FAM32A

Functionⁱ

Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell cycle Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cell cycle

Biological process

Apoptosis, Cell cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM32A Alternative name(s): Ovarian tumor-associated gene 12 Short name: OTAG-12
Gene namesⁱ	Name:FAM32A Synonyms:OTAG12 ORF Names:CGI-144
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105058.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24563 FAM32A
MIMⁱ	614554 gene
neXtProtⁱ	NX_Q9Y421

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26017
Open Targets More...OpenTargetsⁱ	ENSG00000105058
PharmGKBⁱ	PA134956082

Polymorphism and mutation databases

BioMutaⁱ	FAM32A
DMDMⁱ	74753494

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000223250	1 – 112	Protein FAM32AAdd BLAST		112

Proteomic databases

EPDⁱ	Q9Y421
PaxDbⁱ	Q9Y421
PeptideAtlas More...PeptideAtlasⁱ	Q9Y421
PRIDEⁱ	Q9Y421
ProteomicsDBⁱ	86090 86091 [Q9Y421-2] 86092 [Q9Y421-3]
TopDownProteomicsⁱ	Q9Y421-1 [Q9Y421-1]

PTM databases

iPTMnetⁱ	Q9Y421
PhosphoSitePlusⁱ	Q9Y421

Expressionⁱ

Tissue specificityⁱ

Expressed in ovary, with isoform 1 being predominant.1 Publication

Inductionⁱ

By etoposide, puromycin or carboplatin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105058 Expressed in 232 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FAM32A
ExpressionAtlasⁱ	Q9Y421 baseline and differential
Genevisibleⁱ	Q9Y421 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051712

HPAⁱ

HPA051712

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CWC22	Q9HCG8	2	EBI-726146,EBI-373289

With

Entry

#Exp.

IntAct

Notes

CWC22

Q9HCG8

2

EBI-726146,EBI-373289

Protein-protein interaction databases

BioGridⁱ	117488, 13 interactors
IntActⁱ	Q9Y421, 4 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y421
STRINGⁱ	9606.ENSP00000263384

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y421
SMRⁱ	Q9Y421
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	9 – 86	Lys-richAdd BLAST		78

Sequence similaritiesⁱ

Belongs to the FAM32 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3410 Eukaryota ENOG41126B2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013811
HOGENOMⁱ	HOG000205758
HOVERGENⁱ	HBG081504
InParanoidⁱ	Q9Y421
KEGG Orthology (KO) More...KOⁱ	K13120
OMAⁱ	LSEHNDM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1285
PhylomeDBⁱ	Q9Y421
TreeFamⁱ	TF314020

Family and domain databases

InterProⁱ	View protein in InterPro IPR013865 DUF1754_euk
PANTHERⁱ	PTHR13282 PTHR13282, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08555 DUF1754, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y421-1) [UniParc]FASTA Add to basket

Also known as: OTAG-12b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE 
        60         70         80         90        100
KRRGLDKRTP AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT 
       110 
EHYDIPKVSW TK

Length:112

Mass (Da):13,178

Last modified:May 1, 2000 - v2

Checksum:ⁱ7FAF15315E9D580C

GO

Isoform 2 (identifier: Q9Y421-2) [UniParc]FASTA Add to basket

Also known as: OTAG-12a

The sequence of this isoform differs from the canonical sequence as follows:
74-112: MERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK → GHQTSCIATGFQGHKANAARSYAWIQNWYCVPSS

« Hide

        10         20         30         40         50
MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE 
        60         70         80         90        100
KRRGLDKRTP AQAAFEKMQE KRQGHQTSCI ATGFQGHKAN AARSYAWIQN 

WYCVPSS

Show »

Length:107

Mass (Da):12,139

Checksum:ⁱB8782C7C98B2953D

GO

Isoform 3 (identifier: Q9Y421-3) [UniParc]FASTA Add to basket

Also known as: OTAG-12c

The sequence of this isoform differs from the canonical sequence as follows:
1-24: MEAYEQVQKGPLKLKGVAELGVTK → MSFS

