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Protein

60S ribosomal protein L36

Gene

RPL36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36
Alternative name(s):
Large ribosomal subunit protein eL361 Publication
Gene namesi
Name:RPL36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130255.12
HGNCiHGNC:13631 RPL36
MIMi617893 gene
neXtProtiNX_Q9Y3U8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130255
PharmGKBiPA34730

Polymorphism and mutation databases

BioMutaiRPL36
DMDMi7388073

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001950072 – 10560S ribosomal protein L36Add BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3U8
MaxQBiQ9Y3U8
PaxDbiQ9Y3U8
PeptideAtlasiQ9Y3U8
PRIDEiQ9Y3U8
ProteomicsDBi86079
TopDownProteomicsiQ9Y3U8

PTM databases

iPTMnetiQ9Y3U8
PhosphoSitePlusiQ9Y3U8
SwissPalmiQ9Y3U8

Expressioni

Gene expression databases

BgeeiENSG00000130255
CleanExiHS_RPL36
ExpressionAtlasiQ9Y3U8 baseline and differential
GenevisibleiQ9Y3U8 HS

Organism-specific databases

HPAiHPA047153

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication3 Publications

Protein-protein interaction databases

BioGridi117388, 138 interactors
CORUMiQ9Y3U8
IntActiQ9Y3U8, 31 interactors
MINTiQ9Y3U8
STRINGi9606.ENSP00000252543

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Li1-105[»]
4V6Xelectron microscopy5.00Ci1-105[»]
5AJ0electron microscopy3.50Ai1-105[»]
5LKSelectron microscopy3.60Li1-105[»]
5T2Celectron microscopy3.60c1-105[»]
6EK0electron microscopy2.90Li1-105[»]
ProteinModelPortaliQ9Y3U8
SMRiQ9Y3U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3452 Eukaryota
COG5051 LUCA
GeneTreeiENSGT00390000011943
HOGENOMiHOG000155312
HOVERGENiHBG002152
InParanoidiQ9Y3U8
KOiK02920
OMAiGTHRRAK
OrthoDBiEOG091G0YP6
PhylomeDBiQ9Y3U8
TreeFamiTF314463

Family and domain databases

Gene3Di1.10.10.1760, 1 hit
InterProiView protein in InterPro
IPR038097 L36e_sf
IPR000509 Ribosomal_L36e
PANTHERiPTHR10114 PTHR10114, 1 hit
PfamiView protein in Pfam
PF01158 Ribosomal_L36e, 1 hit
PROSITEiView protein in PROSITE
PS01190 RIBOSOMAL_L36E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y3U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRYPMAVG LNKGHKVTKN VSKPRHSRRR GRLTKHTKFV RDMIREVCGF
60 70 80 90 100
APYERRAMEL LKVSKDKRAL KFIKKRVGTH IRAKRKREEL SNVLAAMRKA

AAKKD
Length:105
Mass (Da):12,254
Last modified:January 23, 2007 - v3
Checksum:iFEE8850A62080EB3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29R → H in AAD27776 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05180467K → E. Corresponds to variant dbSNP:rs11556110Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061833 Genomic DNA Translation: BAB79471.1
AL050273 mRNA Translation: CAB43374.1
AF077043 mRNA Translation: AAD27776.1
CR533465 mRNA Translation: CAG38496.1
AK311990 mRNA Translation: BAG34928.1
CH471139 Genomic DNA Translation: EAW69155.1
CH471139 Genomic DNA Translation: EAW69158.1
BC003052 mRNA Translation: AAH03052.1
BC004971 mRNA Translation: AAH04971.1
BC091508 mRNA Translation: AAH91508.1
CCDSiCCDS12147.1
PIRiT08720
RefSeqiNP_056229.2, NM_015414.3
NP_378669.1, NM_033643.2
UniGeneiHs.408018

Genome annotation databases

EnsembliENST00000347512; ENSP00000252543; ENSG00000130255
ENST00000394580; ENSP00000378081; ENSG00000130255
ENST00000577222; ENSP00000464342; ENSG00000130255
ENST00000579649; ENSP00000462609; ENSG00000130255
GeneIDi25873
KEGGihsa:25873
UCSCiuc002mcv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL36_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3U8
Secondary accession number(s): B2R4Y1
, D6W634, Q6FIG1, Q9UQF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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