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Protein

Coiled-coil domain-containing protein 9

Gene

CCDC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 9
Gene namesi
Name:CCDC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105321.12
HGNCiHGNC:24560 CCDC9
neXtProtiNX_Q9Y3X0

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946561

Polymorphism and mutation databases

BioMutaiCCDC9
DMDMi50400700

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894031 – 531Coiled-coil domain-containing protein 9Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei95PhosphothreonineCombined sources1
Modified residuei107Omega-N-methylarginineBy similarity1
Modified residuei111PhosphoserineCombined sources1
Modified residuei121Omega-N-methylarginineBy similarity1
Modified residuei128Omega-N-methylarginineBy similarity1
Modified residuei130Omega-N-methylarginineBy similarity1
Modified residuei131Asymmetric dimethylarginineCombined sources1
Modified residuei133Asymmetric dimethylarginineCombined sources1
Modified residuei135Asymmetric dimethylarginineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei202PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei376PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei521PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y3X0
MaxQBiQ9Y3X0
PaxDbiQ9Y3X0
PeptideAtlasiQ9Y3X0
PRIDEiQ9Y3X0
ProteomicsDBi86083

PTM databases

iPTMnetiQ9Y3X0
PhosphoSitePlusiQ9Y3X0

Miscellaneous databases

PMAP-CutDBiQ9Y3X0

Expressioni

Gene expression databases

BgeeiENSG00000105321 Expressed in 173 organ(s), highest expression level in testis
CleanExiHS_CCDC9
ExpressionAtlasiQ9Y3X0 baseline and differential
GenevisibleiQ9Y3X0 HS

Organism-specific databases

HPAiHPA045624
HPA072007

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-2557532,EBI-717399

Protein-protein interaction databases

BioGridi117544, 46 interactors
IntActiQ9Y3X0, 15 interactors
MINTiQ9Y3X0
STRINGi9606.ENSP00000221922

Structurei

3D structure databases

ProteinModelPortaliQ9Y3X0
SMRiQ9Y3X0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 185Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 144Gly-richAdd BLAST57
Compositional biasi344 – 347Poly-Arg4
Compositional biasi377 – 409Pro-richAdd BLAST33
Compositional biasi410 – 445Glu-richAdd BLAST36
Compositional biasi429 – 440Poly-GluAdd BLAST12

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG0Q Eukaryota
ENOG4111HS1 LUCA
GeneTreeiENSGT00530000063950
HOGENOMiHOG000273887
HOVERGENiHBG050826
InParanoidiQ9Y3X0
OMAiQDHQAPE
OrthoDBiEOG091G12UA
PhylomeDBiQ9Y3X0
TreeFamiTF336272