« Hide

        10         20         30         40         50
MSFSRKKKKK DKDKAKLLEA MGTSKKNEEE KRRGLDKRTP AQAAFEKMQE 
        60         70         80         90 
KRQMERILKK ASKTHKQRVE DFNRHLDTLT EHYDIPKVSW TK

Show »

Length:92

Mass (Da):11,032

Checksum:ⁱ45051BB82E2515F8

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ENN5	K7ENN5_HUMAN	Protein FAM32A Protein FAM32A	FAM32A	107	Annotation score:
K7EIY1	K7EIY1_HUMAN	Protein FAM32A Protein FAM32A	FAM32A	94	Annotation score:
K7ELZ8	K7ELZ8_HUMAN	Protein FAM32A Protein FAM32A	FAM32A	82	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043860	1 – 24	MEAYE…LGVTK → MSFS in isoform 3. CuratedAdd BLAST		24
Alternative sequenceⁱVSP_043861	74 – 112	MERIL…VSWTK → GHQTSCIATGFQGHKANAAR SYAWIQNWYCVPSS in isoform 2. 1 PublicationAdd BLAST		39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151902 mRNA Translation: AAD34139.1 AL050157 mRNA Translation: CAB43298.2 BC000639 mRNA Translation: AAH00639.1 BC004447 mRNA Translation: AAH04447.1 BC017286 mRNA Translation: AAH17286.1 BU543240 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12341.1 [Q9Y421-1]
PIRⁱ	T08783
NCBI Reference Sequences More...RefSeqⁱ	NP_054796.1, NM_014077.3 [Q9Y421-1]
UniGeneⁱ	Hs.631614

Genome annotation databases

Ensemblⁱ	ENST00000263384; ENSP00000263384; ENSG00000105058 [Q9Y421-1] ENST00000589852; ENSP00000465969; ENSG00000105058 [Q9Y421-3]
GeneIDⁱ	26017
KEGGⁱ	hsa:26017
UCSC genome browser More...UCSCⁱ	uc002ndt.4 human [Q9Y421-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y421	Protein FAM32A		BOVIN		112	UniRef100_Q9Y421
Protein FAM32A		PONAB		112
Family with sequence similarity 32 member A		SAIBB		131
Family with sequence similarity 32, member A, isoform CRA_a		HUMAN		112
FAM32A isoform 1		PANTR		112
+19
Q9Y421-3	FAM32A isoform 2		PONAB		92	UniRef100_A0A2J8T6S8
FAM32A isoform 2		PANTR		92

Protein	Similar proteins		Species	Score	Length	Source
Q9Y421	Protein FAM32A		BOVIN		112	UniRef90_Q9Y421
Protein FAM32A		PONAB		112
Protein FAM32A		RAT		112
Protein FAM32A		MOUSE		112
Family with sequence similarity 32 member A		SAIBB		131
+84
Q9Y421-2	FAM32A isoform 4		PANTR		109	UniRef90_Q9Y421-2
Protein FAM32A		HUMAN		107
Uncharacterized protein		MACMU		107
Uncharacterized protein		COLAP		107
Uncharacterized protein		CERAT		107
+9
Q9Y421-3	Uncharacterized protein		MACMU		92	UniRef90_A0A1D5QU37
FAM32A isoform 2		PONAB		92
FAM32A isoform 2		PANTR		92
UPI0003F10519		CHRAS		91

Protein	Similar proteins		Species	Score	Length	Source
Q9Y421	Protein FAM32A		BOVIN		112	UniRef50_Q9Y421
Protein FAM32A		PONAB		112
Protein FAM32A		RAT		112
Protein FAM32A		MOUSE		112
Family with sequence similarity 32 member A		SAIBB		131
+109
Q9Y421-2	FAM32A isoform 4		PANTR		109	UniRef50_Q9Y421-2
Protein FAM32A		HUMAN		107
Uncharacterized protein		PAPAN		107
Uncharacterized protein		NOMLE		107
Uncharacterized protein		MACNE		107
+12
Q9Y421-3	Uncharacterized protein		SALR5		112	UniRef50_F2ULF1
Uncharacterized protein		MACMU		92
FAM32A isoform 2		PONAB		92
FAM32A isoform 2		PANTR		92
UPI0003F10519		CHRAS		91

