NEU2

Functionⁱ

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.2 Publications

Catalytic activityⁱ

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	21	Substrate	1
Binding siteⁱ	41	Substrate	1
Active siteⁱ	46	Proton acceptor	1
Binding siteⁱ	179	Substrate	1
Binding siteⁱ	181	Substrate	1
Binding siteⁱ	218	Substrate	1
Binding siteⁱ	237	Substrate	1
Binding siteⁱ	304	Substrate	1
Active siteⁱ	334	Nucleophile	1
Active siteⁱ	355	Sequence analysis	1

GO - Molecular functionⁱ

exo-alpha-(2->3)-sialidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22228546
exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
exo-alpha-sialidase activity
Source: CAFA
Inferred from direct assayⁱ
- 26193330

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular oligosaccharide catabolic process
Source: CAFA
Inferred from direct assayⁱ
- 26193330
ganglioside catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 22228546
glycosphingolipid metabolic process Source: Reactome
oligosaccharide catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 22228546

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Biological process	Carbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	3.2.1.18 2681
Reactomeⁱ	R-HSA-1660662 Glycosphingolipid metabolism R-HSA-4085001 Sialic acid metabolism
SABIO-RKⁱ	Q9Y3R4

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH33 Glycoside Hydrolase Family 33

CAZyⁱ

GH33 Glycoside Hydrolase Family 33

Chemistry databases

SwissLipidsⁱ	SLP:000001360

SwissLipidsⁱ

SLP:000001360

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sialidase-2 (EC:3.2.1.18) Alternative name(s): Cytosolic sialidase N-acetyl-alpha-neuraminidase 2
Gene namesⁱ	Name:NEU2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000115488.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7759 NEU2
MIMⁱ	605528 gene
neXtProtⁱ	NX_Q9Y3R4

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	46	D → A: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	218	E → A or Q: Loss of enzyme activity. 1 Publication	1
Mutagenesisⁱ	270	Q → E: No effect on enzyme activity. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000115488
PharmGKBⁱ	PA31561

Chemistry databases

ChEMBLⁱ	CHEMBL3200
Drug and drug target database More...DrugBankⁱ	DB00198 Oseltamivir DB00558 Zanamivir

Polymorphism and mutation databases

BioMutaⁱ	NEU2
DMDMⁱ	229462907

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000208899	1 – 380	Sialidase-2Add BLAST		380

Proteomic databases

PaxDbⁱ	Q9Y3R4
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3R4
PRIDEⁱ	Q9Y3R4
ProteomicsDBⁱ	86068

PTM databases

iPTMnetⁱ	Q9Y3R4
PhosphoSitePlusⁱ	Q9Y3R4

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000115488 Expressed in 8 organ(s), highest expression level in skin of leg
CleanExⁱ	HS_NEU2
Genevisibleⁱ	Q9Y3R4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB022336

HPAⁱ

CAB022336

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NOTCH2NL	Q7Z3S9	6	EBI-10327976,EBI-945833

With

Entry

#Exp.

IntAct

Notes

NOTCH2NL

Q7Z3S9

6

EBI-10327976,EBI-945833

Protein-protein interaction databases

BioGridⁱ	110832, 23 interactors
IntActⁱ	Q9Y3R4, 2 interactors
STRINGⁱ	9606.ENSP00000233840

Chemistry databases

BindingDBⁱ	Q9Y3R4

BindingDBⁱ

Q9Y3R4

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 14	Combined sources	8
Beta strandⁱ	16 – 18	Combined sources	3
Beta strandⁱ	20 – 28	Combined sources	9
Turnⁱ	29 – 32	Combined sources	4
Beta strandⁱ	33 – 40	Combined sources	8
Helixⁱ	46 – 48	Combined sources	3
Beta strandⁱ	51 – 60	Combined sources	10
Turnⁱ	61 – 64	Combined sources	4
Beta strandⁱ	65 – 68	Combined sources	4
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	82 – 91	Combined sources	10
Turnⁱ	93 – 95	Combined sources	3
Beta strandⁱ	98 – 108	Combined sources	11
Helixⁱ	111 – 115	Combined sources	5
Beta strandⁱ	116 – 118	Combined sources	3
Beta strandⁱ	123 – 131	Combined sources	9
Helixⁱ	143 – 147	Combined sources	5
Helixⁱ	148 – 153	Combined sources	6
Beta strandⁱ	154 – 159	Combined sources	6
Beta strandⁱ	174 – 182	Combined sources	9
Beta strandⁱ	185 – 188	Combined sources	4
Beta strandⁱ	191 – 201	Combined sources	11
Beta strandⁱ	213 – 225	Combined sources	13
Beta strandⁱ	230 – 250	Combined sources	21
Beta strandⁱ	259 – 265	Combined sources	7
Turnⁱ	268 – 270	Combined sources	3
Beta strandⁱ	275 – 280	Combined sources	6
Beta strandⁱ	290 – 298	Combined sources	9
Beta strandⁱ	301 – 314	Combined sources	14
Helixⁱ	318 – 320	Combined sources	3
Beta strandⁱ	325 – 342	Combined sources	18
Beta strandⁱ	346 – 356	Combined sources	11
Turnⁱ	357 – 360	Combined sources	4
Beta strandⁱ	361 – 368	Combined sources	8
Helixⁱ	369 – 372	Combined sources	4
Helixⁱ	374 – 376	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y3R4
SMRⁱ	Q9Y3R4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9Y3R4

