Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sialidase-2

Gene

NEU2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21Substrate1
Binding sitei41Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei46Proton acceptor1
Binding sitei179Substrate1
Binding sitei181Substrate1
Binding sitei218Substrate1
Binding sitei237Substrate1
Binding sitei304Substrate1
Active sitei334Nucleophile1
Active sitei355Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.2.1.18 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-4085001 Sialic acid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Y3R4

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH33 Glycoside Hydrolase Family 33

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001360

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialidase-2 (EC:3.2.1.18)
Alternative name(s):
Cytosolic sialidase
N-acetyl-alpha-neuraminidase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEU2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000115488.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7759 NEU2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605528 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y3R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi46D → A: Loss of enzyme activity. 1 Publication1
Mutagenesisi218E → A or Q: Loss of enzyme activity. 1 Publication1
Mutagenesisi270Q → E: No effect on enzyme activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000115488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31561

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3200

Drug and drug target database

More...
DrugBanki
DB00198 Oseltamivir
DB00558 Zanamivir

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEU2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462907

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002088991 – 380Sialidase-2Add BLAST380

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y3R4

PeptideAtlas

More...
PeptideAtlasi
Q9Y3R4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y3R4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
86068

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y3R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y3R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115488 Expressed in 8 organ(s), highest expression level in skin of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_NEU2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y3R4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022336

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLAQ7Z3S96EBI-10327976,EBI-945833

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110832, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y3R4, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000233840

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y3R4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1380
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y3R4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y3R4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y3R4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati127 – 138BNR 1Add BLAST12
Repeati197 – 208BNR 2Add BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi20 – 23FRIP motif4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFVF Eukaryota
ENOG410Y74Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154250

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233778

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052608

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y3R4

KEGG Orthology (KO)

More...
KOi
K12357

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDTLECQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08BI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y3R4

TreeFam database of animal gene trees

More...
TreeFami
TF331063

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011040 Sialidase
IPR026945 Sialidase-2
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10628 PTHR10628, 1 hit
PTHR10628:SF6 PTHR10628:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13088 BNR_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50939 SSF50939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9Y3R4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLPVLQKE SVFQSGAHAY RIPALLYLPG QQSLLAFAEQ RASKKDEHAE
60 70 80 90 100
LIVLRRGDYD APTHQVQWQA QEVVAQARLD GHRSMNPCPL YDAQTGTLFL
110 120 130 140 150
FFIAIPGQVT EQQQLQTRAN VTRLCQVTST DHGRTWSSPR DLTDAAIGPA
160 170 180 190 200
YREWSTFAVG PGHCLQLHDR ARSLVVPAYA YRKLHPIQRP IPSAFCFLSH
210 220 230 240 250
DHGRTWARGH FVAQDTLECQ VAEVETGEQR VVTLNARSHL RARVQAQSTN
260 270 280 290 300
DGLDFQESQL VKKLVEPPPQ GCQGSVISFP SPRSGPGSPA QWLLYTHPTH
310 320 330 340 350
SWQRADLGAY LNPRPPAPEA WSEPVLLAKG SCAYSDLQSM GTGPDGSPLF
360 370 380
GCLYEANDYE EIVFLMFTLK QAFPAEYLPQ
Length:380
Mass (Da):42,254
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD7B08C478F4D0D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02446111S → R. Corresponds to variant dbSNP:rs2233384Ensembl.1
Natural variantiVAR_02446241R → Q Reduced activity; increased sensitivity to inhibition by oseltamivir carboxylate. 1 PublicationCorresponds to variant dbSNP:rs2233385Ensembl.1
Natural variantiVAR_049204145A → T. Corresponds to variant dbSNP:rs2233390Ensembl.1
Natural variantiVAR_055311168H → N2 PublicationsCorresponds to variant dbSNP:rs2233391Ensembl.1
Natural variantiVAR_055312182R → Q. Corresponds to variant dbSNP:rs2233393Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y16535 Genomic DNA Translation: CAB41449.1
AC106876 Genomic DNA Translation: AAY24360.1
CH471063 Genomic DNA Translation: EAW71028.1
BC069151 mRNA Translation: AAH69151.1
BC107053 mRNA Translation: AAI07054.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2501.1

NCBI Reference Sequences

More...
RefSeqi
NP_005374.2, NM_005383.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.532681

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000233840; ENSP00000233840; ENSG00000115488

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4759

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4759

UCSC genome browser

More...
UCSCi
uc010zmn.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16535 Genomic DNA Translation: CAB41449.1
AC106876 Genomic DNA Translation: AAY24360.1
CH471063 Genomic DNA Translation: EAW71028.1
BC069151 mRNA Translation: AAH69151.1
BC107053 mRNA Translation: AAI07054.1
CCDSiCCDS2501.1
RefSeqiNP_005374.2, NM_005383.2
UniGeneiHs.532681

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SNTX-ray1.75A1-380[»]
1SO7X-ray1.49A1-380[»]
1VCUX-ray2.85A/B1-380[»]
2F0ZX-ray2.80A1-380[»]
2F10X-ray2.90A1-380[»]
2F11X-ray2.57A1-380[»]
2F12X-ray2.27A1-380[»]
2F13X-ray2.26A1-380[»]
2F24X-ray1.76A1-380[»]
2F25X-ray1.95A/B1-380[»]
2F26X-ray1.58A1-380[»]
2F27X-ray2.15A/B1-380[»]
2F28X-ray1.67A1-380[»]
2F29X-ray2.92A/B1-380[»]
4NC5X-ray2.51A1-380[»]
4NCSX-ray2.20A1-380[»]
ProteinModelPortaliQ9Y3R4
SMRiQ9Y3R4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110832, 23 interactors
IntActiQ9Y3R4, 2 interactors
STRINGi9606.ENSP00000233840

Chemistry databases

BindingDBiQ9Y3R4
ChEMBLiCHEMBL3200
DrugBankiDB00198 Oseltamivir
DB00558 Zanamivir
SwissLipidsiSLP:000001360

Protein family/group databases

CAZyiGH33 Glycoside Hydrolase Family 33

PTM databases

iPTMnetiQ9Y3R4
PhosphoSitePlusiQ9Y3R4

Polymorphism and mutation databases

BioMutaiNEU2
DMDMi229462907

Proteomic databases

PaxDbiQ9Y3R4
PeptideAtlasiQ9Y3R4
PRIDEiQ9Y3R4
ProteomicsDBi86068

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233840; ENSP00000233840; ENSG00000115488
GeneIDi4759
KEGGihsa:4759
UCSCiuc010zmn.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4759
EuPathDBiHostDB:ENSG00000115488.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NEU2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0029978
HGNCiHGNC:7759 NEU2
HPAiCAB022336
MIMi605528 gene
neXtProtiNX_Q9Y3R4
OpenTargetsiENSG00000115488
PharmGKBiPA31561

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFVF Eukaryota
ENOG410Y74Z LUCA
GeneTreeiENSGT00940000154250
HOGENOMiHOG000233778
HOVERGENiHBG052608
InParanoidiQ9Y3R4
KOiK12357
OMAiQDTLECQ
OrthoDBiEOG091G08BI
PhylomeDBiQ9Y3R4
TreeFamiTF331063

Enzyme and pathway databases

BRENDAi3.2.1.18 2681
ReactomeiR-HSA-1660662 Glycosphingolipid metabolism
R-HSA-4085001 Sialic acid metabolism
SABIO-RKiQ9Y3R4

Miscellaneous databases

EvolutionaryTraceiQ9Y3R4

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NEU2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4759

Protein Ontology

More...
PROi
PR:Q9Y3R4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115488 Expressed in 8 organ(s), highest expression level in skin of leg
CleanExiHS_NEU2
GenevisibleiQ9Y3R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR011040 Sialidase
IPR026945 Sialidase-2
IPR026856 Sialidase_fam
IPR036278 Sialidase_sf
PANTHERiPTHR10628 PTHR10628, 1 hit
PTHR10628:SF6 PTHR10628:SF6, 1 hit
PfamiView protein in Pfam
PF13088 BNR_2, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEUR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3R4
Secondary accession number(s): Q3KNW4, Q6NTB4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 5, 2009
Last modified: December 5, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again