UniProtKB - Q9Y3L3 (3BP1_HUMAN)

BLAST

>sp|Q9Y3L3|3BP1_HUMAN SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQ
SGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLE
RDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHS
HTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRR
SLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMML
LSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLM
TFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTP
SNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGL
FSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPP
RPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPG
TPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNP
AQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN

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History
Entry version 166 (10 Oct 2018)
Sequence version 3 (16 Aug 2004)
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Protein

SH3 domain-binding protein 1

Gene

SH3BP1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563).4 Publications

GO - Molecular functionⁱ

GTPase activator activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22891260
- 24841563
semaphorin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24841563
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22891260
- 26465210
cell junction assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22891260
cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21658605
establishment of epithelial cell apical/basal polarity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22891260
negative regulation of small GTPase mediated signal transduction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
phagocytosis, engulfment
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26465210
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22891260
- 24841563
regulation of actin cytoskeleton organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24841563
regulation of actin filament depolymerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24841563
regulation of blood vessel endothelial cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24841563
semaphorin-plexin signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24841563

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation
Biological process	Phagocytosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SH3 domain-binding protein 1Imported
Gene namesⁱ	Name:SH3BP1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100092.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10824 SH3BP1
MIMⁱ	617368 gene
neXtProtⁱ	NX_Q9Y3L3

Keywords - Cellular componentⁱ

Cell junction, Cell projection, Cytoplasm, Nucleus, Tight junction

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	312	R → A: Probable loss of the GTPase activator activity. Loss of function in cell migration. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23616
Open Targets More...OpenTargetsⁱ	ENSG00000100092
PharmGKBⁱ	PA35732

Polymorphism and mutation databases

BioMutaⁱ	SH3BP1
DMDMⁱ	51338841

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056723	1 – 701	SH3 domain-binding protein 1Add BLAST		701

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	175	PhosphoserineCombined sources	1
Modified residueⁱ	241	PhosphoserineBy similarity	1
Modified residueⁱ	262	PhosphoserineCombined sources	1
Modified residueⁱ	264	PhosphoserineCombined sources	1
Modified residueⁱ	544	PhosphoserineCombined sources	1
Modified residueⁱ	550	PhosphoserineCombined sources	1
Modified residueⁱ	601	PhosphothreonineBy similarity	1
Modified residueⁱ	626	PhosphothreonineCombined sources	1
Modified residueⁱ	653	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y3L3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y3L3
PaxDbⁱ	Q9Y3L3
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3L3
PRIDEⁱ	Q9Y3L3
ProteomicsDBⁱ	86041 86042 [Q9Y3L3-2]

PTM databases

iPTMnetⁱ	Q9Y3L3
PhosphoSitePlusⁱ	Q9Y3L3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100092 Expressed in 122 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SH3BP1
Genevisibleⁱ	Q9Y3L3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000757

HPAⁱ

HPA000757

Interactionⁱ

Subunit structureⁱ

Interacts with RAC1 (By similarity). Interacts with the exocyst via EXOC4 and EXOC8; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (PubMed:21658605). Interacts with CD2AP and CGNL1; probably part of a complex at cell junctions (PubMed:22891260). Interacts with CAPZA1; recruits CAPZA1 to forming cell junctions (PubMed:22891260). May interact with AFDN (PubMed:22891260). Interacts with PLXND1; they dissociate upon SEMA3E binding to PLXND1 allowing SH3BP1 to transduce downstream signal through RAC1 inactivation (PubMed:24841563). Interacts with ABL1, GRB2 and SRC (via SH3 domain) (By similarity).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TERF1	P54274	2	EBI-346869,EBI-710997
TRIP10	Q15642	3	EBI-346869,EBI-739936

GO - Molecular functionⁱ

semaphorin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 24841563
SH3 domain binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117149, 20 interactors
IntActⁱ	Q9Y3L3, 9 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y3L3
STRINGⁱ	9606.ENSP00000350018

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y3L3
SMRⁱ	Q9Y3L3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	17 – 262	BARPROSITE-ProRule annotationAdd BLAST		246
Domainⁱ	276 – 469	Rho-GAPPROSITE-ProRule annotationAdd BLAST		194

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 275	Interaction with CGNL11 PublicationAdd BLAST		275
Regionⁱ	470 – 701	Interaction with CD2AP1 PublicationAdd BLAST		232

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	616 – 625	SH3-bindingBy similarity		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	500 – 693	Pro-richPROSITE-ProRule annotationAdd BLAST		194

