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UniProtKB - Q9Y3Q4 (HCN4_HUMAN)
Protein
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene
HCN4
Organism
Homo sapiens (Human)
Status
Functioni
Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.
5 PublicationsMiscellaneous
Inhibited by extracellular cesium ions.
Activity regulationi
Activated by cAMP. cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening.3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 659 – 662 | 3',5'-cAMP2 Publications | 4 | |
Nucleotide bindingi | 669 – 670 | 3',5'-cAMP2 Publications | 2 | |
Nucleotide bindingi | 710 – 713 | 3',5'-cAMP2 Publications | 4 |
GO - Molecular functioni
- cAMP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- intracellular cAMP-activated cation channel activity Source: UniProtKB
- voltage-gated potassium channel activity Source: UniProtKB
- voltage-gated potassium channel activity involved in SA node cell action potential depolarization Source: BHF-UCL
- voltage-gated sodium channel activity Source: UniProtKB
GO - Biological processi
- blood circulation Source: ProtInc
- cardiac conduction system development Source: BHF-UCL
- cation transport Source: BHF-UCL
- cellular response to cAMP Source: UniProtKB
- cellular response to cGMP Source: UniProtKB
- membrane depolarization during cardiac muscle cell action potential Source: BHF-UCL
- membrane depolarization during SA node cell action potential Source: BHF-UCL
- muscle contraction Source: ProtInc
- potassium ion import across plasma membrane Source: BHF-UCL
- potassium ion transmembrane transport Source: UniProtKB
- regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
- regulation of cardiac muscle contraction Source: BHF-UCL
- regulation of heart rate Source: UniProtKB
- regulation of heart rate by cardiac conduction Source: BHF-UCL
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of membrane depolarization Source: BHF-UCL
- regulation of membrane potential Source: UniProtKB
- SA node cell action potential Source: BHF-UCL
- sinoatrial node development Source: BHF-UCL
- sodium ion import across plasma membrane Source: BHF-UCL
- sodium ion transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Sodium transport, Transport |
Ligand | cAMP, cAMP-binding, Nucleotide-binding, Potassium, Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Q4 |
Reactomei | R-HSA-1296061, HCN channels |
SignaLinki | Q9Y3Q4 |
SIGNORi | Q9Y3Q4 |
Protein family/group databases
TCDBi | 1.A.1.5.10, the voltage-gated ion channel (vic) superfamily 1.A.1.5.11, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
Gene namesi | Name:HCN4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16882, HCN4 |
MIMi | 605206, gene |
neXtProti | NX_Q9Y3Q4 |
VEuPathDBi | HostDB:ENSG00000138622 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications
Plasma Membrane
- HCN channel complex Source: BHF-UCL
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- perinuclear region of cytoplasm Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 266 | CytoplasmicSequence analysisAdd BLAST | 266 | |
Transmembranei | 267 – 287 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 288 – 293 | ExtracellularSequence analysis | 6 | |
Transmembranei | 294 – 314 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 340 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 341 – 361 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 362 – 368 | ExtracellularSequence analysis | 7 | |
Transmembranei | 369 – 389 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 390 – 420 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 421 – 441 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 442 – 464 | ExtracellularSequence analysisAdd BLAST | 23 | |
