UniProtKB - Q9Y421 (FA32A_HUMAN)
Protein
Protein FAM32A
Gene
FAM32A
Organism
Homo sapiens (Human)
Status
Functioni
Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | Q9Y421 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM32AAlternative name(s): Ovarian tumor-associated gene 12 Short name: OTAG-12 |
Gene namesi | Name:FAM32A Synonyms:OTAG12 ORF Names:CGI-144 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105058.11 |
HGNCi | HGNC:24563, FAM32A |
MIMi | 614554, gene |
neXtProti | NX_Q9Y421 |
Subcellular locationi
Nucleus
Nucleus
Nucleus
- nucleolus Source: LIFEdb
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26017 |
OpenTargetsi | ENSG00000105058 |
PharmGKBi | PA134956082 |
Miscellaneous databases
Pharosi | Q9Y421, Tdark |
Polymorphism and mutation databases
BioMutai | FAM32A |
DMDMi | 74753494 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000223250 | 1 – 112 | Protein FAM32AAdd BLAST | 112 |
Proteomic databases
EPDi | Q9Y421 |
jPOSTi | Q9Y421 |
MassIVEi | Q9Y421 |
PaxDbi | Q9Y421 |
PeptideAtlasi | Q9Y421 |
PRIDEi | Q9Y421 |
ProteomicsDBi | 86090 [Q9Y421-1] 86091 [Q9Y421-2] 86092 [Q9Y421-3] |
TopDownProteomicsi | Q9Y421-1 [Q9Y421-1] |
PTM databases
iPTMneti | Q9Y421 |
PhosphoSitePlusi | Q9Y421 |
Expressioni
Tissue specificityi
Expressed in ovary, with isoform 1 being predominant.1 Publication
Inductioni
By etoposide, puromycin or carboplatin.1 Publication
Gene expression databases
Bgeei | ENSG00000105058, Expressed in cortical plate and 245 other tissues |
ExpressionAtlasi | Q9Y421, baseline and differential |
Genevisiblei | Q9Y421, HS |
Organism-specific databases
HPAi | ENSG00000105058, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y421
With | #Exp. | IntAct |
---|---|---|
CWC22 [Q9HCG8] | 2 | EBI-726146,EBI-373289 |
Protein-protein interaction databases
BioGRIDi | 117488, 16 interactors |
IntActi | Q9Y421, 5 interactors |
MINTi | Q9Y421 |
STRINGi | 9606.ENSP00000263384 |
Miscellaneous databases
RNActi | Q9Y421, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 86 | Lys-richAdd BLAST | 78 |
Sequence similaritiesi
Belongs to the FAM32 family.Curated
Phylogenomic databases
eggNOGi | KOG3410, Eukaryota |
GeneTreei | ENSGT00390000013811 |
HOGENOMi | CLU_098435_3_0_1 |
InParanoidi | Q9Y421 |
OMAi | HRMEQVV |
OrthoDBi | 1603617at2759 |
PhylomeDBi | Q9Y421 |
TreeFami | TF314020 |
Family and domain databases
InterProi | View protein in InterPro IPR013865, FAM32A |
PANTHERi | PTHR13282, PTHR13282, 1 hit |
Pfami | View protein in Pfam PF08555, DUF1754, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y421-1) [UniParc]FASTAAdd to basket
Also known as: OTAG-12b
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAYEQVQKG PLKLKGVAEL GVTKRKKKKK DKDKAKLLEA MGTSKKNEEE
60 70 80 90 100
KRRGLDKRTP AQAAFEKMQE KRQMERILKK ASKTHKQRVE DFNRHLDTLT
110
EHYDIPKVSW TK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ELZ8 | K7ELZ8_HUMAN | Protein FAM32A | FAM32A | 82 | Annotation score: | ||
K7EIY1 | K7EIY1_HUMAN | Protein FAM32A | FAM32A | 94 | Annotation score: | ||
K7ENN5 | K7ENN5_HUMAN | Protein FAM32A | FAM32A | 107 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043860 | 1 – 24 | MEAYE…LGVTK → MSFS in isoform 3. CuratedAdd BLAST | 24 | |
