MRPS16

Functionⁱ

GO - Molecular functionⁱ

structural constituent of ribosome
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11402041

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translation
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 11402041
mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome
translation
Source: UniProtKB
Non-traceable author statementⁱ
- 11279123

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 28S ribosomal protein S16, mitochondrial Short name: MRP-S16 Short name: S16mt Alternative name(s): Mitochondrial small ribosomal subunit protein bS16m1 Publication
Gene namesⁱ	Name:MRPS16 Synonyms:RPMS16 ORF Names:CGI-132
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182180.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14048 MRPS16
MIMⁱ	609204 gene
neXtProtⁱ	NX_Q9Y3D3

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Combined oxidative phosphorylation deficiency 2 (COXPD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.

Keywords - Diseaseⁱ

Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51021
MalaCards human disease database More...MalaCardsⁱ	MRPS16
MIMⁱ	610498 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000182180
Orphanetⁱ	254920 Combined oxidative phosphorylation defect type 2
PharmGKBⁱ	PA31000

Polymorphism and mutation databases

BioMutaⁱ	MRPS16

BioMutaⁱ

MRPS16

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 34	MitochondrionSequence analysisAdd BLAST		34
ChainⁱPRO_0000030618	35 – 137	28S ribosomal protein S16, mitochondrialAdd BLAST		103

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	130	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y3D3
PaxDbⁱ	Q9Y3D3
PeptideAtlas More...PeptideAtlasⁱ	Q9Y3D3
PRIDEⁱ	Q9Y3D3
ProteomicsDBⁱ	86020

PTM databases

iPTMnetⁱ	Q9Y3D3
PhosphoSitePlusⁱ	Q9Y3D3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000182180 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MRPS16
ExpressionAtlasⁱ	Q9Y3D3 baseline and differential
Genevisibleⁱ	Q9Y3D3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA050081 HPA054538

HPAⁱ

HPA050081
HPA054538

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS16m has a zinc binding site.1 Publication

Protein-protein interaction databases

BioGridⁱ	119227, 42 interactors
CORUMⁱ	Q9Y3D3
IntActⁱ	Q9Y3D3, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y3D3
STRINGⁱ	9606.ENSP00000362036

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y3D3
SMRⁱ	Q9Y3D3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the bacterial ribosomal protein bS16 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3419 Eukaryota COG0228 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014309
HOGENOMⁱ	HOG000246720
HOVERGENⁱ	HBG017758
InParanoidⁱ	Q9Y3D3
KEGG Orthology (KO) More...KOⁱ	K02959
OMAⁱ	YNKRARD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15N9
PhylomeDBⁱ	Q9Y3D3
TreeFamⁱ	TF105637

Family and domain databases

Gene3Dⁱ	3.30.1320.10, 1 hit
HAMAPⁱ	MF_00385 Ribosomal_S16, 1 hit
InterProⁱ	View protein in InterPro IPR000307 Ribosomal_S16 IPR023803 Ribosomal_S16_dom_sf
PANTHERⁱ	PTHR12919 PTHR12919, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00886 Ribosomal_S16, 1 hit
SUPFAMⁱ	SSF54565 SSF54565, 1 hit
TIGRFAMsⁱ	TIGR00002 S16, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y3D3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ 
        60         70         80         90        100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH 
       110        120        130 
PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET

Length:137

Mass (Da):15,345

Last modified:November 1, 1999 - v1

Checksum:ⁱC12B14B1B357F8D6

GO

Isoform 2 (identifier: Q9Y3D3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
93-137: LAGFFPLHPM...EATDTEATET → KTDARFPEQGEERPEQHHFPEDLAPARGRGL

« Hide

        10         20         30         40         50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ 
        60         70         80         90        100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGKTDARFPE 
       110        120 
QGEERPEQHH FPEDLAPARG RGL

Note: No experimental confirmation available.

Show »

Length:123

Mass (Da):13,829

Checksum:ⁱ7F07429818B68914

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A6ND22	A6ND22_HUMAN		28S ribosomal protein S16, mitochon... 28S ribosomal protein S16, mitochondrial	MRPS16	99	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031525	12	Y → H. Corresponds to variant dbSNP:rs7905009EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056498	93 – 137	LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationAdd BLAST		45

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151890 mRNA Translation: AAD34127.1 AB049948 mRNA Translation: BAB41001.1 AK303204 mRNA Translation: BAG64294.1 AC016394 Genomic DNA No translation available. BC021106 mRNA Translation: AAH21106.1 AB051351 Genomic DNA Translation: BAB54941.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7323.1 [Q9Y3D3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_057149.1, NM_016065.3 [Q9Y3D3-1]
UniGeneⁱ	Hs.180312

Genome annotation databases

Ensemblⁱ	ENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1]
GeneIDⁱ	51021
KEGGⁱ	hsa:51021
UCSC genome browser More...UCSCⁱ	uc001jts.1 human [Q9Y3D3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3D3	MRPS16 isoform 1		PANTR		137	UniRef100_Q9Y3D3
Uncharacterized protein		PANPA		137
Uncharacterized protein		NOMLE		137
Mitochondrial ribosomal protein S16		GORGO		137

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3D3	28S ribosomal protein S16, mitochondrial		MOUSE		135	UniRef90_Q9Y3D3
MRPS16 isoform 1		PANTR		137
Uncharacterized protein		PANPA		137
Uncharacterized protein		NOMLE		137
Mitochondrial ribosomal protein S16		GORGO		137
+10
Q9Y3D3-2	Mitochondrial ribosomal protein S16		SAIBB		99	UniRef90_Q9Y3D3-2
Uncharacterized protein		AOTNA		99
28S ribosomal protein S16, mitochondrial		HUMAN		99
MRPS16 isoform 2		PONAB		99
MRPS16 isoform 2		PANTR		99
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9Y3D3	28S ribosomal protein S16, mitochondrial		MOUSE		135	UniRef50_Q9Y3D3
28S ribosomal protein S16, mitochondrial	)	BOVIN		135
MRPS16 isoform 1		PANTR		137
Uncharacterized protein		PANPA		137
Uncharacterized protein		NOMLE		137
+75
Q9Y3D3-2	28S ribosomal protein S16, mitochondrial		PONAB		137	UniRef50_Q9Y3D3-2
Mitochondrial ribosomal protein S16		SAIBB		99
Uncharacterized protein		CALJA		99
Uncharacterized protein		AOTNA		99
28S ribosomal protein S16, mitochondrial		HUMAN		99
+164

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151890 mRNA Translation: AAD34127.1 AB049948 mRNA Translation: BAB41001.1 AK303204 mRNA Translation: BAG64294.1 AC016394 Genomic DNA No translation available. BC021106 mRNA Translation: AAH21106.1 AB051351 Genomic DNA Translation: BAB54941.1
CCDSⁱ	CCDS7323.1 [Q9Y3D3-1]
RefSeqⁱ	NP_057149.1, NM_016065.3 [Q9Y3D3-1]
UniGeneⁱ	Hs.180312

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J9M	electron microscopy	3.50	AM	1-137	[»]
ProteinModelPortalⁱ	Q9Y3D3
SMRⁱ	Q9Y3D3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119227, 42 interactors
CORUMⁱ	Q9Y3D3
IntActⁱ	Q9Y3D3, 17 interactors
MINTⁱ	Q9Y3D3
STRINGⁱ	9606.ENSP00000362036

PTM databases

iPTMnetⁱ	Q9Y3D3
PhosphoSitePlusⁱ	Q9Y3D3

Polymorphism and mutation databases

BioMutaⁱ	MRPS16

BioMutaⁱ

MRPS16

Proteomic databases

EPDⁱ	Q9Y3D3
PaxDbⁱ	Q9Y3D3
PeptideAtlasⁱ	Q9Y3D3
PRIDEⁱ	Q9Y3D3
ProteomicsDBⁱ	86020

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51021
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1]
GeneIDⁱ	51021
KEGGⁱ	hsa:51021
UCSCⁱ	uc001jts.1 human [Q9Y3D3-1]

Organism-specific databases

CTDⁱ	51021
DisGeNETⁱ	51021
EuPathDBⁱ	HostDB:ENSG00000182180.13
GeneCardsⁱ	MRPS16
HGNCⁱ	HGNC:14048 MRPS16
HPAⁱ	HPA050081 HPA054538
MalaCardsⁱ	MRPS16
MIMⁱ	609204 gene 610498 phenotype
neXtProtⁱ	NX_Q9Y3D3
OpenTargetsⁱ	ENSG00000182180
Orphanetⁱ	254920 Combined oxidative phosphorylation defect type 2
PharmGKBⁱ	PA31000
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3419 Eukaryota COG0228 LUCA
GeneTreeⁱ	ENSGT00390000014309
HOGENOMⁱ	HOG000246720
HOVERGENⁱ	HBG017758
InParanoidⁱ	Q9Y3D3
KOⁱ	K02959
OMAⁱ	YNKRARD
OrthoDBⁱ	EOG091G15N9
PhylomeDBⁱ	Q9Y3D3
TreeFamⁱ	TF105637

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPS16 human
GeneWikiⁱ	MRPS16
GenomeRNAiⁱ	51021
Protein Ontology More...PROⁱ	PR:Q9Y3D3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182180 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_MRPS16
ExpressionAtlasⁱ	Q9Y3D3 baseline and differential
Genevisibleⁱ	Q9Y3D3 HS

Family and domain databases

Gene3Dⁱ	3.30.1320.10, 1 hit
HAMAPⁱ	MF_00385 Ribosomal_S16, 1 hit
InterProⁱ	View protein in InterPro IPR000307 Ribosomal_S16 IPR023803 Ribosomal_S16_dom_sf
PANTHERⁱ	PTHR12919 PTHR12919, 1 hit
Pfamⁱ	View protein in Pfam PF00886 Ribosomal_S16, 1 hit
SUPFAMⁱ	SSF54565 SSF54565, 1 hit
TIGRFAMsⁱ	TIGR00002 S16, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RT16_HUMAN
Accessionⁱ	Q9Y3D3Primary (citable) accession number: Q9Y3D3 Secondary accession number(s): B4E032, Q96Q60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Ribosomal proteins
Ribosomal proteins families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9Y3D3 (RT16_HUMAN)

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28S ribosomal protein S16, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytosol

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