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UniProtKB - Q9Y458 (TBX22_HUMAN)

Entry version 176 (17 Jun 2020)
Sequence version 3 (12 Feb 2003)
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Protein

T-box transcription factor TBX22

Gene

TBX22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi96 – 283T-boxPROSITE-ProRule annotationAdd BLAST188

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-box transcription factor TBX22
Short name:
T-box protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBX22
Synonyms:TBOX22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000122145.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:11600 TBX22

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300307 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y458

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cleft palate with or without ankyloglossia, X-linked (CPX)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_015383118G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.1
Natural variantiVAR_021831121M → V in CPX. 1 Publication1
Natural variantiVAR_021832183P → L in CPX. 1 Publication1
Natural variantiVAR_069900195S → SS in CPX. 1 Publication1
Natural variantiVAR_021829214L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.1
Natural variantiVAR_015384260T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.1
Natural variantiVAR_021830264N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.1
Abruzzo-Erickson syndrome (ABERS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by cleft palate, coloboma, hypospadias, deafness, short stature, and radial synostosis.
Related information in OMIM

Keywords - Diseasei

Deafness, Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		50945

MalaCards human disease database

More...MalaCardsi		TBX22
MIMi302905 phenotype
303400 phenotype

Open Targets

More...OpenTargetsi		ENSG00000122145

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		921 Abruzzo-Erickson syndrome
324601 X-linked cleft palate and ankyloglossia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36363

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y458 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBX22

Domain mapping of disease mutations (DMDM)

More...DMDMi		28381405

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001844551 – 520T-box transcription factor TBX22Add BLAST520

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y458

PeptideAtlas

More...PeptideAtlasi		Q9Y458

PRoteomics IDEntifications database

More...PRIDEi		Q9Y458

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86105 [Q9Y458-1]
86106 [Q9Y458-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y458

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y458

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Seems to be expressed at a low level.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122145 Expressed in right testis and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y458 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y458 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000122145 Group enriched (testis, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119172, 4 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q9Y458

Protein interaction database and analysis system

More...IntActi		Q9Y458, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y458 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y458

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3586 Eukaryota
ENOG410Y98J LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161206

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030727_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y458

KEGG Orthology (KO)

More...KOi		K10186

Identification of Orthologs from Complete Genome Data

More...OMAi		EVYLHNI

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y458

TreeFam database of animal gene trees

More...TreeFami		TF106341

Family and domain databases

Conserved Domains Database

More...CDDi		cd00182 TBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.820, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS

The PANTHER Classification System

More...PANTHERi		PTHR11267 PTHR11267, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00907 T-box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00937 TBOX

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00425 TBOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49417 SSF49417, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y458-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS 
        60         70         80         90        100
AAGKSEPLEK QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE 
       110        120        130        140        150
LWKRFHDIGT EMIITKAGRR MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK 
       160        170        180        190        200
RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP DSPCSGETWM RQIISFDRMK 
       210        220        230        240        250
LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS 
       260        270        280        290        300
FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW 
       310        320        330        340        350
RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL 
       360        370        380        390        400
PTSSLGMPCP EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS 
       410        420        430        440        450
QSLAPLMMEV PMLSSLGVTN SKSGSSEDSS DQYLQAPNST NQMLYGLQSP 
       460        470        480        490        500
GNIFLPNSIT PEALSCSFHP SYDFYRYNFS MPSRLISGSN HLKVNDDSQV 
       510        520
SFGEGKCNHV HWYPAINHYL
Length:520
Mass (Da):57,910
Last modified:February 12, 2003 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1502E19245CC2C93
GO
Isoform 2 (identifier: Q9Y458-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:400
Mass (Da):44,718
Checksum:iC06B60DADD29E6C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SGI2A0A0D9SGI2_HUMAN
T-box transcription factor TBX22
TBX22
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQK0A0A0G2JQK0_HUMAN
T-box transcription factor TBX22
TBX22
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03606616V → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_03606751A → T in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_015383118G → C in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894944EnsemblClinVar.1
Natural variantiVAR_021831121M → V in CPX. 1 Publication1
Natural variantiVAR_021832183P → L in CPX. 1 Publication1
Natural variantiVAR_021833187E → K1 PublicationCorresponds to variant dbSNP:rs34244923EnsemblClinVar.1
Natural variantiVAR_069900195S → SS in CPX. 1 Publication1
Natural variantiVAR_021829214L → P in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894946EnsemblClinVar.1
Natural variantiVAR_069416249F → Y1 Publication1
Natural variantiVAR_015384260T → M in CPX. 1 PublicationCorresponds to variant dbSNP:rs104894943EnsemblClinVar.1
Natural variantiVAR_021830264N → Y in CPX. 1 PublicationCorresponds to variant dbSNP:rs28935177EnsemblClinVar.1
Natural variantiVAR_036068307D → N in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs750292974Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0409871 – 120Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY035371 mRNA Translation: AAK63189.1
AL031000 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98588.1
BC014194 mRNA Translation: AAH14194.2
AF251684 mRNA Translation: AAG23749.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14445.1 [Q9Y458-1]

