FBXO7

Functionⁱ

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.3 Publications

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

protein heterodimerization activity
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18495667
protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18495667
ubiquitin binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 25029497
ubiquitin protein ligase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16510124
ubiquitin-protein transferase activity
Source: Reactome
Inferred from experimentⁱ
- 19028597

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy of mitochondrion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23933751
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
negative regulation of hydrogen peroxide-induced neuron death
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 26310625
negative regulation of lymphocyte differentiation Source: Ensembl
negative regulation of oxidative stress-induced neuron death
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25029497
positive regulation of autophagy of mitochondrion
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 26310625
post-translational protein modification Source: Reactome
protein polyubiquitination Source: Reactome
protein targeting to mitochondrion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23933751
protein ubiquitination
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 16510124
regulation of locomotion
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 26310625
regulation of neuron projection development
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25029497
regulation of protein stability
Source: UniProtKB
Inferred from direct assayⁱ
- 15145941
ubiquitin-dependent protein catabolic process
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 25029497

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Ubl conjugation pathway

Biological process

Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: F-box only protein 7
Gene namesⁱ	Name:FBXO7 Synonyms:FBX7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 22

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100225.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13586 FBXO7
MIMⁱ	605648 gene
neXtProtⁱ	NX_Q9Y3I1

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Parkinson disease 15 (PARK15)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disorder characterized by parkinsonian and pyramidal signs. Clinical manifestations include tremor, bradykinesia, rigidity, postural instability, spasticity, mainly in the lower limbs, and hyperreflexia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_047938	378	R → G in PARK15; no effect on interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs71799110EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	22	T → M: Impairs interaction with PRKN. 1 Publication		1
Mutagenesisⁱ	253	V → E: Abolishes interaction with PSMF1. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25793
GeneReviewsⁱ	FBXO7
MalaCards human disease database More...MalaCardsⁱ	FBXO7
MIMⁱ	260300 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100225
Orphanetⁱ	171695 Parkinsonian-pyramidal syndrome
PharmGKBⁱ	PA28047

Polymorphism and mutation databases

BioMutaⁱ	FBXO7
DMDMⁱ	13124249

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000119885	1 – 522	F-box only protein 7Add BLAST		522

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	432	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	451	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	518	Asymmetric dimethylarginineBy similarity	1

Keywords - PTMⁱ

Methylation

Proteomic databases

EPDⁱ	Q9Y3I1
PaxDbⁱ	Q9Y3I1
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3I1
PRIDEⁱ	Q9Y3I1
ProteomicsDBⁱ	86039 86040 [Q9Y3I1-2]

PTM databases

iPTMnetⁱ	Q9Y3I1
PhosphoSitePlusⁱ	Q9Y3I1
SwissPalmⁱ	Q9Y3I1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000100225 Expressed in 232 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_FBXO7
ExpressionAtlasⁱ	Q9Y3I1 baseline and differential
Genevisibleⁱ	Q9Y3I1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034296 HPA032113 HPA032114

HPAⁱ

CAB034296
HPA032113
HPA032114

Interactionⁱ

Subunit structureⁱ

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Isoform 1 interacts (via the N-terminal Ubl domain) with PRKN. Isoforms that lack the ubiquitin-like domain do not interact with PRKN. Isoform 1 and isoform 2 interact (via N-terminal region) with PINK1. Isoform 3 does not interact with PINK1. Interacts with PSMF1.6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PINK1	Q9BXM7	8	EBI-1161222,EBI-2846068
PRKN	O60260	10	EBI-1161222,EBI-716346
PSMA3	P25788	6	EBI-1161222,EBI-348380
PSME3	P61289	3	EBI-1161222,EBI-355546
PSMF1	Q92530	7	EBI-1161222,EBI-945916
SKP1	P63208	7	EBI-1161222,EBI-307486

GO - Molecular functionⁱ

protein heterodimerization activity
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18495667
protein kinase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 18495667
ubiquitin binding
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 25029497
ubiquitin protein ligase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16510124

