UniProtKB - Q9Y450 (HBS1L_HUMAN)
Protein
HBS1-like protein
Gene
HBS1L
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 267 – 274 | GTPBy similarity | 8 | |
Nucleotide bindingi | 344 – 348 | GTPBy similarity | 5 | |
Nucleotide bindingi | 406 – 409 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: ProtInc
- translation elongation factor activity Source: UniProtKB-KW
GO - Biological processi
- exonucleolytic catabolism of deadenylated mRNA Source: Reactome
- signal transduction Source: ProtInc
- translation Source: GO_Central
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y450 |
Reactomei | R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease |
Names & Taxonomyi
Protein namesi | Recommended name: HBS1-like proteinAlternative name(s): ERFS |
Gene namesi | Name:HBS1L Synonyms:HBS1, KIAA1038 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000112339.14 |
HGNCi | HGNC:4834, HBS1L |
MIMi | 612450, gene |
neXtProti | NX_Q9Y450 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10767 |
OpenTargetsi | ENSG00000112339 |
PharmGKBi | PA29209 |
Miscellaneous databases
Pharosi | Q9Y450, Tbio |
Polymorphism and mutation databases
BioMutai | HBS1L |
DMDMi | 68566500 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091491 | 1 – 684 | HBS1-like proteinAdd BLAST | 684 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 49 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 67 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 117 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 127 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 152 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 154 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 231 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 622 | N6-acetyllysineBy similarity | 1 | ||
Isoform 2 (identifier: Q9Y450-2) | |||||
Modified residuei | 246 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y450 |
jPOSTi | Q9Y450 |
MassIVEi | Q9Y450 |
PaxDbi | Q9Y450 |
PeptideAtlasi | Q9Y450 |
PRIDEi | Q9Y450 |
ProteomicsDBi | 86102 [Q9Y450-1] 86103 [Q9Y450-2] 86104 [Q9Y450-4] |
PTM databases
iPTMneti | Q9Y450 |
MetOSitei | Q9Y450 |
PhosphoSitePlusi | Q9Y450 |
Expressioni
Tissue specificityi
Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000112339, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | Q9Y450, baseline and differential |
Genevisiblei | Q9Y450, HS |
Organism-specific databases
HPAi | ENSG00000112339, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y450
With | #Exp. | IntAct |
---|---|---|
PELO [Q9BRX2] | 4 | EBI-2868258,EBI-1043580 |
Protein-protein interaction databases
BioGRIDi | 115986, 65 interactors |
IntActi | Q9Y450, 36 interactors |
MINTi | Q9Y450 |
STRINGi | 9606.ENSP00000356811 |
Miscellaneous databases
RNActi | Q9Y450, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 258 – 482 | tr-type GPROSITE-ProRule annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 267 – 274 | G1PROSITE-ProRule annotation | 8 | |
Regioni | 323 – 327 | G2PROSITE-ProRule annotation | 5 | |
Regioni | 344 – 347 | G3PROSITE-ProRule annotation | 4 | |
Regioni | 406 – 409 | G4PROSITE-ProRule annotation | 4 | |
Regioni | 445 – 447 | G5PROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0458, Eukaryota |
GeneTreei | ENSGT00940000156274 |
HOGENOMi | CLU_432731_0_0_1 |
InParanoidi | Q9Y450 |
OMAi | VEDEHCI |
OrthoDBi | 397175at2759 |
PhylomeDBi | Q9Y450 |
TreeFami | TF105833 |
Family and domain databases
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR015033, HBS1-like_N IPR037189, HBS1-like_N_sf IPR027417, P-loop_NTPase IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit PF08938, HBS1_N, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF109732, SSF109732, 1 hit SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51722, G_TR_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y450-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MARHRNVRGY NYDEDFEDDD LYGQSVEDDY CISPSTAAQF IYSRRDKPSV
