UniProtKB - Q9Y3N9 (OR2W1_HUMAN)
Protein
Olfactory receptor 2W1
Gene
OR2W1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 2W1Alternative name(s): Hs6M1-15 Olfactory receptor OR6-13 |
Gene namesi | Name:OR2W1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204704.2 |
HGNCi | HGNC:8281 OR2W1 |
neXtProti | NX_Q9Y3N9 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 79 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 80 – 100 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 101 – 120 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 121 – 139 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 140 – 158 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 159 – 195 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 196 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 24 | |
Topological domaini | 220 – 236 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 237 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 260 – 272 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 273 – 292 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 293 – 320 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 26692 |
PharmGKBi | PA32214 |
Polymorphism and mutation databases
BioMutai | OR2W1 |
DMDMi | 14423828 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150511 | 1 – 320 | Olfactory receptor 2W1Add BLAST | 320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 189 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9Y3N9 |
PeptideAtlasi | Q9Y3N9 |
PRIDEi | Q9Y3N9 |
ProteomicsDBi | 86051 |
PTM databases
iPTMneti | Q9Y3N9 |
PhosphoSitePlusi | Q9Y3N9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000204704 Expressed in 5 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9Y3N9 baseline and differential |
Genevisiblei | Q9Y3N9 HS |
Interactioni
Protein-protein interaction databases
BioGridi | 117792, 1 interactor |
STRINGi | 9606.ENSP00000366380 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IVP3 Eukaryota ENOG4111D99 LUCA |
GeneTreei | ENSGT00940000153455 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q9Y3N9 |
KOi | K04257 |
OMAi | LNLPTCG |
OrthoDBi | 897235at2759 |
PhylomeDBi | Q9Y3N9 |
TreeFami | TF336512 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y3N9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDQSNYSSLH GFILLGFSNH PKMEMILSGV VAIFYLITLV GNTAIILASL
60 70 80 90 100
LDSQLHTPMY FFLRNLSFLD LCFTTSIIPQ MLVNLWGPDK TISYVGCIIQ
110 120 130 140 150
LYVYMWLGSV ECLLLAVMSY DRFTAICKPL HYFVVMNPHL CLKMIIMIWS
160 170 180 190 200
ISLANSVVLC TLTLNLPTCG NNILDHFLCE LPALVKIACV DTTTVEMSVF
210 220 230 240 250
ALGIIIVLTP LILILISYGY IAKAVLRTKS KASQRKAMNT CGSHLTVVSM
260 270 280 290 300
FYGTIIYMYL QPGNRASKDQ GKFLTLFYTV ITPSLNPLIY TLRNKDMKDA
310 320
LKKLMRFHHK STKIKRNCKS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010953 | 81 | M → V in allele 6M1-15*03. 1 PublicationCorresponds to variant dbSNP:rs34892006Ensembl. | 1 | |
Natural variantiVAR_010954 | 296 | D → N in allele 6M1-15*02. 1 PublicationCorresponds to variant dbSNP:rs35771565Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302594 Genomic DNA Translation: CAC20514.1 AJ302595 Genomic DNA Translation: CAC20515.1 AJ302596 Genomic DNA Translation: CAC20516.1 AJ302597 Genomic DNA Translation: CAC20517.1 AJ302598 Genomic DNA Translation: CAC20518.1 AJ302599 Genomic DNA Translation: CAC20519.1 AJ302600 Genomic DNA Translation: CAC20520.1 AJ302601 Genomic DNA Translation: CAC20521.1 AJ302602 Genomic DNA Translation: CAC20522.1 AJ302603 Genomic DNA Translation: CAC20523.1 AL035402 Genomic DNA Translation: CAB42853.1 AL662791 Genomic DNA No translation available. AL662865 Genomic DNA No translation available. AL929561 Genomic DNA No translation available. BX248413 Genomic DNA No translation available. CR759957 Genomic DNA No translation available. BX927167 Genomic DNA No translation available. CR936923 Genomic DNA No translation available. CR759835 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03181.1 BC103870 mRNA Translation: AAI03871.1 BC103871 mRNA Translation: AAI03872.1 BC103872 mRNA Translation: AAI03873.1 AF399628 Genomic DNA Translation: AAK95113.1 BK004522 Genomic DNA Translation: DAA04920.1 |
CCDSi | CCDS4656.1 |
RefSeqi | NP_112165.1, NM_030903.3 |
UniGenei | Hs.553526 |
Genome annotation databases
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302594 Genomic DNA Translation: CAC20514.1 AJ302595 Genomic DNA Translation: CAC20515.1 AJ302596 Genomic DNA Translation: CAC20516.1 AJ302597 Genomic DNA Translation: CAC20517.1 AJ302598 Genomic DNA Translation: CAC20518.1 AJ302599 Genomic DNA Translation: CAC20519.1 AJ302600 Genomic DNA Translation: CAC20520.1 AJ302601 Genomic DNA Translation: CAC20521.1 AJ302602 Genomic DNA Translation: CAC20522.1 AJ302603 Genomic DNA Translation: CAC20523.1 AL035402 Genomic DNA Translation: CAB42853.1 AL662791 Genomic DNA No translation available. AL662865 Genomic DNA No translation available. AL929561 Genomic DNA No translation available. BX248413 Genomic DNA No translation available. CR759957 Genomic DNA No translation available. BX927167 Genomic DNA No translation available. CR936923 Genomic DNA No translation available. CR759835 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03181.1 BC103870 mRNA Translation: AAI03871.1 BC103871 mRNA Translation: AAI03872.1 BC103872 mRNA Translation: AAI03873.1 AF399628 Genomic DNA Translation: AAK95113.1 BK004522 Genomic DNA Translation: DAA04920.1 |
CCDSi | CCDS4656.1 |
RefSeqi | NP_112165.1, NM_030903.3 |
UniGenei | Hs.553526 |
3D structure databases
ProteinModelPortali | Q9Y3N9 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 117792, 1 interactor |
STRINGi | 9606.ENSP00000366380 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q9Y3N9 |
PhosphoSitePlusi | Q9Y3N9 |
Polymorphism and mutation databases
BioMutai | OR2W1 |
DMDMi | 14423828 |
Proteomic databases
PaxDbi | Q9Y3N9 |
PeptideAtlasi | Q9Y3N9 |
PRIDEi | Q9Y3N9 |
ProteomicsDBi | 86051 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Organism-specific databases
CTDi | 26692 |
DisGeNETi | 26692 |
EuPathDBi | HostDB:ENSG00000204704.2 |
GeneCardsi | OR2W1 |
HGNCi | HGNC:8281 OR2W1 |
neXtProti | NX_Q9Y3N9 |
PharmGKBi | PA32214 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IVP3 Eukaryota ENOG4111D99 LUCA |
GeneTreei | ENSGT00940000153455 |
HOGENOMi | HOG000041362 |
HOVERGENi | HBG017625 |
InParanoidi | Q9Y3N9 |
KOi | K04257 |
OMAi | LNLPTCG |
OrthoDBi | 897235at2759 |
PhylomeDBi | Q9Y3N9 |
TreeFami | TF336512 |
Enzyme and pathway databases
Reactomei | R-HSA-381753 Olfactory Signaling Pathway |
Miscellaneous databases
GeneWikii | OR2W1 |
GenomeRNAii | 26692 |
PROi | PR:Q9Y3N9 |
Gene expression databases
Bgeei | ENSG00000204704 Expressed in 5 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9Y3N9 baseline and differential |
Genevisiblei | Q9Y3N9 HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000725 Olfact_rcpt |
Pfami | View protein in Pfam PF13853 7tm_4, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR00245 OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | OR2W1_HUMAN | |
Accessioni | Q9Y3N9Primary (citable) accession number: Q9Y3N9 Secondary accession number(s): B0S7Y5 Q9GZL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 13, 2019 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries