UniProtKB - Q9Y3Y4 (PYGO1_HUMAN)
Pygopus homolog 1
PYGO1
Functioni
Involved in signal transduction through the Wnt pathway.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 398 | PHD-typePROSITE-ProRule annotationAdd BLAST | 59 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: FlyBase
GO - Biological processi
- canonical Wnt signaling pathway Source: Ensembl
- hematopoietic progenitor cell differentiation Source: Ensembl
- kidney development Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein localization to nucleus Source: Ensembl
- spermatid nucleus differentiation Source: GO_Central
Keywordsi
Biological process | Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Y4 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex |
SignaLinki | Q9Y3Y4 |
SIGNORi | Q9Y3Y4 |
Names & Taxonomyi
Protein namesi | Recommended name: Pygopus homolog 1 |
Gene namesi | Name:PYGO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30256, PYGO1 |
MIMi | 606902, gene |
neXtProti | NX_Q9Y3Y4 |
VEuPathDBi | HostDB:ENSG00000171016 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 349 | E → A: Reduces interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 350 | V → E: Almost complete loss of interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 351 | N → A: Reduces interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 354 | Q → A: Reduces interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 356 | A → E: Almost complete loss of interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 357 | I → R: Loss of interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 360 | E → A: Loss of interaction with H3K4me2. 1 Publication | 1 | |
Mutagenesisi | 366 | W → E: Loss of interaction with H3K4me2. 1 Publication | 1 |
Organism-specific databases
OpenTargetsi | ENSG00000171016 |
PharmGKBi | PA134875127 |
Miscellaneous databases
Pharosi | Q9Y3Y4, Tdark |
Genetic variation databases
BioMutai | PYGO1 |
DMDMi | 23396828 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097121 | 1 – 419 | Pygopus homolog 1Add BLAST | 419 |
Proteomic databases
jPOSTi | Q9Y3Y4 |
MassIVEi | Q9Y3Y4 |
PaxDbi | Q9Y3Y4 |
PeptideAtlasi | Q9Y3Y4 |
PRIDEi | Q9Y3Y4 |
ProteomicsDBi | 1817 86087 [Q9Y3Y4-1] |
PTM databases
iPTMneti | Q9Y3Y4 |
PhosphoSitePlusi | Q9Y3Y4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000171016, Expressed in lung and 145 other tissues |
Genevisiblei | Q9Y3Y4, HS |
Organism-specific databases
HPAi | ENSG00000171016, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BCL9 via The PHD-type zinc finger motiv, and thereby becomes part of the nuclear beta-catenin/TCF complex.
Identified in a complex with BCL9L, CDC73, CTNNB1 and PYGO1.
Interacts with histone H3 mono-, di- or tri-methylated at 'Lys4' (H3K4me1, H3K4me2, H3K4me3); the interaction is enhanced by the interaction with BCL9.
2 PublicationsBinary interactionsi
Q9Y3Y4
GO - Molecular functioni
- methylated histone binding Source: FlyBase
Protein-protein interaction databases
BioGRIDi | 117557, 21 interactors |
IntActi | Q9Y3Y4, 25 interactors |
MINTi | Q9Y3Y4 |
STRINGi | 9606.ENSP00000302327 |
Miscellaneous databases
RNActi | Q9Y3Y4, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y3Y4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y3Y4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 64 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 175 – 338 | DisorderedSequence analysisAdd BLAST | 164 | |
Regioni | 341 – 388 | Interaction with H3K4me2Add BLAST | 48 | |
Regioni | 373 – 391 | Interaction with BCL91 PublicationAdd BLAST | 19 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 35 – 41 | Nuclear localization signalSequence analysis | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 226 | Polar residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 241 – 308 | Polar residuesSequence analysisAdd BLAST | 68 | |
Compositional biasi | 316 – 333 | Polar residuesSequence analysisAdd BLAST | 18 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 340 – 398 | PHD-typePROSITE-ProRule annotationAdd BLAST | 59 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QTIZ, Eukaryota |
GeneTreei | ENSGT00530000063948 |
HOGENOMi | CLU_686883_0_0_1 |
InParanoidi | Q9Y3Y4 |
OMAi | YNTFRMP |
OrthoDBi | 919773at2759 |
PhylomeDBi | Q9Y3Y4 |
TreeFami | TF333020 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
IDEALi | IID00255 |
InterProi | View protein in InterPro IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPAENSPAPA YKVSSHGGDS GLDGLGGPGV QLGSPDKKKR KANTQGPSFP
60 70 80 90 100
PLSEYAPPPN PNSDHLVAAN PFDDNYNTIS YKPLPSSNPY LGPGYPGFGG
110 120 130 140 150
YSTFRMPPHV PPRMSSPYCG PYSLRNQPHP FPQNPLGMGF NRPHAFNFGP
160 170 180 190 200
HDNSSFGNPS YNNALSQNVN MPNQHFRQNP AENFSQIPPQ NASQVSNPDL
