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Protein

Serine/threonine-protein kinase WNK2

Gene

WNK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.3 Publications

Caution

Was named WNK/'with no lysine(K)' because key residues for catalysis, including the lysine involved in ATP binding, are either not conserved or differ compared to the residues described in other kinase family proteins.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activation requires autophosphorylation of Ser-356. Phosphorylation of Ser-352 also promotes increased activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei205ATP; via amide nitrogenBy similarity1
Binding sitei325ATPBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei342Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi275 – 278ATPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y3S1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase WNK2Curated (EC:2.7.11.1By similarity)
Alternative name(s):
Antigen NY-CO-43
Protein kinase lysine-deficient 2Imported
Protein kinase with no lysine 21 Publication
Serologically defined colon cancer antigen 43
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNK2Imported
Synonyms:KIAA1760Imported, PRKWNK2Imported, SDCCAG43Imported
ORF Names:P/OKcl.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165238.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14542 WNK2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606249 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y3S1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
65268

Open Targets

More...
OpenTargetsi
ENSG00000165238

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33783

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5639

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2281

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WNK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41688799

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000868221 – 2297Serine/threonine-protein kinase WNK2Add BLAST2297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Omega-N-methylarginineBy similarity1
Modified residuei30Omega-N-methylarginineBy similarity1
Modified residuei45Phosphoserine1 Publication1
Modified residuei352Phosphoserine; by autocatalysisBy similarity1
Modified residuei356Phosphoserine; by autocatalysisBy similarity1
Modified residuei560Phosphoserine1 Publication1
Modified residuei1150Phosphoserine1 Publication1
Modified residuei1262Phosphoserine1 Publication1
Modified residuei1588Phosphoserine1 Publication1
Modified residuei1685Phosphoserine1 Publication1
Modified residuei1736Phosphoserine1 Publication1
Modified residuei1817PhosphoserineCombined sources1 Publication1
Modified residuei1818PhosphoserineCombined sources1 Publication1
Modified residuei1862Phosphoserine1 Publication1
Modified residuei1889PhosphoserineBy similarity1
Modified residuei2067Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.2 Publications

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y3S1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y3S1

PeptideAtlas

More...
PeptideAtlasi
Q9Y3S1

PRoteomics IDEntifications database

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PRIDEi
Q9Y3S1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86071
86072 [Q9Y3S1-2]
86073 [Q9Y3S1-3]
86074 [Q9Y3S1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y3S1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y3S1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000165238 Expressed in 181 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

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CleanExi
HS_WNK2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y3S1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y3S1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017813
HPA015555
HPA016519

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with the phosphorylated form of STK39.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122423, 12 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9Y3S1

Protein interaction database and analysis system

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IntActi
Q9Y3S1, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000297954

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y3S1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y3S1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y3S1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini195 – 453Protein kinasePROSITE-ProRule annotationAdd BLAST259

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0584 Eukaryota
ENOG410XQWZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000139922

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050345

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y3S1

KEGG Orthology (KO)

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KOi
K08867

Identification of Orthologs from Complete Genome Data

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OMAi
YDFWESC

Database of Orthologous Groups

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OrthoDBi
EOG091G06LL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y3S1

TreeFam database of animal gene trees

More...
TreeFami
TF315363

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9Y3S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGDGGRRDV PGTLMEPGRG AGPAGMAEPR AKAARPGPQR FLRRSVVESD
60 70 80 90 100
QEEPPGLEAA EAPGPQPPQP LQRRVLLLCK TRRLIAERAR GRPAAPAPAA
110 120 130 140 150
LVAQPGAPGA PADAGPEPVG TQEPGPDPIA AAVETAPAPD GGPREEAAAT
160 170 180 190 200
VRKEDEGAAE AKPEPGRTRR DEPEEEEDDE DDLKAVATSL DGRFLKFDIE
210 220 230 240 250
LGRGSFKTVY KGLDTETWVE VAWCELQDRK LTKLERQRFK EEAEMLKGLQ
260 270 280 290 300
HPNIVRFYDF WESSAKGKRC IVLVTELMTS GTLKTYLKRF KVMKPKVLRS
310 320 330 340 350
WCRQILKGLL FLHTRTPPII HRDLKCDNIF ITGPTGSVKI GDLGLATLKR
360 370 380 390 400
ASFAKSVIGT PEFMAPEMYE EHYDESVDVY AFGMCMLEMA TSEYPYSECQ
410 420 430 440 450
NAAQIYRKVT CGIKPASFEK VHDPEIKEII GECICKNKEE RYEIKDLLSH
460 470 480 490 500
AFFAEDTGVR VELAEEDHGR KSTIALRLWV EDPKKLKGKP KDNGAIEFTF
510 520 530 540 550
DLEKETPDEV AQEMIESGFF HESDVKIVAK SIRDRVALIQ WRRERIWPAL
560 570 580 590 600
QPKEQQDVGS PDKARGPPVP LQVQVTYHAQ AGQPGPPEPE EPEADQHLLP
610 620 630 640 650
PTLPTSATSL ASDSTFDSGQ GSTVYSDSQS SQQSVMLGSL ADAAPSPAQC
660 670 680 690 700
VCSPPVSEGP VLPQSLPSLG AYQQPTAAPG LPVGSVPAPA CPPSLQQHFP
710 720 730 740 750
DPAMSFAPVL PPPSTPMPTG PGQPAPPGQQ PPPLAQPTPL PQVLAPQPVV
760 770 780 790 800
PLQPVPPHLP PYLAPASQVG APAQLKPLQM PQAPLQPLAQ VPPQMPPIPV
810 820 830 840 850
VPPITPLAGI DGLPPALPDL PTATVPPVPP PQYFSPAVIL PSLAAPLPPA
860 870 880 890 900
SPALPLQAVK LPHPPGAPLA MPCRTIVPNA PATIPLLAVA PPGVAALSIH
910 920 930 940 950
SAVAQLPGQP VYPAAFPQMA PTDVPPSPHH TVQNMRATPP QPALPPQPTL
960 970 980 990 1000
PPQPVLPPQP TLPPQPVLPP QPTRPPQPVL PPQPMLPPQP VLPPQPALPV
1010 1020 1030 1040 1050
RPEPLQPHLP EQAAPAATPG SQILLGHPAP YAVDVAAQVP TVPVPPAAVL
1060 1070 1080 1090 1100
SPPLPEVLLP AAPELLPQFP SSLATVSASV QSVPTQTATL LPPANPPLPG
1110 1120 1130 1140 1150
GPGIASPCPT VQLTVEPVQE EQASQDKPPG LPQSCESYGG SDVTSGKELS
1160 1170 1180 1190 1200
DSCEGAFGGG RLEGRAARKH HRRSTRARSR QERASRPRLT ILNVCNTGDK
1210 1220 1230 1240 1250
MVECQLETHN HKMVTFKFDL DGDAPDEIAT YMVEHDFILQ AERETFIEQM
1260 1270 1280 1290 1300
KDVMDKAEDM LSEDTDADRG SDPGTSPPHL STCGLGTGEE SRQSQANAPV
1310 1320 1330 1340 1350
YQQNVLHTGK RWFIICPVAE HPAPEAPESS PPLPLSSLPP EASQGPCRGL
1360 1370 1380 1390 1400
TLPCLPWRRA ACGAVFLSLF SAESAQSKQP PDSAPYKDQL SSKEQPSFLA
1410 1420 1430 1440 1450
SQQLLSQAGP SNPPGAPPAP LAPSSPPVTA LPQDGAAPAT STMPEPASGT
1460 1470 1480 1490 1500
ASQAGGPGTP QGLTSELETS QPLAETHEAP LAVQPLVVGL APCTPAPEAA
1510 1520 1530 1540 1550
STRDASAPRE PLPPPAPEPS PHSGTPQPAL GQPAPLLPAA VGAVSLATSQ
1560 1570 1580 1590 1600
LPSPPLGPTV PPQPPSALES DGEGPPPRVG FVDSTIKSLD EKLRTLLYQE
1610 1620 1630 1640 1650
HVPTSSASAG TPVEVGDRDF TLEPLRGDQP RSEVCGGDLA LPPVPKEAVS
1660 1670 1680 1690 1700
GRVQLPQPLV EKSELAPTRG AVMEQGTSSS MTAESSPRSM LGYDRDGRQV
1710 1720 1730 1740 1750
ASDSHVVPSV PQDVPAFVRP ARVEPTDRDG GEAGESSAEP PPSDMGTVGG
1760 1770 1780 1790 1800
QASHPQTLGA RALGSPRKRP EQQDVSSPAK TVGRFSVVST QDEWTLASPH
1810 1820 1830 1840 1850
SLRYSAPPDV YLDEAPSSPD VKLAVRRAQT ASSIEVGVGE PVSSDSGDEG
1860 1870 1880 1890 1900
PRARPPVQKQ ASLPVSGSVA GDFVKKATAF LQRPSRAGSL GPETPSRVGM
1910 1920 1930 1940 1950
KVPTISVTSF HSQSSYISSD NDSELEDADI KKELQSLREK HLKEISELQS
1960 1970 1980 1990 2000
QQKQEIEALY RRLGKPLPPN VGFFHTAPPT GRRRKTSKSK LKAGKLLNPL
2010 2020 2030 2040 2050
VRQLKVVASS TGHLADSSRG PPAKDPAQAS VGLTADSTGL SGKAVQTQQP
2060 2070 2080 2090 2100
CSVRASLSSD ICSGLASDGG GARGQGWTVY HPTSERVTYK SSSKPRARFL
2110 2120 2130 2140 2150
SGPVSVSIWS ALKRLCLGKE HSSRSSTSSL APGPEPGPQP ALHVQAQVNN
2160 2170 2180 2190 2200
SNNKKGTFTD DLHKLVDEWT SKTVGAAQLK PTLNQLKQTQ KLQDMEAQAG
2210 2220 2230 2240 2250
WAAPGEARAM TAPRAGVGMP RLPPAPGPLS TTVIPGAAPT LSVPTPDGAL
2260 2270 2280 2290
GTARRNQVWF GLRVPPTACC GHSTQPRGGQ RVGSKTASFA ASDPVRS
Length:2,297
Mass (Da):242,676
Last modified:February 2, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33D2EF2BFA6A1BD2
GO
Isoform 21 Publication (identifier: Q9Y3S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1345-1381: Missing.
     2247-2261: DGALGTARRNQVWFG → GSCGPRAVSTPTSYT
     2262-2297: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:2,224
Mass (Da):234,948
Checksum:iBB5BC60D70A6E6D7
GO
Isoform 31 Publication (identifier: Q9Y3S1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.
     680-731: Missing.
     843-845: LAA → RTR
     846-2297: Missing.

Note: Incomplete sequence.1 Publication
Show »
Length:779
Mass (Da):84,868
Checksum:iCC1BEDD3568635CD
GO
Isoform 41 Publication (identifier: Q9Y3S1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2248-2254: GALGTAR → PESEKPD
     2255-2297: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:2,254
Mass (Da):238,279
Checksum:i8C4E5F1DB7EAD99A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W9F9F8W9F9_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
2,217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7T5H0Y7T5_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
2,220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7R3H0Y7R3_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
1,773Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y493H0Y493_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
1,014Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCD1E9PCD1_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
363Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7J9H0Y7J9_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVV2A6PVV2_HUMAN
Serine/threonine-protein kinase WNK...
WNK2
790Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37965 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057114828V → M. Corresponds to variant dbSNP:rs10761203Ensembl.1
Natural variantiVAR_059773974R → L. Corresponds to variant dbSNP:rs10114908Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0506391 – 14Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_050640680 – 731Missing in isoform 3. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_050641843 – 845LAA → RTR in isoform 3. 1 Publication3
Alternative sequenceiVSP_050642846 – 2297Missing in isoform 3. 1 PublicationAdd BLAST1452
Alternative sequenceiVSP_0506431345 – 1381Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_0506442247 – 2261DGALG…QVWFG → GSCGPRAVSTPTSYT in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0506452248 – 2254GALGTAR → PESEKPD in isoform 4. 1 Publication7
Alternative sequenceiVSP_0506462255 – 2297Missing in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_0506472262 – 2297Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ242724 mRNA Translation: CAB44308.5
AL354991 Genomic DNA No translation available.
AL390760 Genomic DNA No translation available.
AL583839 Genomic DNA No translation available.
AB044546 mRNA Translation: BAB18648.1
AB051547 mRNA Translation: BAB21851.2
BC037965 mRNA Translation: AAH37965.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS75858.1 [Q9Y3S1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269323.1, NM_001282394.1 [Q9Y3S1-1]
XP_005252197.1, XM_005252140.2 [Q9Y3S1-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654856

