UniProtKB - Q9Y3D3 (RT16_HUMAN)
28S ribosomal protein S16, mitochondrial
MRPS16
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- mitochondrial translation Source: UniProtKB
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
- translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3D3 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q9Y3D3 |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S16, mitochondrialShort name: MRP-S16 Short name: S16mt Alternative name(s): Mitochondrial small ribosomal subunit protein bS16m1 Publication |
Gene namesi | Name:MRPS16 Synonyms:RPMS16 ORF Names:CGI-132 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14048, MRPS16 |
MIMi | 609204, gene |
neXtProti | NX_Q9Y3D3 |
VEuPathDBi | HostDB:ENSG00000182180.13 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Cytosol
- cytosol Source: HPA
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial small ribosomal subunit Source: UniProtKB
- mitochondrion Source: HPA
Other locations
- small ribosomal subunit Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Combined oxidative phosphorylation deficiency 2 (COXPD2)1 Publication
Keywords - Diseasei
Primary mitochondrial diseaseOrganism-specific databases
DisGeNETi | 51021 |
MalaCardsi | MRPS16 |
MIMi | 610498, phenotype |
OpenTargetsi | ENSG00000182180 |
Orphaneti | 254920, Combined oxidative phosphorylation defect type 2 |
PharmGKBi | PA31000 |
Miscellaneous databases
Pharosi | Q9Y3D3, Tbio |
Genetic variation databases
BioMutai | MRPS16 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | MitochondrionSequence analysisAdd BLAST | 34 | |
ChainiPRO_0000030618 | 35 – 137 | 28S ribosomal protein S16, mitochondrialAdd BLAST | 103 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 130 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y3D3 |
jPOSTi | Q9Y3D3 |
MassIVEi | Q9Y3D3 |
PaxDbi | Q9Y3D3 |
PeptideAtlasi | Q9Y3D3 |
PRIDEi | Q9Y3D3 |
ProteomicsDBi | 5646 86020 [Q9Y3D3-1] |
PTM databases
iPTMneti | Q9Y3D3 |
PhosphoSitePlusi | Q9Y3D3 |
SwissPalmi | Q9Y3D3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182180, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | Q9Y3D3, baseline and differential |
Genevisiblei | Q9Y3D3, HS |
Organism-specific databases
HPAi | ENSG00000182180, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS16m has a zinc binding site.
1 PublicationProtein-protein interaction databases
BioGRIDi | 119227, 129 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y3D3 |
IntActi | Q9Y3D3, 31 interactors |
MINTi | Q9Y3D3 |
STRINGi | 9606.ENSP00000362036 |
Miscellaneous databases
RNActi | Q9Y3D3, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3419, Eukaryota |
GeneTreei | ENSGT00390000014309 |
HOGENOMi | CLU_100590_4_0_1 |
InParanoidi | Q9Y3D3 |
OMAi | YHGGHVV |
OrthoDBi | 1630052at2759 |
PhylomeDBi | Q9Y3D3 |
TreeFami | TF105637 |
Family and domain databases
Gene3Di | 3.30.1320.10, 1 hit |
HAMAPi | MF_00385, Ribosomal_S16, 1 hit |
InterProi | View protein in InterPro IPR000307, Ribosomal_S16 IPR023803, Ribosomal_S16_dom_sf |
PANTHERi | PTHR12919, PTHR12919, 1 hit |
Pfami | View protein in Pfam PF00886, Ribosomal_S16, 1 hit |
SUPFAMi | SSF54565, SSF54565, 1 hit |
TIGRFAMsi | TIGR00002, S16, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ
60 70 80 90 100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH
110 120 130
PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA6ND22 | A6ND22_HUMAN | 28S ribosomal protein S16, mitochon... | MRPS16 | 99 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031525 | 12 | Y → H. Corresponds to variant dbSNP:rs7905009EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056498 | 93 – 137 | LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151890 mRNA Translation: AAD34127.1 AB049948 mRNA Translation: BAB41001.1 AK303204 mRNA Translation: BAG64294.1 AC016394 Genomic DNA No translation available. BC021106 mRNA Translation: AAH21106.1 AB051351 Genomic DNA Translation: BAB54941.1 |
CCDSi | CCDS7323.1 [Q9Y3D3-1] |
RefSeqi | NP_057149.1, NM_016065.3 [Q9Y3D3-1] |
Genome annotation databases
Ensembli | ENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1] |
GeneIDi | 51021 |
KEGGi | hsa:51021 |
