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Entry version 173 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Disintegrin and metalloproteinase domain-containing protein 18

Gene

ADAM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y3Q7

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.957

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 18
Short name:
ADAM 18
Alternative name(s):
Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Short name:
tMDC III
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAM18
Synonyms:TMDC3
ORF Names:UNQ858/PRO1867
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168619.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:196, ADAM18

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y3Q7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini177 – 687ExtracellularSequence analysisAdd BLAST511
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Topological domaini709 – 739CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8749

Open Targets

More...
OpenTargetsi
ENSG00000168619

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24513

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y3Q7, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADAM18

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20137582

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002909617 – 184Sequence analysisAdd BLAST168
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000029097185 – 739Disintegrin and metalloproteinase domain-containing protein 18Add BLAST555

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi293 ↔ 376By similarity
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 360By similarity
Disulfide bondi337 ↔ 342By similarity
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi450 ↔ 471By similarity
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi611N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi624 ↔ 636By similarity
Glycosylationi625N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y3Q7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y3Q7

PeptideAtlas

More...
PeptideAtlasi
Q9Y3Q7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y3Q7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
86061 [Q9Y3Q7-1]
86062 [Q9Y3Q7-2]
86063 [Q9Y3Q7-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Y3Q7, 12 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y3Q7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y3Q7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168619, Expressed in testis and 44 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y3Q7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y3Q7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168619, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
114285, 74 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265707

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y3Q7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y3Q7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini184 – 381Peptidase M12BPROSITE-ProRule annotationAdd BLAST198
Domaini390 – 479DisintegrinPROSITE-ProRule annotationAdd BLAST90
Domaini620 – 654EGF-likeAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi480 – 622Cys-richAdd BLAST143

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.By similarity

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3607, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162281

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012714_4_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y3Q7

KEGG Orthology (KO)

More...
KOi
K16909

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECQFKNC

Database of Orthologous Groups

More...
OrthoDBi
162519at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y3Q7

TreeFam database of animal gene trees

More...
TreeFami
TF314733

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04269, ZnMc_adamalysin_II_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.390.10, 1 hit
4.10.70.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006586, ADAM_Cys-rich
IPR018358, Disintegrin_CS
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR034027, Reprolysin_adamalysin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08516, ADAM_CR, 1 hit
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00608, ACR, 1 hit
SM00050, DISIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57552, SSF57552, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS00427, DISINTEGRIN_1, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFLLLALLTE LGRLQAHEGS EGIFLHVTVP RKIKSNDSEV SERKMIYIIT
60 70 80 90 100
IDGQPYTLHL GKQSFLPQNF LVYTYNETGS LHSVSPYFMM HCHYQGYAAE
110 120 130 140 150
FPNSFVTLSI CSGLRGFLQF ENISYGIEPV ESSARFEHII YQMKNNDPNV
160 170 180 190 200
SILAVNYSHI WQKDQPYKVP LNSQIKNLSK LLPQYLEIYI IVEKALYDYM
210 220 230 240 250
GSEMMAVTQK IVQVIGLVNT MFTQFKLTVI LSSLELWSNE NQISTSGDAD
260 270 280 290 300
DILQRFLAWK RDYLILRPHD IAYLLVYRKH PKYVGATFPG TVCNKSYDAG
310 320 330 340 350
IAMYPDAIGL EGFSVIIAQL LGLNVGLTYD DITQCFCLRA TCIMNHEAVS
360 370 380 390 400
ASGRKIFSNC SMHDYRYFVS KFETKCLQKL SNLQPLHQNQ PVCGNGILES
410 420 430 440 450
NEECDCGNKN ECQFKKCCDY NTCKLKGSVK CGSGPCCTSK CELSIAGTPC
460 470 480 490 500
RKSIDPECDF TEYCNGTSSN CVPDTYALNG RLCKLGTAYC YNGQCQTTDN
510 520 530 540 550
QCAKIFGKGA QGAPFACFKE VNSLHERSEN CGFKNSQPLP CERKDVLCGK
560 570 580 590 600
LACVQPHKNA NKSDAQSTVY SYIQDHVCVS IATGSSMRSD GTDNAYVADG
610 620 630 640 650
TMCGPEMYCV NKTCRKVHLM GYNCNATTKC KGKGICNNFG NCQCFPGHRP
660 670 680 690 700
PDCKFQFGSP GGSIDDGNFQ KSGDFYTEKG YNTHWNNWFI LSFCIFLPFF
710 720 730
IVFTTVIFKR NEISKSCNRE NAEYNRNSSV VSESDDVGH
Length:739
Mass (Da):82,856
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D8BE9A975072CDD
GO
Isoform 2 (identifier: Q9Y3Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-220: Missing.