Alternative sequenceiVSP_043861 | 74 – 112 | MERIL…VSWTK → GHQTSCIATGFQGHKANAAR SYAWIQNWYCVPSS in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151902 mRNA Translation: AAD34139.1 AL050157 mRNA Translation: CAB43298.2 BC000639 mRNA Translation: AAH00639.1 BC004447 mRNA Translation: AAH04447.1 BC017286 mRNA Translation: AAH17286.1 BU543240 mRNA No translation available. |
CCDSi | CCDS12341.1 [Q9Y421-1] |
PIRi | T08783 |
RefSeqi | NP_054796.1, NM_014077.3 [Q9Y421-1] |
Genome annotation databases
Ensembli | ENST00000263384; ENSP00000263384; ENSG00000105058 [Q9Y421-1] ENST00000589852; ENSP00000465969; ENSG00000105058 [Q9Y421-3] |
GeneIDi | 26017 |
KEGGi | hsa:26017 |
UCSCi | uc002ndt.4, human [Q9Y421-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151902 mRNA Translation: AAD34139.1 AL050157 mRNA Translation: CAB43298.2 BC000639 mRNA Translation: AAH00639.1 BC004447 mRNA Translation: AAH04447.1 BC017286 mRNA Translation: AAH17286.1 BU543240 mRNA No translation available. |
CCDSi | CCDS12341.1 [Q9Y421-1] |
PIRi | T08783 |
RefSeqi | NP_054796.1, NM_014077.3 [Q9Y421-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6QDV | electron microscopy | 3.30 | G | 53-112 | [»] | |
SMRi | Q9Y421 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117488, 16 interactors |
IntActi | Q9Y421, 5 interactors |
MINTi | Q9Y421 |
STRINGi | 9606.ENSP00000263384 |
PTM databases
iPTMneti | Q9Y421 |
PhosphoSitePlusi | Q9Y421 |
Polymorphism and mutation databases
BioMutai | FAM32A |
DMDMi | 74753494 |
Proteomic databases
EPDi | Q9Y421 |
jPOSTi | Q9Y421 |
MassIVEi | Q9Y421 |
PaxDbi | Q9Y421 |
PeptideAtlasi | Q9Y421 |
PRIDEi | Q9Y421 |
ProteomicsDBi | 86090 [Q9Y421-1] 86091 [Q9Y421-2] 86092 [Q9Y421-3] |
TopDownProteomicsi | Q9Y421-1 [Q9Y421-1] |
Protocols and materials databases
Antibodypediai | 54347, 46 antibodies |
DNASUi | 26017 |
Genome annotation databases
Ensembli | ENST00000263384; ENSP00000263384; ENSG00000105058 [Q9Y421-1] ENST00000589852; ENSP00000465969; ENSG00000105058 [Q9Y421-3] |
GeneIDi | 26017 |
KEGGi | hsa:26017 |
UCSCi | uc002ndt.4, human [Q9Y421-1] |
Organism-specific databases
CTDi | 26017 |
DisGeNETi | 26017 |
EuPathDBi | HostDB:ENSG00000105058.11 |
GeneCardsi | FAM32A |
HGNCi | HGNC:24563, FAM32A |
HPAi | ENSG00000105058, Low tissue specificity |
MIMi | 614554, gene |
neXtProti | NX_Q9Y421 |
OpenTargetsi | ENSG00000105058 |
PharmGKBi | PA134956082 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3410, Eukaryota |
GeneTreei | ENSGT00390000013811 |
HOGENOMi | CLU_098435_3_0_1 |
InParanoidi | Q9Y421 |
OMAi | HRMEQVV |
OrthoDBi | 1603617at2759 |
PhylomeDBi | Q9Y421 |
TreeFami | TF314020 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y421 |
Miscellaneous databases
BioGRID-ORCSi | 26017, 563 hits in 851 CRISPR screens |
ChiTaRSi | FAM32A, human |
GeneWikii | FAM32A |
GenomeRNAii | 26017 |
Pharosi | Q9Y421, Tdark |
PROi | PR:Q9Y421 |
RNActi | Q9Y421, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105058, Expressed in cortical plate and 245 other tissues |
ExpressionAtlasi | Q9Y421, baseline and differential |
Genevisiblei | Q9Y421, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013865, FAM32A |
PANTHERi | PTHR13282, PTHR13282, 1 hit |
Pfami | View protein in Pfam PF08555, DUF1754, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FA32A_HUMAN | |
Accessioni | Q9Y421Primary (citable) accession number: Q9Y421 Secondary accession number(s): Q9BT02 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | May 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM