UniProtKB - Q9Y458 (TBX22_HUMAN)

BLAST

>sp|Q9Y458|TBX22_HUMAN T-box transcription factor TBX22 OS=Homo sapiens OX=9606 GN=TBX22 PE=1 SV=3
MALSSRARAFSVEALVGRPSKRKLQDPIQAEQPELREKKGGEEEEERRSSAAGKSEPLEK
QPKTEPSTSASSGCGSDSGYGNSSESLEEKDIQMELQGSELWKRFHDIGTEMIITKAGRR
MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHP
DSPCSGETWMRQIISFDRMKLTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQS
LPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKGFRDTGRNRGVLDGLLETYPW
RPSFTLDFKTFGADTQSGSSGSSPVTSSGGAPSPLNSLLSPLCFSPMFHLPTSSLGMPCP
EAYLPNVNLPLCYKICPTNFWQQQPLVLPAPERLASSNSSQSLAPLMMEVPMLSSLGVTN
SKSGSSEDSSDQYLQAPNSTNQMLYGLQSPGNIFLPNSITPEALSCSFHPSYDFYRYNFS
MPSRLISGSNHLKVNDDSQVSFGEGKCNHVHWYPAINHYL

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History
Entry version 165 (07 Nov 2018)
Sequence version 3 (12 Feb 2003)
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Protein

T-box transcription factor TBX22

Gene

TBX22

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	96 – 283	T-boxPROSITE-ProRule annotationAdd BLAST		188

GO - Molecular functionⁱ

DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 17846996
DNA-binding transcription factor activity
Source: UniProtKB
Traceable author statementⁱ
- 11024289
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 17846996

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development
Source: UniProtKB
Traceable author statementⁱ
- 11024289
negative regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 17846996
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 17846996
regulation of transcription, DNA-templated
Source: UniProtKB
Traceable author statementⁱ
- 11024289

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-box transcription factor TBX22 Short name: T-box protein 22
Gene namesⁱ	Name:TBX22 Synonyms:TBOX22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122145.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11600 TBX22
MIMⁱ	300307 gene
neXtProtⁱ	NX_Q9Y458

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cleft palate with or without ankyloglossia, X-linked (CPX)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_015383	118	G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.	1
Natural variantⁱVAR_021831	121	M → V in CPX. 1 Publication	1
Natural variantⁱVAR_021832	183	P → L in CPX. 1 Publication	1
Natural variantⁱVAR_069900	195	S → SS in CPX. 1 Publication	1
Natural variantⁱVAR_021829	214	L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.	1
Natural variantⁱVAR_015384	260	T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.	1
Natural variantⁱVAR_021830	264	N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.	1

Abruzzo-Erickson syndrome (ABERS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by cleft palate, coloboma, hypospadias, deafness, short stature, and radial synostosis.

Keywords - Diseaseⁱ

Deafness, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50945
MalaCards human disease database More...MalaCardsⁱ	TBX22
MIMⁱ	302905 phenotype 303400 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122145
Orphanetⁱ	921 Abruzzo-Erickson syndrome 324601 X-linked cleft palate and ankyloglossia
PharmGKBⁱ	PA36363

Polymorphism and mutation databases

BioMutaⁱ	TBX22
DMDMⁱ	28381405

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184455	1 – 520	T-box transcription factor TBX22Add BLAST		520

Proteomic databases

PaxDbⁱ	Q9Y458
PeptideAtlas More...PeptideAtlasⁱ	Q9Y458
PRIDEⁱ	Q9Y458
ProteomicsDBⁱ	86105 86106 [Q9Y458-2]

PTM databases

iPTMnetⁱ	Q9Y458
PhosphoSitePlusⁱ	Q9Y458

Expressionⁱ

Tissue specificityⁱ

Seems to be expressed at a low level.

Gene expression databases

Bgeeⁱ	ENSG00000122145 Expressed in 31 organ(s), highest expression level in right testis
CleanExⁱ	HS_TBX22
ExpressionAtlasⁱ	Q9Y458 baseline and differential
Genevisibleⁱ	Q9Y458 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
VENTX	O95231	5	EBI-6427217,EBI-10191303

With

Entry

#Exp.

IntAct

Notes

VENTX

O95231

EBI-6427217,EBI-10191303

Protein-protein interaction databases

BioGridⁱ	119172, 4 interactors
ELMⁱ	Q9Y458
IntActⁱ	Q9Y458, 9 interactors
STRINGⁱ	9606.ENSP00000362390

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y458
SMRⁱ	Q9Y458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG3586 Eukaryota ENOG410Y98J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118897
HOGENOMⁱ	HOG000039966
HOVERGENⁱ	HBG055831
InParanoidⁱ	Q9Y458
KEGG Orthology (KO) More...KOⁱ	K10186
OMAⁱ	KQYYVAI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I8R
PhylomeDBⁱ	Q9Y458
TreeFamⁱ	TF106341

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00182 TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR036960 T-box_sf IPR001699 TF_T-box IPR018186 TF_T-box_CS
PANTHERⁱ	PTHR11267 PTHR11267, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00907 T-box, 1 hit
PRINTSⁱ	PR00937 TBOX
SMARTⁱ	View protein in SMART SM00425 TBOX, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283 TBOX_1, 1 hit PS01264 TBOX_2, 1 hit PS50252 TBOX_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y458-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS 
        60         70         80         90        100
AAGKSEPLEK QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE 
       110        120        130        140        150
LWKRFHDIGT EMIITKAGRR MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK 
       160        170        180        190        200
RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP DSPCSGETWM RQIISFDRMK 
       210        220        230        240        250
LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS 
       260        270        280        290        300
FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 
       310        320        330        340        350
RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL 
       360        370        380        390        400
PTSSLGMPCP EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS 
       410        420        430        440        450
QSLAPLMMEV PMLSSLGVTN SKSGSSEDSS DQYLQAPNST NQMLYGLQSP 
       460        470        480        490        500
GNIFLPNSIT PEALSCSFHP SYDFYRYNFS MPSRLISGSN HLKVNDDSQV 
       510        520
SFGEGKCNHV HWYPAINHYL

Length:520

Mass (Da):57,910

Last modified:February 12, 2003 - v3

Checksum:ⁱ1502E19245CC2C93

Isoform 2 (identifier: Q9Y458-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-120: Missing.

« Hide

        10         20         30         40         50
MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL 
        60         70         80         90        100
CIIPRFYVHP DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY 
       110        120        130        140        150
KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS FKETEFTTVT AYQNQQITKL 
       160        170        180        190        200
KIERNPFAKG FRDTGRNRGV LDGLLETYPW RPSFTLDFKT FGADTQSGSS 
       210        220        230        240        250
GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP EAYLPNVNLP 
       260        270        280        290        300
LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN 
       310        320        330        340        350
SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP 
       360        370        380        390        400
SYDFYRYNFS MPSRLISGSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL

Show »

Length:400

Mass (Da):44,718

Checksum:ⁱC06B60DADD29E6C3

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0D9SGI2	A0A0D9SGI2_HUMAN	T-box transcription factor TBX22 T-box transcription factor TBX22	TBX22	127	Annotation score:
A0A0G2JQK0	A0A0G2JQK0_HUMAN	T-box transcription factor TBX22 T-box transcription factor TBX22	TBX22	71	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036066	16	V → A in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_036067	51	A → T in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_015383	118	G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.	1
Natural variantⁱVAR_021831	121	M → V in CPX. 1 Publication	1
Natural variantⁱVAR_021832	183	P → L in CPX. 1 Publication	1
Natural variantⁱVAR_021833	187	E → K1 PublicationCorresponds to variant dbSNP:rs34244923EnsemblClinVar.	1
Natural variantⁱVAR_069900	195	S → SS in CPX. 1 Publication	1
Natural variantⁱVAR_021829	214	L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.	1
Natural variantⁱVAR_069416	249	F → Y1 Publication	1
Natural variantⁱVAR_015384	260	T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.	1
Natural variantⁱVAR_021830	264	N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.	1
Natural variantⁱVAR_036068	307	D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs750292974Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040987	1 – 120	Missing in isoform 2. 1 PublicationAdd BLAST		120

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035371 mRNA Translation: AAK63189.1 AL031000 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98588.1 BC014194 mRNA Translation: AAH14194.2 AF251684 mRNA Translation: AAG23749.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14445.1 [Q9Y458-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001103348.1, NM_001109878.1 [Q9Y458-1] NP_001103349.1, NM_001109879.1 [Q9Y458-2] NP_001290404.1, NM_001303475.1 [Q9Y458-2] NP_058650.1, NM_016954.2 [Q9Y458-1] XP_011529274.1, XM_011530972.1
UniGeneⁱ	Hs.374253

Genome annotation databases

Ensemblⁱ	ENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1] ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1] ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1] ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]
GeneIDⁱ	50945
KEGGⁱ	hsa:50945
UCSC genome browser More...UCSCⁱ	uc004edj.2 human [Q9Y458-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	Isoform 2 of T-box transcription factor TBX22		HUMAN		400	UniRef100_Q9Y458
T-box22 (Fragment)		HUMAN		58