UCSCi | uc001jts.1, human [Q9Y3D3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151890 mRNA Translation: AAD34127.1 AB049948 mRNA Translation: BAB41001.1 AK303204 mRNA Translation: BAG64294.1 AC016394 Genomic DNA No translation available. BC021106 mRNA Translation: AAH21106.1 AB051351 Genomic DNA Translation: BAB54941.1 |
CCDSi | CCDS7323.1 [Q9Y3D3-1] |
RefSeqi | NP_057149.1, NM_016065.3 [Q9Y3D3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J9M | electron microscopy | 3.50 | AM | 1-137 | [»] | |
6NU2 | electron microscopy | 3.90 | AM | 10-125 | [»] | |
6NU3 | electron microscopy | 4.40 | AM | 1-137 | [»] | |
6RW4 | electron microscopy | 2.97 | M | 1-137 | [»] | |
6RW5 | electron microscopy | 3.14 | M | 1-137 | [»] | |
6VLZ | electron microscopy | 2.97 | AM | 1-137 | [»] | |
6VMI | electron microscopy | 2.96 | AM | 1-137 | [»] | |
6ZM5 | electron microscopy | 2.89 | AM | 1-137 | [»] | |
6ZM6 | electron microscopy | 2.59 | AM | 1-137 | [»] | |
6ZS9 | electron microscopy | 4.00 | AM | 1-137 | [»] | |
6ZSA | electron microscopy | 4.00 | AM | 1-136 | [»] | |
6ZSB | electron microscopy | 4.50 | AM | 1-137 | [»] | |
6ZSC | electron microscopy | 3.50 | AM | 1-137 | [»] | |
6ZSD | electron microscopy | 3.70 | AM | 1-137 | [»] | |
6ZSE | electron microscopy | 5.00 | AM | 1-137 | [»] | |
6ZSG | electron microscopy | 4.00 | AM | 1-137 | [»] | |
7A5F | electron microscopy | 4.40 | M6 | 1-137 | [»] | |
7A5G | electron microscopy | 4.33 | M6 | 1-137 | [»] | |
7A5I | electron microscopy | 3.70 | M6 | 1-137 | [»] | |
7A5K | electron microscopy | 3.70 | M6 | 1-137 | [»] | |
SMRi | Q9Y3D3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119227, 129 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y3D3 |
IntActi | Q9Y3D3, 31 interactors |
MINTi | Q9Y3D3 |
STRINGi | 9606.ENSP00000362036 |
PTM databases
iPTMneti | Q9Y3D3 |
PhosphoSitePlusi | Q9Y3D3 |
SwissPalmi | Q9Y3D3 |
Genetic variation databases
BioMutai | MRPS16 |
Proteomic databases
EPDi | Q9Y3D3 |
jPOSTi | Q9Y3D3 |
MassIVEi | Q9Y3D3 |
PaxDbi | Q9Y3D3 |
PeptideAtlasi | Q9Y3D3 |
PRIDEi | Q9Y3D3 |
ProteomicsDBi | 5646 86020 [Q9Y3D3-1] |
Protocols and materials databases
Antibodypediai | 45368, 116 antibodies |
DNASUi | 51021 |
Genome annotation databases
Ensembli | ENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1] |
GeneIDi | 51021 |
KEGGi | hsa:51021 |
UCSCi | uc001jts.1, human [Q9Y3D3-1] |
Organism-specific databases
CTDi | 51021 |
DisGeNETi | 51021 |
GeneCardsi | MRPS16 |
HGNCi | HGNC:14048, MRPS16 |
HPAi | ENSG00000182180, Low tissue specificity |
MalaCardsi | MRPS16 |
MIMi | 609204, gene 610498, phenotype |
neXtProti | NX_Q9Y3D3 |
OpenTargetsi | ENSG00000182180 |
Orphaneti | 254920, Combined oxidative phosphorylation defect type 2 |
PharmGKBi | PA31000 |
VEuPathDBi | HostDB:ENSG00000182180.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3419, Eukaryota |
GeneTreei | ENSGT00390000014309 |
HOGENOMi | CLU_100590_4_0_1 |
InParanoidi | Q9Y3D3 |
OMAi | YHGGHVV |
OrthoDBi | 1630052at2759 |
PhylomeDBi | Q9Y3D3 |
TreeFami | TF105637 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y3D3 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q9Y3D3 |
Miscellaneous databases
BioGRID-ORCSi | 51021, 425 hits in 1009 CRISPR screens |
ChiTaRSi | MRPS16, human |
GeneWikii | MRPS16 |
GenomeRNAii | 51021 |
Pharosi | Q9Y3D3, Tbio |
PROi | PR:Q9Y3D3 |
RNActi | Q9Y3D3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182180, Expressed in left adrenal gland and 216 other tissues |
ExpressionAtlasi | Q9Y3D3, baseline and differential |
Genevisiblei | Q9Y3D3, HS |
Family and domain databases
Gene3Di | 3.30.1320.10, 1 hit |
HAMAPi | MF_00385, Ribosomal_S16, 1 hit |
InterProi | View protein in InterPro IPR000307, Ribosomal_S16 IPR023803, Ribosomal_S16_dom_sf |
PANTHERi | PTHR12919, PTHR12919, 1 hit |
Pfami | View protein in Pfam PF00886, Ribosomal_S16, 1 hit |
SUPFAMi | SSF54565, SSF54565, 1 hit |
TIGRFAMsi | TIGR00002, S16, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RT16_HUMAN | |
Accessioni | Q9Y3D3Primary (citable) accession number: Q9Y3D3 Secondary accession number(s): B4E032, Q96Q60 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 27, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families