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Protein

TSC22 domain family protein 4

Gene

TSC22D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • response to osmotic stress Source: GO_Central

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 4
Alternative name(s):
TSC22-related-inducible leucine zipper protein 2
Tsc-22-like protein THG-1
Gene namesi
Name:TSC22D4
Synonyms:THG1, TILZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000166925.8
HGNCiHGNC:21696 TSC22D4
MIMi611914 gene
neXtProtiNX_Q9Y3Q8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi81628
OpenTargetsiENSG00000166925
PharmGKBiPA142670698

Polymorphism and mutation databases

BioMutaiTSC22D4
DMDMi14195254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193741 – 395TSC22 domain family protein 4Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei57PhosphothreonineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei190PhosphoserineCombined sources1
Modified residuei211PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei229PhosphothreonineCombined sources1
Modified residuei260PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3Q8
PaxDbiQ9Y3Q8
PeptideAtlasiQ9Y3Q8
PRIDEiQ9Y3Q8
ProteomicsDBi86064

PTM databases

iPTMnetiQ9Y3Q8
PhosphoSitePlusiQ9Y3Q8

Expressioni

Gene expression databases

BgeeiENSG00000166925 Expressed in 216 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TSC22D4
ExpressionAtlasiQ9Y3Q8 baseline and differential
GenevisibleiQ9Y3Q8 HS

Organism-specific databases

HPAiHPA006757

Interactioni

Subunit structurei

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.

Binary interactionsi

Protein-protein interaction databases

BioGridi123563, 90 interactors
IntActiQ9Y3Q8, 58 interactors
MINTiQ9Y3Q8
STRINGi9606.ENSP00000300181

Structurei

3D structure databases

ProteinModelPortaliQ9Y3Q8
SMRiQ9Y3Q8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 365Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000015349
HOVERGENiHBG069048
InParanoidiQ9Y3Q8
OMAiCVDIYER
OrthoDBiEOG091G06PM
PhylomeDBiQ9Y3Q8
TreeFamiTF338725

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3Q8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP
60 70 80 90 100
DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL
110 120 130 140 150
EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS
160 170 180 190 200
WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET
210 220 230 240 250
GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE
260 270 280 290 300
EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI
310 320 330 340 350
SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE
360 370 380 390
LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV
Length:395
Mass (Da):41,026
Last modified:June 1, 2001 - v2
Checksum:iDA08B5617C9BB151
GO
Isoform 2 (identifier: Q9Y3Q8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.

Note: No experimental confirmation available.
Show »
Length:156
Mass (Da):16,685
Checksum:iF240ECD884DDFFF6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ77H7BZ77_HUMAN
TSC22 domain family protein 4
TSC22D4
211Annotation score:
H7C0M8H7C0M8_HUMAN
TSC22 domain family protein 4
TSC22D4
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355 – 356NA → KR in CAB43491 (PubMed:10488076).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036284329V → M in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562451 – 239Missing in isoform 2. 1 PublicationAdd BLAST239

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133115 mRNA Translation: CAB43491.1
AK297702 mRNA Translation: BAG60060.1
AC092849 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23831.1
CH471091 Genomic DNA Translation: EAW76527.1
CH471091 Genomic DNA Translation: EAW76528.1
CH471091 Genomic DNA Translation: EAW76529.1
CH471091 Genomic DNA Translation: EAW76531.1
BC001486 mRNA Translation: AAH01486.1
BC001966 mRNA Translation: AAH01966.1
BC002972 mRNA Translation: AAH02972.1
BC010406 mRNA Translation: AAH10406.1
CCDSiCCDS5695.1 [Q9Y3Q8-1]
RefSeqiNP_001289972.1, NM_001303043.1 [Q9Y3Q8-1]
NP_112197.1, NM_030935.4 [Q9Y3Q8-1]
UniGeneiHs.469798

Genome annotation databases

EnsembliENST00000300181; ENSP00000300181; ENSG00000166925 [Q9Y3Q8-1]
ENST00000393991; ENSP00000377560; ENSG00000166925 [Q9Y3Q8-2]
GeneIDi81628
KEGGihsa:81628
UCSCiuc003uva.3 human [Q9Y3Q8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133115 mRNA Translation: CAB43491.1
AK297702 mRNA Translation: BAG60060.1
AC092849 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23831.1
CH471091 Genomic DNA Translation: EAW76527.1
CH471091 Genomic DNA Translation: EAW76528.1
CH471091 Genomic DNA Translation: EAW76529.1
CH471091 Genomic DNA Translation: EAW76531.1
BC001486 mRNA Translation: AAH01486.1
BC001966 mRNA Translation: AAH01966.1
BC002972 mRNA Translation: AAH02972.1
BC010406 mRNA Translation: AAH10406.1
CCDSiCCDS5695.1 [Q9Y3Q8-1]
RefSeqiNP_001289972.1, NM_001303043.1 [Q9Y3Q8-1]
NP_112197.1, NM_030935.4 [Q9Y3Q8-1]
UniGeneiHs.469798

3D structure databases

ProteinModelPortaliQ9Y3Q8
SMRiQ9Y3Q8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123563, 90 interactors
IntActiQ9Y3Q8, 58 interactors
MINTiQ9Y3Q8
STRINGi9606.ENSP00000300181

PTM databases

iPTMnetiQ9Y3Q8
PhosphoSitePlusiQ9Y3Q8

Polymorphism and mutation databases

BioMutaiTSC22D4
DMDMi14195254

Proteomic databases

EPDiQ9Y3Q8
PaxDbiQ9Y3Q8
PeptideAtlasiQ9Y3Q8
PRIDEiQ9Y3Q8
ProteomicsDBi86064

Protocols and materials databases

DNASUi81628
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300181; ENSP00000300181; ENSG00000166925 [Q9Y3Q8-1]
ENST00000393991; ENSP00000377560; ENSG00000166925 [Q9Y3Q8-2]
GeneIDi81628
KEGGihsa:81628
UCSCiuc003uva.3 human [Q9Y3Q8-1]

Organism-specific databases

CTDi81628
DisGeNETi81628
EuPathDBiHostDB:ENSG00000166925.8
GeneCardsiTSC22D4
HGNCiHGNC:21696 TSC22D4
HPAiHPA006757
MIMi611914 gene
neXtProtiNX_Q9Y3Q8
OpenTargetsiENSG00000166925
PharmGKBiPA142670698
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000015349
HOVERGENiHBG069048
InParanoidiQ9Y3Q8
OMAiCVDIYER
OrthoDBiEOG091G06PM
PhylomeDBiQ9Y3Q8
TreeFamiTF338725

Miscellaneous databases

GenomeRNAii81628
PROiPR:Q9Y3Q8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166925 Expressed in 216 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_TSC22D4
ExpressionAtlasiQ9Y3Q8 baseline and differential
GenevisibleiQ9Y3Q8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT22D4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3Q8
Secondary accession number(s): A4D2C3, A8MWR6, D6W5V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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