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UniProtKB - Q9Y3Q8 (T22D4_HUMAN)
Protein
TSC22 domain family protein 4
Gene
TSC22D4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor.
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: InterPro
- response to osmotic stress Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Q8 |
SignaLinki | Q9Y3Q8 |
Names & Taxonomyi
Protein namesi | Recommended name: TSC22 domain family protein 4Alternative name(s): TSC22-related-inducible leucine zipper protein 2 Tsc-22-like protein THG-1 |
Gene namesi | Name:TSC22D4 Synonyms:THG1, TILZ2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21696, TSC22D4 |
MIMi | 611914, gene |
neXtProti | NX_Q9Y3Q8 |
VEuPathDBi | HostDB:ENSG00000166925 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 81628 |
OpenTargetsi | ENSG00000166925 |
PharmGKBi | PA142670698 |
Miscellaneous databases
Pharosi | Q9Y3Q8, Tbio |
Genetic variation databases
BioMutai | TSC22D4 |
DMDMi | 14195254 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219374 | 1 – 395 | TSC22 domain family protein 4Add BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 49 | PhosphoserineCombined sources | 1 | |
Modified residuei | 57 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 62 | PhosphoserineCombined sources | 1 | |
Modified residuei | 165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 187 | PhosphoserineBy similarity | 1 | |
Modified residuei | 189 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineCombined sources | 1 | |
Modified residuei | 211 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 225 | PhosphoserineCombined sources | 1 | |
Modified residuei | 229 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 260 | PhosphoserineBy similarity | 1 | |
Modified residuei | 264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 279 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y3Q8 |
jPOSTi | Q9Y3Q8 |
MassIVEi | Q9Y3Q8 |
MaxQBi | Q9Y3Q8 |
PaxDbi | Q9Y3Q8 |
PeptideAtlasi | Q9Y3Q8 |
PRIDEi | Q9Y3Q8 |
ProteomicsDBi | 2262 86064 [Q9Y3Q8-1] |
PTM databases
iPTMneti | Q9Y3Q8 |
PhosphoSitePlusi | Q9Y3Q8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166925, Expressed in C1 segment of cervical spinal cord and 230 other tissues |
ExpressionAtlasi | Q9Y3Q8, baseline and differential |
Genevisiblei | Q9Y3Q8, HS |
Organism-specific databases
HPAi | ENSG00000166925, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.
Binary interactionsi
Q9Y3Q8
Protein-protein interaction databases
BioGRIDi | 123563, 121 interactors |
IntActi | Q9Y3Q8, 94 interactors |
MINTi | Q9Y3Q8 |
STRINGi | 9606.ENSP00000300181 |
Miscellaneous databases
RNActi | Q9Y3Q8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 86 | DisorderedSequence analysisAdd BLAST | 86 | |
Regioni | 103 – 237 | DisorderedSequence analysisAdd BLAST | 135 | |
Regioni | 344 – 365 | Leucine-zipperAdd BLAST | 22 | |
Regioni | 376 – 395 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 26 – 48 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 193 – 210 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the TSC-22/Dip/Bun family.Curated
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000161400 |
HOGENOMi | CLU_052826_0_0_1 |
InParanoidi | Q9Y3Q8 |
OMAi | FYFFPDA |
PhylomeDBi | Q9Y3Q8 |
TreeFami | TF338725 |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun IPR042553, TSC22D4 |
PANTHERi | PTHR47610, PTHR47610, 1 hit |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y3Q8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP
60 70 80 90 100
DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL
110 120 130 140 150
EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS
160 170 180 190 200
WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET
210 220 230 240 250
GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE
260 270 280 290 300
EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI
310 320 330 340 350
SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE
360 370 380 390
LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7BZ77 | H7BZ77_HUMAN | TSC22 domain family protein 4 | TSC22D4 | 211 | Annotation score: | ||
H7C0M8 | H7C0M8_HUMAN | TSC22 domain family protein 4 | TSC22D4 | 168 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 355 – 356 | NA → KR in CAB43491 (PubMed:10488076).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036284 | 329 | V → M in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056245 | 1 – 239 | Missing in isoform 2. 1 PublicationAdd BLAST | 239 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133115 mRNA Translation: CAB43491.1 AK297702 mRNA Translation: BAG60060.1 AC092849 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23831.1 CH471091 Genomic DNA Translation: EAW76527.1 CH471091 Genomic DNA Translation: EAW76528.1 CH471091 Genomic DNA Translation: EAW76529.1 CH471091 Genomic DNA Translation: EAW76531.1 BC001486 mRNA Translation: AAH01486.1 BC001966 mRNA Translation: AAH01966.1 BC002972 mRNA Translation: AAH02972.1 BC010406 mRNA Translation: AAH10406.1 |
CCDSi | CCDS5695.1 [Q9Y3Q8-1] |
RefSeqi | NP_001289972.1, NM_001303043.1 [Q9Y3Q8-1] NP_112197.1, NM_030935.4 [Q9Y3Q8-1] |
Genome annotation databases
Ensembli | ENST00000300181.7; ENSP00000300181.2; ENSG00000166925.9 ENST00000393991.5; ENSP00000377560.1; ENSG00000166925.9 [Q9Y3Q8-2] |
GeneIDi | 81628 |
KEGGi | hsa:81628 |
MANE-Selecti | ENST00000300181.7; ENSP00000300181.2; NM_030935.5; NP_112197.1 |
UCSCi | uc003uva.3, human [Q9Y3Q8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ133115 mRNA Translation: CAB43491.1 AK297702 mRNA Translation: BAG60060.1 AC092849 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23831.1 CH471091 Genomic DNA Translation: EAW76527.1 CH471091 Genomic DNA Translation: EAW76528.1 CH471091 Genomic DNA Translation: EAW76529.1 CH471091 Genomic DNA Translation: EAW76531.1 BC001486 mRNA Translation: AAH01486.1 BC001966 mRNA Translation: AAH01966.1 BC002972 mRNA Translation: AAH02972.1 BC010406 mRNA Translation: AAH10406.1 |
CCDSi | CCDS5695.1 [Q9Y3Q8-1] |
RefSeqi | NP_001289972.1, NM_001303043.1 [Q9Y3Q8-1] NP_112197.1, NM_030935.4 [Q9Y3Q8-1] |
3D structure databases
AlphaFoldDBi | Q9Y3Q8 |
SMRi | Q9Y3Q8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123563, 121 interactors |
IntActi | Q9Y3Q8, 94 interactors |
MINTi | Q9Y3Q8 |
STRINGi | 9606.ENSP00000300181 |
PTM databases
iPTMneti | Q9Y3Q8 |
PhosphoSitePlusi | Q9Y3Q8 |
Genetic variation databases
BioMutai | TSC22D4 |
DMDMi | 14195254 |
Proteomic databases
EPDi | Q9Y3Q8 |
jPOSTi | Q9Y3Q8 |
MassIVEi | Q9Y3Q8 |
MaxQBi | Q9Y3Q8 |
PaxDbi | Q9Y3Q8 |
PeptideAtlasi | Q9Y3Q8 |
PRIDEi | Q9Y3Q8 |
ProteomicsDBi | 2262 86064 [Q9Y3Q8-1] |
Protocols and materials databases
ABCDi | Q9Y3Q8, 7 sequenced antibodies |
Antibodypediai | 1818, 137 antibodies from 26 providers |
DNASUi | 81628 |
Genome annotation databases
Ensembli | ENST00000300181.7; ENSP00000300181.2; ENSG00000166925.9 ENST00000393991.5; ENSP00000377560.1; ENSG00000166925.9 [Q9Y3Q8-2] |
GeneIDi | 81628 |
KEGGi | hsa:81628 |
MANE-Selecti | ENST00000300181.7; ENSP00000300181.2; NM_030935.5; NP_112197.1 |
UCSCi | uc003uva.3, human [Q9Y3Q8-1] |
Organism-specific databases
CTDi | 81628 |
DisGeNETi | 81628 |
GeneCardsi | TSC22D4 |
HGNCi | HGNC:21696, TSC22D4 |
HPAi | ENSG00000166925, Tissue enhanced (brain) |
MIMi | 611914, gene |
neXtProti | NX_Q9Y3Q8 |
OpenTargetsi | ENSG00000166925 |
PharmGKBi | PA142670698 |
VEuPathDBi | HostDB:ENSG00000166925 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4797, Eukaryota |
GeneTreei | ENSGT00940000161400 |
HOGENOMi | CLU_052826_0_0_1 |
InParanoidi | Q9Y3Q8 |
OMAi | FYFFPDA |
PhylomeDBi | Q9Y3Q8 |
TreeFami | TF338725 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Q8 |
SignaLinki | Q9Y3Q8 |
Miscellaneous databases
BioGRID-ORCSi | 81628, 16 hits in 1103 CRISPR screens |
ChiTaRSi | TSC22D4, human |
GenomeRNAii | 81628 |
Pharosi | Q9Y3Q8, Tbio |
PROi | PR:Q9Y3Q8 |
RNActi | Q9Y3Q8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166925, Expressed in C1 segment of cervical spinal cord and 230 other tissues |
ExpressionAtlasi | Q9Y3Q8, baseline and differential |
Genevisiblei | Q9Y3Q8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000580, TSC-22_Dip_Bun IPR042553, TSC22D4 |
PANTHERi | PTHR47610, PTHR47610, 1 hit |
Pfami | View protein in Pfam PF01166, TSC22, 1 hit |
PROSITEi | View protein in PROSITE PS01289, TSC22, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | T22D4_HUMAN | |
Accessioni | Q9Y3Q8Primary (citable) accession number: Q9Y3Q8 Secondary accession number(s): A4D2C3, A8MWR6, D6W5V9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families