Family and domain databases

InterProiView protein in InterPro
IPR029336 DUF4594
PANTHERiPTHR15635 PTHR15635, 1 hit
PfamiView protein in Pfam
PF15266 DUF4594, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y3X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATLDLKSK EEKDAELDKR IEALRRKNEA LIRRYQEIEE DRKKAELEGV
60 70 80 90 100
AVTAPRKGRS VEKENVAVES EKNLGPSRRS PGTPRPPGAS KGGRTPPQQG
110 120 130 140 150
GRAGMGRASR SWEGSPGEQP RGGGAGGRGR RGRGRGSPHL SGAGDTSISD
160 170 180 190 200
RKSKEWEERR RQNIEKMNEE MEKIAEYERN QREGVLEPNP VRNFLDDPRR
210 220 230 240 250
RSGPLEESER DRREESRRHG RNWGGPDFER VRCGLEHERQ GRRAGLGSAG
260 270 280 290 300
DMTLSMTGRE RSEYLRWKQE REKIDQERLQ RHRKPTGQWR REWDAEKTDG
310 320 330 340 350
MFKDGPVPAH EPSHRYDDQA WARPPKPPTF GEFLSQHKAE ASSRRRRKSS
360 370 380 390 400
RPQAKAAPRA YSDHDDRWET KEGAASPAPE TPQPTSPETS PKETPMQPPE
410 420 430 440 450
IPAPAHRPPE DEGEENEGEE DEEWEDISED EEEEEIEVEE GDEEEPAQDH
460 470 480 490 500
QAPEAAPTGI PCSEQAHGVP FSPEEPLLEP QAPGTPSSPF SPPSGHQPVS
510 520 530
DWGEEVELNS PRTTHLAGAL SPGEAWPFES V
Length:531
Mass (Da):59,703
Last modified:November 1, 1999 - v1
Checksum:iDE6C474F3253C30C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QYB4M0QYB4_HUMAN
Coiled-coil domain-containing prote...
CCDC9
128Annotation score:
M0QZR0M0QZR0_HUMAN
Coiled-coil domain-containing prote...
CCDC9
56Annotation score:
M0R2W0M0R2W0_HUMAN
Coiled-coil domain-containing prote...
CCDC9
48Annotation score:
A0A2R8Y4Z8A0A2R8Y4Z8_HUMAN
Coiled-coil domain-containing prote...
CCDC9
587Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033670215E → D. Corresponds to variant dbSNP:rs2032811Ensembl.1
Natural variantiVAR_033671456A → V. Corresponds to variant dbSNP:rs35119724Ensembl.1
Natural variantiVAR_050767478L → P. Corresponds to variant dbSNP:rs888836Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050284 mRNA Translation: CAB43385.1
BC002787 mRNA Translation: AAH02787.1
BC009743 mRNA Translation: AAH09743.1
CCDSiCCDS12698.1
PIRiT08760
RefSeqiNP_056418.1, NM_015603.2
XP_016882067.1, XM_017026578.1
UniGeneiHs.227782

Genome annotation databases

EnsembliENST00000221922; ENSP00000221922; ENSG00000105321
GeneIDi26093
KEGGihsa:26093
UCSCiuc010xym.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050284 mRNA Translation: CAB43385.1
BC002787 mRNA Translation: AAH02787.1
BC009743 mRNA Translation: AAH09743.1
CCDSiCCDS12698.1
PIRiT08760
RefSeqiNP_056418.1, NM_015603.2
XP_016882067.1, XM_017026578.1
UniGeneiHs.227782

3D structure databases

ProteinModelPortaliQ9Y3X0
SMRiQ9Y3X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117544, 46 interactors
IntActiQ9Y3X0, 15 interactors
MINTiQ9Y3X0
STRINGi9606.ENSP00000221922

PTM databases

iPTMnetiQ9Y3X0
PhosphoSitePlusiQ9Y3X0

Polymorphism and mutation databases

BioMutaiCCDC9
DMDMi50400700

Proteomic databases

EPDiQ9Y3X0
MaxQBiQ9Y3X0
PaxDbiQ9Y3X0
PeptideAtlasiQ9Y3X0
PRIDEiQ9Y3X0
ProteomicsDBi86083

Protocols and materials databases

DNASUi26093
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221922; ENSP00000221922; ENSG00000105321
GeneIDi26093
KEGGihsa:26093
UCSCiuc010xym.3 human

Organism-specific databases

CTDi26093
EuPathDBiHostDB:ENSG00000105321.12
GeneCardsiCCDC9
HGNCiHGNC:24560 CCDC9
HPAiHPA045624
HPA072007
neXtProtiNX_Q9Y3X0
PharmGKBiPA134946561
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG0Q Eukaryota
ENOG4111HS1 LUCA
GeneTreeiENSGT00530000063950
HOGENOMiHOG000273887
HOVERGENiHBG050826
InParanoidiQ9Y3X0
OMAiQDHQAPE
OrthoDBiEOG091G12UA
PhylomeDBiQ9Y3X0
TreeFamiTF336272

Miscellaneous databases

GenomeRNAii26093
PMAP-CutDBiQ9Y3X0
PROiPR:Q9Y3X0

Gene expression databases

BgeeiENSG00000105321 Expressed in 173 organ(s), highest expression level in testis
CleanExiHS_CCDC9
ExpressionAtlasiQ9Y3X0 baseline and differential
GenevisibleiQ9Y3X0 HS

Family and domain databases

InterProiView protein in InterPro
IPR029336 DUF4594
PANTHERiPTHR15635 PTHR15635, 1 hit
PfamiView protein in Pfam
PF15266 DUF4594, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCDC9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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