView protein in InterPro
IPR028318, DYRK1A/B_MNB
IPR011009, Kinase-like_dom_sf
IPR044131, PKc_DYR1A/1B
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR24058:SF12, PTHR24058:SF12, 1 hit
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYR1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y463
Secondary accession number(s): O75258, O75788, O75789
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 25, 2022
This is version 204 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again