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UniProtKB - Q9Y3R4 (NEUR2_HUMAN)

Entry version 166 (10 Feb 2021)
Sequence version 2 (05 May 2009)
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Protein

Sialidase-2

Gene

NEU2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homopolymer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.24 mM for ganglioside GM3 (in the presence of Triton X-100)1 Publication
  2. KM=0.14 mM for ganglioside GD1a (in the presence of Triton X-100)1 Publication
  3. KM=0.51 mM for ganglioside GD1b (in the presence of Triton X-100)1 Publication
  4. KM=0.38 mM for ganglioside GT1b (in the presence of Triton X-100)1 Publication
  5. KM=0.28 mM for neolactoside IV3-alpha-NeuAc-nLc4Cer(d18:1(4E)) (in the presence of Triton X-100)1 Publication
  6. KM=0.31 mM for alpha(2->3)-sialyllactose1 Publication
  1. Vmax=67 µmol/min/mg enzyme toward ganglioside GM3 (in the presence of Triton X-100)1 Publication
  2. Vmax=322 µmol/min/mg enzyme toward ganglioside GD1a (in the presence of Triton X-100)1 Publication
  3. Vmax=5.45 µmol/min/mg enzyme toward ganglioside GD1b (in the presence of Triton X-100)1 Publication
  4. Vmax=190 µmol/min/mg enzyme toward ganglioside GT1b (in the presence of Triton X-100)1 Publication
  5. Vmax=253 µmol/min/mg enzyme toward ganglioside neolactoside IV3-alpha-NeuAc-nLc4Cer(d18:1(4E)) (in the presence of Triton X-100)1 Publication
  6. Vmax=10 µmol/min/mg enzyme toward alpha(2->3)-sialyllactose1 Publication
  7. Vmax=12.7 µmol/min/mg enzyme toward fetuin1 Publication
  8. Vmax=0.75 µmol/min/mg enzyme toward TF/transferrin1 Publication
  9. Vmax=0.70 µmol/min/mg enzyme toward alpha-1-acid glycoprotein1 Publication

pH dependencei

Optimum pH is 5.6.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21Substrate1
Binding sitei41Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei46Proton acceptor1 Publication1
Binding sitei179Substrate1
Binding sitei181Substrate1
Binding sitei218Substrate1
Binding sitei237Substrate1
Binding sitei304Substrate1
Active sitei334Nucleophile1
Active sitei355Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y3R4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism
R-HSA-4085001, Sialic acid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9Y3R4

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH33, Glycoside Hydrolase Family 33

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialidase-2 (EC:3.2.1.182 Publications)
Alternative name(s):
Cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEU2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7759, NEU2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605528, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3R4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000115488.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi46D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi218E → A or Q: Loss of enzyme activity. 1 Publication1
Mutagenesisi270Q → E: No effect on enzyme activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4759

Open Targets

More...OpenTargetsi		ENSG00000115488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31561

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y3R4, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3200

Drug and drug target database

More...DrugBanki		DB03991, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
DB07960, 5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC ACID
DB00198, Oseltamivir
DB00558, Zanamivir

DrugCentral

More...DrugCentrali		Q9Y3R4

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NEU2

Domain mapping of disease mutations (DMDM)

More...DMDMi		229462907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002088991 – 380Sialidase-2Add BLAST380

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y3R4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3R4

PeptideAtlas

More...PeptideAtlasi		Q9Y3R4

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3R4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		86068

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000115488, Expressed in skin of leg and 13 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3R4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000115488, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110832, 24 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y3R4, 21 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000233840

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y3R4

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y3R4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3R4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y3R4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati127 – 138BNR 1Add BLAST12
Repeati197 – 208BNR 2Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi20 – 23FRIP motif4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSFT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024620_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3R4

Identification of Orthologs from Complete Genome Data

More...OMAi		HDHGRTW

Database of Orthologous Groups

More...OrthoDBi		652179at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3R4

TreeFam database of animal gene trees

More...TreeFami		TF331063

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011040, Sialidase
IPR026945, Sialidase-2
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf

The PANTHER Classification System

More...PANTHERi		PTHR10628, PTHR10628, 1 hit
PTHR10628:SF6, PTHR10628:SF6, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13088, BNR_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50939, SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y3R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE 
        60         70         80         90        100
LIVLRRGDYD APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL 
       110        120        130        140        150
FFIAIPGQVT EQQQLQTRAN VTRLCQVTST DHGRTWSSPR DLTDAAIGPA 
       160        170        180        190        200
YREWSTFAVG PGHCLQLHDR ARSLVVPAYA YRKLHPIQRP IPSAFCFLSH 
       210        220        230        240        250
DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL RARVQAQSTN 
       260        270        280        290        300
DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH 
       310        320        330        340        350
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF 
       360        370        380
GCLYEANDYE EIVFLMFTLK QAFPAEYLPQ
Length:380
Mass (Da):42,254
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD7B08C478F4D0D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02446111S → R. Corresponds to variant dbSNP:rs2233384Ensembl.1
Natural variantiVAR_02446241R → Q Reduced activity; increased sensitivity to inhibition by oseltamivir carboxylate. 1 PublicationCorresponds to variant dbSNP:rs2233385Ensembl.1
Natural variantiVAR_049204145A → T. Corresponds to variant dbSNP:rs2233390Ensembl.1
Natural variantiVAR_055311168H → N2 PublicationsCorresponds to variant dbSNP:rs2233391Ensembl.1
Natural variantiVAR_055312182R → Q. Corresponds to variant dbSNP:rs2233393Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y16535 Genomic DNA Translation: CAB41449.1
AC106876 Genomic DNA Translation: AAY24360.1
CH471063 Genomic DNA Translation: EAW71028.1
BC069151 mRNA Translation: AAH69151.1
BC107053 mRNA Translation: AAI07054.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2501.1

NCBI Reference Sequences

More...RefSeqi		NP_005374.2, NM_005383.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000233840; ENSP00000233840; ENSG00000115488

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4759

UCSC genome browser

More...UCSCi		uc010zmn.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16535 Genomic DNA Translation: CAB41449.1
AC106876 Genomic DNA Translation: AAY24360.1
CH471063 Genomic DNA Translation: EAW71028.1
BC069151 mRNA Translation: AAH69151.1
BC107053 mRNA Translation: AAI07054.1
CCDSiCCDS2501.1
RefSeqiNP_005374.2, NM_005383.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SNTX-ray1.75A1-380[»]
1SO7X-ray1.49A1-380[»]
1VCUX-ray2.85A/B1-380[»]
2F0ZX-ray2.80A1-380[»]
2F10X-ray2.90A1-380[»]
2F11X-ray2.57A1-380[»]
2F12X-ray2.27A1-380[»]
2F13X-ray2.26A1-380[»]
2F24X-ray1.76A1-380[»]
2F25X-ray1.95A/B1-380[»]
2F26X-ray1.58A1-380[»]
2F27X-ray2.15A/B1-380[»]
2F28X-ray1.67A1-380[»]
2F29X-ray2.92A/B1-380[»]
4NC5X-ray2.51A1-380[»]
4NCSX-ray2.20A1-380[»]
SMRiQ9Y3R4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110832, 24 interactors
IntActiQ9Y3R4, 21 interactors
STRINGi9606.ENSP00000233840

Chemistry databases

BindingDBiQ9Y3R4
ChEMBLiCHEMBL3200
DrugBankiDB03991, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid
DB07960, 5-ACETAMIDO-5,6-DIHYDRO-4-HYDROXY-6-ISOBUTOXY-4H-PYRAN-2-CARBOXYLIC ACID
DB00198, Oseltamivir
DB00558, Zanamivir
DrugCentraliQ9Y3R4
SwissLipidsiSLP:000001360

Protein family/group databases

CAZyiGH33, Glycoside Hydrolase Family 33

PTM databases

iPTMnetiQ9Y3R4
PhosphoSitePlusiQ9Y3R4

Genetic variation databases

BioMutaiNEU2
DMDMi229462907

Proteomic databases

MassIVEiQ9Y3R4
PaxDbiQ9Y3R4
PeptideAtlasiQ9Y3R4
PRIDEiQ9Y3R4
ProteomicsDBi86068

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34447, 258 antibodies

Genome annotation databases

EnsembliENST00000233840; ENSP00000233840; ENSG00000115488
GeneIDi4759
KEGGihsa:4759
UCSCiuc010zmn.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4759
DisGeNETi4759

GeneCards: human genes, protein and diseases

More...GeneCardsi		NEU2
HGNCiHGNC:7759, NEU2
HPAiENSG00000115488, Tissue enriched (skin)
MIMi605528, gene
neXtProtiNX_Q9Y3R4
OpenTargetsiENSG00000115488
PharmGKBiPA31561
VEuPathDBiHostDB:ENSG00000115488.3

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSFT, Eukaryota
GeneTreeiENSGT00950000182944
HOGENOMiCLU_024620_2_1_1
InParanoidiQ9Y3R4
OMAiHDHGRTW
OrthoDBi652179at2759
PhylomeDBiQ9Y3R4
TreeFamiTF331063

Enzyme and pathway databases

BRENDAi3.2.1.18, 2681
PathwayCommonsiQ9Y3R4
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism
R-HSA-4085001, Sialic acid metabolism
SABIO-RKiQ9Y3R4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4759, 2 hits in 875 CRISPR screens
EvolutionaryTraceiQ9Y3R4

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NEU2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4759
PharosiQ9Y3R4, Tbio

Protein Ontology

More...PROi		PR:Q9Y3R4
RNActiQ9Y3R4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000115488, Expressed in skin of leg and 13 other tissues
GenevisibleiQ9Y3R4, HS

Family and domain databases

InterProiView protein in InterPro
IPR011040, Sialidase
IPR026945, Sialidase-2
IPR026856, Sialidase_fam
IPR036278, Sialidase_sf
PANTHERiPTHR10628, PTHR10628, 1 hit
PTHR10628:SF6, PTHR10628:SF6, 1 hit
PfamiView protein in Pfam
PF13088, BNR_2, 1 hit
SUPFAMiSSF50939, SSF50939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUR2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3R4
Secondary accession number(s): Q3KNW4, Q6NTB4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 5, 2009
Last modified: February 10, 2021
This is version 166 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
  7. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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