Domainⁱ

The BAR domain mediates interaction with the exocyst components EXOC4 and EXOC8 and is required for the function in cell migration (PubMed:21658605). It also mediates the interaction with PLXND1 (PubMed:24841563).2 Publications

Keywords - Domainⁱ

SH3-binding

Phylogenomic databases

eggNOGⁱ	KOG4270 Eukaryota ENOG410XRR2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118863
HOGENOMⁱ	HOG000179193
HOVERGENⁱ	HBG000015
InParanoidⁱ	Q9Y3L3
KEGG Orthology (KO) More...KOⁱ	K20652
OMAⁱ	AGALKCY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02YP
PhylomeDBⁱ	Q9Y3L3
TreeFamⁱ	TF316514

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit 1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR004148 BAR_dom IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03114 BAR, 1 hit PF00620 RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00721 BAR, 1 hit SM00324 RhoGAP, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 2 hits SSF48350 SSF48350, 1 hit
PROSITEⁱ	View protein in PROSITE PS51021 BAR, 1 hit PS50238 RHOGAP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y3L3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMKRQLHRMR QLAQTGSLGR TPETAEFLGE DLLQVEQRLE PAKRAAHNIH 
        60         70         80         90        100
KRLQACLQGQ SGADMDKRVK KLPLMALSTT MAESFKELDP DSSMGKALEM 
       110        120        130        140        150
SCAIQNQLAR ILAEFEMTLE RDVLQPLSRL SEEELPAILK HKKSLQKLVS 
       160        170        180        190        200
DWNTLKSRLS QATKNSGSSQ GLGGSPGSHS HTTMANKVET LKEEEEELKR 
       210        220        230        240        250
KVEQCRDEYL ADLYHFVTKE DSYANYFIRL LEIQADYHRR SLSSLDTALA 
       260        270        280        290        300
ELRENHGQAD HSPSMTATHF PRVYGVSLAT HLQELGREIA LPIEACVMML 
       310        320        330        340        350
LSEGMKEEGL FRLAAGASVL KRLKQTMASD PHSLEEFCSD PHAVAGALKS 
       360        370        380        390        400
YLRELPEPLM TFDLYDDWMR AASLKEPGAR LQALQEVCSR LPPENLSNLR 
       410        420        430        440        450
YLMKFLARLA EEQEVNKMTP SNIAIVLGPN LLWPPEKEGD QAQLDAASVS 
       460        470        480        490        500
SIQVVGVVEA LIQSADTLFP GDINFNVSGL FSAVTLQDTV SDRLASEELP 
       510        520        530        540        550
STAVPTPATT PAPAPAPAPA PAPALASAAT KERTESEVPP RPASPKVTRS 
       560        570        580        590        600
PPETAAPVED MARRTKRPAP ARPTMPPPQV SGSRSSPPAP PLPPGSGSPG 
       610        620        630        640        650
TPQALPRRLV GSSLRAPTVP PPLPPTPPQP ARRQSRRSPA SPSPASPGPA 
       660        670        680        690        700
SPSPVSLSNP AQVDLGAATA EGGAPEAISG VPTPPAIPPQ PRPRSLASET 

N

Length:701

Mass (Da):75,713

Last modified:August 16, 2004 - v3

Checksum:ⁱ877D144E81F0F974

Isoform 2 (identifier: Q9Y3L3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
440-452: DQAQLDAASVSSI → TEPARELGSQTLC
453-701: Missing.

« Hide

        10         20         30         40         50
MMKRQLHRMR QLAQTGSLGR TPETAEFLGE DLLQVEQRLE PAKRAAHNIH 
        60         70         80         90        100
KRLQACLQGQ SGADMDKRVK KLPLMALSTT MAESFKELDP DSSMGKALEM 
       110        120        130        140        150
SCAIQNQLAR ILAEFEMTLE RDVLQPLSRL SEEELPAILK HKKSLQKLVS 
       160        170        180        190        200
DWNTLKSRLS QATKNSGSSQ GLGGSPGSHS HTTMANKVET LKEEEEELKR 
       210        220        230        240        250
KVEQCRDEYL ADLYHFVTKE DSYANYFIRL LEIQADYHRR SLSSLDTALA 
       260        270        280        290        300
ELRENHGQAD HSPSMTATHF PRVYGVSLAT HLQELGREIA LPIEACVMML 
       310        320        330        340        350
LSEGMKEEGL FRLAAGASVL KRLKQTMASD PHSLEEFCSD PHAVAGALKS 
       360        370        380        390        400
YLRELPEPLM TFDLYDDWMR AASLKEPGAR LQALQEVCSR LPPENLSNLR 
       410        420        430        440        450
YLMKFLARLA EEQEVNKMTP SNIAIVLGPN LLWPPEKEGT EPARELGSQT 

LC

Show »

Length:452

Mass (Da):50,820

Checksum:ⁱA2C33CFBB2532FD0

Isoform Long BGIN1 Publication (identifier: Q6ZT62-1) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q6ZT62.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a naturally occurring readthrough transcript which produces a SH3BP1-PDXP fusion protein. Translation initiation occurs at a non-canonical CUG codon.1 Publication

Length:677

Mass (Da):73,599

Isoform Short BGIN1 Publication (identifier: Q6ZT62-2) [UniParc]FASTA Add to basket

The sequence of this isoform can be found in the external entry Q6ZT62.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Produced by alternative initiation at Met-73 of isoform long BGIN.1 Publication

Length:605

Mass (Da):66,180

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A2R8Y5V0	A0A2R8Y5V0_HUMAN	SH3 domain-binding protein 1 SH3 domain-binding protein 1	SH3BP1	387	Annotation score:
F8WEQ3	F8WEQ3_HUMAN	SH3 domain-binding protein 1 SH3 domain-binding protein 1	SH3BP1	20	Annotation score:

Sequence cautionⁱ

The sequence AAH08282 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC85842 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC85842 differs from that shown. Reason: Erroneous termination at position 56. Translated as Cys.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_033450	511	P → L. Corresponds to variant dbSNP:rs929038Ensembl.		1
Natural variantⁱVAR_033451	656	S → F. Corresponds to variant dbSNP:rs2269548Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_011373	440 – 452	DQAQL…SVSSI → TEPARELGSQTLC in isoform 2. 1 PublicationAdd BLAST		13
Alternative sequenceⁱVSP_011374	453 – 701	Missing in isoform 2. 1 PublicationAdd BLAST		249

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR456576 mRNA Translation: CAG30462.1 AK124370 mRNA Translation: BAC85842.1 Sequence problems. Z83844 Genomic DNA No translation available. BC008282 mRNA Translation: AAH08282.1 Different initiation. AL157480 mRNA Translation: CAB75671.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13952.2 [Q9Y3L3-1]
PIRⁱ	T46916
NCBI Reference Sequences More...RefSeqⁱ	NP_061830.3, NM_018957.3 [Q9Y3L3-1]
UniGeneⁱ	Hs.601143

Genome annotation databases

Ensemblⁱ	ENST00000357436; ENSP00000350018; ENSG00000100092 [Q9Y3L3-1] ENST00000417536; ENSP00000411979; ENSG00000100092 [Q9Y3L3-2]
GeneIDⁱ	23616
KEGGⁱ	hsa:23616
UCSC genome browser More...UCSCⁱ	uc003atg.2 human [Q9Y3L3-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3L3	SH3-domain binding protein 1, isoform CRA_d (Fragment)		HUMAN		701	UniRef100_Q9Y3L3
Q6ZT62-2	Bargin		HUMAN		677	UniRef100_Q6ZT62

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3L3	SH3-domain binding protein 1, isoform CRA_d (Fragment)		HUMAN		701	UniRef90_Q9Y3L3
Uncharacterized protein		MACMU		709
Uncharacterized protein		CERAT		709
Uncharacterized protein		PAPAN		709
Uncharacterized protein		CHLSB		709
+41
Q9Y3L3-2	SH3 domain-binding protein 1 isoform X3		NEOSC		559	UniRef90_Q9Y3L3-2
SH3BP1 isoform 3		PANTR		452
SH3BP1 isoform 1		PONAB		452
Q6ZT62-2	Bargin		HUMAN		677	UniRef90_Q6ZT62
SH3 domain-binding protein 1		TARSY		665
Uncharacterized protein		OTOGA		597
Uncharacterized protein		AOTNA		79
UPI000D09B44C		PANTR		669
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3L3	SH3-domain binding protein 1, isoform CRA_d (Fragment)		HUMAN		701	UniRef50_Q9Y3L3
Uncharacterized protein		CERAT		709
Uncharacterized protein		MACMU		709
Uncharacterized protein		CHLSB		709
Uncharacterized protein		PAPAN		709
+61
Q9Y3L3-2	SH3 domain-binding protein 1 isoform X3		NEOSC		559	UniRef50_Q9Y3L3-2
SH3BP1 isoform 3		PANTR		452
SH3BP1 isoform 1		PONAB		452
Uncharacterized protein		CAVPO		569
SH3 domain-binding protein 1 isoform X3		MESAU		585
+14
Q6ZT62-2	SH3 domain-binding protein 1	)	MOUSE		680	UniRef50_P55194
SH3 domain-binding protein 1		RAT		689
Bargin		HUMAN		677
Uncharacterized protein		NOMLE		682
SH3 domain-binding protein 1		DIPOR		733
+193

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR456576 mRNA Translation: CAG30462.1 AK124370 mRNA Translation: BAC85842.1 Sequence problems. Z83844 Genomic DNA No translation available. BC008282 mRNA Translation: AAH08282.1 Different initiation. AL157480 mRNA Translation: CAB75671.2
CCDSⁱ	CCDS13952.2 [Q9Y3L3-1]
PIRⁱ	T46916
RefSeqⁱ	NP_061830.3, NM_018957.3 [Q9Y3L3-1]
UniGeneⁱ	Hs.601143

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4J9D	X-ray	1.50	B/D/F	616-625	[»]
	4J9F	X-ray	1.09	B/D/F	616-625	[»]
ProteinModelPortalⁱ	Q9Y3L3
SMRⁱ	Q9Y3L3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117149, 20 interactors
IntActⁱ	Q9Y3L3, 9 interactors
MINTⁱ	Q9Y3L3
STRINGⁱ	9606.ENSP00000350018

PTM databases

iPTMnetⁱ	Q9Y3L3
PhosphoSitePlusⁱ	Q9Y3L3

Polymorphism and mutation databases

BioMutaⁱ	SH3BP1
DMDMⁱ	51338841

Proteomic databases

EPDⁱ	Q9Y3L3
MaxQBⁱ	Q9Y3L3
PaxDbⁱ	Q9Y3L3
PeptideAtlasⁱ	Q9Y3L3
PRIDEⁱ	Q9Y3L3
ProteomicsDBⁱ	86041 86042 [Q9Y3L3-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23616
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357436; ENSP00000350018; ENSG00000100092 [Q9Y3L3-1] ENST00000417536; ENSP00000411979; ENSG00000100092 [Q9Y3L3-2]
GeneIDⁱ	23616
KEGGⁱ	hsa:23616
UCSCⁱ	uc003atg.2 human [Q9Y3L3-1]

Organism-specific databases

CTDⁱ	23616
DisGeNETⁱ	23616
EuPathDBⁱ	HostDB:ENSG00000100092.20
GeneCardsⁱ	SH3BP1
H-InvDBⁱ	HIX0016448 HIX0016449
HGNCⁱ	HGNC:10824 SH3BP1
HPAⁱ	HPA000757
MIMⁱ	617368 gene
neXtProtⁱ	NX_Q9Y3L3
OpenTargetsⁱ	ENSG00000100092
PharmGKBⁱ	PA35732
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4270 Eukaryota ENOG410XRR2 LUCA
GeneTreeⁱ	ENSGT00760000118863
HOGENOMⁱ	HOG000179193
HOVERGENⁱ	HBG000015
InParanoidⁱ	Q9Y3L3
KOⁱ	K20652
OMAⁱ	AGALKCY
OrthoDBⁱ	EOG091G02YP
PhylomeDBⁱ	Q9Y3L3
TreeFamⁱ	TF316514

Miscellaneous databases

ChiTaRSⁱ	SH3BP1 human
GeneWikiⁱ	SH3BP1
GenomeRNAiⁱ	23616
Protein Ontology More...PROⁱ	PR:Q9Y3L3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100092 Expressed in 122 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_SH3BP1
Genevisibleⁱ	Q9Y3L3 HS

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit 1.20.1270.60, 1 hit
InterProⁱ	View protein in InterPro IPR027267 AH/BAR_dom_sf IPR004148 BAR_dom IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom
Pfamⁱ	View protein in Pfam PF03114 BAR, 1 hit PF00620 RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00721 BAR, 1 hit SM00324 RhoGAP, 1 hit
SUPFAMⁱ	SSF103657 SSF103657, 2 hits SSF48350 SSF48350, 1 hit
PROSITEⁱ	View protein in PROSITE PS51021 BAR, 1 hit PS50238 RHOGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	3BP1_HUMAN
Accessionⁱ	Q9Y3L3Primary (citable) accession number: Q9Y3L3 Secondary accession number(s): Q5R3N0 , Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	August 16, 2004
	Last modified:	October 10, 2018
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y3L3 (3BP1_HUMAN)

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SH3 domain-binding protein 1

SH3BP1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Other locations

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