UniProtKB - Q9Y3Y4 (PYGO1_HUMAN)

BLAST

>sp|Q9Y3Y4|PYGO1_HUMAN Pygopus homolog 1 OS=Homo sapiens OX=9606 GN=PYGO1 PE=1 SV=2
MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN
PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG
PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP
AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD
FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA
NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE
ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA

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History
Entry version 140 (07 Nov 2018)
Sequence version 2 (19 Sep 2002)
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Protein

Pygopus homolog 1

Gene

PYGO1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in signal transduction through the Wnt pathway.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	340 – 398	PHD-typePROSITE-ProRule annotationAdd BLAST		59

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
methylated histone binding
Source: FlyBase
Inferred from direct assayⁱ
- 18498752

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

beta-catenin-TCF complex assembly Source: Reactome
canonical Wnt signaling pathway Source: Ensembl
hematopoietic progenitor cell differentiation Source: Ensembl
kidney development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of transcription by RNA polymerase II Source: Ensembl
post-embryonic development Source: Ensembl
protein localization to nucleus Source: Ensembl
spermatid nucleus differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Wnt signaling pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORⁱ	Q9Y3Y4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Pygopus homolog 1
Gene namesⁱ	Name:PYGO1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171016.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30256 PYGO1
MIMⁱ	606902 gene
neXtProtⁱ	NX_Q9Y3Y4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	349	E → A: Reduces interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	350	V → E: Almost complete loss of interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	351	N → A: Reduces interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	354	Q → A: Reduces interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	356	A → E: Almost complete loss of interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	357	I → R: Loss of interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	360	E → A: Loss of interaction with H3K4me2. 1 Publication	1
Mutagenesisⁱ	366	W → E: Loss of interaction with H3K4me2. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26108
Open Targets More...OpenTargetsⁱ	ENSG00000171016
PharmGKBⁱ	PA134875127

Polymorphism and mutation databases

DMDMⁱ	23396828

DMDMⁱ

23396828

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097121	1 – 419	Pygopus homolog 1Add BLAST		419

Proteomic databases

PaxDbⁱ	Q9Y3Y4
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3Y4
PRIDEⁱ	Q9Y3Y4
ProteomicsDBⁱ	86087

PTM databases

iPTMnetⁱ	Q9Y3Y4
PhosphoSitePlusⁱ	Q9Y3Y4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171016 Expressed in 126 organ(s), highest expression level in lung
CleanExⁱ	HS_PYGO1
Genevisibleⁱ	Q9Y3Y4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042248

HPAⁱ

HPA042248

Interactionⁱ

Subunit structureⁱ

Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex. Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1. Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
BCL9	O00512	7	EBI-3397474,EBI-533127

With

Entry

#Exp.

IntAct

Notes

BCL9

O00512

EBI-3397474,EBI-533127

GO - Molecular functionⁱ

methylated histone binding
Source: FlyBase
Inferred from direct assayⁱ
- 18498752

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117557, 6 interactors
IntActⁱ	Q9Y3Y4, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y3Y4
STRINGⁱ	9606.ENSP00000302327

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	340 – 342	Combined sources	3
Turnⁱ	344 – 346	Combined sources	3
Beta strandⁱ	356 – 359	Combined sources	4
Turnⁱ	360 – 363	Combined sources	4
Beta strandⁱ	366 – 368	Combined sources	3
Helixⁱ	369 – 372	Combined sources	4
Helixⁱ	376 – 384	Combined sources	9
Beta strandⁱ	388 – 390	Combined sources	3
Helixⁱ	393 – 396	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y3Y4
SMRⁱ	Q9Y3Y4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9Y3Y4

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	341 – 388	Interaction with H3K4me2Add BLAST		48
Regionⁱ	373 – 391	Interaction with BCL91 PublicationAdd BLAST		19

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	35 – 41	Nuclear localization signalSequence analysis		7

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	47 – 135	Pro-richAdd BLAST		89
Compositional biasⁱ	153 – 305	Asn-richAdd BLAST		153

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	340 – 398	PHD-typePROSITE-ProRule annotationAdd BLAST		59

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IDYF Eukaryota ENOG4111FFC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063948
HOGENOMⁱ	HOG000001580
HOVERGENⁱ	HBG053774
InParanoidⁱ	Q9Y3Y4
OMAⁱ	LHPSRHG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KKH
PhylomeDBⁱ	Q9Y3Y4
TreeFamⁱ	TF333020