Show »
Length:715
Mass (Da):80,183
Checksum:iEF8EB71EBA6AB9DB
GO
Isoform 3 (identifier: Q9Y3Q7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-182: IKNLSKLL → VTVIILML
     183-739: Missing.

Show »
Length:182
Mass (Da):20,853
Checksum:i8B524D83BC944C8B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RK96E5RK96_HUMAN
Disintegrin and metalloproteinase d...
ADAM18
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIP0E5RIP0_HUMAN
Disintegrin and metalloproteinase d...
ADAM18
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_066312170P → S in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267601916Ensembl.1
Natural variantiVAR_051588212V → F. Corresponds to variant dbSNP:rs10093794Ensembl.1
Natural variantiVAR_066313284V → G in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066314344M → I in a cutaneous metastatic melanoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs267601918Ensembl.1
Natural variantiVAR_066315362M → K in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_066316536S → L in a cutaneous metastatic melanoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043285175 – 182IKNLSKLL → VTVIILML in isoform 3. 1 Publication8
Alternative sequenceiVSP_043286183 – 739Missing in isoform 3. 1 PublicationAdd BLAST557
Alternative sequenceiVSP_012033197 – 220Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ133004 mRNA Translation: CAB40812.1
AY358321 mRNA Translation: AAQ88687.1
AK313961 mRNA Translation: BAG36677.1
AC109633 Genomic DNA No translation available.
AC136365 Genomic DNA No translation available.
BC034624 mRNA Translation: AAH34624.1
BC070279 mRNA Translation: AAH70279.1
BC121045 mRNA Translation: AAI21046.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55225.1 [Q9Y3Q7-3]
CCDS6113.1 [Q9Y3Q7-1]
CCDS83287.1 [Q9Y3Q7-2]

NCBI Reference Sequences

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RefSeqi
NP_001177885.1, NM_001190956.1 [Q9Y3Q7-3]
NP_001307242.1, NM_001320313.1 [Q9Y3Q7-2]
NP_055052.1, NM_014237.2 [Q9Y3Q7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000265707; ENSP00000265707; ENSG00000168619 [Q9Y3Q7-1]
ENST00000379866; ENSP00000369195; ENSG00000168619 [Q9Y3Q7-2]
ENST00000520772; ENSP00000429908; ENSG00000168619 [Q9Y3Q7-3]
ENST00000613609; ENSP00000482348; ENSG00000278548 [Q9Y3Q7-1]
ENST00000633688; ENSP00000488128; ENSG00000278548 [Q9Y3Q7-3]
ENST00000633768; ENSP00000488176; ENSG00000278548 [Q9Y3Q7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8749

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8749

UCSC genome browser

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UCSCi
uc003xnh.4, human [Q9Y3Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133004 mRNA Translation: CAB40812.1
AY358321 mRNA Translation: AAQ88687.1
AK313961 mRNA Translation: BAG36677.1
AC109633 Genomic DNA No translation available.
AC136365 Genomic DNA No translation available.
BC034624 mRNA Translation: AAH34624.1
BC070279 mRNA Translation: AAH70279.1
BC121045 mRNA Translation: AAI21046.1
CCDSiCCDS55225.1 [Q9Y3Q7-3]
CCDS6113.1 [Q9Y3Q7-1]
CCDS83287.1 [Q9Y3Q7-2]
RefSeqiNP_001177885.1, NM_001190956.1 [Q9Y3Q7-3]
NP_001307242.1, NM_001320313.1 [Q9Y3Q7-2]
NP_055052.1, NM_014237.2 [Q9Y3Q7-1]

3D structure databases

SMRiQ9Y3Q7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114285, 74 interactors
STRINGi9606.ENSP00000265707

Protein family/group databases

MEROPSiM12.957

PTM databases

GlyGeniQ9Y3Q7, 12 sites
iPTMnetiQ9Y3Q7
PhosphoSitePlusiQ9Y3Q7

Polymorphism and mutation databases

BioMutaiADAM18
DMDMi20137582

Proteomic databases

MassIVEiQ9Y3Q7
PaxDbiQ9Y3Q7
PeptideAtlasiQ9Y3Q7
PRIDEiQ9Y3Q7
ProteomicsDBi86061 [Q9Y3Q7-1]
86062 [Q9Y3Q7-2]
86063 [Q9Y3Q7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23870, 38 antibodies

Genome annotation databases

EnsembliENST00000265707; ENSP00000265707; ENSG00000168619 [Q9Y3Q7-1]
ENST00000379866; ENSP00000369195; ENSG00000168619 [Q9Y3Q7-2]
ENST00000520772; ENSP00000429908; ENSG00000168619 [Q9Y3Q7-3]
ENST00000613609; ENSP00000482348; ENSG00000278548 [Q9Y3Q7-1]
ENST00000633688; ENSP00000488128; ENSG00000278548 [Q9Y3Q7-3]
ENST00000633768; ENSP00000488176; ENSG00000278548 [Q9Y3Q7-2]
GeneIDi8749
KEGGihsa:8749
UCSCiuc003xnh.4, human [Q9Y3Q7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8749
DisGeNETi8749
EuPathDBiHostDB:ENSG00000168619.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ADAM18
HGNCiHGNC:196, ADAM18
HPAiENSG00000168619, Tissue enriched (testis)
neXtProtiNX_Q9Y3Q7
OpenTargetsiENSG00000168619
PharmGKBiPA24513

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3607, Eukaryota
GeneTreeiENSGT00940000162281
HOGENOMiCLU_012714_4_3_1
InParanoidiQ9Y3Q7
KOiK16909
OMAiECQFKNC
OrthoDBi162519at2759
PhylomeDBiQ9Y3Q7
TreeFamiTF314733

Enzyme and pathway databases

PathwayCommonsiQ9Y3Q7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
8749, 2 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADAM18, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ADAM18

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8749
PharosiQ9Y3Q7, Tdark

Protein Ontology

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PROi
PR:Q9Y3Q7
RNActiQ9Y3Q7, protein

Gene expression databases

BgeeiENSG00000168619, Expressed in testis and 44 other tissues
ExpressionAtlasiQ9Y3Q7, baseline and differential
GenevisibleiQ9Y3Q7, HS

Family and domain databases

CDDicd04269, ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586, ADAM_Cys-rich
IPR018358, Disintegrin_CS
IPR001762, Disintegrin_dom
IPR036436, Disintegrin_dom_sf
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR034027, Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516, ADAM_CR, 1 hit
PF00200, Disintegrin, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
SMARTiView protein in SMART
SM00608, ACR, 1 hit
SM00050, DISIN, 1 hit
SUPFAMiSSF57552, SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS00427, DISINTEGRIN_1, 1 hit
PS50214, DISINTEGRIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3Q7
Secondary accession number(s): B2R9Y0
, Q0VAI4, Q6IRW9, Q6UXJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 173 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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