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Protein

Zinc finger protein 330

Gene

ZNF330

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

GO - Molecular functioni

  • metal ion binding Source: UniProtKB
  • zinc ion binding Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 330
Alternative name(s):
Nucleolar autoantigen 36
Nucleolar cysteine-rich protein
Gene namesi
Name:ZNF330
Synonyms:NOA36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109445.10
HGNCiHGNC:15462 ZNF330
MIMi609550 gene
neXtProtiNX_Q9Y3S2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109445
PharmGKBiPA134925405

Polymorphism and mutation databases

BioMutaiZNF330
DMDMi51702204

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000665901 – 320Zinc finger protein 330Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3S2
MaxQBiQ9Y3S2
PaxDbiQ9Y3S2
PeptideAtlasiQ9Y3S2
PRIDEiQ9Y3S2
ProteomicsDBi86075

PTM databases

iPTMnetiQ9Y3S2
PhosphoSitePlusiQ9Y3S2
SwissPalmiQ9Y3S2

Expressioni

Tissue specificityi

Widely expressed. Higher expression seen in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000109445 Expressed in 237 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF330
ExpressionAtlasiQ9Y3S2 baseline and differential
GenevisibleiQ9Y3S2 HS

Organism-specific databases

HPAiHPA015705
HPA056325

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi118131, 4 interactors
IntActiQ9Y3S2, 47 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9Y3S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi3 – 11Nuclear localization signalSequence analysis9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 286Asp/Glu-rich (acidic)Add BLAST18

Sequence similaritiesi

Belongs to the NOA36 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri42 – 58C4-type 1Sequence analysisAdd BLAST17
Zinc fingeri67 – 104C4-type 2Sequence analysisAdd BLAST38
Zinc fingeri129 – 149C4-type 3Sequence analysisAdd BLAST21
Zinc fingeri175 – 189C4-type 4Sequence analysisAdd BLAST15

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEDV Eukaryota
ENOG410XNTY LUCA
GeneTreeiENSGT00390000017043
HOGENOMiHOG000030400
HOVERGENiHBG057282
InParanoidiQ9Y3S2
OMAiTHACTCP
OrthoDBiEOG091G0DRZ
PhylomeDBiQ9Y3S2
TreeFamiTF323303

Family and domain databases

InterProiView protein in InterPro
IPR010531 NOA36
PANTHERiPTHR13214 PTHR13214, 1 hit
PfamiView protein in Pfam
PF06524 NOA36, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q9Y3S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKKKTGARK KAENRREREK QLRASRSTID LAKHPCNASM ECDKCQRRQK
60 70 80 90 100
NRAFCYFCNS VQKLPICAQC GKTKCMMKSS DCVIKHAGVY STGLAMVGAI
110 120 130 140 150
CDFCEAWVCH GRKCLSTHAC ACPLTDAECV ECERGVWDHG GRIFSCSFCH
160 170 180 190 200
NFLCEDDQFE HQASCQVLEA ETFKCVSCNR LGQHSCLRCK ACFCDDHTRS
210 220 230 240 250
KVFKQEKGKQ PPCPKCGHET QETKDLSMST RSLKFGRQTG GEEGDGASGY
260 270 280 290 300
DAYWKNLSSD KYGDTSYHDE EEDEYEAEDD EEEEDEGRKD SDTESSDLFT
310 320
NLNLGRTYAS GYAHYEEQEN
Length:320
Mass (Da):36,201
Last modified:November 1, 1999 - v1
Checksum:iCC7F03EE70BF8FD1
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBR7D6RBR7_HUMAN
Zinc finger protein 330
ZNF330
229Annotation score:
D6R8Y9D6R8Y9_HUMAN
Zinc finger protein 330
ZNF330
153Annotation score:
D6R9C8D6R9C8_HUMAN
Zinc finger protein 330
ZNF330
139Annotation score:
D6RCK7D6RCK7_HUMAN
Zinc finger protein 330
ZNF330
77Annotation score:
D6R9Q8D6R9Q8_HUMAN
Zinc finger protein 330
ZNF330
41Annotation score:
D6RBS7D6RBS7_HUMAN
Zinc finger protein 330
ZNF330
35Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05150028T → A. Corresponds to variant dbSNP:rs35353789Ensembl.1
Natural variantiVAR_051501298L → M. Corresponds to variant dbSNP:rs34631212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA Translation: CAB43112.1
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA Translation: CAC18679.1
AK315463 mRNA Translation: BAG37850.1
CH471056 Genomic DNA Translation: EAX05089.1
BC004421 mRNA Translation: AAH04421.1
CCDSiCCDS3754.1
RefSeqiNP_001278931.1, NM_001292002.1
NP_055302.1, NM_014487.5
XP_016863522.1, XM_017008033.1
UniGeneiHs.120766

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445
GeneIDi27309
KEGGihsa:27309
UCSCiuc003iiq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006591 mRNA Translation: CAB43112.1
AJ404873
, AJ404874, AJ404875, AJ404876, AJ404877, AJ404878, AJ404879, AJ404880 Genomic DNA Translation: CAC18679.1
AK315463 mRNA Translation: BAG37850.1
CH471056 Genomic DNA Translation: EAX05089.1
BC004421 mRNA Translation: AAH04421.1
CCDSiCCDS3754.1
RefSeqiNP_001278931.1, NM_001292002.1
NP_055302.1, NM_014487.5
XP_016863522.1, XM_017008033.1
UniGeneiHs.120766

3D structure databases

ProteinModelPortaliQ9Y3S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118131, 4 interactors
IntActiQ9Y3S2, 47 interactors

PTM databases

iPTMnetiQ9Y3S2
PhosphoSitePlusiQ9Y3S2
SwissPalmiQ9Y3S2

Polymorphism and mutation databases

BioMutaiZNF330
DMDMi51702204

Proteomic databases

EPDiQ9Y3S2
MaxQBiQ9Y3S2
PaxDbiQ9Y3S2
PeptideAtlasiQ9Y3S2
PRIDEiQ9Y3S2
ProteomicsDBi86075

Protocols and materials databases

DNASUi27309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262990; ENSP00000262990; ENSG00000109445
GeneIDi27309
KEGGihsa:27309
UCSCiuc003iiq.5 human

Organism-specific databases

CTDi27309
EuPathDBiHostDB:ENSG00000109445.10
GeneCardsiZNF330
HGNCiHGNC:15462 ZNF330
HPAiHPA015705
HPA056325
MIMi609550 gene
neXtProtiNX_Q9Y3S2
OpenTargetsiENSG00000109445
PharmGKBiPA134925405
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEDV Eukaryota
ENOG410XNTY LUCA
GeneTreeiENSGT00390000017043
HOGENOMiHOG000030400
HOVERGENiHBG057282
InParanoidiQ9Y3S2
OMAiTHACTCP
OrthoDBiEOG091G0DRZ
PhylomeDBiQ9Y3S2
TreeFamiTF323303

Miscellaneous databases

ChiTaRSiZNF330 human
GeneWikiiZNF330
GenomeRNAii27309
PROiPR:Q9Y3S2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109445 Expressed in 237 organ(s), highest expression level in amniotic fluid
CleanExiHS_ZNF330
ExpressionAtlasiQ9Y3S2 baseline and differential
GenevisibleiQ9Y3S2 HS

Family and domain databases

InterProiView protein in InterPro
IPR010531 NOA36
PANTHERiPTHR13214 PTHR13214, 1 hit
PfamiView protein in Pfam
PF06524 NOA36, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZN330_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3S2
Secondary accession number(s): B2RDA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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