UniProtKB - Q9Y3M8 (STA13_HUMAN)
Protein
StAR-related lipid transfer protein 13
Gene
STARD13
Organism
Homo sapiens (Human)
Status
Functioni
GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.2 Publications
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
- lipid binding Source: InterPro
GO - Biological processi
- actin cytoskeleton organization Source: GO_Central
- endothelial cell migration Source: MGI
- endothelial tube lumen extension Source: MGI
- negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
- regulation of Rho protein signal transduction Source: GO_Central
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3M8 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9Y3M8 |
Names & Taxonomyi
Protein namesi | Recommended name: StAR-related lipid transfer protein 13Alternative name(s): 46H23.2 Deleted in liver cancer 2 protein Short name: DLC-2 Rho GTPase-activating protein START domain-containing protein 13 Short name: StARD13 |
Gene namesi | Name:STARD13 Synonyms:DLC2, GT650 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19164, STARD13 |
MIMi | 609866, gene |
neXtProti | NX_Q9Y3M8 |
VEuPathDBi | HostDB:ENSG00000133121.20 |
Subcellular locationi
Cytoplasm and Cytosol
Mitochondrion
Other locations
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- lipid droplet Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, Membrane, MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 699 | R → A: Loss of RhoGAP activity. 1 Publication | 1 | |
Mutagenesisi | 736 | K → E: Loss of RhoGAP activity. 1 Publication | 1 | |
Mutagenesisi | 740 | R → E: Loss of RhoGAP activity. 1 Publication | 1 |
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 90627 |
OpenTargetsi | ENSG00000133121 |
PharmGKBi | PA38806 |
Miscellaneous databases
Pharosi | Q9Y3M8, Tbio |
Genetic variation databases
BioMutai | STARD13 |
DMDMi | 90185285 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000220679 | 1 – 1113 | StAR-related lipid transfer protein 13Add BLAST | 1113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 411 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y3M8 |
jPOSTi | Q9Y3M8 |
MassIVEi | Q9Y3M8 |
PaxDbi | Q9Y3M8 |
PeptideAtlasi | Q9Y3M8 |
PRIDEi | Q9Y3M8 |
ProteomicsDBi | 86045 [Q9Y3M8-1] 86046 [Q9Y3M8-2] 86047 [Q9Y3M8-3] 86048 [Q9Y3M8-4] 86049 [Q9Y3M8-5] |
PTM databases
iPTMneti | Q9Y3M8 |
PhosphoSitePlusi | Q9Y3M8 |
Expressioni
Tissue specificityi
Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.2 Publications
Gene expression databases
Bgeei | ENSG00000133121, Expressed in sural nerve and 216 other tissues |
ExpressionAtlasi | Q9Y3M8, baseline and differential |
Genevisiblei | Q9Y3M8, HS |
Organism-specific databases
HPAi | ENSG00000133121, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with TAX1BP1.
2 PublicationsBinary interactionsi
Q9Y3M8
With | #Exp. | IntAct |
---|---|---|
TAX1BP1 [Q86VP1] | 2 | EBI-465487,EBI-529518 |
Protein-protein interaction databases
BioGRIDi | 124744, 43 interactors |
IntActi | Q9Y3M8, 15 interactors |
MINTi | Q9Y3M8 |
STRINGi | 9606.ENSP00000338785 |
Miscellaneous databases
RNActi | Q9Y3M8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y3M8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y3M8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 122 | SAMAdd BLAST | 68 | |
Domaini | 663 – 868 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 206 | |
Domaini | 899 – 1107 | STARTPROSITE-ProRule annotationAdd BLAST | 209 |
Phylogenomic databases
eggNOGi | KOG2200, Eukaryota |
GeneTreei | ENSGT00950000183061 |
HOGENOMi | CLU_004367_0_0_1 |
InParanoidi | Q9Y3M8 |
OMAi | HGWTCLS |
PhylomeDBi | Q9Y3M8 |
TreeFami | TF314044 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit PF07647, SAM_2, 1 hit PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00234, START, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS50848, START, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y3M8-1) [UniParc]FASTAAdd to basket
Also known as: DLC2alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFSQVPRTPA SGCYYLNSMT PEGQEMYLRF DQTTRRSPYR MSRILARHQL
60 70 80 90 100
VTKIQQEIEA KEACDWLRAA GFPQYAQLYE DSQFPINIVA VKNDHDFLEK
110 120 130 140 150
DLVEPLCRRL NTLNKCASMK LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS
160 170 180 190 200
RRWSRVDDLY TLLPRGDRNG SPGGTGMRNT TSSESVLTDL SEPEVCSIHS
210 220 230 240 250
ESSGGSDSRS QPGQCCTDNP VMLDAPLVSS SLPQPPRDVL NHPFHPKNEK
260 270 280 290 300
PTRARAKSFL KRMETLRGKG AHGRHKGSGR TGGLVISGPM LQQEPESFKA
310 320 330 340 350
MQCIQIPNGD LQNSPPPACR KGLPCSGKSS GESSPSEHSS SGVSTPCLKE
360 370 380 390 400
RKCHEANKRG GMYLEDLDVL AGTALPDAGD QSRMHEFHSQ ENLVVHIPKD
410 420 430 440 450
HKPGTFPKAL SIESLSPTDS SNGVNWRTGS ISLGREQVPG AREPRLMASC
460 470 480 490 500
HRASRVSIYD NVPGSHLYAS TGDLLDLEKD DLFPHLDDIL QHVNGLQEVV
510 520 530 540 550
DDWSKDVLPE LQTHDTLVGE PGLSTFPSPN QITLDFEGNS VSEGRTTPSD
560 570 580 590 600
VERDVTSLNE SEPPGVRDRR DSGVGASLTR PNRRLRWNSF QLSHQPRPAP
610 620 630 640 650
ASPHISSQTA SQLSLLQRFS LLRLTAIMEK HSMSNKHGWT WSVPKFMKRM
660 670 680 690 700
KVPDYKDKAV FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK
710 720 730 740 750
SGVKSRIHAL RQMNENFPEN VNYEDQSAYD VADMVKQFFR DLPEPLFTNK
760 770 780 790 800
LSETFLHIYQ YVSKEQRLQA VQAAILLLAD ENREVLQTLL CFLNDVVNLV
810 820 830 840 850
EENQMTPMNL AVCLAPSLFH LNLLKKESSP RVIQKKYATG KPDQKDLNEN
860 870 880 890 900
LAAAQGLAHM IMECDRLFEV PHELVAQSRN SYVEAEIHVP TLEELGTQLE
910 920 930 940 950
ESGATFHTYL NHLIQGLQKE AKEKFKGWVT CSSTDNTDLA FKKVGDGNPL
960 970 980 990 1000
KLWKASVEVE APPSVVLNRV LRERHLWDED FVQWKVVETL DRQTEIYQYV
1010 1020 1030 1040 1050
LNSMAPHPSR DFVVLRTWKT DLPKGMCTLV SLSVEHEEAQ LLGGVRAVVM
1060 1070 1080 1090 1100
DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE WYSKGFGHLC AAEVARIRNS
1110
FQPLIAEGPE TKI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRG5 | H3BRG5_HUMAN | StAR-related lipid transfer protein... | STARD13 | 606 | Annotation score: | ||
H3BUW7 | H3BUW7_HUMAN | StAR-related lipid transfer protein... | STARD13 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 143 | K → R in AAQ72791 (PubMed:14697242).Curated | 1 | |
Sequence conflicti | 397 | I → V in AAQ72791 (PubMed:14697242).Curated | 1 | |
Sequence conflicti | 1097 | I → T in AAQ72791 (PubMed:14697242).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037494 | 175 | T → M. Corresponds to variant dbSNP:rs9568878Ensembl. | 1 | |
Natural variantiVAR_022098 | 250 | K → R. Corresponds to variant dbSNP:rs3742321Ensembl. | 1 | |
Natural variantiVAR_037495 | 383 | R → P. Corresponds to variant dbSNP:rs34425674Ensembl. | 1 | |
Natural variantiVAR_037496 | 798 | N → S. Corresponds to variant dbSNP:rs35144435Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017353 | 1 – 118 | Missing in isoform 3. 2 PublicationsAdd BLAST | 118 | |
Alternative sequenceiVSP_017354 | 1 – 56 | MFSQV…TKIQQ → MLEPSSVLHANVNQAPLWCL VLRWCRECKDTVCGGKQKSR VNHTFQRR in isoform 2 and isoform 5. 2 PublicationsAdd BLAST | 56 | |
Alternative sequenceiVSP_017355 | 1 – 56 | MFSQV…TKIQQ → MSTGTQPKTKVLSDKRPKER V in isoform 4. 1 PublicationAdd BLAST | 56 | |
Alternative sequenceiVSP_017356 | 695 | V → E in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_017357 | 696 – 1113 | Missing in isoform 5. 1 PublicationAdd BLAST | 418 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY082589 mRNA Translation: AAL91648.1 AY366448 mRNA Translation: AAQ72791.1 AY082590 mRNA Translation: AAL91649.1 AY082591 mRNA Translation: AAL91650.1 AL049801 mRNA Translation: CAB42562.1 BX647695 mRNA Translation: CAI46026.1 Z84483 Genomic DNA Translation: CAC94774.1 AL139187 Genomic DNA No translation available. AL627232 Genomic DNA No translation available. BC046563 mRNA Translation: AAH46563.1 |
CCDSi | CCDS9348.1 [Q9Y3M8-1] CCDS9349.1 [Q9Y3M8-2] CCDS9350.1 [Q9Y3M8-3] |
PIRi | H59432 |
RefSeqi | NP_001230395.1, NM_001243466.1 [Q9Y3M8-5] NP_001230403.1, NM_001243474.1 NP_001230405.1, NM_001243476.2 NP_443083.1, NM_052851.2 [Q9Y3M8-3] NP_821074.1, NM_178006.3 [Q9Y3M8-1] NP_821075.1, NM_178007.2 [Q9Y3M8-2] |
Genome annotation databases
Ensembli | ENST00000255486; ENSP00000255486; ENSG00000133121 [Q9Y3M8-2] ENST00000336934; ENSP00000338785; ENSG00000133121 [Q9Y3M8-1] ENST00000399365; ENSP00000382300; ENSG00000133121 [Q9Y3M8-3] |
GeneIDi | 90627 |
KEGGi | hsa:90627 |
UCSCi | uc001uuu.4, human [Q9Y3M8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY082589 mRNA Translation: AAL91648.1 AY366448 mRNA Translation: AAQ72791.1 AY082590 mRNA Translation: AAL91649.1 AY082591 mRNA Translation: AAL91650.1 AL049801 mRNA Translation: CAB42562.1 BX647695 mRNA Translation: CAI46026.1 Z84483 Genomic DNA Translation: CAC94774.1 AL139187 Genomic DNA No translation available. AL627232 Genomic DNA No translation available. BC046563 mRNA Translation: AAH46563.1 |
CCDSi | CCDS9348.1 [Q9Y3M8-1] CCDS9349.1 [Q9Y3M8-2] CCDS9350.1 [Q9Y3M8-3] |
PIRi | H59432 |
RefSeqi | NP_001230395.1, NM_001243466.1 [Q9Y3M8-5] NP_001230403.1, NM_001243474.1 NP_001230405.1, NM_001243476.2 NP_443083.1, NM_052851.2 [Q9Y3M8-3] NP_821074.1, NM_178006.3 [Q9Y3M8-1] NP_821075.1, NM_178007.2 [Q9Y3M8-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2H80 | NMR | - | A | 56-120 | [»] | |
2JW2 | NMR | - | A | 56-120 | [»] | |
2PSO | X-ray | 2.80 | A/B/C | 903-1113 | [»] | |
SMRi | Q9Y3M8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124744, 43 interactors |
IntActi | Q9Y3M8, 15 interactors |
MINTi | Q9Y3M8 |
STRINGi | 9606.ENSP00000338785 |
PTM databases
iPTMneti | Q9Y3M8 |
PhosphoSitePlusi | Q9Y3M8 |
Genetic variation databases
BioMutai | STARD13 |
DMDMi | 90185285 |
Proteomic databases
EPDi | Q9Y3M8 |
jPOSTi | Q9Y3M8 |
MassIVEi | Q9Y3M8 |
PaxDbi | Q9Y3M8 |
PeptideAtlasi | Q9Y3M8 |
PRIDEi | Q9Y3M8 |
ProteomicsDBi | 86045 [Q9Y3M8-1] 86046 [Q9Y3M8-2] 86047 [Q9Y3M8-3] 86048 [Q9Y3M8-4] 86049 [Q9Y3M8-5] |
Protocols and materials databases
Antibodypediai | 35333, 115 antibodies |
Genome annotation databases
Ensembli | ENST00000255486; ENSP00000255486; ENSG00000133121 [Q9Y3M8-2] ENST00000336934; ENSP00000338785; ENSG00000133121 [Q9Y3M8-1] ENST00000399365; ENSP00000382300; ENSG00000133121 [Q9Y3M8-3] |
GeneIDi | 90627 |
KEGGi | hsa:90627 |
UCSCi | uc001uuu.4, human [Q9Y3M8-1] |
Organism-specific databases
CTDi | 90627 |
DisGeNETi | 90627 |
GeneCardsi | STARD13 |
HGNCi | HGNC:19164, STARD13 |
HPAi | ENSG00000133121, Low tissue specificity |
MIMi | 609866, gene |
neXtProti | NX_Q9Y3M8 |
OpenTargetsi | ENSG00000133121 |
PharmGKBi | PA38806 |
VEuPathDBi | HostDB:ENSG00000133121.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2200, Eukaryota |
GeneTreei | ENSGT00950000183061 |
HOGENOMi | CLU_004367_0_0_1 |
InParanoidi | Q9Y3M8 |
OMAi | HGWTCLS |
PhylomeDBi | Q9Y3M8 |
TreeFami | TF314044 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3M8 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9Y3M8 |
Miscellaneous databases
BioGRID-ORCSi | 90627, 6 hits in 992 CRISPR screens |
ChiTaRSi | STARD13, human |
EvolutionaryTracei | Q9Y3M8 |
GeneWikii | STARD13 |
GenomeRNAii | 90627 |
Pharosi | Q9Y3M8, Tbio |
PROi | PR:Q9Y3M8 |
RNActi | Q9Y3M8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133121, Expressed in sural nerve and 216 other tissues |
ExpressionAtlasi | Q9Y3M8, baseline and differential |
Genevisiblei | Q9Y3M8, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR001660, SAM IPR013761, SAM/pointed_sf IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit PF07647, SAM_2, 1 hit PF01852, START, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit SM00234, START, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit PS50848, START, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STA13_HUMAN | |
Accessioni | Q9Y3M8Primary (citable) accession number: Q9Y3M8 Secondary accession number(s): A2A309 Q86XT1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 15, 2002 |
Last sequence update: | March 7, 2006 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references