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UniProtKB - Q9Y3Y2 (CHTOP_HUMAN)

Entry version 164 (07 Oct 2020)
Sequence version 2 (11 Oct 2004)
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Protein

Chromatin target of PRMT1 protein

Gene

CHTOP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).By similarity3 Publications
Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transcription, Transcription regulation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y3Y2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin target of PRMT1 protein
Alternative name(s):
Friend of PRMT1 protein
Small arginine- and glycine-rich protein
Short name:
SRAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHTOP
Synonyms:C1orf77, FOP
ORF Names:HT031, PP7704
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000160679.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:24511, CHTOP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614206, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3Y2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi195R → A: Loss of 5hmc binding; when associated with A-197; A-199; A-201 and A-203. 1 Publication1
Mutagenesisi197R → A: Loss of 5hmc binding; when associated with A-195; A-199; A-201 and A-203. 1 Publication1
Mutagenesisi199R → A: Loss of 5hmc binding; when associated with A-195; A-197; A-201 and A-203. 1 Publication1
Mutagenesisi201R → A: Loss of 5hmc binding; when associated with A-195; A-197; A-199 and A-203. 1 Publication1
Mutagenesisi203R → A: Loss of 5hmc binding; when associated with A-195; A-197; A-199 and A-201. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		26097

Open Targets

More...OpenTargetsi		ENSG00000160679

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672526

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y3Y2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHTOP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000892632 – 248Chromatin target of PRMT1 proteinAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei33PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei242PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5 (By similarity).By similarity1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y3Y2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y3Y2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y3Y2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3Y2

PeptideAtlas

More...PeptideAtlasi		Q9Y3Y2

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3Y2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86084 [Q9Y3Y2-1]
86085 [Q9Y3Y2-3]
86086 [Q9Y3Y2-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3Y2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y3Y2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3Y2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160679, Expressed in tendon of biceps brachii and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y3Y2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3Y2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160679, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PRMT1 and PRMT5 (PubMed:25284789).

Interacts with the 5FMC complex; the interaction is methylation-dependent.

Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent.

Interacts with ZNF148 (By similarity).

Component of the transcription/export (TREX) complex at least composed of ALYREF/THOC4, DDX39B, SARNP/CIP29, CHTOP and the THO subcomplex; TREX seems to have dynamic structure involving ATP-dependent remodeling; in the complex interacts (methylated) with ALYREF/THOC4 and with DDX39B in a methylation-independent manner.

Interacts (methylated) with NXF1; the interaction is mutually exclusive with the NXF1:THOC5 interaction (PubMed:23299939, PubMed:23826332).

Interacts with WDR77 and ERH (PubMed:25284789).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117547, 101 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y3Y2

Protein interaction database and analysis system

More...IntActi		Q9Y3Y2, 70 interactors

Molecular INTeraction database

More...MINTi		Q9Y3Y2

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357679

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y3Y2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3Y2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni153 – 206Interaction with PRMT1By similarityAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi194 – 203GAR motif; involved in 5hmC binding1 Publication10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 208Arg/Gly-richAdd BLAST122

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV0X, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_087638_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3Y2

Identification of Orthologs from Complete Genome Data

More...OMAi		RFTNMMK

Database of Orthologous Groups

More...OrthoDBi		1598721at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3Y2

TreeFam database of animal gene trees

More...TreeFami		TF331447

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025715, FoP_C

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13865, FoP_duplication, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01218, FoP_duplication, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3Y2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQSAPKVV LKSTTKMSLN ERFTNMLKNK QPTPVNIRAS MQQQQQLASA 
        60         70         80         90        100
RNRRLAQQME NRPSVQAALK LKQSLKQRLG KSNIQARLGR PIGALARGAI 
       110        120        130        140        150
GGRGLPIIQR GLPRGGLRGG RATRTLLRGG MSLRGQNLLR GGRAVAPRMG 
       160        170        180        190        200
LRRGGVRGRG GPGRGGLGRG AMGRGGIGGR GRGMIGRGRG GFGGRGRGRG 
       210        220        230        240 
RGRGALARPV LTKEQLDNQL DAYMSKTKGH LDAELDAYMA QTDPETND
Length:248
Mass (Da):26,397
Last modified:October 11, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3D97D16610FCE0E6
GO
Isoform 2 (identifier: Q9Y3Y2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: Q → QK

Show »
Length:249
Mass (Da):26,525
Checksum:i938006D98E4F28FE
GO
Isoform 3 (identifier: Q9Y3Y2-4) [UniParc]FASTAAdd to basket
Also known as: SRAG-5

The sequence of this isoform differs from the canonical sequence as follows:
     134-179: Missing.

Show »
Length:202
Mass (Da):21,918
Checksum:i20AEC438CB993D76
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R700X6R700_HUMAN
Chromatin target of PRMT1 protein
CHTOP
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T7Y7Q5T7Y7_HUMAN
Chromatin target of PRMT1 protein
CHTOP
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1B7A0A087X1B7_HUMAN
Chromatin target of PRMT1 protein
CHTOP
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02733 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH70027 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAL55869 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti72K → N in AAH59949 (PubMed:15489334).Curated1
Sequence conflicti180R → P in CAB43362 (PubMed:17974005).Curated1
Sequence conflicti238Y → H in CAB43362 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01727773Q → QK in isoform 2. 1 Publication1
Alternative sequenceiVSP_040496134 – 179Missing in isoform 3. CuratedAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF261137 mRNA Translation: AAG44673.1
AF318362 mRNA Translation: AAL55869.1 Frameshift.
AL162258 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53290.1
CH471121 Genomic DNA Translation: EAW53295.1
BC002733 mRNA Translation: AAH02733.1 Different initiation.
BC059949 mRNA Translation: AAH59949.1
BC070027 mRNA Translation: AAH70027.1 Different initiation.
BC108721 mRNA Translation: AAI08722.1
BC120961 mRNA Translation: AAI20962.1
BC120962 mRNA Translation: AAI20963.1
AL050260 mRNA Translation: CAB43362.2
AL512704 mRNA Translation: CAC21650.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1048.1 [Q9Y3Y2-1]
CCDS72917.1 [Q9Y3Y2-3]
CCDS81380.1 [Q9Y3Y2-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T08660