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00628 PHD, 1 hit
SMARTⁱ	View protein in SMART SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Y3Y4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAENSPAPA YKVSSHGGDS GLDGLGGPGV QLGSPDKKKR KANTQGPSFP 
        60         70         80         90        100
PLSEYAPPPN PNSDHLVAAN PFDDNYNTIS YKPLPSSNPY LGPGYPGFGG 
       110        120        130        140        150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP 
       160        170        180        190        200
HDNSSFGNPS YNNALSQNVN MPNQHFRQNP AENFSQIPPQ NASQVSNPDL 
       210        220        230        240        250
ASNFVPGNNS NFTSPLESNH SFIPPPNTFG QAKAPPPKQD FTQGATKNTN 
       260        270        280        290        300
QNSSAHPPHL NMDDTVNQSN IELKNVNRNN AVNQENSRSS STEATNNNPA 
       310        320        330        340        350
NGTQNKPRQP RGAADACTTE KSNKSSLHPN RHGHSSSDPV YPCGICTNEV 
       360        370        380        390        400
NDDQDAILCE ASCQKWFHRI CTGMTETAYG LLTAEASAVW GCDTCMADKD 
       410 
VQLMRTRETF GPSAVGSDA

Length:419

Mass (Da):45,116

Last modified:September 19, 2002 - v2

Checksum:ⁱD5D4E4AA416FD8E4

Isoform 2 (identifier: Q9Y3Y4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-16: MPAENSPAPAYKVSSH → MSAEQEKDPISLKRVR

« Hide

        10         20         30         40         50
MSAEQEKDPI SLKRVRGGDS GLDGLGGPGV QLGSPDKKKR KANTQGPSFP 
        60         70         80         90        100
PLSEYAPPPN PNSDHLVAAN PFDDNYNTIS YKPLPSSNPY LGPGYPGFGG 
       110        120        130        140        150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP 
       160        170        180        190        200
HDNSSFGNPS YNNALSQNVN MPNQHFRQNP AENFSQIPPQ NASQVSNPDL 
       210        220        230        240        250
ASNFVPGNNS NFTSPLESNH SFIPPPNTFG QAKAPPPKQD FTQGATKNTN 
       260        270        280        290        300
QNSSAHPPHL NMDDTVNQSN IELKNVNRNN AVNQENSRSS STEATNNNPA 
       310        320        330        340        350
NGTQNKPRQP RGAADACTTE KSNKSSLHPN RHGHSSSDPV YPCGICTNEV 
       360        370        380        390        400
NDDQDAILCE ASCQKWFHRI CTGMTETAYG LLTAEASAVW GCDTCMADKD 
       410 
VQLMRTRETF GPSAVGSDA

Show »

Length:419

Mass (Da):45,318

Checksum:ⁱE30602D469C7E1CD

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051292	299	P → H. Corresponds to variant dbSNP:rs11858624Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056648	1 – 16	MPAEN…KVSSH → MSAEQEKDPISLKRVR in isoform 2. 1 PublicationAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF457207 mRNA Translation: AAL91370.1 EF625686 mRNA Translation: ABU93489.1 AC012378 Genomic DNA No translation available. AC022083 Genomic DNA No translation available. AL049925 mRNA Translation: CAB43209.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10155.1 [Q9Y3Y4-1] CCDS81885.1 [Q9Y3Y4-2]
PIRⁱ	T08663
NCBI Reference Sequences More...RefSeqⁱ	NP_001317255.1, NM_001330326.1 [Q9Y3Y4-2] NP_056432.1, NM_015617.2 [Q9Y3Y4-1] XP_011519748.1, XM_011521446.2 [Q9Y3Y4-2]
UniGeneⁱ	Hs.256587 Hs.87194

Genome annotation databases

Ensemblⁱ	ENST00000302000; ENSP00000302327; ENSG00000171016 [Q9Y3Y4-1] ENST00000563719; ENSP00000457777; ENSG00000171016 [Q9Y3Y4-2] ENST00000645724; ENSP00000496139; ENSG00000171016 [Q9Y3Y4-2]
GeneIDⁱ	26108
KEGGⁱ	hsa:26108
UCSC genome browser More...UCSCⁱ	uc002adf.3 human [Q9Y3Y4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3Y4	Pygopus family PHD finger 1		MYOLU		422	UniRef90_Q9Y3Y4
Uncharacterized protein		AOTNA		420
Pygopus family PHD finger 1		SAIBB		420
Uncharacterized protein		CALJA		420
Uncharacterized protein		Cebus capucinus imitator		420
+93