210 220 230 240 250
ASNFVPGNNS NFTSPLESNH SFIPPPNTFG QAKAPPPKQD FTQGATKNTN
260 270 280 290 300
QNSSAHPPHL NMDDTVNQSN IELKNVNRNN AVNQENSRSS STEATNNNPA
310 320 330 340 350
NGTQNKPRQP RGAADACTTE KSNKSSLHPN RHGHSSSDPV YPCGICTNEV
360 370 380 390 400
NDDQDAILCE ASCQKWFHRI CTGMTETAYG LLTAEASAVW GCDTCMADKD
410
VQLMRTRETF GPSAVGSDA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051292 | 299 | P → H. Corresponds to variant dbSNP:rs11858624Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056648 | 1 – 16 | MPAEN…KVSSH → MSAEQEKDPISLKRVR in isoform 2. 1 PublicationAdd BLAST | 16 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF457207 mRNA Translation: AAL91370.1 EF625686 mRNA Translation: ABU93489.1 AC012378 Genomic DNA No translation available. AC022083 Genomic DNA No translation available. AL049925 mRNA Translation: CAB43209.1 |
CCDSi | CCDS10155.1 [Q9Y3Y4-1] CCDS81885.1 [Q9Y3Y4-2] |
PIRi | T08663 |
RefSeqi | NP_001317255.1, NM_001330326.1 [Q9Y3Y4-2] NP_056432.1, NM_015617.2 [Q9Y3Y4-1] XP_011519748.1, XM_011521446.2 |
Genome annotation databases
Ensembli | ENST00000302000; ENSP00000302327; ENSG00000171016 ENST00000563719; ENSP00000457777; ENSG00000171016 [Q9Y3Y4-2] ENST00000645724; ENSP00000496139; ENSG00000171016 [Q9Y3Y4-2] |
GeneIDi | 26108 |
KEGGi | hsa:26108 |
MANE-Selecti | ENST00000563719.4; ENSP00000457777.1; NM_001367806.1; NP_001354735.1 [Q9Y3Y4-2] |
UCSCi | uc002adf.3, human [Q9Y3Y4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF457207 mRNA Translation: AAL91370.1 EF625686 mRNA Translation: ABU93489.1 AC012378 Genomic DNA No translation available. AC022083 Genomic DNA No translation available. AL049925 mRNA Translation: CAB43209.1 |
CCDSi | CCDS10155.1 [Q9Y3Y4-1] CCDS81885.1 [Q9Y3Y4-2] |
PIRi | T08663 |
RefSeqi | NP_001317255.1, NM_001330326.1 [Q9Y3Y4-2] NP_056432.1, NM_015617.2 [Q9Y3Y4-1] XP_011519748.1, XM_011521446.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VP7 | X-ray | 1.65 | A | 333-402 | [»] | |
2VPB | X-ray | 1.59 | A | 333-397 | [»] | |
2VPD | X-ray | 2.77 | A/C | 333-398 | [»] | |
2VPE | X-ray | 1.70 | A/C | 340-398 | [»] | |
2VPG | X-ray | 1.60 | A/C | 340-398 | [»] | |
SMRi | Q9Y3Y4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117557, 21 interactors |
IntActi | Q9Y3Y4, 25 interactors |
MINTi | Q9Y3Y4 |
STRINGi | 9606.ENSP00000302327 |
PTM databases
iPTMneti | Q9Y3Y4 |
PhosphoSitePlusi | Q9Y3Y4 |
Genetic variation databases
BioMutai | PYGO1 |
DMDMi | 23396828 |
Proteomic databases
jPOSTi | Q9Y3Y4 |
MassIVEi | Q9Y3Y4 |
PaxDbi | Q9Y3Y4 |
PeptideAtlasi | Q9Y3Y4 |
PRIDEi | Q9Y3Y4 |
ProteomicsDBi | 1817 86087 [Q9Y3Y4-1] |
Protocols and materials databases
Antibodypediai | 25101, 156 antibodies from 23 providers |
DNASUi | 26108 |
Genome annotation databases
Ensembli | ENST00000302000; ENSP00000302327; ENSG00000171016 ENST00000563719; ENSP00000457777; ENSG00000171016 [Q9Y3Y4-2] ENST00000645724; ENSP00000496139; ENSG00000171016 [Q9Y3Y4-2] |
GeneIDi | 26108 |
KEGGi | hsa:26108 |
MANE-Selecti | ENST00000563719.4; ENSP00000457777.1; NM_001367806.1; NP_001354735.1 [Q9Y3Y4-2] |
UCSCi | uc002adf.3, human [Q9Y3Y4-1] |
Organism-specific databases
CTDi | 26108 |
GeneCardsi | PYGO1 |
HGNCi | HGNC:30256, PYGO1 |
HPAi | ENSG00000171016, Low tissue specificity |
MIMi | 606902, gene |
neXtProti | NX_Q9Y3Y4 |
OpenTargetsi | ENSG00000171016 |
PharmGKBi | PA134875127 |
VEuPathDBi | HostDB:ENSG00000171016 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTIZ, Eukaryota |
GeneTreei | ENSGT00530000063948 |
HOGENOMi | CLU_686883_0_0_1 |
InParanoidi | Q9Y3Y4 |
OMAi | YNTFRMP |
OrthoDBi | 919773at2759 |
PhylomeDBi | Q9Y3Y4 |
TreeFami | TF333020 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Y4 |
Reactomei | R-HSA-201722, Formation of the beta-catenin:TCF transactivating complex R-HSA-3769402, Deactivation of the beta-catenin transactivating complex |
SignaLinki | Q9Y3Y4 |
SIGNORi | Q9Y3Y4 |
Miscellaneous databases
BioGRID-ORCSi | 26108, 9 hits in 1043 CRISPR screens |
ChiTaRSi | PYGO1, human |
EvolutionaryTracei | Q9Y3Y4 |
GenomeRNAii | 26108 |
Pharosi | Q9Y3Y4, Tdark |
PROi | PR:Q9Y3Y4 |
RNActi | Q9Y3Y4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171016, Expressed in lung and 145 other tissues |
Genevisiblei | Q9Y3Y4, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
IDEALi | IID00255 |
InterProi | View protein in InterPro IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00628, PHD, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PYGO1_HUMAN | |
Accessioni | Q9Y3Y4Primary (citable) accession number: Q9Y3Y4 Secondary accession number(s): A7Y2D6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 19, 2002 | |
Last modified: | February 23, 2022 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references