TSC22D4

Functionⁱ

Transcriptional repressor.

GO - Molecular functionⁱ

RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of activation-induced cell death of T cells Source: GO_Central
negative regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 10488076
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TSC22 domain family protein 4 Alternative name(s): TSC22-related-inducible leucine zipper protein 2 Tsc-22-like protein THG-1
Gene namesⁱ	Name:TSC22D4 Synonyms:THG1, TILZ2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166925.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21696 TSC22D4
MIMⁱ	611914 gene
neXtProtⁱ	NX_Q9Y3Q8

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81628
Open Targets More...OpenTargetsⁱ	ENSG00000166925
PharmGKBⁱ	PA142670698

Polymorphism and mutation databases

BioMutaⁱ	TSC22D4
DMDMⁱ	14195254

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219374	1 – 395	TSC22 domain family protein 4Add BLAST		395

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	49	PhosphoserineCombined sources	1
Modified residueⁱ	57	PhosphothreonineCombined sources	1
Modified residueⁱ	62	PhosphoserineCombined sources	1
Modified residueⁱ	165	PhosphoserineCombined sources	1
Modified residueⁱ	187	PhosphoserineBy similarity	1
Modified residueⁱ	189	PhosphoserineBy similarity	1
Modified residueⁱ	190	PhosphoserineCombined sources	1
Modified residueⁱ	211	PhosphothreonineCombined sources	1
Modified residueⁱ	225	PhosphoserineCombined sources	1
Modified residueⁱ	229	PhosphothreonineCombined sources	1
Modified residueⁱ	260	PhosphoserineBy similarity	1
Modified residueⁱ	264	PhosphoserineBy similarity	1
Modified residueⁱ	279	PhosphoserineCombined sources	1
Modified residueⁱ	370	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y3Q8
PaxDbⁱ	Q9Y3Q8
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3Q8
PRIDEⁱ	Q9Y3Q8
ProteomicsDBⁱ	86064

PTM databases

iPTMnetⁱ	Q9Y3Q8
PhosphoSitePlusⁱ	Q9Y3Q8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166925 Expressed in 216 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_TSC22D4
ExpressionAtlasⁱ	Q9Y3Q8 baseline and differential
Genevisibleⁱ	Q9Y3Q8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006757

HPAⁱ

HPA006757

Interactionⁱ

Subunit structureⁱ

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AIFM1	O95831	2	EBI-739485,EBI-356440
APIP	Q96GX9	3	EBI-739485,EBI-359248
CCDC146	Q8IYE0-2	3	EBI-739485,EBI-10247802
CDC23	Q9UJX2	3	EBI-739485,EBI-396137
KEAP1	Q14145	3	EBI-739485,EBI-751001
LMO2	P25791	3	EBI-739485,EBI-739696
MAD2L1	Q13257	4	EBI-739485,EBI-78203
MYLIP	Q8WY64	3	EBI-739485,EBI-6952711
NRBP1	Q9UHY1	4	EBI-739485,EBI-749731
NRBP2	D3DWK9	3	EBI-739485,EBI-10176870
PCBP1	Q15365	2	EBI-739485,EBI-946095
PIH1D1	Q9NWS0	4	EBI-739485,EBI-357318
PIN1	Q13526	6	EBI-739485,EBI-714158
POLR1C	O15160	5	EBI-739485,EBI-1055079
PPL	O60437	3	EBI-739485,EBI-368321
PRKAA1	Q13131	3	EBI-739485,EBI-1181405
PRKAA2	P54646	3	EBI-739485,EBI-1383852
SMAD3	P84022	2	EBI-739485,EBI-347161
ZBTB24	O43167	5	EBI-739485,EBI-744471
ZMYND10	O75800	5	EBI-739485,EBI-747061

Protein-protein interaction databases

BioGridⁱ	123563, 90 interactors
IntActⁱ	Q9Y3Q8, 58 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y3Q8
STRINGⁱ	9606.ENSP00000300181

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y3Q8
SMRⁱ	Q9Y3Q8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	344 – 365	Leucine-zipperAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4797 Eukaryota ENOG411251N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063062
HOGENOMⁱ	HOG000015349
HOVERGENⁱ	HBG069048
InParanoidⁱ	Q9Y3Q8
OMAⁱ	CVDIYER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06PM
PhylomeDBⁱ	Q9Y3Q8
TreeFamⁱ	TF338725

Family and domain databases

InterProⁱ	View protein in InterPro IPR000580 TSC-22_Dip_Bun
PANTHERⁱ	PTHR12348 PTHR12348, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01166 TSC22, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEⁱ	View protein in PROSITE PS01289 TSC22, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9Y3Q8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP 
        60         70         80         90        100
DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL 
       110        120        130        140        150
EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS 
       160        170        180        190        200
WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET 
       210        220        230        240        250
GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE 
       260        270        280        290        300
EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI 
       310        320        330        340        350
SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE 
       360        370        380        390 
LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV

Length:395

Mass (Da):41,026

Last modified:June 1, 2001 - v2

Checksum:ⁱDA08B5617C9BB151

GO

Isoform 2 (identifier: Q9Y3Q8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-239: Missing.

« Hide

        10         20         30         40         50
MRLRMELGAP EEMGQVPPLD SRPSSPALYF THDASLVHKS PDPFGAVAAQ 
        60         70         80         90        100
KFSLAHSMLA ISGHLDSDDD SGSGSLVGID NKIEQAMDLV KSHLMFAVRE 
       110        120        130        140        150
EVEVLKEQIR ELAERNAALE QENGLLRALA SPEQLAQLPS SGVPRLGPPA 

PNGPSV

Note: No experimental confirmation available.

Show »

Length:156

Mass (Da):16,685

Checksum:ⁱF240ECD884DDFFF6

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H7BZ77	H7BZ77_HUMAN		TSC22 domain family protein 4 TSC22 domain family protein 4	TSC22D4	211	Annotation score:
	H7C0M8	H7C0M8_HUMAN		TSC22 domain family protein 4 TSC22 domain family protein 4	TSC22D4	168	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	355 – 356	NA → KR in CAB43491 (PubMed:10488076).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036284	329	V → M in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056245	1 – 239	Missing in isoform 2. 1 PublicationAdd BLAST		239

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ133115 mRNA Translation: CAB43491.1 AK297702 mRNA Translation: BAG60060.1 AC092849 Genomic DNA No translation available. CH236956 Genomic DNA Translation: EAL23831.1 CH471091 Genomic DNA Translation: EAW76527.1 CH471091 Genomic DNA Translation: EAW76528.1 CH471091 Genomic DNA Translation: EAW76529.1 CH471091 Genomic DNA Translation: EAW76531.1 BC001486 mRNA Translation: AAH01486.1 BC001966 mRNA Translation: AAH01966.1 BC002972 mRNA Translation: AAH02972.1 BC010406 mRNA Translation: AAH10406.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5695.1 [Q9Y3Q8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001289972.1, NM_001303043.1 [Q9Y3Q8-1] NP_112197.1, NM_030935.4 [Q9Y3Q8-1]
UniGeneⁱ	Hs.469798

Genome annotation databases

Ensemblⁱ	ENST00000300181; ENSP00000300181; ENSG00000166925 [Q9Y3Q8-1] ENST00000393991; ENSP00000377560; ENSG00000166925 [Q9Y3Q8-2]
GeneIDⁱ	81628
KEGGⁱ	hsa:81628
UCSC genome browser More...UCSCⁱ	uc003uva.3 human [Q9Y3Q8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3Q8	Isoform 2 of TSC22 domain family protein 4		HUMAN		156	UniRef90_Q9Y3Q8
TSC22 domain family member 4		PANTR		395
TSC22 domain family member 4		CALJA		395
TSC22 domain family member 4		MACMU		395
TSC22 domain family member 4		PAPAN		395
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3Q8	TSC22 domain family protein 4		RAT		387	UniRef50_Q9Y3Q8
TSC22 domain family protein 4		MOUSE		387
Isoform 2 of TSC22 domain family protein 4		HUMAN		156
TSC22 domain family member 4		GORGO		395
TSC22 domain family member 4		PONAB		395
+125

Entry informationⁱ

Entry nameⁱ	T22D4_HUMAN
Accessionⁱ	Q9Y3Q8Primary (citable) accession number: Q9Y3Q8 Secondary accession number(s): A4D2C3, A8MWR6, D6W5V9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y3Q8 (T22D4_HUMAN)

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TSC22 domain family protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