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UniProtKB - Q9Y3L5 (RAP2C_HUMAN)
Protein
Ras-related protein Rap-2c
Gene
RAP2C
Organism
Homo sapiens (Human)
Status
Functioni
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
1 PublicationCatalytic activityi
- EC:3.6.5.2By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 17 | GTPBy similarity | 8 | |
Nucleotide bindingi | 57 – 61 | GTPBy similarity | 5 | |
Nucleotide bindingi | 116 – 119 | GTPBy similarity | 4 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- G protein activity Source: UniProtKB-EC
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
GO - Biological processi
- establishment of endothelial intestinal barrier Source: UniProtKB
- negative regulation of cell migration Source: UniProtKB
- positive regulation of protein autophosphorylation Source: UniProtKB
- Rap protein signal transduction Source: UniProtKB
- regulation of protein tyrosine kinase activity Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3L5 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9Y3L5 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RAP2C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21165, RAP2C |
neXtProti | NX_Q9Y3L5 |
VEuPathDBi | HostDB:ENSG00000123728 |
Subcellular locationi
Endosome
- Recycling endosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Ensembl
Endosome
- recycling endosome membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- bicellular tight junction Source: UniProtKB
- cell-cell contact zone Source: UniProtKB
- cytoplasm Source: UniProtKB
- tertiary granule membrane Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Endosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57826 |
OpenTargetsi | ENSG00000123728 |
PharmGKBi | PA134899238 |
Miscellaneous databases
Pharosi | Q9Y3L5, Tbio |
Genetic variation databases
BioMutai | RAP2C |
DMDMi | 47117343 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000030221 | 1 – 180 | Ras-related protein Rap-2cAdd BLAST | 180 | |
PropeptideiPRO_0000030222 | 181 – 183 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 176 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 177 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 180 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 180 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.By similarity
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
EPDi | Q9Y3L5 |
jPOSTi | Q9Y3L5 |
MassIVEi | Q9Y3L5 |
MaxQBi | Q9Y3L5 |
PaxDbi | Q9Y3L5 |
PeptideAtlasi | Q9Y3L5 |
PRIDEi | Q9Y3L5 |
ProteomicsDBi | 86043 |
PTM databases
iPTMneti | Q9Y3L5 |
MetOSitei | Q9Y3L5 |
PhosphoSitePlusi | Q9Y3L5 |
SwissPalmi | Q9Y3L5 |
Expressioni
Tissue specificityi
Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.2 Publications
Gene expression databases
Bgeei | ENSG00000123728, Expressed in body of uterus and 242 other tissues |
ExpressionAtlasi | Q9Y3L5, baseline and differential |
Genevisiblei | Q9Y3L5, HS |
Organism-specific databases
HPAi | ENSG00000123728, Tissue enhanced (endometrium) |
Interactioni
Binary interactionsi
Q9Y3L5
With | #Exp. | IntAct |
---|---|---|
RAP1GDS1 - isoform 5 [P52306-5] | 3 | EBI-2856617,EBI-12832744 |
Protein-protein interaction databases
BioGRIDi | 121785, 40 interactors |
IntActi | Q9Y3L5, 23 interactors |
MINTi | Q9Y3L5 |
STRINGi | 9606.ENSP00000340274 |
Miscellaneous databases
RNActi | Q9Y3L5, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 32 – 40 | Effector regionCurated | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000157245 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | Q9Y3L5 |
OMAi | QFTGINE |
OrthoDBi | 1353024at2759 |
PhylomeDBi | Q9Y3L5 |
TreeFami | TF313014 |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y3L5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP
60 70 80 90 100
SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI
110 120 130 140 150
VRVKRYEKVP LILVGNKVDL EPEREVMSSE GRALAQEWGC PFMETSAKSK
160 170 180
SMVDELFAEI VRQMNYSSLP EKQDQCCTTC VVQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2C3 | A0A087X2C3_HUMAN | RAP2C, member of RAS oncogene famil... | RAP2C hCG_2043125 | 117 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 135 | A → V in AAH03403 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY298955 mRNA Translation: AAP55684.1 AL049685 mRNA Translation: CAB41256.1 AK124801 mRNA Translation: BAG54098.1 Z78022 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11782.1 BC003403 mRNA Translation: AAH03403.1 |
CCDSi | CCDS14632.1 |
RefSeqi | NP_001258115.1, NM_001271186.1 NP_001258116.1, NM_001271187.1 NP_067006.3, NM_021183.4 XP_011529678.1, XM_011531376.1 |
Genome annotation databases
Ensembli | ENST00000342983.6; ENSP00000340274.2; ENSG00000123728.10 ENST00000370874.2; ENSP00000359911.1; ENSG00000123728.10 |
GeneIDi | 57826 |
KEGGi | hsa:57826 |
MANE-Selecti | ENST00000370874.2; ENSP00000359911.1; NM_001271186.2; NP_001258115.1 |
UCSCi | uc004ewp.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY298955 mRNA Translation: AAP55684.1 AL049685 mRNA Translation: CAB41256.1 AK124801 mRNA Translation: BAG54098.1 Z78022 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11782.1 BC003403 mRNA Translation: AAH03403.1 |
CCDSi | CCDS14632.1 |
RefSeqi | NP_001258115.1, NM_001271186.1 NP_001258116.1, NM_001271187.1 NP_067006.3, NM_021183.4 XP_011529678.1, XM_011531376.1 |
3D structure databases
AlphaFoldDBi | Q9Y3L5 |
SMRi | Q9Y3L5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121785, 40 interactors |
IntActi | Q9Y3L5, 23 interactors |
MINTi | Q9Y3L5 |
STRINGi | 9606.ENSP00000340274 |
PTM databases
iPTMneti | Q9Y3L5 |
MetOSitei | Q9Y3L5 |
PhosphoSitePlusi | Q9Y3L5 |
SwissPalmi | Q9Y3L5 |
Genetic variation databases
BioMutai | RAP2C |
DMDMi | 47117343 |
Proteomic databases
EPDi | Q9Y3L5 |
jPOSTi | Q9Y3L5 |
MassIVEi | Q9Y3L5 |
MaxQBi | Q9Y3L5 |
PaxDbi | Q9Y3L5 |
PeptideAtlasi | Q9Y3L5 |
PRIDEi | Q9Y3L5 |
ProteomicsDBi | 86043 |
Protocols and materials databases
Antibodypediai | 56035, 127 antibodies from 24 providers |
DNASUi | 57826 |
Genome annotation databases
Ensembli | ENST00000342983.6; ENSP00000340274.2; ENSG00000123728.10 ENST00000370874.2; ENSP00000359911.1; ENSG00000123728.10 |
GeneIDi | 57826 |
KEGGi | hsa:57826 |
MANE-Selecti | ENST00000370874.2; ENSP00000359911.1; NM_001271186.2; NP_001258115.1 |
UCSCi | uc004ewp.5, human |
Organism-specific databases
CTDi | 57826 |
DisGeNETi | 57826 |
GeneCardsi | RAP2C |
HGNCi | HGNC:21165, RAP2C |
HPAi | ENSG00000123728, Tissue enhanced (endometrium) |
neXtProti | NX_Q9Y3L5 |
OpenTargetsi | ENSG00000123728 |
PharmGKBi | PA134899238 |
VEuPathDBi | HostDB:ENSG00000123728 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000157245 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | Q9Y3L5 |
OMAi | QFTGINE |
OrthoDBi | 1353024at2759 |
PhylomeDBi | Q9Y3L5 |
TreeFami | TF313014 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3L5 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9Y3L5 |
Miscellaneous databases
BioGRID-ORCSi | 57826, 15 hits in 708 CRISPR screens |
ChiTaRSi | RAP2C, human |
GenomeRNAii | 57826 |
Pharosi | Q9Y3L5, Tbio |
PROi | PR:Q9Y3L5 |
RNActi | Q9Y3L5, protein |
Gene expression databases
Bgeei | ENSG00000123728, Expressed in body of uterus and 242 other tissues |
ExpressionAtlasi | Q9Y3L5, baseline and differential |
Genevisiblei | Q9Y3L5, HS |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAP2C_HUMAN | |
Accessioni | Q9Y3L5Primary (citable) accession number: Q9Y3L5 Secondary accession number(s): B3KWD6, Q5H9H9, Q9BTS0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | November 1, 1999 | |
Last modified: | May 25, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families