Intramembranei | 465 – 486 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 487 – 496 | ExtracellularSequence analysis | 10 | |
Transmembranei | 497 – 517 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 518 – 1203 | CytoplasmicSequence analysisAdd BLAST | 686 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Sick sinus syndrome 2 (SSS2)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionThe term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors. SSS2 onset is in utero or at birth.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066614 | 485 | A → V in SSS2; results in a significant reduction of current density compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs1454748709Ensembl. | 1 | |
Natural variantiVAR_026534 | 553 | D → N in SSS2. 1 PublicationCorresponds to variant dbSNP:rs104894485EnsemblClinVar. | 1 | |
Natural variantiVAR_026535 | 672 | S → R in SSS2; results in decreased affinity for cAMP but does not abolish channel activation; shifts the current activation range to hyperpolarized voltages; slows channel opening and speeds up channel closure. 2 PublicationsCorresponds to variant dbSNP:rs104894488EnsemblClinVar. | 1 |
Brugada syndrome 8 (BRGDA8)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionA tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
Related information in OMIMKeywords - Diseasei
Brugada syndrome, Disease variantOrganism-specific databases
DisGeNETi | 10021 |
GeneReviewsi | HCN4 |
MalaCardsi | HCN4 |
MIMi | 163800, phenotype 613123, phenotype |
OpenTargetsi | ENSG00000138622 |
Orphaneti | 130, Brugada syndrome 166282, Familial sick sinus syndrome |
PharmGKBi | PA394 |
Miscellaneous databases
Pharosi | Q9Y3Q4, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1250417 |
DrugCentrali | Q9Y3Q4 |
GuidetoPHARMACOLOGYi | 403 |
Genetic variation databases
BioMutai | HCN4 |
DMDMi | 38605641 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054117 | 1 – 1203 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4Add BLAST | 1203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 138 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1105 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1108 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9Y3Q4 |
jPOSTi | Q9Y3Q4 |
MassIVEi | Q9Y3Q4 |
MaxQBi | Q9Y3Q4 |
PaxDbi | Q9Y3Q4 |
PeptideAtlasi | Q9Y3Q4 |
PRIDEi | Q9Y3Q4 |
ProteomicsDBi | 86060 |
PTM databases
GlyGeni | Q9Y3Q4, 1 site |
iPTMneti | Q9Y3Q4 |
PhosphoSitePlusi | Q9Y3Q4 |
Expressioni
Tissue specificityi
Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.2 Publications
Gene expression databases
Bgeei | ENSG00000138622, Expressed in heart left ventricle and 76 other tissues |
Genevisiblei | Q9Y3Q4, HS |
Organism-specific databases
HPAi | ENSG00000138622, Group enriched (brain, heart muscle, testis) |
Interactioni
Subunit structurei
Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.
2 PublicationsBinary interactionsi
Q9Y3Q4
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-1753521,EBI-1753521 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 115338, 4 interactors |
ComplexPortali | CPX-131, HCN4 channel complex |
DIPi | DIP-52325N |
IntActi | Q9Y3Q4, 3 interactors |
STRINGi | 9606.ENSP00000261917 |
Chemistry databases
BindingDBi | Q9Y3Q4 |
Miscellaneous databases
RNActi | Q9Y3Q4, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y3Q4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y3Q4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 182 | DisorderedSequence analysisAdd BLAST | 182 | |
Regioni | 209 – 260 | Involved in subunit assemblyBy similarityAdd BLAST | 52 | |