EvolutionaryTraceⁱ

Q9Y3R4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	127 – 138	BNR 1Add BLAST		12
Repeatⁱ	197 – 208	BNR 2Add BLAST		12

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	20 – 23	FRIP motif		4

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IFVF Eukaryota ENOG410Y74Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011171
HOGENOMⁱ	HOG000233778
HOVERGENⁱ	HBG052608
InParanoidⁱ	Q9Y3R4
KEGG Orthology (KO) More...KOⁱ	K12357
OMAⁱ	QDTLECQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08BI
PhylomeDBⁱ	Q9Y3R4
TreeFamⁱ	TF331063

Family and domain databases

InterProⁱ	View protein in InterPro IPR011040 Sialidase IPR026945 Sialidase-2 IPR026856 Sialidase_fam IPR036278 Sialidase_sf
PANTHERⁱ	PTHR10628 PTHR10628, 1 hit PTHR10628:SF6 PTHR10628:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13088 BNR_2, 1 hit
SUPFAMⁱ	SSF50939 SSF50939, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Y3R4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE 
        60         70         80         90        100
LIVLRRGDYD APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL 
       110        120        130        140        150
FFIAIPGQVT EQQQLQTRAN VTRLCQVTST DHGRTWSSPR DLTDAAIGPA 
       160        170        180        190        200
YREWSTFAVG PGHCLQLHDR ARSLVVPAYA YRKLHPIQRP IPSAFCFLSH 
       210        220        230        240        250
DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL RARVQAQSTN 
       260        270        280        290        300
DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH 
       310        320        330        340        350
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF 
       360        370        380
GCLYEANDYE EIVFLMFTLK QAFPAEYLPQ

Length:380

Mass (Da):42,254

Last modified:May 5, 2009 - v2

Checksum:ⁱAD7B08C478F4D0D9

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024461	11	S → R. Corresponds to variant dbSNP:rs2233384Ensembl.	1
Natural variantⁱVAR_024462	41	R → Q Reduced activity; increased sensitivity to inhibition by oseltamivir carboxylate. 1 PublicationCorresponds to variant dbSNP:rs2233385Ensembl.	1
Natural variantⁱVAR_049204	145	A → T. Corresponds to variant dbSNP:rs2233390Ensembl.	1
Natural variantⁱVAR_055311	168	H → N2 PublicationsCorresponds to variant dbSNP:rs2233391Ensembl.	1
Natural variantⁱVAR_055312	182	R → Q. Corresponds to variant dbSNP:rs2233393Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y16535 Genomic DNA Translation: CAB41449.1 AC106876 Genomic DNA Translation: AAY24360.1 CH471063 Genomic DNA Translation: EAW71028.1 BC069151 mRNA Translation: AAH69151.1 BC107053 mRNA Translation: AAI07054.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2501.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005374.2, NM_005383.2
UniGeneⁱ	Hs.532681

Genome annotation databases

Ensemblⁱ	ENST00000233840; ENSP00000233840; ENSG00000115488
GeneIDⁱ	4759
KEGGⁱ	hsa:4759
UCSC genome browser More...UCSCⁱ	uc010zmn.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3R4	Neuraminidase 2		CHLSB		381	UniRef90_Q9Y3R4
Neuraminidase 2		MACFA		381
Neuraminidase 2		PAPAN		381
Neuraminidase 2		MACMU		381
Neuraminidase 2		CERAT		381
+26

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3R4	Sialidase-2		RAT		379	UniRef50_Q9Y3R4
Sialidase-2		CRIGR		379
Uncharacterized protein		MACMU		381
Neuraminidase 2		MACNE		381
Neuraminidase 2		MACFA		381
+251

Entry informationⁱ

Entry nameⁱ	NEUR2_HUMAN
Accessionⁱ	Q9Y3R4Primary (citable) accession number: Q9Y3R4 Secondary accession number(s): Q3KNW4, Q6NTB4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
	Last sequence update:	May 5, 2009
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y3R4 (NEUR2_HUMAN)

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Sialidase-2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