60 70 80 90 100
EPVEEYDYED LKESSNSVSN HQLSGFDQAR LYSCLDHMRE VLGDAVPDEI
110 120 130 140 150
LIEAVLKNKF DVQKALSGVL EQDRVQSLKD KNEATVSTGK IAKGKPVDSQ
160 170 180 190 200
TSRSESEIVP KVAKMTVSGK KQTMGFEVPG VSSEENGHSF HTPQKGPPIE
210 220 230 240 250
DAIASSDVLE TASKSANPPH TIQASEEQSS TPAPVKKSGK LRQQIDVKAE
260 270 280 290 300
LEKRQGGKQL LNLVVIGHVD AGKSTLMGHM LYLLGNINKR TMHKYEQESK
310 320 330 340 350
KAGKASFAYA WVLDETGEER ERGVTMDVGM TKFETTTKVI TLMDAPGHKD
360 370 380 390 400
FIPNMITGAA QADVAVLVVD ASRGEFEAGF ETGGQTREHG LLVRSLGVTQ
410 420 430 440 450
LAVAVNKMDQ VNWQQERFQE ITGKLGHFLK QAGFKESDVG FIPTSGLSGE
460 470 480 490 500
NLITRSQSSE LTKWYKGLCL LEQIDSFKPP QRSIDKPFRL CVSDVFKDQG
510 520 530 540 550
SGFCITGKIE AGYIQTGDRL LAMPPNETCT VKGITLHDEP VDWAAAGDHV
560 570 580 590 600
SLTLVGMDII KINVGCIFCG PKVPIKACTR FRARILIFNI EIPITKGFPV
610 620 630 640 650
LLHYQTVSEP AVIKRLISVL NKSTGEVTKK KPKFLTKGQN ALVELQTQRP
660 670 680
IALELYKDFK ELGRFMLRYG GSTIAAGVVT EIKE
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z524 | B7Z524_HUMAN | HBS1-like protein | HBS1L | 520 | Annotation score: | ||
H0YDX7 | H0YDX7_HUMAN | HBS1-like protein | HBS1L | 554 | Annotation score: | ||
J3QT46 | J3QT46_HUMAN | HBS1-like protein | HBS1L | 619 | Annotation score: | ||
E9PHZ9 | E9PHZ9_HUMAN | HBS1-like protein | HBS1L | 243 | Annotation score: | ||
E9PS53 | E9PS53_HUMAN | HBS1-like protein | HBS1L | 142 | Annotation score: | ||
E9PMN1 | E9PMN1_HUMAN | HBS1-like protein | HBS1L | 167 | Annotation score: | ||
E9PJ90 | E9PJ90_HUMAN | HBS1-like protein | HBS1L | 118 | Annotation score: | ||
H0YES5 | H0YES5_HUMAN | HBS1-like protein | HBS1L | 170 | Annotation score: | ||
E9PN23 | E9PN23_HUMAN | HBS1-like protein | HBS1L | 141 | Annotation score: | ||
E9PLR4 | E9PLR4_HUMAN | HBS1-like protein | HBS1L | 215 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048963 | 440 | G → S. Corresponds to variant dbSNP:rs4435957Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041068 | 37 – 78 | Missing in isoform 3. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_013624 | 145 – 684 | KPVDS…TEIKE → VLFSSSEVSADNVQSSYPQS ANHLDYSSKPFDFASSVGKY GLSHNSSVPTHCLLHRKKKL DTRKSEKKLESCKLTKELSL ANLIHDMSRDSCESQPSVRL SSTDSLESLLSKNLDADLLR PHASECISKDDSAFKEIPDL KTIIIKGTTPNNSLYIQNNS LSDFQNIPVQDSLGSSNNPL YLTSSLENMTVDNLNASKET EVGNVSLVEQSAKNHTFKND NLQFSQCESPSLTELFQEHK ENNISQCFTLSDLCNQSSAS FTDLSLGSFPLSQLANRCQS SPGISELTGSLSSLAFHKAS PTRDLENLSLSELIAETIDV DNSQIKKESFEVSLSEVRSP GIDSNIDLSVLIKNPDFVPK PVVDPSIAPSSRTKVLSSKL GKNSNFAKDNKKNNKGSLTR KPPFSLSWTKALAARPSAFA STLCLRYPLKSCKRRTLDLY KTFLYSRQVQDVKDKEISPL VAITPFDFKSASPDDIVKAN QKKAFTRE in isoform 2. 1 PublicationAdd BLAST | 540 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U87791 mRNA Translation: AAD00645.1 AJ459826 mRNA Translation: CAD30873.1 AJ459827 mRNA Translation: CAD30874.1 AK295545 mRNA Translation: BAH12101.1 AL353596 Genomic DNA No translation available. AL445190 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47982.1 BC001465 mRNA Translation: AAH01465.1 BC040849 mRNA Translation: AAH40849.1 AB028961 mRNA Translation: BAA82990.1 |
CCDSi | CCDS47479.1 [Q9Y450-4] CCDS47480.1 [Q9Y450-2] CCDS5173.1 [Q9Y450-1] |
RefSeqi | NP_001138630.1, NM_001145158.1 [Q9Y450-4] NP_001138679.1, NM_001145207.1 [Q9Y450-2] NP_006611.1, NM_006620.3 [Q9Y450-1] |
Genome annotation databases
Ensembli | ENST00000367822; ENSP00000356796; ENSG00000112339 [Q9Y450-2] ENST00000367826; ENSP00000356800; ENSG00000112339 [Q9Y450-4] ENST00000367837; ENSP00000356811; ENSG00000112339 [Q9Y450-1] |
GeneIDi | 10767 |
KEGGi | hsa:10767 |
UCSCi | uc003qez.4, human [Q9Y450-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U87791 mRNA Translation: AAD00645.1 AJ459826 mRNA Translation: CAD30873.1 AJ459827 mRNA Translation: CAD30874.1 AK295545 mRNA Translation: BAH12101.1 AL353596 Genomic DNA No translation available. AL445190 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47982.1 BC001465 mRNA Translation: AAH01465.1 BC040849 mRNA Translation: AAH40849.1 AB028961 mRNA Translation: BAA82990.1 |
CCDSi | CCDS47479.1 [Q9Y450-4] CCDS47480.1 [Q9Y450-2] CCDS5173.1 [Q9Y450-1] |
RefSeqi | NP_001138630.1, NM_001145158.1 [Q9Y450-4] NP_001138679.1, NM_001145207.1 [Q9Y450-2] NP_006611.1, NM_006620.3 [Q9Y450-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5LZW | electron microscopy | 3.53 | jj | 1-684 | [»] | |
5LZX | electron microscopy | 3.67 | jj | 1-684 | [»] | |
5LZY | electron microscopy | 3.99 | jj | 1-684 | [»] | |
5LZZ | electron microscopy | 3.47 | jj | 1-684 | [»] | |
SMRi | Q9Y450 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115986, 65 interactors |
IntActi | Q9Y450, 36 interactors |
MINTi | Q9Y450 |
STRINGi | 9606.ENSP00000356811 |
PTM databases
iPTMneti | Q9Y450 |
MetOSitei | Q9Y450 |
PhosphoSitePlusi | Q9Y450 |
Polymorphism and mutation databases
BioMutai | HBS1L |
DMDMi | 68566500 |
Proteomic databases
EPDi | Q9Y450 |
jPOSTi | Q9Y450 |
MassIVEi | Q9Y450 |
PaxDbi | Q9Y450 |
PeptideAtlasi | Q9Y450 |
PRIDEi | Q9Y450 |
ProteomicsDBi | 86102 [Q9Y450-1] 86103 [Q9Y450-2] 86104 [Q9Y450-4] |
Protocols and materials databases
Antibodypediai | 32972, 349 antibodies |
DNASUi | 10767 |
Genome annotation databases
Ensembli | ENST00000367822; ENSP00000356796; ENSG00000112339 [Q9Y450-2] ENST00000367826; ENSP00000356800; ENSG00000112339 [Q9Y450-4] ENST00000367837; ENSP00000356811; ENSG00000112339 [Q9Y450-1] |
GeneIDi | 10767 |
KEGGi | hsa:10767 |
UCSCi | uc003qez.4, human [Q9Y450-1] |
Organism-specific databases
CTDi | 10767 |
DisGeNETi | 10767 |
EuPathDBi | HostDB:ENSG00000112339.14 |
GeneCardsi | HBS1L |
HGNCi | HGNC:4834, HBS1L |
HPAi | ENSG00000112339, Low tissue specificity |
MIMi | 612450, gene |
neXtProti | NX_Q9Y450 |
OpenTargetsi | ENSG00000112339 |
PharmGKBi | PA29209 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0458, Eukaryota |
GeneTreei | ENSGT00940000156274 |
HOGENOMi | CLU_432731_0_0_1 |
InParanoidi | Q9Y450 |
OMAi | VEDEHCI |
OrthoDBi | 397175at2759 |
PhylomeDBi | Q9Y450 |
TreeFami | TF105833 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y450 |
Reactomei | R-HSA-429958, mRNA decay by 3' to 5' exoribonuclease |
Miscellaneous databases
BioGRID-ORCSi | 10767, 89 hits in 840 CRISPR screens |
ChiTaRSi | HBS1L, human |
GenomeRNAii | 10767 |
Pharosi | Q9Y450, Tbio |
PROi | PR:Q9Y450 |
RNActi | Q9Y450, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112339, Expressed in corpus callosum and 240 other tissues |
ExpressionAtlasi | Q9Y450, baseline and differential |
Genevisiblei | Q9Y450, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004161, EFTu-like_2 IPR015033, HBS1-like_N IPR037189, HBS1-like_N_sf IPR027417, P-loop_NTPase IPR000795, TF_GTP-bd_dom IPR009000, Transl_B-barrel_sf IPR009001, Transl_elong_EF1A/Init_IF2_C IPR004160, Transl_elong_EFTu/EF1A_C |
Pfami | View protein in Pfam PF00009, GTP_EFTU, 1 hit PF03144, GTP_EFTU_D2, 1 hit PF03143, GTP_EFTU_D3, 1 hit PF08938, HBS1_N, 1 hit |
PRINTSi | PR00315, ELONGATNFCT |
SUPFAMi | SSF109732, SSF109732, 1 hit SSF50447, SSF50447, 1 hit SSF50465, SSF50465, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51722, G_TR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBS1L_HUMAN | |
Accessioni | Q9Y450Primary (citable) accession number: Q9Y450 Secondary accession number(s): B7Z365 Q9UPW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations