Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - Q9Y3Q8 (T22D4_HUMAN)

Entry version 184 (25 May 2022)
Sequence version 2 (01 Jun 2001)
Previous versions | rss
Add a publicationFeedback
Protein

TSC22 domain family protein 4

Gene

TSC22D4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y3Q8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y3Q8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TSC22 domain family protein 4
Alternative name(s):
TSC22-related-inducible leucine zipper protein 2
Tsc-22-like protein THG-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSC22D4
Synonyms:THG1, TILZ2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21696, TSC22D4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611914, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3Q8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166925

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		81628

Open Targets

More...OpenTargetsi		ENSG00000166925

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670698

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y3Q8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TSC22D4

Domain mapping of disease mutations (DMDM)

More...DMDMi		14195254

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193741 – 395TSC22 domain family protein 4Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei49PhosphoserineCombined sources1
Modified residuei57PhosphothreonineCombined sources1
Modified residuei62PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei187PhosphoserineBy similarity1
Modified residuei189PhosphoserineBy similarity1
Modified residuei190PhosphoserineCombined sources1
Modified residuei211PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei229PhosphothreonineCombined sources1
Modified residuei260PhosphoserineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y3Q8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y3Q8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y3Q8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y3Q8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3Q8

PeptideAtlas

More...PeptideAtlasi		Q9Y3Q8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3Q8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		2262
86064 [Q9Y3Q8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3Q8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3Q8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166925, Expressed in C1 segment of cervical spinal cord and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y3Q8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3Q8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166925, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123563, 121 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y3Q8, 94 interactors

Molecular INTeraction database

More...MINTi		Q9Y3Q8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000300181

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y3Q8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y3Q8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3Q8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 86DisorderedSequence analysisAdd BLAST86
Regioni103 – 237DisorderedSequence analysisAdd BLAST135
Regioni344 – 365Leucine-zipperAdd BLAST22
Regioni376 – 395DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Polar residuesSequence analysisAdd BLAST21
Compositional biasi26 – 48Pro residuesSequence analysisAdd BLAST23
Compositional biasi193 – 210Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4797, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161400

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_052826_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3Q8

Identification of Orthologs from Complete Genome Data

More...OMAi		FYFFPDA

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3Q8

TreeFam database of animal gene trees

More...TreeFami		TF338725

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000580, TSC-22_Dip_Bun
IPR042553, TSC22D4

The PANTHER Classification System

More...PANTHERi		PTHR47610, PTHR47610, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01166, TSC22, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01289, TSC22, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3Q8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDP PTPQPPTGPP PRLPNGEPSP 
        60         70         80         90        100
DPGGKGTPRN GSPPPGAPSS RFRVVKLPHG LGEPYRRGRW TCVDVYERDL 
       110        120        130        140        150
EPHSFGGLLE GIRGASGGAG GRSLDSRLEL ASLGLGAPTP PSGLSQGPTS 
       160        170        180        190        200
WLRPPPTSPG PQARSFTGGL GQLVVPSKAK AEKPPLSASS PQQRPPEPET 
       210        220        230        240        250
GESAGTSRAA TPLPSLRVEA EAGGSGARTP PLSRRKAVDM RLRMELGAPE 
       260        270        280        290        300
EMGQVPPLDS RPSSPALYFT HDASLVHKSP DPFGAVAAQK FSLAHSMLAI 
       310        320        330        340        350
SGHLDSDDDS GSGSLVGIDN KIEQAMDLVK SHLMFAVREE VEVLKEQIRE 
       360        370        380        390 
LAERNAALEQ ENGLLRALAS PEQLAQLPSS GVPRLGPPAP NGPSV
Length:395
Mass (Da):41,026
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA08B5617C9BB151
GO
Isoform 2 (identifier: Q9Y3Q8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.

Show »
Length:156
Mass (Da):16,685
Checksum:iF240ECD884DDFFF6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ77H7BZ77_HUMAN
TSC22 domain family protein 4
TSC22D4
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0M8H7C0M8_HUMAN
TSC22 domain family protein 4
TSC22D4
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti355 – 356NA → KR in CAB43491 (PubMed:10488076).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036284329V → M in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0562451 – 239Missing in isoform 2. 1 PublicationAdd BLAST239

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ133115 mRNA Translation: CAB43491.1
AK297702 mRNA Translation: BAG60060.1
AC092849 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23831.1
CH471091 Genomic DNA Translation: EAW76527.1
CH471091 Genomic DNA Translation: EAW76528.1
CH471091 Genomic DNA Translation: EAW76529.1
CH471091 Genomic DNA Translation: EAW76531.1
BC001486 mRNA Translation: AAH01486.1
BC001966 mRNA Translation: AAH01966.1
BC002972 mRNA Translation: AAH02972.1
BC010406 mRNA Translation: AAH10406.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5695.1 [Q9Y3Q8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001289972.1, NM_001303043.1 [Q9Y3Q8-1]
NP_112197.1, NM_030935.4 [Q9Y3Q8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000300181.7; ENSP00000300181.2; ENSG00000166925.9
ENST00000393991.5; ENSP00000377560.1; ENSG00000166925.9 [Q9Y3Q8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81628

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81628

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000300181.7; ENSP00000300181.2; NM_030935.5; NP_112197.1

UCSC genome browser

More...UCSCi		uc003uva.3, human [Q9Y3Q8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133115 mRNA Translation: CAB43491.1
AK297702 mRNA Translation: BAG60060.1
AC092849 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23831.1
CH471091 Genomic DNA Translation: EAW76527.1
CH471091 Genomic DNA Translation: EAW76528.1
CH471091 Genomic DNA Translation: EAW76529.1
CH471091 Genomic DNA Translation: EAW76531.1
BC001486 mRNA Translation: AAH01486.1
BC001966 mRNA Translation: AAH01966.1
BC002972 mRNA Translation: AAH02972.1
BC010406 mRNA Translation: AAH10406.1
CCDSiCCDS5695.1 [Q9Y3Q8-1]
RefSeqiNP_001289972.1, NM_001303043.1 [Q9Y3Q8-1]
NP_112197.1, NM_030935.4 [Q9Y3Q8-1]

3D structure databases

AlphaFoldDBiQ9Y3Q8
SMRiQ9Y3Q8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123563, 121 interactors
IntActiQ9Y3Q8, 94 interactors
MINTiQ9Y3Q8
STRINGi9606.ENSP00000300181

PTM databases

iPTMnetiQ9Y3Q8
PhosphoSitePlusiQ9Y3Q8

Genetic variation databases

BioMutaiTSC22D4
DMDMi14195254

Proteomic databases

EPDiQ9Y3Q8
jPOSTiQ9Y3Q8
MassIVEiQ9Y3Q8
MaxQBiQ9Y3Q8
PaxDbiQ9Y3Q8
PeptideAtlasiQ9Y3Q8
PRIDEiQ9Y3Q8
ProteomicsDBi2262
86064 [Q9Y3Q8-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9Y3Q8, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1818, 137 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		81628

Genome annotation databases

EnsembliENST00000300181.7; ENSP00000300181.2; ENSG00000166925.9
ENST00000393991.5; ENSP00000377560.1; ENSG00000166925.9 [Q9Y3Q8-2]
GeneIDi81628
KEGGihsa:81628
MANE-SelectiENST00000300181.7; ENSP00000300181.2; NM_030935.5; NP_112197.1
UCSCiuc003uva.3, human [Q9Y3Q8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81628
DisGeNETi81628

GeneCards: human genes, protein and diseases

More...GeneCardsi		TSC22D4
HGNCiHGNC:21696, TSC22D4
HPAiENSG00000166925, Tissue enhanced (brain)
MIMi611914, gene
neXtProtiNX_Q9Y3Q8
OpenTargetsiENSG00000166925
PharmGKBiPA142670698
VEuPathDBiHostDB:ENSG00000166925

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4797, Eukaryota
GeneTreeiENSGT00940000161400
HOGENOMiCLU_052826_0_0_1
InParanoidiQ9Y3Q8
OMAiFYFFPDA
PhylomeDBiQ9Y3Q8
TreeFamiTF338725

Enzyme and pathway databases

PathwayCommonsiQ9Y3Q8
SignaLinkiQ9Y3Q8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81628, 16 hits in 1103 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TSC22D4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81628
PharosiQ9Y3Q8, Tbio

Protein Ontology

More...PROi		PR:Q9Y3Q8
RNActiQ9Y3Q8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166925, Expressed in C1 segment of cervical spinal cord and 230 other tissues
ExpressionAtlasiQ9Y3Q8, baseline and differential
GenevisibleiQ9Y3Q8, HS

Family and domain databases

InterProiView protein in InterPro
IPR000580, TSC-22_Dip_Bun
IPR042553, TSC22D4
PANTHERiPTHR47610, PTHR47610, 1 hit
PfamiView protein in Pfam
PF01166, TSC22, 1 hit
PROSITEiView protein in PROSITE
PS01289, TSC22, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT22D4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3Q8
Secondary accession number(s): A4D2C3, A8MWR6, D6W5V9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again