UniProtKB - Q9Y3M9 (ZN337_HUMAN)
Protein
Zinc finger protein 337
Gene
ZNF337
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 180 – 202 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 208 – 230 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 236 – 258 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 264 – 286 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 292 – 314 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 348 – 370 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 376 – 398 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 404 – 426 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 460 – 482 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 538 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 544 – 566 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 572 – 594 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 600 – 622 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 628 – 650 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 656 – 679 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 685 – 707 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 713 – 735 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3M9 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 337 |
Gene namesi | Name:ZNF337 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15809, ZNF337 |
neXtProti | NX_Q9Y3M9 |
VEuPathDBi | HostDB:ENSG00000130684.13 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26152 |
OpenTargetsi | ENSG00000130684 |
PharmGKBi | PA38043 |
Miscellaneous databases
Pharosi | Q9Y3M9, Tdark |
Genetic variation databases
BioMutai | ZNF337 |
DMDMi | 20141069 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047540 | 1 – 751 | Zinc finger protein 337Add BLAST | 751 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 458 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9Y3M9 |
jPOSTi | Q9Y3M9 |
MassIVEi | Q9Y3M9 |
PaxDbi | Q9Y3M9 |
PeptideAtlasi | Q9Y3M9 |
PRIDEi | Q9Y3M9 |
ProteomicsDBi | 5036 86050 [Q9Y3M9-1] |
PTM databases
iPTMneti | Q9Y3M9 |
PhosphoSitePlusi | Q9Y3M9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130684, Expressed in right hemisphere of cerebellum and 237 other tissues |
Genevisiblei | Q9Y3M9, HS |
Organism-specific databases
HPAi | ENSG00000130684, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9Y3M9
Protein-protein interaction databases
BioGRIDi | 117583, 10 interactors |
IntActi | Q9Y3M9, 12 interactors |
MINTi | Q9Y3M9 |
STRINGi | 9606.ENSP00000365619 |
Miscellaneous databases
RNActi | Q9Y3M9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 83 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 180 – 202 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 208 – 230 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 236 – 258 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 264 – 286 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 292 – 314 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 320 – 342 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 348 – 370 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 376 – 398 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 404 – 426 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 432 – 454 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 460 – 482 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 488 – 510 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 516 – 538 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 544 – 566 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 572 – 594 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 600 – 622 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 628 – 650 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 656 – 679 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 685 – 707 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 713 – 735 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164820 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9Y3M9 |
OMAi | KTVMGPQ |
OrthoDBi | 908238at2759 |
PhylomeDBi | Q9Y3M9 |
TreeFami | TF343410 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 20 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 12 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 19 hits PS50157, ZINC_FINGER_C2H2_2, 20 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Y3M9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPQGARRQA FLAFGDVTVD FTQKEWRLLS PAQRALYREV TLENYSHLVS
60 70 80 90 100
LGILHSKPEL IRRLEQGEVP WGEERRRRPG PCAGIYAEHV LRPKNLGLAH
110 120 130 140 150
QRQQQLQFSD QSFQSDTAEG QEKEKSTKPM AFSSPPLRHA VSSRRRNSVV
160 170 180 190 200
EIESSQGQRE NPTEIDKVLK GIENSRWGAF KCAERGQDFS RKMMVIIHKK
210 220 230 240 250
AHSRQKLFTC RECHQGFRDE SALLLHQNTH TGEKSYVCSV CGRGFSLKAN
