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Protein

28S ribosomal protein S16, mitochondrial

Gene

MRPS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S16, mitochondrial
Short name:
MRP-S16
Short name:
S16mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein bS16m1 Publication
Gene namesi
Name:MRPS16
Synonyms:RPMS16
ORF Names:CGI-132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000182180.13
HGNCiHGNC:14048 MRPS16
MIMi609204 gene
neXtProtiNX_Q9Y3D3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Combined oxidative phosphorylation deficiency 2 (COXPD2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum.
See also OMIM:610498

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNETi51021
MalaCardsiMRPS16
MIMi610498 phenotype
OpenTargetsiENSG00000182180
Orphaneti254920 Combined oxidative phosphorylation defect type 2
PharmGKBiPA31000

Polymorphism and mutation databases

BioMutaiMRPS16

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
ChainiPRO_000003061835 – 13728S ribosomal protein S16, mitochondrialAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y3D3
PaxDbiQ9Y3D3
PeptideAtlasiQ9Y3D3
PRIDEiQ9Y3D3
ProteomicsDBi86020

PTM databases

iPTMnetiQ9Y3D3
PhosphoSitePlusiQ9Y3D3

Expressioni

Gene expression databases

BgeeiENSG00000182180 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExiHS_MRPS16
ExpressionAtlasiQ9Y3D3 baseline and differential
GenevisibleiQ9Y3D3 HS

Organism-specific databases

HPAiHPA050081
HPA054538

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS16m has a zinc binding site.1 Publication

Protein-protein interaction databases

BioGridi119227, 42 interactors
CORUMiQ9Y3D3
IntActiQ9Y3D3, 17 interactors
MINTiQ9Y3D3
STRINGi9606.ENSP00000362036

Structurei

3D structure databases

ProteinModelPortaliQ9Y3D3
SMRiQ9Y3D3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3419 Eukaryota
COG0228 LUCA
GeneTreeiENSGT00390000014309
HOGENOMiHOG000246720
HOVERGENiHBG017758
InParanoidiQ9Y3D3
KOiK02959
OMAiYNKRARD
OrthoDBiEOG091G15N9
PhylomeDBiQ9Y3D3
TreeFamiTF105637

Family and domain databases

Gene3Di3.30.1320.10, 1 hit
HAMAPiMF_00385 Ribosomal_S16, 1 hit
InterProiView protein in InterPro
IPR000307 Ribosomal_S16
IPR023803 Ribosomal_S16_dom_sf
PANTHERiPTHR12919 PTHR12919, 1 hit
PfamiView protein in Pfam
PF00886 Ribosomal_S16, 1 hit
SUPFAMiSSF54565 SSF54565, 1 hit
TIGRFAMsiTIGR00002 S16, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y3D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ
60 70 80 90 100
LGSYDPLPNS HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH
110 120 130
PMMITNAERL RRKRAREVLL ASQKTDAEAT DTEATET
Length:137
Mass (Da):15,345
Last modified:November 1, 1999 - v1
Checksum:iC12B14B1B357F8D6
GO
Isoform 2 (identifier: Q9Y3D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-137: LAGFFPLHPM...EATDTEATET → KTDARFPEQGEERPEQHHFPEDLAPARGRGL

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,829
Checksum:i7F07429818B68914
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6ND22A6ND22_HUMAN
28S ribosomal protein S16, mitochon...
MRPS16
99Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03152512Y → H. Corresponds to variant dbSNP:rs7905009EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05649893 – 137LAGFF…EATET → KTDARFPEQGEERPEQHHFP EDLAPARGRGL in isoform 2. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA Translation: AAD34127.1
AB049948 mRNA Translation: BAB41001.1
AK303204 mRNA Translation: BAG64294.1
AC016394 Genomic DNA No translation available.
BC021106 mRNA Translation: AAH21106.1
AB051351 Genomic DNA Translation: BAB54941.1
CCDSiCCDS7323.1 [Q9Y3D3-1]
RefSeqiNP_057149.1, NM_016065.3 [Q9Y3D3-1]
UniGeneiHs.180312

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1]
GeneIDi51021
KEGGihsa:51021
UCSCiuc001jts.1 human [Q9Y3D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151890 mRNA Translation: AAD34127.1
AB049948 mRNA Translation: BAB41001.1
AK303204 mRNA Translation: BAG64294.1
AC016394 Genomic DNA No translation available.
BC021106 mRNA Translation: AAH21106.1
AB051351 Genomic DNA Translation: BAB54941.1
CCDSiCCDS7323.1 [Q9Y3D3-1]
RefSeqiNP_057149.1, NM_016065.3 [Q9Y3D3-1]
UniGeneiHs.180312

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AM1-137[»]
ProteinModelPortaliQ9Y3D3
SMRiQ9Y3D3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119227, 42 interactors
CORUMiQ9Y3D3
IntActiQ9Y3D3, 17 interactors
MINTiQ9Y3D3
STRINGi9606.ENSP00000362036

PTM databases

iPTMnetiQ9Y3D3
PhosphoSitePlusiQ9Y3D3

Polymorphism and mutation databases

BioMutaiMRPS16

Proteomic databases

EPDiQ9Y3D3
PaxDbiQ9Y3D3
PeptideAtlasiQ9Y3D3
PRIDEiQ9Y3D3
ProteomicsDBi86020

Protocols and materials databases

DNASUi51021
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372945; ENSP00000362036; ENSG00000182180 [Q9Y3D3-1]
GeneIDi51021
KEGGihsa:51021
UCSCiuc001jts.1 human [Q9Y3D3-1]

Organism-specific databases

CTDi51021
DisGeNETi51021
EuPathDBiHostDB:ENSG00000182180.13
GeneCardsiMRPS16
HGNCiHGNC:14048 MRPS16
HPAiHPA050081
HPA054538
MalaCardsiMRPS16
MIMi609204 gene
610498 phenotype
neXtProtiNX_Q9Y3D3
OpenTargetsiENSG00000182180
Orphaneti254920 Combined oxidative phosphorylation defect type 2
PharmGKBiPA31000
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3419 Eukaryota
COG0228 LUCA
GeneTreeiENSGT00390000014309
HOGENOMiHOG000246720
HOVERGENiHBG017758
InParanoidiQ9Y3D3
KOiK02959
OMAiYNKRARD
OrthoDBiEOG091G15N9
PhylomeDBiQ9Y3D3
TreeFamiTF105637

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS16 human
GeneWikiiMRPS16
GenomeRNAii51021
PROiPR:Q9Y3D3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182180 Expressed in 204 organ(s), highest expression level in left adrenal gland
CleanExiHS_MRPS16
ExpressionAtlasiQ9Y3D3 baseline and differential
GenevisibleiQ9Y3D3 HS

Family and domain databases

Gene3Di3.30.1320.10, 1 hit
HAMAPiMF_00385 Ribosomal_S16, 1 hit
InterProiView protein in InterPro
IPR000307 Ribosomal_S16
IPR023803 Ribosomal_S16_dom_sf
PANTHERiPTHR12919 PTHR12919, 1 hit
PfamiView protein in Pfam
PF00886 Ribosomal_S16, 1 hit
SUPFAMiSSF54565 SSF54565, 1 hit
TIGRFAMsiTIGR00002 S16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y3D3
Secondary accession number(s): B4E032, Q96Q60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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