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117326, 87 interactors
Database of interacting proteins More...DIPⁱ	DIP-36125N
IntActⁱ	Q9Y3I1, 36 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y3I1
STRINGⁱ	9606.ENSP00000266087

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	181 – 190	Combined sources	10
Helixⁱ	195 – 209	Combined sources	15
Beta strandⁱ	213 – 216	Combined sources	4
Turnⁱ	220 – 222	Combined sources	3
Beta strandⁱ	228 – 230	Combined sources	3
Beta strandⁱ	233 – 239	Combined sources	7
Helixⁱ	241 – 243	Combined sources	3
Beta strandⁱ	247 – 255	Combined sources	9
Beta strandⁱ	258 – 267	Combined sources	10
Beta strandⁱ	270 – 279	Combined sources	10
Helixⁱ	281 – 283	Combined sources	3
Helixⁱ	287 – 289	Combined sources	3
Helixⁱ	294 – 297	Combined sources	4
Helixⁱ	301 – 311	Combined sources	11
Helixⁱ	313 – 323	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y3I1
SMRⁱ	Q9Y3I1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	329 – 375	F-boxPROSITE-ProRule annotationAdd BLAST		47

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 88	Ubiquitin-likeAdd BLAST	88
Regionⁱ	92 – 129	Important for interaction with PINK11 PublicationAdd BLAST	38
Regionⁱ	129 – 169	Important for interaction with CDK6Add BLAST	41
Regionⁱ	180 – 324	Important for dimerization and interaction with PSMF11 PublicationAdd BLAST	145
Regionⁱ	381 – 522	Important for interaction with CDK6Add BLAST	142

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	481 – 484	RFDP motif		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	423 – 514	Pro-richAdd BLAST		92

Domainⁱ

The ubiquitin-like region mediates interaction with PRKN.

The proline-rich region is important for protein-protein interactions.

Phylogenomic databases

eggNOGⁱ	ENOG410IGV9 Eukaryota ENOG410XQUZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006670
HOGENOMⁱ	HOG000112551
HOVERGENⁱ	HBG005648
InParanoidⁱ	Q9Y3I1
KEGG Orthology (KO) More...KOⁱ	K10293
OMAⁱ	HPIPFYP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FNN
PhylomeDBⁱ	Q9Y3I1
TreeFamⁱ	TF329830

Family and domain databases

InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR021625 PI31_Prot_N IPR029071 Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12937 F-box-like, 1 hit PF11566 PI31_Prot_N, 1 hit
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y3I1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL 
        60         70         80         90        100
NYKDPLTGDE ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN 
       110        120        130        140        150
NEQPSLATSS NQTSMQDEQP SDSFQGQAAQ SGVWNDDSML GPSQNFEAES 
       160        170        180        190        200
IQDNAHMAEG TGFYPSEPML CSESVEGQVP HSLETLYQSA DCSDANDALI 
       210        220        230        240        250
VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH PLCEGSSATL 
       260        270        280        290        300
TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD 
       310        320        330        340        350
LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR 
       360        370        380        390        400
SVLSLSAVCR DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH 
       410        420        430        440        450
IQRKESPKGR FVMLLPSSTH TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ 
       460        470        480        490        500
RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP RFDPVGPLPG PNPILPGRGG 
       510        520 
PNDRFPFRPS RGRPTDGRLS FM

Length:522

Mass (Da):58,503

Last modified:November 1, 1999 - v1

Checksum:ⁱC4E5E70A0747287A

GO

Isoform 2 (identifier: Q9Y3I1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-79: Missing.
80-91: DDIPAPNIPSST → MARPPGGSGPLL