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151902 mRNA Translation: AAD34139.1 AL050157 mRNA Translation: CAB43298.2 BC000639 mRNA Translation: AAH00639.1 BC004447 mRNA Translation: AAH04447.1 BC017286 mRNA Translation: AAH17286.1 BU543240 mRNA No translation available.
CCDSⁱ	CCDS12341.1 [Q9Y421-1]
PIRⁱ	T08783
RefSeqⁱ	NP_054796.1, NM_014077.3 [Q9Y421-1]
UniGeneⁱ	Hs.631614

3D structure databases

ProteinModelPortalⁱ	Q9Y421
SMRⁱ	Q9Y421
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117488, 13 interactors
IntActⁱ	Q9Y421, 4 interactors
MINTⁱ	Q9Y421
STRINGⁱ	9606.ENSP00000263384

PTM databases

iPTMnetⁱ	Q9Y421
PhosphoSitePlusⁱ	Q9Y421

Polymorphism and mutation databases

BioMutaⁱ	FAM32A
DMDMⁱ	74753494

Proteomic databases

EPDⁱ	Q9Y421
PaxDbⁱ	Q9Y421
PeptideAtlasⁱ	Q9Y421
PRIDEⁱ	Q9Y421
ProteomicsDBⁱ	86090 86091 [Q9Y421-2] 86092 [Q9Y421-3]
TopDownProteomicsⁱ	Q9Y421-1 [Q9Y421-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26017
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000263384; ENSP00000263384; ENSG00000105058 [Q9Y421-1] ENST00000589852; ENSP00000465969; ENSG00000105058 [Q9Y421-3]
GeneIDⁱ	26017
KEGGⁱ	hsa:26017
UCSCⁱ	uc002ndt.4 human [Q9Y421-1]

Organism-specific databases

CTDⁱ	26017
DisGeNETⁱ	26017
EuPathDBⁱ	HostDB:ENSG00000105058.11
GeneCardsⁱ	FAM32A
H-InvDBⁱ	HIX0014865
HGNCⁱ	HGNC:24563 FAM32A
HPAⁱ	HPA051712
MIMⁱ	614554 gene
neXtProtⁱ	NX_Q9Y421
OpenTargetsⁱ	ENSG00000105058
PharmGKBⁱ	PA134956082
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3410 Eukaryota ENOG41126B2 LUCA
GeneTreeⁱ	ENSGT00390000013811
HOGENOMⁱ	HOG000205758
HOVERGENⁱ	HBG081504
InParanoidⁱ	Q9Y421
KOⁱ	K13120
OMAⁱ	LSEHNDM
OrthoDBⁱ	EOG091G1285
PhylomeDBⁱ	Q9Y421
TreeFamⁱ	TF314020

Miscellaneous databases

ChiTaRSⁱ	FAM32A human
GeneWikiⁱ	FAM32A
GenomeRNAiⁱ	26017
Protein Ontology More...PROⁱ	PR:Q9Y421
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105058 Expressed in 232 organ(s), highest expression level in frontal cortex
CleanExⁱ	HS_FAM32A
ExpressionAtlasⁱ	Q9Y421 baseline and differential
Genevisibleⁱ	Q9Y421 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013865 DUF1754_euk
PANTHERⁱ	PTHR13282 PTHR13282, 1 hit
Pfamⁱ	View protein in Pfam PF08555 DUF1754, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA32A_HUMAN
Accessionⁱ	Q9Y421Primary (citable) accession number: Q9Y421 Secondary accession number(s): Q9BT02
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
	Last sequence update:	May 1, 2000
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q9Y421 (FA32A_HUMAN)

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Protein FAM32A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