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Protein

Vesicle transport protein GOT1B

Gene

GOLT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle transport protein GOT1B
Alternative name(s):
Germ cell tumor 2
Golgi transport 1 homolog B
Putative NF-kappa-B-activating protein 470
hGOT1a
Gene namesi
Name:GOLT1B
Synonyms:GCT2, GOT1A
ORF Names:CGI-141, HDCMA39P, UNQ432/PRO793
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111711.9
HGNCiHGNC:20175 GOLT1B
MIMi615078 gene
neXtProtiNX_Q9Y3E0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 32LumenalSequence analysis2
Transmembranei33 – 53Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini54 – 68CytoplasmicSequence analysisAdd BLAST15
Transmembranei69 – 89Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini90LumenalSequence analysis1
Transmembranei91 – 109Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini110 – 138CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51026
OpenTargetsiENSG00000111711
PharmGKBiPA134898810

Polymorphism and mutation databases

BioMutaiGOLT1B
DMDMi20534680

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002185821 – 138Vesicle transport protein GOT1BAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y3E0
MaxQBiQ9Y3E0
PaxDbiQ9Y3E0
PeptideAtlasiQ9Y3E0
PRIDEiQ9Y3E0
ProteomicsDBi86027
TopDownProteomicsiQ9Y3E0

PTM databases

iPTMnetiQ9Y3E0
PhosphoSitePlusiQ9Y3E0

Expressioni

Tissue specificityi

Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.1 Publication

Gene expression databases

BgeeiENSG00000111711 Expressed in 222 organ(s), highest expression level in secondary oocyte
CleanExiHS_GOLT1B
ExpressionAtlasiQ9Y3E0 baseline and differential
GenevisibleiQ9Y3E0 HS

Organism-specific databases

HPAiHPA055909
HPA066383

Interactioni

Protein-protein interaction databases

BioGridi119232, 178 interactors
IntActiQ9Y3E0, 188 interactors
MINTiQ9Y3E0
STRINGi9606.ENSP00000229314

Structurei

3D structure databases

ProteinModelPortaliQ9Y3E0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 108Phe-richAdd BLAST92

Sequence similaritiesi

Belongs to the GOT1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1743 Eukaryota
COG5120 LUCA
GeneTreeiENSGT00390000014507
HOGENOMiHOG000035939
HOVERGENiHBG009362
InParanoidiQ9Y3E0
OMAiFYFFARK
OrthoDBiEOG091G10MS
PhylomeDBiQ9Y3E0
TreeFamiTF300267

Family and domain databases

InterProiView protein in InterPro
IPR007305 Vesicle_transpt_Got1/SFT2
PfamiView protein in Pfam
PF04178 Got1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y3E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISLTDTQKI GMGLTGFGVF FLFFGMILFF DKALLAIGNV LFVAGLAFVI
60 70 80 90 100
GLERTFRFFF QKHKMKATGF FLGGVFVVLI GWPLIGMIFE IYGFFLLFRG
110 120 130
FFPVVVGFIR RVPVLGSLLN LPGIRSFVDK VGESNNMV
Length:138
Mass (Da):15,426
Last modified:November 1, 1999 - v1
Checksum:i2EB85823C34EFAFA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H6U7F5H6U7_HUMAN
Vesicle transport protein GOT1B
GOLT1B
128Annotation score:
G3V1U5G3V1U5_HUMAN
Golgi transport 1 homolog B (S. cer...
GOLT1B hCG_25051
74Annotation score:
F5GWD8F5GWD8_HUMAN
Vesicle transport protein GOT1B
GOLT1B
40Annotation score:
F5GXH6F5GXH6_HUMAN
Vesicle transport protein GOT1B
GOLT1B
42Annotation score:

Sequence cautioni

The sequence AAF65181 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37I → T in AAF65181 (Ref. 5) Curated1
Sequence conflicti54R → K in CAG33670 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151899 mRNA Translation: AAD34136.1
AL136571 mRNA Translation: CAB66506.1
AB097020 mRNA Translation: BAC77373.1
AY358975 mRNA Translation: AAQ89334.1
AF068292 mRNA Translation: AAF65181.1 Different initiation.
CR457389 mRNA Translation: CAG33670.1
AK311920 mRNA Translation: BAG34861.1
CH471094 Genomic DNA Translation: EAW96443.1
BC012455 mRNA Translation: AAH12455.1
CCDSiCCDS8689.1
PIRiT46908
RefSeqiNP_057156.1, NM_016072.4
UniGeneiHs.62275

Genome annotation databases

EnsembliENST00000229314; ENSP00000229314; ENSG00000111711
GeneIDi51026
KEGGihsa:51026
UCSCiuc001rez.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151899 mRNA Translation: AAD34136.1
AL136571 mRNA Translation: CAB66506.1
AB097020 mRNA Translation: BAC77373.1
AY358975 mRNA Translation: AAQ89334.1
AF068292 mRNA Translation: AAF65181.1 Different initiation.
CR457389 mRNA Translation: CAG33670.1
AK311920 mRNA Translation: BAG34861.1
CH471094 Genomic DNA Translation: EAW96443.1
BC012455 mRNA Translation: AAH12455.1
CCDSiCCDS8689.1
PIRiT46908
RefSeqiNP_057156.1, NM_016072.4
UniGeneiHs.62275

3D structure databases

ProteinModelPortaliQ9Y3E0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119232, 178 interactors
IntActiQ9Y3E0, 188 interactors
MINTiQ9Y3E0
STRINGi9606.ENSP00000229314

PTM databases

iPTMnetiQ9Y3E0
PhosphoSitePlusiQ9Y3E0

Polymorphism and mutation databases

BioMutaiGOLT1B
DMDMi20534680

Proteomic databases

EPDiQ9Y3E0
MaxQBiQ9Y3E0
PaxDbiQ9Y3E0
PeptideAtlasiQ9Y3E0
PRIDEiQ9Y3E0
ProteomicsDBi86027
TopDownProteomicsiQ9Y3E0

Protocols and materials databases

DNASUi51026
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229314; ENSP00000229314; ENSG00000111711
GeneIDi51026
KEGGihsa:51026
UCSCiuc001rez.3 human

Organism-specific databases

CTDi51026
DisGeNETi51026
EuPathDBiHostDB:ENSG00000111711.9
GeneCardsiGOLT1B
HGNCiHGNC:20175 GOLT1B
HPAiHPA055909
HPA066383
MIMi615078 gene
neXtProtiNX_Q9Y3E0
OpenTargetsiENSG00000111711
PharmGKBiPA134898810
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1743 Eukaryota
COG5120 LUCA
GeneTreeiENSGT00390000014507
HOGENOMiHOG000035939
HOVERGENiHBG009362
InParanoidiQ9Y3E0
OMAiFYFFARK
OrthoDBiEOG091G10MS
PhylomeDBiQ9Y3E0
TreeFamiTF300267

Miscellaneous databases

GeneWikiiGOLT1B
GenomeRNAii51026
PROiPR:Q9Y3E0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111711 Expressed in 222 organ(s), highest expression level in secondary oocyte
CleanExiHS_GOLT1B
ExpressionAtlasiQ9Y3E0 baseline and differential
GenevisibleiQ9Y3E0 HS

Family and domain databases

InterProiView protein in InterPro
IPR007305 Vesicle_transpt_Got1/SFT2
PfamiView protein in Pfam
PF04178 Got1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOT1B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3E0
Secondary accession number(s): B2R4R4
, Q54A40, Q6I9W6, Q9P1R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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