UniProtKB - Q9Y3I1 (FBX7_HUMAN)
F-box only protein 7
FBXO7
Functioni
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- protein kinase binding Source: ParkinsonsUK-UCL
- ubiquitin binding Source: ParkinsonsUK-UCL
- ubiquitin ligase-substrate adaptor activity Source: UniProtKB
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
- ubiquitin-protein transferase activity Source: ProtInc
GO - Biological processi
- autophagy of mitochondrion Source: UniProtKB
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
- negative regulation of hydrogen peroxide-induced neuron death Source: ParkinsonsUK-UCL
- negative regulation of lymphocyte differentiation Source: Ensembl
- negative regulation of oxidative stress-induced neuron death Source: ParkinsonsUK-UCL
- positive regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
- post-translational protein modification Source: Reactome
- protein polyubiquitination Source: Reactome
- protein targeting to mitochondrion Source: UniProtKB
- protein ubiquitination Source: ParkinsonsUK-UCL
- regulation of locomotion Source: ParkinsonsUK-UCL
- regulation of neuron projection development Source: ParkinsonsUK-UCL
- regulation of protein stability Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3I1 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box only protein 7 |
Gene namesi | Name:FBXO7 Synonyms:FBX7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100225.17 |
HGNCi | HGNC:13586, FBXO7 |
MIMi | 605648, gene |
neXtProti | NX_Q9Y3I1 |
Subcellular locationi
Cytosol
Nucleus
Mitochondrion
Other locations
Note: Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria.
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: ParkinsonsUK-UCL
Other locations
- classical Lewy body Source: ParkinsonsUK-UCL
- cytoplasm Source: ParkinsonsUK-UCL
- glial cytoplasmic inclusion Source: ParkinsonsUK-UCL
- Lewy body core Source: ParkinsonsUK-UCL
- Lewy body corona Source: ParkinsonsUK-UCL
- Lewy neurite Source: ParkinsonsUK-UCL
- protein-containing complex Source: LIFEdb
- SCF ubiquitin ligase complex Source: UniProtKB
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Involvement in diseasei
Parkinson disease 15 (PARK15)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047938 | 378 | R → G in PARK15; no effect on interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs71799110EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 22 | T → M: Impairs interaction with PRKN. 1 Publication | 1 | |
Mutagenesisi | 253 | V → E: Abolishes interaction with PSMF1. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Neurodegeneration, Parkinson disease, ParkinsonismOrganism-specific databases
DisGeNETi | 25793 |
GeneReviewsi | FBXO7 |
MalaCardsi | FBXO7 |
MIMi | 260300, phenotype |
OpenTargetsi | ENSG00000100225 |
Orphaneti | 171695, Parkinsonian-pyramidal syndrome |
PharmGKBi | PA28047 |
Miscellaneous databases
Pharosi | Q9Y3I1, Tbio |
Polymorphism and mutation databases
BioMutai | FBXO7 |
DMDMi | 13124249 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000119885 | 1 – 522 | F-box only protein 7Add BLAST | 522 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 432 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 451 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 518 | Asymmetric dimethylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
EPDi | Q9Y3I1 |
jPOSTi | Q9Y3I1 |
MassIVEi | Q9Y3I1 |
PaxDbi | Q9Y3I1 |
PeptideAtlasi | Q9Y3I1 |
PRIDEi | Q9Y3I1 |
ProteomicsDBi | 65179 86039 [Q9Y3I1-1] 86040 [Q9Y3I1-2] |
PTM databases
iPTMneti | Q9Y3I1 |
PhosphoSitePlusi | Q9Y3I1 |
SwissPalmi | Q9Y3I1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100225, Expressed in bone marrow and 243 other tissues |
ExpressionAtlasi | Q9Y3I1, baseline and differential |
Genevisiblei | Q9Y3I1, HS |
Organism-specific databases
HPAi | ENSG00000100225, Low tissue specificity |
Interactioni
Subunit structurei
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7.
Interacts via its C-terminal proline-rich region with DLGAP5.
Interacts with BIRC2.
Interacts with CDK6 and promotes its interaction with D-type cyclin. Isoform 1 interacts (via the N-terminal Ubl domain) with PRKN. Isoforms that lack the ubiquitin-like domain do not interact with PRKN. Isoform 1 and isoform 2 interact (via N-terminal region) with PINK1. Isoform 3 does not interact with PINK1.
Interacts with PSMF1.
6 PublicationsBinary interactionsi
Hide detailsQ9Y3I1
Isoform 1 [Q9Y3I1-1]
With | #Exp. | IntAct |
---|---|---|
PINK1 [Q9BXM7] | 2 | EBI-9102965,EBI-2846068 |
PRKN [O60260] | 2 | EBI-9102965,EBI-716346 |
GO - Molecular functioni
- protein heterodimerization activity Source: ParkinsonsUK-UCL
- protein kinase binding Source: ParkinsonsUK-UCL
- ubiquitin binding Source: ParkinsonsUK-UCL
- ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGRIDi | 117326, 536 interactors |
DIPi | DIP-36125N |
IntActi | Q9Y3I1, 65 interactors |
MINTi | Q9Y3I1 |
STRINGi | 9606.ENSP00000266087 |
Miscellaneous databases
RNActi | Q9Y3I1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y3I1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 329 – 375 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 88 | Ubiquitin-likeAdd BLAST | 88 | |
Regioni | 92 – 129 | Important for interaction with PINK11 PublicationAdd BLAST | 38 | |
Regioni | 129 – 169 | Important for interaction with CDK6Add BLAST | 41 | |
Regioni | 180 – 324 | Important for dimerization and interaction with PSMF11 PublicationAdd BLAST | 145 | |
Regioni | 381 – 522 | Important for interaction with CDK6Add BLAST | 142 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 481 – 484 | RFDP motif | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 423 – 514 | Pro-richAdd BLAST | 92 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502QTNJ, Eukaryota |
GeneTreei | ENSGT00390000006670 |
HOGENOMi | CLU_039588_0_0_1 |
InParanoidi | Q9Y3I1 |
OMAi | ICLVLED |
OrthoDBi | 999024at2759 |
PhylomeDBi | Q9Y3I1 |
TreeFami | TF329830 |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR021625, PI31_Prot_N IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF11566, PI31_Prot_N, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL
60 70 80 90 100
NYKDPLTGDE ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN
110 120 130 140 150
NEQPSLATSS NQTSMQDEQP SDSFQGQAAQ SGVWNDDSML GPSQNFEAES
160 170 180 190 200
IQDNAHMAEG TGFYPSEPML CSESVEGQVP HSLETLYQSA DCSDANDALI
210 220 230 240 250
VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH PLCEGSSATL
260 270 280 290 300
TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD
310 320 330 340 350
LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR
360 370 380 390 400
SVLSLSAVCR DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH
410 420 430 440 450
IQRKESPKGR FVMLLPSSTH TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ
460 470 480 490 500
RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP RFDPVGPLPG PNPILPGRGG
510 520
PNDRFPFRPS RGRPTDGRLS FM
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A282 | A2A282_HUMAN | F-box only protein 7 | FBXO7 | 54 | Annotation score: | ||
F8WDR9 | F8WDR9_HUMAN | F-box only protein 7 | FBXO7 | 49 | Annotation score: | ||
F8WBR0 | F8WBR0_HUMAN | F-box only protein 7 | FBXO7 | 41 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | Q → H in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 84 | A → P in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 154 | N → S in BAG63187 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 169 | M → L in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 224 | M → L in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 241 | P → H in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 328 | D → N in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 413 | M → L in AAF04471 (PubMed:10531035).Curated | 1 | |
Sequence conflicti | 475 | F → L in AAF04471 (PubMed:10531035).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021408 | 115 | M → I4 PublicationsCorresponds to variant dbSNP:rs11107EnsemblClinVar. | 1 | |
Natural variantiVAR_047938 | 378 | R → G in PARK15; no effect on interaction with PRKN. 2 PublicationsCorresponds to variant dbSNP:rs71799110EnsemblClinVar. | 1 | |
Natural variantiVAR_066022 | 481 | R → C Found in two patients with Kufor-Rakeb syndrome also carrying R-877 in ATP13A2. 1 PublicationCorresponds to variant dbSNP:rs148272407EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044723 | 1 – 114 | Missing in isoform 3. 1 PublicationAdd BLAST | 114 | |
Alternative sequenceiVSP_041073 | 1 – 79 | Missing in isoform 2. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_041074 | 80 – 91 | DDIPA…IPSST → MARPPGGSGPLL in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF233225 mRNA Translation: AAF67155.1 AL050254 mRNA Translation: CAB43356.1 CR456491 mRNA Translation: CAG30377.1 AK297841 mRNA Translation: BAG60175.1 AK301716 mRNA Translation: BAG63187.1 AL021937 Genomic DNA No translation available. AL035068 Genomic DNA No translation available. Z71183 Genomic DNA No translation available. BC008361 mRNA Translation: AAH08361.1 AF129537 mRNA Translation: AAF04471.1 Different initiation. |
CCDSi | CCDS13907.1 [Q9Y3I1-1] CCDS46695.1 [Q9Y3I1-2] CCDS58806.1 [Q9Y3I1-3] |
RefSeqi | NP_001028196.1, NM_001033024.1 [Q9Y3I1-2] NP_001244919.1, NM_001257990.1 [Q9Y3I1-3] NP_036311.3, NM_012179.3 [Q9Y3I1-1] |
Genome annotation databases
Ensembli | ENST00000266087; ENSP00000266087; ENSG00000100225 [Q9Y3I1-1] ENST00000397426; ENSP00000380571; ENSG00000100225 [Q9Y3I1-3] ENST00000452138; ENSP00000388547; ENSG00000100225 [Q9Y3I1-2] |
GeneIDi | 25793 |
KEGGi | hsa:25793 |
UCSCi | uc003amq.4, human [Q9Y3I1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF233225 mRNA Translation: AAF67155.1 AL050254 mRNA Translation: CAB43356.1 CR456491 mRNA Translation: CAG30377.1 AK297841 mRNA Translation: BAG60175.1 AK301716 mRNA Translation: BAG63187.1 AL021937 Genomic DNA No translation available. AL035068 Genomic DNA No translation available. Z71183 Genomic DNA No translation available. BC008361 mRNA Translation: AAH08361.1 AF129537 mRNA Translation: AAF04471.1 Different initiation. |
CCDSi | CCDS13907.1 [Q9Y3I1-1] CCDS46695.1 [Q9Y3I1-2] CCDS58806.1 [Q9Y3I1-3] |
RefSeqi | NP_001028196.1, NM_001033024.1 [Q9Y3I1-2] NP_001244919.1, NM_001257990.1 [Q9Y3I1-3] NP_036311.3, NM_012179.3 [Q9Y3I1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4L9C | X-ray | 2.10 | A/B | 180-335 | [»] | |
4L9H | X-ray | 2.00 | A | 180-335 | [»] | |
SMRi | Q9Y3I1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117326, 536 interactors |
DIPi | DIP-36125N |
IntActi | Q9Y3I1, 65 interactors |
MINTi | Q9Y3I1 |
STRINGi | 9606.ENSP00000266087 |
PTM databases
iPTMneti | Q9Y3I1 |
PhosphoSitePlusi | Q9Y3I1 |
SwissPalmi | Q9Y3I1 |
Polymorphism and mutation databases
BioMutai | FBXO7 |
DMDMi | 13124249 |
Proteomic databases
EPDi | Q9Y3I1 |
jPOSTi | Q9Y3I1 |
MassIVEi | Q9Y3I1 |
PaxDbi | Q9Y3I1 |
PeptideAtlasi | Q9Y3I1 |
PRIDEi | Q9Y3I1 |
ProteomicsDBi | 65179 86039 [Q9Y3I1-1] 86040 [Q9Y3I1-2] |
Protocols and materials databases
Antibodypediai | 25270, 166 antibodies |
DNASUi | 25793 |
Genome annotation databases
Ensembli | ENST00000266087; ENSP00000266087; ENSG00000100225 [Q9Y3I1-1] ENST00000397426; ENSP00000380571; ENSG00000100225 [Q9Y3I1-3] ENST00000452138; ENSP00000388547; ENSG00000100225 [Q9Y3I1-2] |
GeneIDi | 25793 |
KEGGi | hsa:25793 |
UCSCi | uc003amq.4, human [Q9Y3I1-1] |
Organism-specific databases
CTDi | 25793 |
DisGeNETi | 25793 |
EuPathDBi | HostDB:ENSG00000100225.17 |
GeneCardsi | FBXO7 |
GeneReviewsi | FBXO7 |
HGNCi | HGNC:13586, FBXO7 |
HPAi | ENSG00000100225, Low tissue specificity |
MalaCardsi | FBXO7 |
MIMi | 260300, phenotype 605648, gene |
neXtProti | NX_Q9Y3I1 |
OpenTargetsi | ENSG00000100225 |
Orphaneti | 171695, Parkinsonian-pyramidal syndrome |
PharmGKBi | PA28047 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTNJ, Eukaryota |
GeneTreei | ENSGT00390000006670 |
HOGENOMi | CLU_039588_0_0_1 |
InParanoidi | Q9Y3I1 |
OMAi | ICLVLED |
OrthoDBi | 999024at2759 |
PhylomeDBi | Q9Y3I1 |
TreeFami | TF329830 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
PathwayCommonsi | Q9Y3I1 |
Reactomei | R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 25793, 30 hits in 849 CRISPR screens |
ChiTaRSi | FBXO7, human |
GeneWikii | FBXO7 |
GenomeRNAii | 25793 |
Pharosi | Q9Y3I1, Tbio |
PROi | PR:Q9Y3I1 |
RNActi | Q9Y3I1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100225, Expressed in bone marrow and 243 other tissues |
ExpressionAtlasi | Q9Y3I1, baseline and differential |
Genevisiblei | Q9Y3I1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR021625, PI31_Prot_N IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF12937, F-box-like, 1 hit PF11566, PI31_Prot_N, 1 hit |
SMARTi | View protein in SMART SM00256, FBOX, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBX7_HUMAN | |
Accessioni | Q9Y3I1Primary (citable) accession number: Q9Y3I1 Secondary accession number(s): B4DNB3 Q9UKT2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations