TBX22

Functionⁱ

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	96 – 283	T-boxPROSITE-ProRule annotationAdd BLAST		188

GO - Molecular functionⁱ

DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- "TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression."
  Andreou A.M., Pauws E., Jones M.C., Singh M.K., Bussen M., Doudney K., Moore G.E., Kispert A., Brosens J.J., Stanier P.
  Am J Hum Genet 81:700-712(2007) [PubMed] [Europe PMC] [Abstract]
DNA-binding transcription factor activity
Source: UniProtKB
Traceable author statementⁱ
- Ref.1
  "Molecular characterization of a new human T-box gene (TBX22) located in Xq21.1 encoding a protein containing a truncated T-domain."
  Laugier-Anfossi F., Villard L.
  Gene 255:289-296(2000) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II cis-regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- "TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression."
  Andreou A.M., Pauws E., Jones M.C., Singh M.K., Bussen M., Doudney K., Moore G.E., Kispert A., Brosens J.J., Stanier P.
  Am J Hum Genet 81:700-712(2007) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y458

PathwayCommonsⁱ

Q9Y458

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-box transcription factor TBX22 Short name: T-box protein 22
Gene namesⁱ	Name:TBX22 Synonyms:TBOX22
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11600, TBX22
MIMⁱ	300307, gene
neXtProtⁱ	NX_Q9Y458
VEuPathDBⁱ	HostDB:ENSG00000122145.14

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cleft palate with or without ankyloglossia, X-linked (CPX)3 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_015383	118	G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.	1
Natural variantⁱVAR_021831	121	M → V in CPX. 1 Publication	1
Natural variantⁱVAR_021832	183	P → L in CPX. 1 Publication	1
Natural variantⁱVAR_069900	195	S → SS in CPX. 1 Publication	1
Natural variantⁱVAR_021829	214	L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.	1
Natural variantⁱVAR_015384	260	T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.	1
Natural variantⁱVAR_021830	264	N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.	1

Abruzzo-Erickson syndrome (ABERS)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA disease characterized by cleft palate, coloboma, hypospadias, deafness, short stature, and radial synostosis.

Related information in OMIM

Keywords - Diseaseⁱ

Deafness, Disease variant, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50945
MalaCards human disease database More...MalaCardsⁱ	TBX22
MIMⁱ	302905, phenotype 303400, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000122145
Orphanetⁱ	921, Abruzzo-Erickson syndrome 324601, X-linked cleft palate and ankyloglossia
PharmGKBⁱ	PA36363

Miscellaneous databases

Pharosⁱ	Q9Y458, Tbio

Pharosⁱ

Q9Y458, Tbio

Genetic variation databases

BioMutaⁱ	TBX22
DMDMⁱ	28381405

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184455	1 – 520	T-box transcription factor TBX22Add BLAST		520

Proteomic databases

MassIVEⁱ	Q9Y458
PaxDbⁱ	Q9Y458
PeptideAtlas More...PeptideAtlasⁱ	Q9Y458
PRIDEⁱ	Q9Y458
ProteomicsDBⁱ	86105 [Q9Y458-1] 86106 [Q9Y458-2]

PTM databases

iPTMnetⁱ	Q9Y458
PhosphoSitePlusⁱ	Q9Y458

Expressionⁱ

Tissue specificityⁱ

Seems to be expressed at a low level.

Gene expression databases

Bgeeⁱ	ENSG00000122145, Expressed in right testis and 40 other tissues
ExpressionAtlasⁱ	Q9Y458, baseline and differential
Genevisibleⁱ	Q9Y458, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000122145, Group enriched (testis, thyroid gland)

HPAⁱ

ENSG00000122145, Group enriched (testis, thyroid gland)

Interactionⁱ

Binary interactionsⁱ

Hide details

Q9Y458

With	#Exp.	IntAct
ATXN1 [P54253]	3	EBI-6427217,EBI-930964
ATXN3 [P54252]	3	EBI-6427217,EBI-946046
HOXC8 [P31273]	3	EBI-6427217,EBI-1752118
HTT [P42858]	12	EBI-6427217,EBI-466029
PITX1 [P78337]	3	EBI-6427217,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]	3	EBI-6427217,EBI-12138495
PROP1 [O75360]	3	EBI-6427217,EBI-9027467
TARDBP [Q13148]	6	EBI-6427217,EBI-372899
TLX3 [O43711]	3	EBI-6427217,EBI-3939165
VENTX [O95231]	6	EBI-6427217,EBI-10191303
YOD1 [Q5VVQ6]	3	EBI-6427217,EBI-2510804

Protein-protein interaction databases

BioGRIDⁱ	119172, 8 interactors
ELMⁱ	Q9Y458
IntActⁱ	Q9Y458, 15 interactors
STRINGⁱ	9606.ENSP00000362390

Miscellaneous databases

RNActⁱ	Q9Y458, protein

RNActⁱ

Q9Y458, protein

Structureⁱ

3D structure databases

SMRⁱ	Q9Y458
ModBaseⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 91	DisorderedSequence analysisAdd BLAST		91

