Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y3M9 (ZN337_HUMAN)

Entry version 186 (10 Feb 2021)
Sequence version 2 (01 Mar 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Zinc finger protein 337

Gene

ZNF337

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri180 – 202C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 679C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri685 – 707C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y3M9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 337
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF337
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15809, ZNF337

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3M9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130684.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		26152

Open Targets

More...OpenTargetsi		ENSG00000130684

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38043

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y3M9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF337

Domain mapping of disease mutations (DMDM)

More...DMDMi		20141069

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475401 – 751Zinc finger protein 337Add BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y3M9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y3M9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y3M9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3M9

PeptideAtlas

More...PeptideAtlasi		Q9Y3M9

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3M9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5036
86050 [Q9Y3M9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3M9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3M9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130684, Expressed in right hemisphere of cerebellum and 237 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3M9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130684, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117583, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y3M9, 12 interactors

Molecular INTeraction database

More...MINTi		Q9Y3M9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365619

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y3M9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3M9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 83KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 202C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 679C2H2-type 18PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri685 – 707C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri713 – 735C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3M9

Identification of Orthologs from Complete Genome Data

More...OMAi		KTVMGPQ

Database of Orthologous Groups

More...OrthoDBi		908238at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3M9

TreeFam database of animal gene trees

More...TreeFami		TF343410

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 20 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 12 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 19 hits
PS50157, ZINC_FINGER_C2H2_2, 20 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y3M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPQGARRQA FLAFGDVTVD FTQKEWRLLS PAQRALYREV TLENYSHLVS 
        60         70         80         90        100
LGILHSKPEL IRRLEQGEVP WGEERRRRPG PCAGIYAEHV LRPKNLGLAH 
       110        120        130        140        150
QRQQQLQFSD QSFQSDTAEG QEKEKSTKPM AFSSPPLRHA VSSRRRNSVV 
       160        170        180        190        200
EIESSQGQRE NPTEIDKVLK GIENSRWGAF KCAERGQDFS RKMMVIIHKK 
       210        220        230        240        250
AHSRQKLFTC RECHQGFRDE SALLLHQNTH TGEKSYVCSV CGRGFSLKAN 
       260        270        280        290        300
LLRHQRTHSG EKPFLCKVCG RGYTSKSYLT VHERTHTGEK PYECQECGRR 
       310        320        330        340        350
FNDKSSYNKH LKAHSGEKPF VCKECGRGYT NKSYFVVHKR IHSGEKPYRC 
       360        370        380        390        400
QECGRGFSNK SHLITHQRTH SGEKPFACRQ CKQSFSVKGS LLRHQRTHSG 
       410        420        430        440        450
EKPFVCKDCE RSFSQKSTLV YHQRTHSGEK PFVCRECGQG FIQKSTLVKH 
       460        470        480        490        500
QITHSEEKPF VCKDCGRGFI QKSTFTLHQR THSEEKPYGC RECGRRFRDK 
       510        520        530        540        550
SSYNKHLRAH LGEKRFFCRD CGRGFTLKPN LTIHQRTHSG EKPFMCKQCE 
       560        570        580        590        600
KSFSLKANLL RHQWTHSGER PFNCKDCGRG FILKSTLLFH QKTHSGEKPF 
       610        620        630        640        650
ICSECGQGFI WKSNLVKHQL AHSGKQPFVC KECGRGFNWK GNLLTHQRTH 
       660        670        680        690        700
SGEKPFVCNV CGQGFSWKRS LTRHHWRIHS KEKPFVCQEC KRGYTSKSDL 
       710        720        730        740        750
TVHERIHTGE RPYECQECGR KFSNKSYYSK HLKRHLREKR FCTGSVGEAS 

S
Length:751
Mass (Da):86,875
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i482D9F9A57EC980E
GO
Isoform 2 (identifier: Q9Y3M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-83: Missing.

Show »
Length:719
Mass (Da):83,170
Checksum:iE5D6D46499633BC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti476T → A in CAB43216 (PubMed:17974005).Curated1
Sequence conflicti653E → V in CAB43216 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02421317V → I. Corresponds to variant dbSNP:rs926487Ensembl.1
Natural variantiVAR_052814467R → G. Corresponds to variant dbSNP:rs16987972Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05594952 – 83Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK299811 mRNA Translation: BAG61684.1
AL031673 Genomic DNA No translation available.
BC021298 mRNA Translation: AAH21298.1
AL049942 mRNA Translation: CAB43216.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13174.1 [Q9Y3M9-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T08674

NCBI Reference Sequences

More...RefSeqi		NP_001277190.1, NM_001290261.1 [Q9Y3M9-1]
NP_056470.1, NM_015655.3 [Q9Y3M9-1]
XP_005260759.1, XM_005260702.3 [Q9Y3M9-2]
XP_006723621.1, XM_006723558.3 [Q9Y3M9-1]
XP_011527521.1, XM_011529219.2 [Q9Y3M9-1]
XP_016883291.1, XM_017027802.1
XP_016883292.1, XM_017027803.1 [Q9Y3M9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000252979; ENSP00000252979; ENSG00000130684 [Q9Y3M9-1]
ENST00000376436; ENSP00000365619; ENSG00000130684 [Q9Y3M9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		26152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:26152

UCSC genome browser

More...UCSCi		uc002wva.4, human [Q9Y3M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299811 mRNA Translation: BAG61684.1
AL031673 Genomic DNA No translation available.
BC021298 mRNA Translation: AAH21298.1
AL049942 mRNA Translation: CAB43216.1
CCDSiCCDS13174.1 [Q9Y3M9-1]
PIRiT08674
RefSeqiNP_001277190.1, NM_001290261.1 [Q9Y3M9-1]
NP_056470.1, NM_015655.3 [Q9Y3M9-1]
XP_005260759.1, XM_005260702.3 [Q9Y3M9-2]
XP_006723621.1, XM_006723558.3 [Q9Y3M9-1]
XP_011527521.1, XM_011529219.2 [Q9Y3M9-1]
XP_016883291.1, XM_017027802.1
XP_016883292.1, XM_017027803.1 [Q9Y3M9-2]

3D structure databases

SMRiQ9Y3M9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117583, 10 interactors
IntActiQ9Y3M9, 12 interactors
MINTiQ9Y3M9
STRINGi9606.ENSP00000365619

PTM databases

iPTMnetiQ9Y3M9
PhosphoSitePlusiQ9Y3M9

Genetic variation databases

BioMutaiZNF337
DMDMi20141069

Proteomic databases

EPDiQ9Y3M9
jPOSTiQ9Y3M9
MassIVEiQ9Y3M9
PaxDbiQ9Y3M9
PeptideAtlasiQ9Y3M9
PRIDEiQ9Y3M9
ProteomicsDBi5036
86050 [Q9Y3M9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10099, 136 antibodies

Genome annotation databases

EnsembliENST00000252979; ENSP00000252979; ENSG00000130684 [Q9Y3M9-1]
ENST00000376436; ENSP00000365619; ENSG00000130684 [Q9Y3M9-1]
GeneIDi26152
KEGGihsa:26152
UCSCiuc002wva.4, human [Q9Y3M9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		26152
DisGeNETi26152

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF337
HGNCiHGNC:15809, ZNF337
HPAiENSG00000130684, Low tissue specificity
neXtProtiNX_Q9Y3M9
OpenTargetsiENSG00000130684
PharmGKBiPA38043
VEuPathDBiHostDB:ENSG00000130684.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164820
HOGENOMiCLU_002678_44_5_1
InParanoidiQ9Y3M9
OMAiKTVMGPQ
OrthoDBi908238at2759
PhylomeDBiQ9Y3M9
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ9Y3M9
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		26152, 3 hits in 896 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF337, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		26152
PharosiQ9Y3M9, Tdark

Protein Ontology

More...PROi		PR:Q9Y3M9
RNActiQ9Y3M9, protein

Gene expression databases

BgeeiENSG00000130684, Expressed in right hemisphere of cerebellum and 237 other tissues
GenevisibleiQ9Y3M9, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 20 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 19 hits
PS50157, ZINC_FINGER_C2H2_2, 20 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN337_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3M9
Secondary accession number(s): B4DSM2, Q9Y3Y5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: February 10, 2021
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again