Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sialidase-2

Gene

NEU2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.2 Publications

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21Substrate1
Binding sitei41Substrate1
Active sitei46Proton acceptor1
Binding sitei179Substrate1
Binding sitei181Substrate1
Binding sitei218Substrate1
Binding sitei237Substrate1
Binding sitei304Substrate1
Active sitei334Nucleophile1
Active sitei355Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.2.1.18 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-4085001 Sialic acid metabolism
SABIO-RKiQ9Y3R4

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

Chemistry databases

SwissLipidsiSLP:000001360

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase-2 (EC:3.2.1.18)
Alternative name(s):
Cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
Gene namesi
Name:NEU2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115488.3
HGNCiHGNC:7759 NEU2
MIMi605528 gene
neXtProtiNX_Q9Y3R4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi46D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi218E → A or Q: Loss of enzyme activity. 1 Publication1
Mutagenesisi270Q → E: No effect on enzyme activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000115488
PharmGKBiPA31561

Chemistry databases

ChEMBLiCHEMBL3200
DrugBankiDB00198 Oseltamivir
DB00558 Zanamivir

Polymorphism and mutation databases

BioMutaiNEU2
DMDMi229462907

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002088991 – 380Sialidase-2Add BLAST380

Proteomic databases

PaxDbiQ9Y3R4
PeptideAtlasiQ9Y3R4
PRIDEiQ9Y3R4
ProteomicsDBi86068

PTM databases

iPTMnetiQ9Y3R4
PhosphoSitePlusiQ9Y3R4

Expressioni

Tissue specificityi

Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.1 Publication

Gene expression databases

BgeeiENSG00000115488 Expressed in 8 organ(s), highest expression level in skin of leg
CleanExiHS_NEU2
GenevisibleiQ9Y3R4 HS

Organism-specific databases

HPAiCAB022336

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S96EBI-10327976,EBI-945833

Protein-protein interaction databases

BioGridi110832, 23 interactors
IntActiQ9Y3R4, 2 interactors
STRINGi9606.ENSP00000233840

Chemistry databases

BindingDBiQ9Y3R4

Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y3R4
SMRiQ9Y3R4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y3R4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati127 – 138BNR 1Add BLAST12
Repeati197 – 208BNR 2Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 23FRIP motif4

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IFVF Eukaryota
ENOG410Y74Z LUCA
GeneTreeiENSGT00390000011171
HOGENOMiHOG000233778
HOVERGENiHBG052608
InParanoidiQ9Y3R4
KOiK12357
OMAiQDTLECQ
OrthoDBiEOG091G08BI
PhylomeDBiQ9Y3R4
TreeFamiTF331063

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026945 Sialidase-2
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PTHR10628:SF6 PTHR10628:SF6, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y3R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE
60 70 80 90 100
LIVLRRGDYD APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL
110 120 130 140 150
FFIAIPGQVT EQQQLQTRAN VTRLCQVTST DHGRTWSSPR DLTDAAIGPA
160 170 180 190 200
YREWSTFAVG PGHCLQLHDR ARSLVVPAYA YRKLHPIQRP IPSAFCFLSH
210 220 230 240 250
DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL RARVQAQSTN
260 270 280 290 300
DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH
310 320 330 340 350
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF
360 370 380
GCLYEANDYE EIVFLMFTLK QAFPAEYLPQ
Length:380
Mass (Da):42,254
Last modified:May 5, 2009 - v2
Checksum:iAD7B08C478F4D0D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02446111S → R. Corresponds to variant dbSNP:rs2233384Ensembl.1
Natural variantiVAR_02446241R → Q Reduced activity; increased sensitivity to inhibition by oseltamivir carboxylate. 1 PublicationCorresponds to variant dbSNP:rs2233385Ensembl.1
Natural variantiVAR_049204145A → T. Corresponds to variant dbSNP:rs2233390Ensembl.1
Natural variantiVAR_055311168H → N2 PublicationsCorresponds to variant dbSNP:rs2233391Ensembl.1
Natural variantiVAR_055312182R → Q. Corresponds to variant dbSNP:rs2233393Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16535 Genomic DNA Translation: CAB41449.1
AC106876 Genomic DNA Translation: AAY24360.1
CH471063 Genomic DNA Translation: EAW71028.1
BC069151 mRNA Translation: AAH69151.1
BC107053 mRNA Translation: AAI07054.1
CCDSiCCDS2501.1
RefSeqiNP_005374.2, NM_005383.2
UniGeneiHs.532681

Genome annotation databases

EnsembliENST00000233840; ENSP00000233840; ENSG00000115488
GeneIDi4759
KEGGihsa:4759
UCSCiuc010zmn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNEUR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3R4
Secondary accession number(s): Q3KNW4, Q6NTB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 5, 2009
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again