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	24 – 61	Basic and acidic residuesSequence analysisAdd BLAST		38
Compositional biasⁱ	62 – 87	Polar residuesSequence analysisAdd BLAST		26

Phylogenomic databases

eggNOGⁱ	KOG3586, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000161206
HOGENOMⁱ	CLU_030727_1_0_1
InParanoidⁱ	Q9Y458
OMAⁱ	EVYLHNI
PhylomeDBⁱ	Q9Y458
TreeFamⁱ	TF106341

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00182, TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS
PANTHERⁱ	PTHR11267, PTHR11267, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00907, T-box, 1 hit
PRINTSⁱ	PR00937, TBOX
SMARTⁱ	View protein in SMART SM00425, TBOX, 1 hit
SUPFAMⁱ	SSF49417, SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283, TBOX_1, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y458-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS 
        60         70         80         90        100
AAGKSEPLEK QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE 
       110        120        130        140        150
LWKRFHDIGT EMIITKAGRR MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK 
       160        170        180        190        200
RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP DSPCSGETWM RQIISFDRMK 
       210        220        230        240        250
LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS 
       260        270        280        290        300
FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 
       310        320        330        340        350
RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL 
       360        370        380        390        400
PTSSLGMPCP EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS 
       410        420        430        440        450
QSLAPLMMEV PMLSSLGVTN SKSGSSEDSS DQYLQAPNST NQMLYGLQSP 
       460        470        480        490        500
GNIFLPNSIT PEALSCSFHP SYDFYRYNFS MPSRLISGSN HLKVNDDSQV 
       510        520
SFGEGKCNHV HWYPAINHYL

Length:520

Mass (Da):57,910

Last modified:February 12, 2003 - v3

Checksum:ⁱ1502E19245CC2C93

GO

Isoform 2 (identifier: Q9Y458-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-120: Missing.

« Hide

        10         20         30         40         50
MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL 
        60         70         80         90        100
CIIPRFYVHP DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY 
       110        120        130        140        150
KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS FKETEFTTVT AYQNQQITKL 
       160        170        180        190        200
KIERNPFAKG FRDTGRNRGV LDGLLETYPW RPSFTLDFKT FGADTQSGSS 
       210        220        230        240        250
GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP EAYLPNVNLP 
       260        270        280        290        300
LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN 
       310        320        330        340        350
SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP 
       360        370        380        390        400
SYDFYRYNFS MPSRLISGSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL

Show »

Length:400

Mass (Da):44,718

Checksum:ⁱC06B60DADD29E6C3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0D9SGI2	A0A0D9SGI2_HUMAN	T-box transcription factor TBX22 T-box transcription factor TBX22	TBX22	127	Annotation score:
A0A0G2JQK0	A0A0G2JQK0_HUMAN	T-box transcription factor TBX22 T-box transcription factor TBX22	TBX22	71	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_036066	16	V → A in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_036067	51	A → T in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_015383	118	G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.	1
Natural variantⁱVAR_021831	121	M → V in CPX. 1 Publication	1
Natural variantⁱVAR_021832	183	P → L in CPX. 1 Publication	1
Natural variantⁱVAR_021833	187	E → K1 PublicationCorresponds to variant dbSNP:rs34244923EnsemblClinVar.	1
Natural variantⁱVAR_069900	195	S → SS in CPX. 1 Publication	1
Natural variantⁱVAR_021829	214	L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.	1
Natural variantⁱVAR_069416	249	F → Y1 Publication	1
Natural variantⁱVAR_015384	260	T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.	1
Natural variantⁱVAR_021830	264	N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.	1
Natural variantⁱVAR_036068	307	D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs750292974Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040987	1 – 120	Missing in isoform 2. 1 PublicationAdd BLAST		120

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035371 mRNA Translation: AAK63189.1 AL031000 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98588.1 BC014194 mRNA Translation: AAH14194.2 AF251684 mRNA Translation: AAG23749.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14445.1 [Q9Y458-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001103348.1, NM_001109878.1 [Q9Y458-1] NP_001103349.1, NM_001109879.1 [Q9Y458-2] NP_001290404.1, NM_001303475.1 [Q9Y458-2] NP_058650.1, NM_016954.2 [Q9Y458-1] XP_011529274.1, XM_011530972.1

Genome annotation databases

Ensemblⁱ	ENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1] ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1] ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1] ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]
GeneIDⁱ	50945
KEGGⁱ	hsa:50945
UCSC genome browser More...UCSCⁱ	uc004edj.2, human [Q9Y458-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	T-box22 (Fragment)		HUMAN		58	UniRef100_Q9Y458
Isoform 2 of T-box transcription factor TBX22		HUMAN		400

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	T-box22 (Fragment)		HUMAN		58	UniRef90_Q9Y458
TBX22 isoform 1		PANTR		520
TBX22 isoform 1		PONAB		520
T-box transcription factor 22		PANPA		520
Uncharacterized protein		NOMLE		520
+43