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000297954; ENSP00000297954; ENSG00000165238 [Q9Y3S1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
65268

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:65268

UCSC genome browser

More...
UCSCi
uc004ati.3 human [Q9Y3S1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242724 mRNA Translation: CAB44308.5
AL354991 Genomic DNA No translation available.
AL390760 Genomic DNA No translation available.
AL583839 Genomic DNA No translation available.
AB044546 mRNA Translation: BAB18648.1
AB051547 mRNA Translation: BAB21851.2
BC037965 mRNA Translation: AAH37965.1 Different initiation.
CCDSiCCDS75858.1 [Q9Y3S1-1]
RefSeqiNP_001269323.1, NM_001282394.1 [Q9Y3S1-1]
XP_005252197.1, XM_005252140.2 [Q9Y3S1-2]
UniGeneiHs.654856

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6ELMX-ray1.14A454-549[»]
6FBKX-ray1.74A454-549[»]
ProteinModelPortaliQ9Y3S1
SMRiQ9Y3S1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122423, 12 interactors
ELMiQ9Y3S1
IntActiQ9Y3S1, 9 interactors
STRINGi9606.ENSP00000297954

Chemistry databases

BindingDBiQ9Y3S1
ChEMBLiCHEMBL5639
GuidetoPHARMACOLOGYi2281

PTM databases

iPTMnetiQ9Y3S1
PhosphoSitePlusiQ9Y3S1

Polymorphism and mutation databases

BioMutaiWNK2
DMDMi41688799

Proteomic databases

EPDiQ9Y3S1
PaxDbiQ9Y3S1
PeptideAtlasiQ9Y3S1
PRIDEiQ9Y3S1
ProteomicsDBi86071
86072 [Q9Y3S1-2]
86073 [Q9Y3S1-3]
86074 [Q9Y3S1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297954; ENSP00000297954; ENSG00000165238 [Q9Y3S1-1]
GeneIDi65268
KEGGihsa:65268
UCSCiuc004ati.3 human [Q9Y3S1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65268
DisGeNETi65268
EuPathDBiHostDB:ENSG00000165238.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WNK2
HGNCiHGNC:14542 WNK2
HPAiCAB017813
HPA015555
HPA016519
MIMi606249 gene
neXtProtiNX_Q9Y3S1
OpenTargetsiENSG00000165238
PharmGKBiPA33783

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0584 Eukaryota
ENOG410XQWZ LUCA
GeneTreeiENSGT00940000157161
HOGENOMiHOG000139922
HOVERGENiHBG050345
InParanoidiQ9Y3S1
KOiK08867
OMAiYDFWESC
OrthoDBiEOG091G06LL
PhylomeDBiQ9Y3S1
TreeFamiTF315363

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
SignaLinkiQ9Y3S1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WNK2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
WNK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
65268

Protein Ontology

More...
PROi
PR:Q9Y3S1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165238 Expressed in 181 organ(s), highest expression level in apex of heart
CleanExiHS_WNK2
ExpressionAtlasiQ9Y3S1 baseline and differential
GenevisibleiQ9Y3S1 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWNK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3S1
Secondary accession number(s): Q5VWF1
, Q5VWF2, Q8IY36, Q9C0A3, Q9H3P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 2, 2004
Last modified: December 5, 2018
This is version 167 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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