« Hide

        10         20         30         40         50
MARPPGGSGP LLDSEHSSLQ NNEQPSLATS SNQTSMQDEQ PSDSFQGQAA 
        60         70         80         90        100
QSGVWNDDSM LGPSQNFEAE SIQDNAHMAE GTGFYPSEPM LCSESVEGQV 
       110        120        130        140        150
PHSLETLYQS ADCSDANDAL IVLIHLLMLE SGYIPQGTEA KALSMPEKWK 
       160        170        180        190        200
LSGVYKLQYM HPLCEGSSAT LTCVPLGNLI VVNATLKINN EIRSVKRLQL 
       210        220        230        240        250
LPESFICKEK LGENVANIYK DLQKLSRLFK DQLVYPLLAF TRQALNLPDV 
       260        270        280        290        300
FGLVVLPLEL KLRIFRLLDV RSVLSLSAVC RDLFTASNDP LLWRFLYLRD 
       310        320        330        340        350
FRDNTVRVQD TDWKELYRKR HIQRKESPKG RFVMLLPSST HTIPFYPNPL 
       360        370        380        390        400
HPRPFPSSRL PPGIIGGEYD QRPTLPYVGD PISSLIPGPG ETPSQFPPLR 
       410        420        430        440 
PRFDPVGPLP GPNPILPGRG GPNDRFPFRP SRGRPTDGRL SFM

Show »

Length:443

Mass (Da):49,358

Checksum:ⁱ263A319CE0096FFB

GO

Isoform 3 (identifier: Q9Y3I1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-114: Missing.

« Hide

        10         20         30         40         50
MQDEQPSDSF QGQAAQSGVW NDDSMLGPSQ NFEAESIQDN AHMAEGTGFY 
        60         70         80         90        100
PSEPMLCSES VEGQVPHSLE TLYQSADCSD ANDALIVLIH LLMLESGYIP 
       110        120        130        140        150
QGTEAKALSM PEKWKLSGVY KLQYMHPLCE GSSATLTCVP LGNLIVVNAT 
       160        170        180        190        200
LKINNEIRSV KRLQLLPESF ICKEKLGENV ANIYKDLQKL SRLFKDQLVY 
       210        220        230        240        250
PLLAFTRQAL NLPDVFGLVV LPLELKLRIF RLLDVRSVLS LSAVCRDLFT 
       260        270        280        290        300
ASNDPLLWRF LYLRDFRDNT VRVQDTDWKE LYRKRHIQRK ESPKGRFVML 
       310        320        330        340        350
LPSSTHTIPF YPNPLHPRPF PSSRLPPGII GGEYDQRPTL PYVGDPISSL 
       360        370        380        390        400
IPGPGETPSQ FPPLRPRFDP VGPLPGPNPI LPGRGGPNDR FPFRPSRGRP 

TDGRLSFM

Note: No experimental confirmation available.

Show »

Length:408

Mass (Da):45,781

Checksum:ⁱFE4FE5ECFEAC37C5

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WDR9	F8WDR9_HUMAN	F-box only protein 7 F-box only protein 7	FBXO7	49	Annotation score:
F8WBR0	F8WBR0_HUMAN	F-box only protein 7 F-box only protein 7	FBXO7	41	Annotation score:
A2A282	A2A282_HUMAN	F-box only protein 7 F-box only protein 7	FBXO7	54	Annotation score:

Sequence cautionⁱ

The sequence AAF04471 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	79	Q → H in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	84	A → P in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	154	N → S in BAG63187 (PubMed:14702039).Curated	1
Sequence conflictⁱ	169	M → L in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	224	M → L in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	241	P → H in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	328	D → N in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	413	M → L in AAF04471 (PubMed:10531035).Curated	1
Sequence conflictⁱ	475	F → L in AAF04471 (PubMed:10531035).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021408	115	M → I4 PublicationsCorresponds to variant dbSNP:rs11107EnsemblClinVar.	1
Natural variantⁱVAR_047938	378	R → G in PARK15; no effect on interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs71799110EnsemblClinVar.	1
Natural variantⁱVAR_066022	481	R → C Found in two patients with Kufor-Rakeb syndrome also carrying R-877 in ATP13A2. 1 PublicationCorresponds to variant dbSNP:rs148272407Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044723	1 – 114	Missing in isoform 3. 1 PublicationAdd BLAST	114
Alternative sequenceⁱVSP_041073	1 – 79	Missing in isoform 2. 1 PublicationAdd BLAST	79
Alternative sequenceⁱVSP_041074	80 – 91	DDIPA…IPSST → MARPPGGSGPLL in isoform 2. 1 PublicationAdd BLAST	12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF233225 mRNA Translation: AAF67155.1 AL050254 mRNA Translation: CAB43356.1 CR456491 mRNA Translation: CAG30377.1 AK297841 mRNA Translation: BAG60175.1 AK301716 mRNA Translation: BAG63187.1 AL021937 Genomic DNA No translation available. AL035068 Genomic DNA No translation available. Z71183 Genomic DNA No translation available. BC008361 mRNA Translation: AAH08361.1 AF129537 mRNA Translation: AAF04471.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13907.1 [Q9Y3I1-1] CCDS46695.1 [Q9Y3I1-2] CCDS58806.1 [Q9Y3I1-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001028196.1, NM_001033024.1 [Q9Y3I1-2] NP_001244919.1, NM_001257990.1 [Q9Y3I1-3] NP_036311.3, NM_012179.3 [Q9Y3I1-1]
UniGeneⁱ	Hs.5912

Genome annotation databases

Ensemblⁱ	ENST00000266087; ENSP00000266087; ENSG00000100225 [Q9Y3I1-1] ENST00000397426; ENSP00000380571; ENSG00000100225 [Q9Y3I1-3] ENST00000452138; ENSP00000388547; ENSG00000100225 [Q9Y3I1-2]
GeneIDⁱ	25793
KEGGⁱ	hsa:25793
UCSC genome browser More...UCSCⁱ	uc003amq.4 human [Q9Y3I1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3I1	F-box only protein 7		HUMAN		41	UniRef100_Q9Y3I1
Isoform 3 of F-box only protein 7		HUMAN		408
UPI00002075D5		HUMAN		366

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3I1	F-box only protein 7		HUMAN		41	UniRef90_Q9Y3I1
F-box protein 7		PONAB		614
Uncharacterized protein		CHLSB		522
F-box protein 7		PANTR		522
F-box only protein 7		PAPAN		522
+30
Q9Y3I1-2	F-box only protein 7 isoform 1		CALJA		522	UniRef90_Q9Y3I1-2
F-box only protein 7 isoform 1 (Predicted)		PLEMO		522
Uncharacterized protein		Cebus capucinus imitator		522
Uncharacterized protein		RHIBE		522
Uncharacterized protein		AOTNA		522
+38

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3I1	F-box only protein 7		BOVIN		522	UniRef50_Q9Y3I1
F-box only protein 7		MOUSE		523
F-box only protein 7		RAT		522
F-box only protein 7		HUMAN		41
F-box protein 7		PONAB		614
+360

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF233225 mRNA Translation: AAF67155.1 AL050254 mRNA Translation: CAB43356.1 CR456491 mRNA Translation: CAG30377.1 AK297841 mRNA Translation: BAG60175.1 AK301716 mRNA Translation: BAG63187.1 AL021937 Genomic DNA No translation available. AL035068 Genomic DNA No translation available. Z71183 Genomic DNA No translation available. BC008361 mRNA Translation: AAH08361.1 AF129537 mRNA Translation: AAF04471.1 Different initiation.
CCDSⁱ	CCDS13907.1 [Q9Y3I1-1] CCDS46695.1 [Q9Y3I1-2] CCDS58806.1 [Q9Y3I1-3]
RefSeqⁱ	NP_001028196.1, NM_001033024.1 [Q9Y3I1-2] NP_001244919.1, NM_001257990.1 [Q9Y3I1-3] NP_036311.3, NM_012179.3 [Q9Y3I1-1]
UniGeneⁱ	Hs.5912