Regioni | 836 – 856 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 870 – 897 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 918 – 1203 | DisorderedSequence analysisAdd BLAST | 286 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 106 – 120 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 121 – 137 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 159 – 175 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 918 – 937 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 1027 – 1041 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1055 – 1070 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1082 – 1107 | Polar residuesSequence analysisAdd BLAST | 26 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel HCN family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0498, Eukaryota |
GeneTreei | ENSGT00940000154743 |
HOGENOMi | CLU_005746_15_0_1 |
InParanoidi | Q9Y3Q4 |
OMAi | PCYTPSG |
OrthoDBi | 281394at2759 |
PhylomeDBi | Q9Y3Q4 |
TreeFami | TF318250 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR013621, Ion_trans_N IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF08412, Ion_trans_N, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y3Q4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKLPPSMRK RLYSLPQQVG AKAWIMDEEE DAEEEGAGGR QDPSRRSIRL
60 70 80 90 100
RPLPSPSPSA AAGGTESRSS ALGAADSEGP ARGAGKSSTN GDCRRFRGSL
110 120 130 140 150
ASLGSRGGGS GGTGSGSSHG HLHDSAEERR LIAEGDASPG EDRTPPGLAA
160 170 180 190 200
EPERPGASAQ PAASPPPPQQ PPQPASASCE QPSVDTAIKV EGGAAAGDQI
210 220 230 240 250
LPEAEVRLGQ AGFMQRQFGA MLQPGVNKFS LRMFGSQKAV EREQERVKSA
260 270 280 290 300
GFWIIHPYSD FRFYWDLTML LLMVGNLIII PVGITFFKDE NTTPWIVFNV
310 320 330 340 350
VSDTFFLIDL VLNFRTGIVV EDNTEIILDP QRIKMKYLKS WFMVDFISSI
360 370 380 390 400
PVDYIFLIVE TRIDSEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ
410 420 430 440 450
WEEIFHMTYD LASAVVRIVN LIGMMLLLCH WDGCLQFLVP MLQDFPDDCW
460 470 480 490 500
VSINNMVNNS WGKQYSYALF KAMSHMLCIG YGRQAPVGMS DVWLTMLSMI
510 520 530 540 550
VGATCYAMFI GHATALIQSL DSSRRQYQEK YKQVEQYMSF HKLPPDTRQR
560 570 580 590 600
IHDYYEHRYQ GKMFDEESIL GELSEPLREE IINFNCRKLV ASMPLFANAD
610 620 630 640 650
PNFVTSMLTK LRFEVFQPGD YIIREGTIGK KMYFIQHGVV SVLTKGNKET
660 670 680 690 700
KLADGSYFGE ICLLTRGRRT ASVRADTYCR LYSLSVDNFN EVLEEYPMMR
710 720 730 740 750
RAFETVALDR LDRIGKKNSI LLHKVQHDLN SGVFNYQENE IIQQIVQHDR
760 770 780 790 800
EMAHCAHRVQ AAASATPTPT PVIWTPLIQA PLQAAAATTS VAIALTHHPR
810 820 830 840 850
LPAAIFRPPP GSGLGNLGAG QTPRHLKRLQ SLIPSALGSA SPASSPSQVD
860 870 880 890 900
TPSSSSFHIQ QLAGFSAPAG LSPLLPSSSS SPPPGACGSP SAPTPSAGVA
910 920 930 940 950
ATTIAGFGHF HKALGGSLSS SDSPLLTPLQ PGARSPQAAQ PSPAPPGARG
960 970 980 990 1000
GLGLPEHFLP PPPSSRSPSS SPGQLGQPPG ELSLGLATGP LSTPETPPRQ
1010 1020 1030 1040 1050
PEPPSLVAGA SGGASPVGFT PRGGLSPPGH SPGPPRTFPS APPRASGSHG
1060 1070 1080 1090 1100
SLLLPPASSP PPPQVPQRRG TPPLTPGRLT QDLKLISASQ PALPQDGAQT
1110 1120 1130 1140 1150
LRRASPHSSG ESMAAFPLFP RAGGGSGGSG SSGGLGPPGR PYGAIPGQHV
1160 1170 1180 1190 1200
TLPRKTSSGS LPPPLSLFGA RATSSGGPPL TAGPQREPGA RPEPVRSKLP
SNL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 110 | S → T in CAB52754 (PubMed:10430953).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_066614 | 485 | A → V in SSS2; results in a significant reduction of current density compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs1454748709Ensembl. | 1 | |
Natural variantiVAR_026534 | 553 | D → N in SSS2. 1 PublicationCorresponds to variant dbSNP:rs104894485EnsemblClinVar. | 1 | |
Natural variantiVAR_026535 | 672 | S → R in SSS2; results in decreased affinity for cAMP but does not abolish channel activation; shifts the current activation range to hyperpolarized voltages; slows channel opening and speeds up channel closure. 2 PublicationsCorresponds to variant dbSNP:rs104894488EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132429 mRNA Translation: CAB42604.1 AJ238850 mRNA Translation: CAB52754.1 |
CCDSi | CCDS10248.1 |