260 270 280 290 300
LLRHQRTHSG EKPFLCKVCG RGYTSKSYLT VHERTHTGEK PYECQECGRR
310 320 330 340 350
FNDKSSYNKH LKAHSGEKPF VCKECGRGYT NKSYFVVHKR IHSGEKPYRC
360 370 380 390 400
QECGRGFSNK SHLITHQRTH SGEKPFACRQ CKQSFSVKGS LLRHQRTHSG
410 420 430 440 450
EKPFVCKDCE RSFSQKSTLV YHQRTHSGEK PFVCRECGQG FIQKSTLVKH
460 470 480 490 500
QITHSEEKPF VCKDCGRGFI QKSTFTLHQR THSEEKPYGC RECGRRFRDK
510 520 530 540 550
SSYNKHLRAH LGEKRFFCRD CGRGFTLKPN LTIHQRTHSG EKPFMCKQCE
560 570 580 590 600
KSFSLKANLL RHQWTHSGER PFNCKDCGRG FILKSTLLFH QKTHSGEKPF
610 620 630 640 650
ICSECGQGFI WKSNLVKHQL AHSGKQPFVC KECGRGFNWK GNLLTHQRTH
660 670 680 690 700
SGEKPFVCNV CGQGFSWKRS LTRHHWRIHS KEKPFVCQEC KRGYTSKSDL
710 720 730 740 750
TVHERIHTGE RPYECQECGR KFSNKSYYSK HLKRHLREKR FCTGSVGEAS
S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 476 | T → A in CAB43216 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 653 | E → V in CAB43216 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024213 | 17 | V → I. Corresponds to variant dbSNP:rs926487Ensembl. | 1 | |
Natural variantiVAR_052814 | 467 | R → G. Corresponds to variant dbSNP:rs16987972Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055949 | 52 – 83 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299811 mRNA Translation: BAG61684.1 AL031673 Genomic DNA No translation available. BC021298 mRNA Translation: AAH21298.1 AL049942 mRNA Translation: CAB43216.1 |
CCDSi | CCDS13174.1 [Q9Y3M9-1] |
PIRi | T08674 |
RefSeqi | NP_001277190.1, NM_001290261.1 [Q9Y3M9-1] NP_056470.1, NM_015655.3 [Q9Y3M9-1] XP_005260759.1, XM_005260702.3 [Q9Y3M9-2] XP_006723621.1, XM_006723558.3 [Q9Y3M9-1] XP_011527521.1, XM_011529219.2 [Q9Y3M9-1] XP_016883291.1, XM_017027802.1 XP_016883292.1, XM_017027803.1 [Q9Y3M9-2] |
Genome annotation databases
Ensembli | ENST00000252979; ENSP00000252979; ENSG00000130684 [Q9Y3M9-1] ENST00000376436; ENSP00000365619; ENSG00000130684 [Q9Y3M9-1] |
GeneIDi | 26152 |
KEGGi | hsa:26152 |
UCSCi | uc002wva.4, human [Q9Y3M9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK299811 mRNA Translation: BAG61684.1 AL031673 Genomic DNA No translation available. BC021298 mRNA Translation: AAH21298.1 AL049942 mRNA Translation: CAB43216.1 |
CCDSi | CCDS13174.1 [Q9Y3M9-1] |
PIRi | T08674 |
RefSeqi | NP_001277190.1, NM_001290261.1 [Q9Y3M9-1] NP_056470.1, NM_015655.3 [Q9Y3M9-1] XP_005260759.1, XM_005260702.3 [Q9Y3M9-2] XP_006723621.1, XM_006723558.3 [Q9Y3M9-1] XP_011527521.1, XM_011529219.2 [Q9Y3M9-1] XP_016883291.1, XM_017027802.1 XP_016883292.1, XM_017027803.1 [Q9Y3M9-2] |
3D structure databases
SMRi | Q9Y3M9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117583, 10 interactors |
IntActi | Q9Y3M9, 12 interactors |
MINTi | Q9Y3M9 |
STRINGi | 9606.ENSP00000365619 |
PTM databases
iPTMneti | Q9Y3M9 |
PhosphoSitePlusi | Q9Y3M9 |
Genetic variation databases
BioMutai | ZNF337 |
DMDMi | 20141069 |
Proteomic databases
EPDi | Q9Y3M9 |
jPOSTi | Q9Y3M9 |
MassIVEi | Q9Y3M9 |
PaxDbi | Q9Y3M9 |
PeptideAtlasi | Q9Y3M9 |
PRIDEi | Q9Y3M9 |
ProteomicsDBi | 5036 86050 [Q9Y3M9-1] |
Protocols and materials databases
Antibodypediai | 10099, 136 antibodies |
Genome annotation databases
Ensembli | ENST00000252979; ENSP00000252979; ENSG00000130684 [Q9Y3M9-1] ENST00000376436; ENSP00000365619; ENSG00000130684 [Q9Y3M9-1] |
GeneIDi | 26152 |
KEGGi | hsa:26152 |
UCSCi | uc002wva.4, human [Q9Y3M9-1] |
Organism-specific databases
CTDi | 26152 |
DisGeNETi | 26152 |
GeneCardsi | ZNF337 |
HGNCi | HGNC:15809, ZNF337 |
HPAi | ENSG00000130684, Low tissue specificity |
neXtProti | NX_Q9Y3M9 |
OpenTargetsi | ENSG00000130684 |
PharmGKBi | PA38043 |
VEuPathDBi | HostDB:ENSG00000130684.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164820 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9Y3M9 |
OMAi | KTVMGPQ |
OrthoDBi | 908238at2759 |
PhylomeDBi | Q9Y3M9 |
TreeFami | TF343410 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3M9 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 26152, 3 hits in 896 CRISPR screens |
ChiTaRSi | ZNF337, human |
GenomeRNAii | 26152 |
Pharosi | Q9Y3M9, Tdark |
PROi | PR:Q9Y3M9 |
RNActi | Q9Y3M9, protein |
Gene expression databases
Bgeei | ENSG00000130684, Expressed in right hemisphere of cerebellum and 237 other tissues |
Genevisiblei | Q9Y3M9, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 15 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 20 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 12 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 19 hits PS50157, ZINC_FINGER_C2H2_2, 20 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN337_HUMAN | |
Accessioni | Q9Y3M9Primary (citable) accession number: Q9Y3M9 Secondary accession number(s): B4DSM2, Q9Y3Y5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants