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UniProtKB - Q9Y3M8 (STA13_HUMAN)

Protein

StAR-related lipid transfer protein 13

Gene

STARD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
StAR-related lipid transfer protein 13
Alternative name(s):
46H23.2
Deleted in liver cancer 2 protein
Short name:
DLC-2
Rho GTPase-activating protein
START domain-containing protein 13
Short name:
StARD13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STARD13
Synonyms:DLC2, GT650
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000133121.20

Human Gene Nomenclature Database

More...HGNCi		HGNC:19164 STARD13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609866 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y3M8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi699R → A: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi736K → E: Loss of RhoGAP activity. 1 Publication1
Mutagenesisi740R → E: Loss of RhoGAP activity. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		90627

Open Targets

More...OpenTargetsi		ENSG00000133121

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38806

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		STARD13

Domain mapping of disease mutations (DMDM)

More...DMDMi		90185285

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206791 – 1113StAR-related lipid transfer protein 13Add BLAST1113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei411PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y3M8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y3M8

PeptideAtlas

More...PeptideAtlasi		Q9Y3M8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y3M8

ProteomicsDB human proteome resource

More...ProteomicsDBi		86045
86046 [Q9Y3M8-2]
86047 [Q9Y3M8-3]
86048 [Q9Y3M8-4]
86049 [Q9Y3M8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y3M8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y3M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133121 Expressed in 205 organ(s), highest expression level in tibial nerve

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y3M8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y3M8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039535
HPA058867

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Interacts with TAX1BP1.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TAX1BP1Q86VP12EBI-465487,EBI-529518

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124744, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y3M8, 11 interactors

Molecular INTeraction database

More...MINTi		Q9Y3M8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000338785

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9Y3M8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y3M8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y3M8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 122SAMAdd BLAST68
Domaini663 – 868Rho-GAPPROSITE-ProRule annotationAdd BLAST206
Domaini899 – 1107STARTPROSITE-ProRule annotationAdd BLAST209

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2200 Eukaryota
ENOG410XQ10 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153557

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG055955

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y3M8

KEGG Orthology (KO)

More...KOi		K20632

Identification of Orthologs from Complete Genome Data

More...OMAi		RTTPSDM

Database of Orthologous Groups

More...OrthoDBi		EOG091G00OE

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y3M8

TreeFam database of animal gene trees

More...TreeFami		TF314044

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3M8-1) [UniParc]FASTAAdd to basket
Also known as: DLC2alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSQVPRTPA SGCYYLNSMT PEGQEMYLRF DQTTRRSPYR MSRILARHQL 
        60         70         80         90        100
VTKIQQEIEA KEACDWLRAA GFPQYAQLYE DSQFPINIVA VKNDHDFLEK 
       110        120        130        140        150
DLVEPLCRRL NTLNKCASMK LDVNFQRKKG DDSDEEDLCI SNKWTFQRTS 
       160        170        180        190        200
RRWSRVDDLY TLLPRGDRNG SPGGTGMRNT TSSESVLTDL SEPEVCSIHS 
       210        220        230        240        250
ESSGGSDSRS QPGQCCTDNP VMLDAPLVSS SLPQPPRDVL NHPFHPKNEK 
       260        270        280        290        300
PTRARAKSFL KRMETLRGKG AHGRHKGSGR TGGLVISGPM LQQEPESFKA 
       310        320        330        340        350
MQCIQIPNGD LQNSPPPACR KGLPCSGKSS GESSPSEHSS SGVSTPCLKE 
       360        370        380        390        400
RKCHEANKRG GMYLEDLDVL AGTALPDAGD QSRMHEFHSQ ENLVVHIPKD 
       410        420        430        440        450
HKPGTFPKAL SIESLSPTDS SNGVNWRTGS ISLGREQVPG AREPRLMASC 
       460        470        480        490        500
HRASRVSIYD NVPGSHLYAS TGDLLDLEKD DLFPHLDDIL QHVNGLQEVV 
       510        520        530        540        550
DDWSKDVLPE LQTHDTLVGE PGLSTFPSPN QITLDFEGNS VSEGRTTPSD 
       560        570        580        590        600
VERDVTSLNE SEPPGVRDRR DSGVGASLTR PNRRLRWNSF QLSHQPRPAP 
       610        620        630        640        650
ASPHISSQTA SQLSLLQRFS LLRLTAIMEK HSMSNKHGWT WSVPKFMKRM 
       660        670        680        690        700
KVPDYKDKAV FGVPLIVHVQ RTGQPLPQSI QQALRYLRSN CLDQVGLFRK 
       710        720        730        740        750
SGVKSRIHAL RQMNENFPEN VNYEDQSAYD VADMVKQFFR DLPEPLFTNK 
       760        770        780        790        800
LSETFLHIYQ YVSKEQRLQA VQAAILLLAD ENREVLQTLL CFLNDVVNLV 
       810        820        830        840        850
EENQMTPMNL AVCLAPSLFH LNLLKKESSP RVIQKKYATG KPDQKDLNEN 
       860        870        880        890        900
LAAAQGLAHM IMECDRLFEV PHELVAQSRN SYVEAEIHVP TLEELGTQLE 
       910        920        930        940        950
ESGATFHTYL NHLIQGLQKE AKEKFKGWVT CSSTDNTDLA FKKVGDGNPL 
       960        970        980        990       1000
KLWKASVEVE APPSVVLNRV LRERHLWDED FVQWKVVETL DRQTEIYQYV 
      1010       1020       1030       1040       1050
LNSMAPHPSR DFVVLRTWKT DLPKGMCTLV SLSVEHEEAQ LLGGVRAVVM 
      1060       1070       1080       1090       1100
DSQYLIEPCG SGKSRLTHIC RIDLKGHSPE WYSKGFGHLC AAEVARIRNS 
      1110 
FQPLIAEGPE TKI
Length:1,113
Mass (Da):124,967
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i314F809C23E6E1E4
GO
Isoform 2 (identifier: Q9Y3M8-2) [UniParc]FASTAAdd to basket
Also known as: DLC2beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR

Show »
Length:1,105
Mass (Da):123,893
Checksum:iC447ADE6F7AAF9D8
GO
Isoform 3 (identifier: Q9Y3M8-3) [UniParc]FASTAAdd to basket
Also known as: DLC2gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.

Show »
Length:995
Mass (Da):111,192
Checksum:i3F608FA94A4EF8BF
GO
Isoform 4 (identifier: Q9Y3M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MSTGTQPKTKVLSDKRPKERV

Show »
Length:1,078
Mass (Da):120,684
Checksum:i1B108966B3EDC44D
GO
Isoform 5 (identifier: Q9Y3M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: MFSQVPRTPA...RHQLVTKIQQ → MLEPSSVLHA...SRVNHTFQRR
     695-695: V → E
     696-1113: Missing.

Show »
Length:687
Mass (Da):76,367
Checksum:i4E1B65EA0FDCB836
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRG5H3BRG5_HUMAN
StAR-related lipid transfer protein...
STARD13
606Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUW7H3BUW7_HUMAN
StAR-related lipid transfer protein...
STARD13
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti143K → R in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti397I → V in AAQ72791 (PubMed:14697242).Curated1
Sequence conflicti1097I → T in AAQ72791 (PubMed:14697242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037494175T → M. Corresponds to variant dbSNP:rs9568878Ensembl.1
Natural variantiVAR_022098250K → R. Corresponds to variant dbSNP:rs3742321Ensembl.1
Natural variantiVAR_037495383R → P. Corresponds to variant dbSNP:rs34425674Ensembl.1
Natural variantiVAR_037496798N → S. Corresponds to variant dbSNP:rs35144435Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0173531 – 118Missing in isoform 3. 2 PublicationsAdd BLAST118
Alternative sequenceiVSP_0173541 – 56MFSQV…TKIQQ → MLEPSSVLHANVNQAPLWCL VLRWCRECKDTVCGGKQKSR VNHTFQRR in isoform 2 and isoform 5. 2 PublicationsAdd BLAST56
Alternative sequenceiVSP_0173551 – 56MFSQV…TKIQQ → MSTGTQPKTKVLSDKRPKER V in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_017356695V → E in isoform 5. 1 Publication1
Alternative sequenceiVSP_017357696 – 1113Missing in isoform 5. 1 PublicationAdd BLAST418

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY082589 mRNA Translation: AAL91648.1
AY366448 mRNA Translation: AAQ72791.1
AY082590 mRNA Translation: AAL91649.1
AY082591 mRNA Translation: AAL91650.1
AL049801 mRNA Translation: CAB42562.1
BX647695 mRNA Translation: CAI46026.1
Z84483 Genomic DNA Translation: CAC94774.1
AL139187 Genomic DNA No translation available.
AL627232 Genomic DNA No translation available.
BC046563 mRNA Translation: AAH46563.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9348.1 [Q9Y3M8-1]
CCDS9349.1 [Q9Y3M8-2]
CCDS9350.1 [Q9Y3M8-3]

Protein sequence database of the Protein Information Resource

More...PIRi		H59432

NCBI Reference Sequences

More...RefSeqi		NP_001230395.1, NM_001243466.1 [Q9Y3M8-5]
NP_001230403.1, NM_001243474.1
NP_001230405.1, NM_001243476.2
NP_443083.1, NM_052851.2 [Q9Y3M8-3]
NP_821074.1, NM_178006.3 [Q9Y3M8-1]
NP_821075.1, NM_178007.2 [Q9Y3M8-2]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.156551
Hs.507704
Hs.721224

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000255486; ENSP00000255486; ENSG00000133121 [Q9Y3M8-2]
ENST00000336934; ENSP00000338785; ENSG00000133121 [Q9Y3M8-1]
ENST00000399365; ENSP00000382300; ENSG00000133121 [Q9Y3M8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90627

UCSC genome browser

More...UCSCi		uc001uuu.4 human [Q9Y3M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082589 mRNA Translation: AAL91648.1
AY366448 mRNA Translation: AAQ72791.1
AY082590 mRNA Translation: AAL91649.1
AY082591 mRNA Translation: AAL91650.1
AL049801 mRNA Translation: CAB42562.1
BX647695 mRNA Translation: CAI46026.1
Z84483 Genomic DNA Translation: CAC94774.1
AL139187 Genomic DNA No translation available.
AL627232 Genomic DNA No translation available.
BC046563 mRNA Translation: AAH46563.1
CCDSiCCDS9348.1 [Q9Y3M8-1]
CCDS9349.1 [Q9Y3M8-2]
CCDS9350.1 [Q9Y3M8-3]
PIRiH59432
RefSeqiNP_001230395.1, NM_001243466.1 [Q9Y3M8-5]
NP_001230403.1, NM_001243474.1
NP_001230405.1, NM_001243476.2
NP_443083.1, NM_052851.2 [Q9Y3M8-3]
NP_821074.1, NM_178006.3 [Q9Y3M8-1]
NP_821075.1, NM_178007.2 [Q9Y3M8-2]
UniGeneiHs.156551
Hs.507704
Hs.721224

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H80NMR-A56-120[»]
2JW2NMR-A56-120[»]
2PSOX-ray2.80A/B/C903-1113[»]
ProteinModelPortaliQ9Y3M8
SMRiQ9Y3M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124744, 38 interactors
IntActiQ9Y3M8, 11 interactors
MINTiQ9Y3M8
STRINGi9606.ENSP00000338785

PTM databases

iPTMnetiQ9Y3M8
PhosphoSitePlusiQ9Y3M8

Polymorphism and mutation databases

BioMutaiSTARD13
DMDMi90185285

Proteomic databases

EPDiQ9Y3M8
PaxDbiQ9Y3M8
PeptideAtlasiQ9Y3M8
PRIDEiQ9Y3M8
ProteomicsDBi86045
86046 [Q9Y3M8-2]
86047 [Q9Y3M8-3]
86048 [Q9Y3M8-4]
86049 [Q9Y3M8-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255486; ENSP00000255486; ENSG00000133121 [Q9Y3M8-2]
ENST00000336934; ENSP00000338785; ENSG00000133121 [Q9Y3M8-1]
ENST00000399365; ENSP00000382300; ENSG00000133121 [Q9Y3M8-3]
GeneIDi90627
KEGGihsa:90627
UCSCiuc001uuu.4 human [Q9Y3M8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90627
DisGeNETi90627
EuPathDBiHostDB:ENSG00000133121.20

GeneCards: human genes, protein and diseases

More...GeneCardsi		STARD13

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0171887
HGNCiHGNC:19164 STARD13
HPAiHPA039535
HPA058867
MIMi609866 gene
neXtProtiNX_Q9Y3M8
OpenTargetsiENSG00000133121
PharmGKBiPA38806

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
GeneTreeiENSGT00940000153557
HOVERGENiHBG055955
InParanoidiQ9Y3M8
KOiK20632
OMAiRTTPSDM
OrthoDBiEOG091G00OE
PhylomeDBiQ9Y3M8
TreeFamiTF314044

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		STARD13 human
EvolutionaryTraceiQ9Y3M8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		STARD13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90627

Protein Ontology

More...PROi		PR:Q9Y3M8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133121 Expressed in 205 organ(s), highest expression level in tibial nerve
ExpressionAtlasiQ9Y3M8 baseline and differential
GenevisibleiQ9Y3M8 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTA13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y3M8
Secondary accession number(s): A2A309
, A2A310, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 7, 2006
Last modified: December 5, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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