RefSeqi | NP_005468.1, NM_005477.2 |
Genome annotation databases
Ensembli | ENST00000261917; ENSP00000261917; ENSG00000138622 |
GeneIDi | 10021 |
KEGGi | hsa:10021 |
MANE-Selecti | ENST00000261917.4; ENSP00000261917.3; NM_005477.3; NP_005468.1 |
UCSCi | uc002avp.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ132429 mRNA Translation: CAB42604.1 AJ238850 mRNA Translation: CAB52754.1 |
CCDSi | CCDS10248.1 |
RefSeqi | NP_005468.1, NM_005477.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MNG | NMR | - | A | 579-707 | [»] | |
3OTF | X-ray | 2.40 | A | 521-739 | [»] | |
3U11 | X-ray | 2.50 | A/B | 521-723 | [»] | |
4HBN | X-ray | 2.60 | A | 521-724 | [»] | |
4KL1 | X-ray | 2.70 | A/B/C/D | 521-713 | [»] | |
4NVP | X-ray | 2.50 | A | 521-723 | [»] | |
6GYN | electron microscopy | 3.40 | A/B/C/D | 201-719 | [»] | |
6GYO | electron microscopy | 3.40 | A/B/C/D | 201-719 | [»] | |
SMRi | Q9Y3Q4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115338, 4 interactors |
ComplexPortali | CPX-131, HCN4 channel complex |
DIPi | DIP-52325N |
IntActi | Q9Y3Q4, 3 interactors |
STRINGi | 9606.ENSP00000261917 |
Chemistry databases
BindingDBi | Q9Y3Q4 |
ChEMBLi | CHEMBL1250417 |
DrugCentrali | Q9Y3Q4 |
GuidetoPHARMACOLOGYi | 403 |
Protein family/group databases
TCDBi | 1.A.1.5.10, the voltage-gated ion channel (vic) superfamily 1.A.1.5.11, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | Q9Y3Q4, 1 site |
iPTMneti | Q9Y3Q4 |
PhosphoSitePlusi | Q9Y3Q4 |
Genetic variation databases
BioMutai | HCN4 |
DMDMi | 38605641 |
Proteomic databases
EPDi | Q9Y3Q4 |
jPOSTi | Q9Y3Q4 |
MassIVEi | Q9Y3Q4 |
MaxQBi | Q9Y3Q4 |
PaxDbi | Q9Y3Q4 |
PeptideAtlasi | Q9Y3Q4 |
PRIDEi | Q9Y3Q4 |
ProteomicsDBi | 86060 |
Protocols and materials databases
ABCDi | Q9Y3Q4, 1 sequenced antibody |
Antibodypediai | 26787, 182 antibodies from 31 providers |
DNASUi | 10021 |
Genome annotation databases
Ensembli | ENST00000261917; ENSP00000261917; ENSG00000138622 |
GeneIDi | 10021 |
KEGGi | hsa:10021 |
MANE-Selecti | ENST00000261917.4; ENSP00000261917.3; NM_005477.3; NP_005468.1 |
UCSCi | uc002avp.3, human |
Organism-specific databases
CTDi | 10021 |
DisGeNETi | 10021 |
GeneCardsi | HCN4 |
GeneReviewsi | HCN4 |
HGNCi | HGNC:16882, HCN4 |
HPAi | ENSG00000138622, Group enriched (brain, heart muscle, testis) |
MalaCardsi | HCN4 |
MIMi | 163800, phenotype 605206, gene 613123, phenotype |
neXtProti | NX_Q9Y3Q4 |
OpenTargetsi | ENSG00000138622 |
Orphaneti | 130, Brugada syndrome 166282, Familial sick sinus syndrome |
PharmGKBi | PA394 |
VEuPathDBi | HostDB:ENSG00000138622 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0498, Eukaryota |
GeneTreei | ENSGT00940000154743 |
HOGENOMi | CLU_005746_15_0_1 |
InParanoidi | Q9Y3Q4 |
OMAi | PCYTPSG |
OrthoDBi | 281394at2759 |
PhylomeDBi | Q9Y3Q4 |
TreeFami | TF318250 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3Q4 |
Reactomei | R-HSA-1296061, HCN channels |
SignaLinki | Q9Y3Q4 |
SIGNORi | Q9Y3Q4 |
Miscellaneous databases
BioGRID-ORCSi | 10021, 10 hits in 1030 CRISPR screens |
ChiTaRSi | HCN4, human |
EvolutionaryTracei | Q9Y3Q4 |
GeneWikii | HCN4 |
GenomeRNAii | 10021 |
Pharosi | Q9Y3Q4, Tclin |
PROi | PR:Q9Y3Q4 |
RNActi | Q9Y3Q4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000138622, Expressed in heart left ventricle and 76 other tissues |
Genevisiblei | Q9Y3Q4, HS |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR013621, Ion_trans_N IPR003938, K_chnl_volt-dep_EAG/ELK/ERG IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit PF08412, Ion_trans_N, 1 hit |
PRINTSi | PR01463, EAGCHANLFMLY |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HCN4_HUMAN | |
Accessioni | Q9Y3Q4Primary (citable) accession number: Q9Y3Q4 Secondary accession number(s): Q9UMQ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families