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3Y4	Pygopus family PHD finger 1		MYOLU		422	UniRef50_Q9Y3Y4
Uncharacterized protein		AOTNA		420
Pygopus family PHD finger 1		SAIBB		420
Uncharacterized protein		CALJA		420
Uncharacterized protein		Cebus capucinus imitator		420
+126

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF457207 mRNA Translation: AAL91370.1 EF625686 mRNA Translation: ABU93489.1 AC012378 Genomic DNA No translation available. AC022083 Genomic DNA No translation available. AL049925 mRNA Translation: CAB43209.1
CCDSⁱ	CCDS10155.1 [Q9Y3Y4-1] CCDS81885.1 [Q9Y3Y4-2]
PIRⁱ	T08663
RefSeqⁱ	NP_001317255.1, NM_001330326.1 [Q9Y3Y4-2] NP_056432.1, NM_015617.2 [Q9Y3Y4-1] XP_011519748.1, XM_011521446.2 [Q9Y3Y4-2]
UniGeneⁱ	Hs.256587 Hs.87194

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VP7	X-ray	1.65	A	333-402	[»]
	2VPB	X-ray	1.59	A	333-397	[»]
	2VPD	X-ray	2.77	A/C	333-398	[»]
	2VPE	X-ray	1.70	A/C	340-398	[»]
	2VPG	X-ray	1.60	A/C	340-398	[»]
ProteinModelPortalⁱ	Q9Y3Y4
SMRⁱ	Q9Y3Y4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117557, 6 interactors
IntActⁱ	Q9Y3Y4, 7 interactors
MINTⁱ	Q9Y3Y4
STRINGⁱ	9606.ENSP00000302327

PTM databases

iPTMnetⁱ	Q9Y3Y4
PhosphoSitePlusⁱ	Q9Y3Y4

Polymorphism and mutation databases

DMDMⁱ	23396828

DMDMⁱ

23396828

Proteomic databases

PaxDbⁱ	Q9Y3Y4
PeptideAtlasⁱ	Q9Y3Y4
PRIDEⁱ	Q9Y3Y4
ProteomicsDBⁱ	86087

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26108
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302000; ENSP00000302327; ENSG00000171016 [Q9Y3Y4-1] ENST00000563719; ENSP00000457777; ENSG00000171016 [Q9Y3Y4-2] ENST00000645724; ENSP00000496139; ENSG00000171016 [Q9Y3Y4-2]
GeneIDⁱ	26108
KEGGⁱ	hsa:26108
UCSCⁱ	uc002adf.3 human [Q9Y3Y4-1]

Organism-specific databases

CTDⁱ	26108
DisGeNETⁱ	26108
EuPathDBⁱ	HostDB:ENSG00000171016.11
GeneCardsⁱ	PYGO1
HGNCⁱ	HGNC:30256 PYGO1
HPAⁱ	HPA042248
MIMⁱ	606902 gene
neXtProtⁱ	NX_Q9Y3Y4
OpenTargetsⁱ	ENSG00000171016
PharmGKBⁱ	PA134875127
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDYF Eukaryota ENOG4111FFC LUCA
GeneTreeⁱ	ENSGT00530000063948
HOGENOMⁱ	HOG000001580
HOVERGENⁱ	HBG053774
InParanoidⁱ	Q9Y3Y4
OMAⁱ	LHPSRHG
OrthoDBⁱ	EOG091G0KKH
PhylomeDBⁱ	Q9Y3Y4
TreeFamⁱ	TF333020

Enzyme and pathway databases

Reactomeⁱ	R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402 Deactivation of the beta-catenin transactivating complex
SIGNORⁱ	Q9Y3Y4

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y3Y4
GenomeRNAiⁱ	26108
Protein Ontology More...PROⁱ	PR:Q9Y3Y4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171016 Expressed in 126 organ(s), highest expression level in lung
CleanExⁱ	HS_PYGO1
Genevisibleⁱ	Q9Y3Y4 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF00628 PHD, 1 hit
SMARTⁱ	View protein in SMART SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PYGO1_HUMAN
Accessionⁱ	Q9Y3Y4Primary (citable) accession number: Q9Y3Y4 Secondary accession number(s): A7Y2D6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	September 19, 2002
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q9Y3Y4 (PYGO1_HUMAN)

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Pygopus homolog 1

PYGO1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