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	Isoform 2 of T-box transcription factor TBX22		HUMAN		400	UniRef90_Q9Y458
T-box 22		PANTR		520
T-box 22		PONAB		520
T-box 22		GORGO		520
Uncharacterized protein		NOMLE		520
+30

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	T-box transcription factor TBX22		MOUSE		517	UniRef50_Q9Y458
Isoform 2 of T-box transcription factor TBX22		HUMAN		400
Uncharacterized protein		NOMLE		520
T-box 22		PONAB		520
T-box 22		GORGO		520
+194

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035371 mRNA Translation: AAK63189.1 AL031000 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98588.1 BC014194 mRNA Translation: AAH14194.2 AF251684 mRNA Translation: AAG23749.1
CCDSⁱ	CCDS14445.1 [Q9Y458-1]
RefSeqⁱ	NP_001103348.1, NM_001109878.1 [Q9Y458-1] NP_001103349.1, NM_001109879.1 [Q9Y458-2] NP_001290404.1, NM_001303475.1 [Q9Y458-2] NP_058650.1, NM_016954.2 [Q9Y458-1] XP_011529274.1, XM_011530972.1
UniGeneⁱ	Hs.374253

3D structure databases

ProteinModelPortalⁱ	Q9Y458
SMRⁱ	Q9Y458
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119172, 4 interactors
ELMⁱ	Q9Y458
IntActⁱ	Q9Y458, 9 interactors
STRINGⁱ	9606.ENSP00000362390

PTM databases

iPTMnetⁱ	Q9Y458
PhosphoSitePlusⁱ	Q9Y458

Polymorphism and mutation databases

BioMutaⁱ	TBX22
DMDMⁱ	28381405

Proteomic databases

PaxDbⁱ	Q9Y458
PeptideAtlasⁱ	Q9Y458
PRIDEⁱ	Q9Y458
ProteomicsDBⁱ	86105 86106 [Q9Y458-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50945
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1] ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1] ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1] ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]
GeneIDⁱ	50945
KEGGⁱ	hsa:50945
UCSCⁱ	uc004edj.2 human [Q9Y458-1]

Organism-specific databases

CTDⁱ	50945
DisGeNETⁱ	50945
EuPathDBⁱ	HostDB:ENSG00000122145.14
GeneCardsⁱ	TBX22
HGNCⁱ	HGNC:11600 TBX22
MalaCardsⁱ	TBX22
MIMⁱ	300307 gene 302905 phenotype 303400 phenotype
neXtProtⁱ	NX_Q9Y458
OpenTargetsⁱ	ENSG00000122145
Orphanetⁱ	921 Abruzzo-Erickson syndrome 324601 X-linked cleft palate and ankyloglossia
PharmGKBⁱ	PA36363
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3586 Eukaryota ENOG410Y98J LUCA
GeneTreeⁱ	ENSGT00760000118897
HOGENOMⁱ	HOG000039966
HOVERGENⁱ	HBG055831
InParanoidⁱ	Q9Y458
KOⁱ	K10186
OMAⁱ	KQYYVAI
OrthoDBⁱ	EOG091G0I8R
PhylomeDBⁱ	Q9Y458
TreeFamⁱ	TF106341

Miscellaneous databases

GeneWikiⁱ	TBX22
GenomeRNAiⁱ	50945
Protein Ontology More...PROⁱ	PR:Q9Y458
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122145 Expressed in 31 organ(s), highest expression level in right testis
CleanExⁱ	HS_TBX22
ExpressionAtlasⁱ	Q9Y458 baseline and differential
Genevisibleⁱ	Q9Y458 HS

Family and domain databases

CDDⁱ	cd00182 TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR036960 T-box_sf IPR001699 TF_T-box IPR018186 TF_T-box_CS
PANTHERⁱ	PTHR11267 PTHR11267, 1 hit
Pfamⁱ	View protein in Pfam PF00907 T-box, 1 hit
PRINTSⁱ	PR00937 TBOX
SMARTⁱ	View protein in SMART SM00425 TBOX, 1 hit
SUPFAMⁱ	SSF49417 SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283 TBOX_1, 1 hit PS01264 TBOX_2, 1 hit PS50252 TBOX_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBX22_HUMAN
Accessionⁱ	Q9Y458Primary (citable) accession number: Q9Y458 Secondary accession number(s): Q5JZ06, Q96LC0, Q9HBF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	February 12, 2003
	Last modified:	November 7, 2018
	This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y458 (TBX22_HUMAN)

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T-box transcription factor TBX22

TBX22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