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4L9C	X-ray	2.10	A/B	180-335	[»]
	4L9H	X-ray	2.00	A	180-335	[»]
ProteinModelPortalⁱ	Q9Y3I1
SMRⁱ	Q9Y3I1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117326, 87 interactors
DIPⁱ	DIP-36125N
IntActⁱ	Q9Y3I1, 36 interactors
MINTⁱ	Q9Y3I1
STRINGⁱ	9606.ENSP00000266087

PTM databases

iPTMnetⁱ	Q9Y3I1
PhosphoSitePlusⁱ	Q9Y3I1
SwissPalmⁱ	Q9Y3I1

Polymorphism and mutation databases

BioMutaⁱ	FBXO7
DMDMⁱ	13124249

Proteomic databases

EPDⁱ	Q9Y3I1
PaxDbⁱ	Q9Y3I1
PeptideAtlasⁱ	Q9Y3I1
PRIDEⁱ	Q9Y3I1
ProteomicsDBⁱ	86039 86040 [Q9Y3I1-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	25793
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000266087; ENSP00000266087; ENSG00000100225 [Q9Y3I1-1] ENST00000397426; ENSP00000380571; ENSG00000100225 [Q9Y3I1-3] ENST00000452138; ENSP00000388547; ENSG00000100225 [Q9Y3I1-2]
GeneIDⁱ	25793
KEGGⁱ	hsa:25793
UCSCⁱ	uc003amq.4 human [Q9Y3I1-1]

Organism-specific databases

CTDⁱ	25793
DisGeNETⁱ	25793
EuPathDBⁱ	HostDB:ENSG00000100225.17
GeneCardsⁱ	FBXO7
GeneReviewsⁱ	FBXO7
HGNCⁱ	HGNC:13586 FBXO7
HPAⁱ	CAB034296 HPA032113 HPA032114
MalaCardsⁱ	FBXO7
MIMⁱ	260300 phenotype 605648 gene
neXtProtⁱ	NX_Q9Y3I1
OpenTargetsⁱ	ENSG00000100225
Orphanetⁱ	171695 Parkinsonian-pyramidal syndrome
PharmGKBⁱ	PA28047
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGV9 Eukaryota ENOG410XQUZ LUCA
GeneTreeⁱ	ENSGT00390000006670
HOGENOMⁱ	HOG000112551
HOVERGENⁱ	HBG005648
InParanoidⁱ	Q9Y3I1
KOⁱ	K10293
OMAⁱ	HPIPFYP
OrthoDBⁱ	EOG091G0FNN
PhylomeDBⁱ	Q9Y3I1
TreeFamⁱ	TF329830

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSⁱ	FBXO7 human
GeneWikiⁱ	FBXO7
GenomeRNAiⁱ	25793
Protein Ontology More...PROⁱ	PR:Q9Y3I1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100225 Expressed in 232 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_FBXO7
ExpressionAtlasⁱ	Q9Y3I1 baseline and differential
Genevisibleⁱ	Q9Y3I1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036047 F-box-like_dom_sf IPR001810 F-box_dom IPR021625 PI31_Prot_N IPR029071 Ubiquitin-like_domsf
Pfamⁱ	View protein in Pfam PF12937 F-box-like, 1 hit PF11566 PI31_Prot_N, 1 hit
SMARTⁱ	View protein in SMART SM00256 FBOX, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF81383 SSF81383, 1 hit
PROSITEⁱ	View protein in PROSITE PS50181 FBOX, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FBX7_HUMAN
Accessionⁱ	Q9Y3I1Primary (citable) accession number: Q9Y3I1 Secondary accession number(s): B4DNB3 Q9UKT2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniRef

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UniProtKB - Q9Y3I1 (FBX7_HUMAN)

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F-box only protein 7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Cytosol

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