Protein	Similar proteins		Species	Score	Length	Source
Q9Y458	T-box transcription factor TBX22		MOUSE		517	UniRef50_Q9Y458
T-box22 (Fragment)		HUMAN		58
Uncharacterized protein		NOMLE		520
TBX22 isoform 1		PONAB		520
T-box transcription factor 22		GORGO		520
+386

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY035371 mRNA Translation: AAK63189.1 AL031000 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98588.1 BC014194 mRNA Translation: AAH14194.2 AF251684 mRNA Translation: AAG23749.1
CCDSⁱ	CCDS14445.1 [Q9Y458-1]
RefSeqⁱ	NP_001103348.1, NM_001109878.1 [Q9Y458-1] NP_001103349.1, NM_001109879.1 [Q9Y458-2] NP_001290404.1, NM_001303475.1 [Q9Y458-2] NP_058650.1, NM_016954.2 [Q9Y458-1] XP_011529274.1, XM_011530972.1

3D structure databases

SMRⁱ	Q9Y458
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	119172, 8 interactors
ELMⁱ	Q9Y458
IntActⁱ	Q9Y458, 15 interactors
STRINGⁱ	9606.ENSP00000362390

PTM databases

iPTMnetⁱ	Q9Y458
PhosphoSitePlusⁱ	Q9Y458

Genetic variation databases

BioMutaⁱ	TBX22
DMDMⁱ	28381405

Proteomic databases

MassIVEⁱ	Q9Y458
PaxDbⁱ	Q9Y458
PeptideAtlasⁱ	Q9Y458
PRIDEⁱ	Q9Y458
ProteomicsDBⁱ	86105 [Q9Y458-1] 86106 [Q9Y458-2]

Protocols and materials databases

Antibodypediaⁱ	510, 208 antibodies
The DNASU plasmid repository More...DNASUⁱ	50945

Genome annotation databases

Ensemblⁱ	ENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1] ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1] ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1] ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]
GeneIDⁱ	50945
KEGGⁱ	hsa:50945
UCSCⁱ	uc004edj.2, human [Q9Y458-1]

Organism-specific databases

CTDⁱ	50945
DisGeNETⁱ	50945
GeneCardsⁱ	TBX22
HGNCⁱ	HGNC:11600, TBX22
HPAⁱ	ENSG00000122145, Group enriched (testis, thyroid gland)
MalaCardsⁱ	TBX22
MIMⁱ	300307, gene 302905, phenotype 303400, phenotype
neXtProtⁱ	NX_Q9Y458
OpenTargetsⁱ	ENSG00000122145
Orphanetⁱ	921, Abruzzo-Erickson syndrome 324601, X-linked cleft palate and ankyloglossia
PharmGKBⁱ	PA36363
VEuPathDBⁱ	HostDB:ENSG00000122145.14
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3586, Eukaryota
GeneTreeⁱ	ENSGT00940000161206
HOGENOMⁱ	CLU_030727_1_0_1
InParanoidⁱ	Q9Y458
OMAⁱ	EVYLHNI
PhylomeDBⁱ	Q9Y458
TreeFamⁱ	TF106341

Enzyme and pathway databases

PathwayCommonsⁱ	Q9Y458

PathwayCommonsⁱ

Q9Y458

Miscellaneous databases

BioGRID-ORCSⁱ	50945, 9 hits in 632 CRISPR screens
ChiTaRSⁱ	TBX22, human
GeneWikiⁱ	TBX22
GenomeRNAiⁱ	50945
Pharosⁱ	Q9Y458, Tbio
Protein Ontology More...PROⁱ	PR:Q9Y458
RNActⁱ	Q9Y458, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122145, Expressed in right testis and 40 other tissues
ExpressionAtlasⁱ	Q9Y458, baseline and differential
Genevisibleⁱ	Q9Y458, HS

Family and domain databases

CDDⁱ	cd00182, TBOX, 1 hit
Gene3Dⁱ	2.60.40.820, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR036960, T-box_sf IPR001699, TF_T-box IPR018186, TF_T-box_CS
PANTHERⁱ	PTHR11267, PTHR11267, 1 hit
Pfamⁱ	View protein in Pfam PF00907, T-box, 1 hit
PRINTSⁱ	PR00937, TBOX
SMARTⁱ	View protein in SMART SM00425, TBOX, 1 hit
SUPFAMⁱ	SSF49417, SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS01283, TBOX_1, 1 hit PS01264, TBOX_2, 1 hit PS50252, TBOX_3, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TBX22_HUMAN
Accessionⁱ	Q9Y458Primary (citable) accession number: Q9Y458 Secondary accession number(s): Q5JZ06, Q96LC0, Q9HBF1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
	Last sequence update:	February 12, 2003
	Last modified:	June 2, 2021
	This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y458 (TBX22_HUMAN)

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T-box transcription factor TBX22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Q9Y458

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