NCBI Reference Sequences

More...RefSeqi		NP_001193541.1, NM_001206612.1 [Q9Y3Y2-3]
NP_001231593.1, NM_001244664.1
NP_001304006.1, NM_001317077.1 [Q9Y3Y2-4]
NP_056422.2, NM_015607.3 [Q9Y3Y2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368690; ENSP00000357679; ENSG00000160679 [Q9Y3Y2-3]
ENST00000368694; ENSP00000357683; ENSG00000160679 [Q9Y3Y2-1]
ENST00000403433; ENSP00000385228; ENSG00000160679 [Q9Y3Y2-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26097

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26097

UCSC genome browser

More...UCSCi		uc001fcm.3, human [Q9Y3Y2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261137 mRNA Translation: AAG44673.1
AF318362 mRNA Translation: AAL55869.1 Frameshift.
AL162258 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53290.1
CH471121 Genomic DNA Translation: EAW53295.1
BC002733 mRNA Translation: AAH02733.1 Different initiation.
BC059949 mRNA Translation: AAH59949.1
BC070027 mRNA Translation: AAH70027.1 Different initiation.
BC108721 mRNA Translation: AAI08722.1
BC120961 mRNA Translation: AAI20962.1
BC120962 mRNA Translation: AAI20963.1
AL050260 mRNA Translation: CAB43362.2
AL512704 mRNA Translation: CAC21650.2
CCDSiCCDS1048.1 [Q9Y3Y2-1]
CCDS72917.1 [Q9Y3Y2-3]
CCDS81380.1 [Q9Y3Y2-4]
PIRiT08660
RefSeqiNP_001193541.1, NM_001206612.1 [Q9Y3Y2-3]
NP_001231593.1, NM_001244664.1
NP_001304006.1, NM_001317077.1 [Q9Y3Y2-4]
NP_056422.2, NM_015607.3 [Q9Y3Y2-1]

3D structure databases

SMRiQ9Y3Y2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117547, 101 interactors
CORUMiQ9Y3Y2
IntActiQ9Y3Y2, 70 interactors
MINTiQ9Y3Y2
STRINGi9606.ENSP00000357679

PTM databases

iPTMnetiQ9Y3Y2
MetOSiteiQ9Y3Y2
PhosphoSitePlusiQ9Y3Y2

Polymorphism and mutation databases

BioMutaiCHTOP

Proteomic databases

EPDiQ9Y3Y2
jPOSTiQ9Y3Y2
MassIVEiQ9Y3Y2
PaxDbiQ9Y3Y2
PeptideAtlasiQ9Y3Y2
PRIDEiQ9Y3Y2
ProteomicsDBi86084 [Q9Y3Y2-1]
86085 [Q9Y3Y2-3]
86086 [Q9Y3Y2-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34133, 137 antibodies

Genome annotation databases

EnsembliENST00000368690; ENSP00000357679; ENSG00000160679 [Q9Y3Y2-3]
ENST00000368694; ENSP00000357683; ENSG00000160679 [Q9Y3Y2-1]
ENST00000403433; ENSP00000385228; ENSG00000160679 [Q9Y3Y2-4]
GeneIDi26097
KEGGihsa:26097
UCSCiuc001fcm.3, human [Q9Y3Y2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26097
DisGeNETi26097
EuPathDBiHostDB:ENSG00000160679.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHTOP
HGNCiHGNC:24511, CHTOP
HPAiENSG00000160679, Low tissue specificity
MIMi614206, gene
neXtProtiNX_Q9Y3Y2
OpenTargetsiENSG00000160679
PharmGKBiPA142672526

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV0X, Eukaryota
GeneTreeiENSGT00390000002869
HOGENOMiCLU_087638_0_0_1
InParanoidiQ9Y3Y2
OMAiRFTNMMK
OrthoDBi1598721at2759
PhylomeDBiQ9Y3Y2
TreeFamiTF331447

Enzyme and pathway databases

PathwayCommonsiQ9Y3Y2
ReactomeiR-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26097, 137 hits in 884 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHTOP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26097
PharosiQ9Y3Y2, Tbio

Protein Ontology

More...PROi		PR:Q9Y3Y2
RNActiQ9Y3Y2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160679, Expressed in tendon of biceps brachii and 244 other tissues
ExpressionAtlasiQ9Y3Y2, baseline and differential
GenevisibleiQ9Y3Y2, HS

Family and domain databases

InterProiView protein in InterPro
IPR025715, FoP_C
PfamiView protein in Pfam
PF13865, FoP_duplication, 1 hit
SMARTiView protein in SMART
SM01218, FoP_duplication, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHTOP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3Y2
Secondary accession number(s): D3DV55
, Q0VAQ8, Q2VPI9, Q5T7Y8, Q5T7Y9, Q5T7Z0, Q6NSM4, Q6PB28, Q8WYT9, Q9BUC5, Q9H034, Q9H2L0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 11, 2004
Last modified: October 7, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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