NCBI Reference Sequences

More...RefSeqi		NP_001103348.1, NM_001109878.1 [Q9Y458-1]
NP_001103349.1, NM_001109879.1 [Q9Y458-2]
NP_001290404.1, NM_001303475.1 [Q9Y458-2]
NP_058650.1, NM_016954.2 [Q9Y458-1]
XP_011529274.1, XM_011530972.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1]
ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1]
ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1]
ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		50945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:50945

UCSC genome browser

More...UCSCi		uc004edj.2 human [Q9Y458-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY035371 mRNA Translation: AAK63189.1
AL031000 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98588.1
BC014194 mRNA Translation: AAH14194.2
AF251684 mRNA Translation: AAG23749.1
CCDSiCCDS14445.1 [Q9Y458-1]
RefSeqiNP_001103348.1, NM_001109878.1 [Q9Y458-1]
NP_001103349.1, NM_001109879.1 [Q9Y458-2]
NP_001290404.1, NM_001303475.1 [Q9Y458-2]
NP_058650.1, NM_016954.2 [Q9Y458-1]
XP_011529274.1, XM_011530972.1

3D structure databases

SMRiQ9Y458
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119172, 4 interactors
ELMiQ9Y458
IntActiQ9Y458, 11 interactors
STRINGi9606.ENSP00000362390

PTM databases

iPTMnetiQ9Y458
PhosphoSitePlusiQ9Y458

Polymorphism and mutation databases

BioMutaiTBX22
DMDMi28381405

Proteomic databases

PaxDbiQ9Y458
PeptideAtlasiQ9Y458
PRIDEiQ9Y458
ProteomicsDBi86105 [Q9Y458-1]
86106 [Q9Y458-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		510 195 antibodies

The DNASU plasmid repository

More...DNASUi		50945

Genome annotation databases

EnsembliENST00000373294; ENSP00000362390; ENSG00000122145 [Q9Y458-1]
ENST00000373296; ENSP00000362393; ENSG00000122145 [Q9Y458-1]
ENST00000619509; ENSP00000479825; ENSG00000277800 [Q9Y458-1]
ENST00000628957; ENSP00000487295; ENSG00000277800 [Q9Y458-1]
GeneIDi50945
KEGGihsa:50945
UCSCiuc004edj.2 human [Q9Y458-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		50945
DisGeNETi50945
EuPathDBiHostDB:ENSG00000122145.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBX22
HGNCiHGNC:11600 TBX22
HPAiENSG00000122145 Group enriched (testis, thyroid gland)
MalaCardsiTBX22
MIMi300307 gene
302905 phenotype
303400 phenotype
neXtProtiNX_Q9Y458
OpenTargetsiENSG00000122145
Orphaneti921 Abruzzo-Erickson syndrome
324601 X-linked cleft palate and ankyloglossia
PharmGKBiPA36363

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3586 Eukaryota
ENOG410Y98J LUCA
GeneTreeiENSGT00940000161206
HOGENOMiCLU_030727_1_0_1
InParanoidiQ9Y458
KOiK10186
OMAiEVYLHNI
PhylomeDBiQ9Y458
TreeFamiTF106341

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		50945 3 hits in 436 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TBX22 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TBX22

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		50945
PharosiQ9Y458 Tbio

Protein Ontology

More...PROi		PR:Q9Y458
RNActiQ9Y458 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122145 Expressed in right testis and 30 other tissues
ExpressionAtlasiQ9Y458 baseline and differential
GenevisibleiQ9Y458 HS

Family and domain databases

CDDicd00182 TBOX, 1 hit
Gene3Di2.60.40.820, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR036960 T-box_sf
IPR001699 TF_T-box
IPR018186 TF_T-box_CS
PANTHERiPTHR11267 PTHR11267, 1 hit
PfamiView protein in Pfam
PF00907 T-box, 1 hit
PRINTSiPR00937 TBOX
SMARTiView protein in SMART
SM00425 TBOX, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS01283 TBOX_1, 1 hit
PS01264 TBOX_2, 1 hit
PS50252 TBOX_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBX22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y458
Secondary accession number(s): Q5JZ06, Q96LC0, Q9HBF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 12, 2003
Last modified: June 17, 2020
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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